Abstract Number: 3215 • 2015 ACR/ARHP Annual Meeting
Bim Suppresses the Development of SLE By Limiting Macrophage Inflammatory Responses
Background/Purpose: The Bcl-2 family guards the mitochondrial apoptotic pathway. Among numerous Bcl-2 antagonists, only the loss of Bim in mice leads to the development of…Abstract Number: 1262 • 2014 ACR/ARHP Annual Meeting
Mechanisms of Muscular Necrosis in Auto-Immune Myopathies Associated with Anti-Signal Recognition Particle and Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme a Reductase Antibodies: Pathogenic Role of Auto-Antibodies
Background/Purpose: Necrotizing auto-immune myopathies (NAM) are a group of acquired idiopathic inflammatory myopathies characterized by severe muscle weakness and no or mild extra-muscular involvement. Definition of…Abstract Number: 911 • 2014 ACR/ARHP Annual Meeting
Bioluminescent Imaging of Histidyl-Transfer RNA Synthetase-Induced Myositis Reveals Early-Phase Involvement of NF-Kb-Mediated Inflammation
Background/Purpose: The idiopathic inflammatory myopathies represent a group of autoimmune diseases that target muscle as well as extra-muscular organs, leading to significant morbidity and mortality. …Abstract Number: 773 • 2014 ACR/ARHP Annual Meeting
Functional Autoantibodies from Patients with Systemic Sclerosis Reactive to Angiotensin II Type 1 and Endothelin-1 Type a Receptor Induce Inflammatory Lymphocyte Infiltration into Lungs of Mice
Background/Purpose Functional autoantibodies reactive to the angiotensin II type 1 receptor (AT1R) and endothelin 1 type A receptor (ETAR) were found in elevated levels in…Abstract Number: 1 • 2014 ACR/ARHP Annual Meeting
Lymphocyte Proliferation to a Cross-Reactive Gut Commensal Candidate in Antiphospholipid Syndrome
Background/Purpose: Antiphospholipid syndrome (APS) is an autoimmune clotting disorder of unknown etiology targeting a major autoantigen, β2-glycoprotein I (β2GPI). Infectious triggers have been implicated in…Abstract Number: 2730 • 2014 ACR/ARHP Annual Meeting
FcγRIIIa Ligation in Human Peripheral CD4+ T-Cells Generate TH17 like Population
Background/Purpose: Cytokines produced during TH17 response, IL-17A and IL17F drive inflammation and autoimmunity. They also act as a bridge between adaptive and innate immunity. Immune…Abstract Number: 2687 • 2014 ACR/ARHP Annual Meeting
Estrogen-Mediated STAT1 Activation By Estrogen Receptor a Induces TLR8 Expression: A Novel Pathogenic Mechanism in Systemic Lupus Erythematosus
Background/Purpose: Many autoimmune disorders, including Systemic Lupus Erythematosus (SLE) display female gender predominance. Previous studies have demonstrated significant hormonal contributions to SLE pathogenesis, including estrogen,…Abstract Number: 2686 • 2014 ACR/ARHP Annual Meeting
Gene Array Analysis Reveals Unique Estrogen Signature in Peripheral Blood Mononuclear Cells of Patients with Systemic Lupus Erythematosus
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune disorder predominately affecting females in the reproductive age range. Estrogen is present at higher levels in this…Abstract Number: 2530 • 2014 ACR/ARHP Annual Meeting
PRE.MARK-TNF Test Based on Iga-Specific Autoantigens Predicts Therapy Response in Rheumatoid Arthritis Patients Treated with TNFα Inhibitors
Background/Purpose One third of rheumatoid arthritis patients treated with biologicals targeting TNFα are therapy non-responders. We have earlier investigated the difference in seroreactivity of patients…Abstract Number: 2219 • 2014 ACR/ARHP Annual Meeting
Contribution of Tripartite Motif Proteins Modulating Membrane Repair to the Pathogenesis of Autoimmune-Mediated Myositis
Background/Purpose: The idiopathic inflammatory myopathies are a heterogeneous group of diseases that result in autoimmunity toward muscles and lead to tissue destruction, but the pathogenesis…Abstract Number: 2186 • 2014 ACR/ARHP Annual Meeting
Clinical and Immunologic Correlates in Cocaine Users with Serum Anti-Neutrophil Cytoplasmic Antibodies
Background/Purpose: Illicit cocaine use is associated with the development of serum anti-neutrophil cytoplasmic autoantibodies (ANCA) and a variety of clinical manifestations. However, the mechanisms linking…Abstract Number: 2162 • 2014 ACR/ARHP Annual Meeting
Immunological Abnormalities in Adult Patients with Parvovirus B19 Infection : A study of 23 Cases
Background/Purpose In adults, parvovirus B19 infection can induce joint symptoms and cutaneous manifestations which are known to be transient most of the time. It has…Abstract Number: 1472 • 2014 ACR/ARHP Annual Meeting
Synovial Fluid from Rheumatoid Arthritis Patients Modulates the Immunophenotype and Viability of Monocytes
Background/Purpose Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by infiltration of the synovium by inflammatory cells that destroys the cartilage and the…Abstract Number: 1902 • 2013 ACR/ARHP Annual Meeting
Characterization Of HLA-DRB1 Distribution By 3rd Hypervariable Region Sequence In Systemic Sclerosis and Control Populations
Background/Purpose: HLA class II genes are associated with a wide spectrum of autoimmune diseases. Specific alleles at the DRB1, DQA1 and DQB1 loci are associated…Abstract Number: 1792 • 2013 ACR/ARHP Annual Meeting
Inhibition Of Chemokine Receptors CCR1 and CCR6 As Promising Therapies For Autoimmune Diseases Such As Rheumatoid Arthritis and Psoriasis
Background/Purpose: Chemokines are key regulators of leukocyte activation and recruitment to sites of inflammation. Of particular relevance in rheumatoid arthritis (RA), the chemokine receptors CCR1…
ACR Meeting Abstracts