ACR Meeting Abstracts

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Abstracts tagged "Auto-immunity"

  • Abstract Number: 295 • 2017 ACR/ARHP Annual Meeting

    Ex Vivo Induced Neutrophil Extracellular Traps Are Intrinsically Different in Anca-Associated Vasculitis and Systemic Lupus Erythematosus

    Laura van Dam1, Tineke Kraaij1, Sylvia Kamerling1, Hans U. Scherer2, Charles Pusey3, Ton Rabelink1, Cees van Kooten1 and Onno Teng1, 1Nephrology, Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Imperial College, London, United Kingdom

    -          Background/Purpose: Neutrophil extracellular traps (NETs) are immunogenic, extracellular DNA structures that harness important autoantigens to be recognized by the adaptive immune system. NETs are…
  • Abstract Number: 112 • 2017 Pediatric Rheumatology Symposium

    Use of Rituximab and Risk of Re-hospitalization for Children with Neuromyelitis Optica Spectrum Disorder

    Sabrina Gmuca1, Amy T. Waldman2, Pamela F. Weiss3 and Jeffrey S. Gerber2, 1Pediatric Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, 2The Children's Hospital of Philadelphia, Philadelphia, PA, 3Division of Rheumatology, Center for Pediatric Clincial Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: First-line use of rituximab for neuromyelitis optica spectrum disorder (NMOSD) is common but the benefits of early immunosuppression remain unclear. We aimed to determine…
  • Abstract Number: 4 • 2016 ACR/ARHP Annual Meeting

    Rheumatoid Arthritis (RA)-Related Joint Symptoms and Thoracic Bone Mineral Density in an RA-Free Community Dwelling Population

    Jan M. Hughes-Austin1, Joachim H. Ix2, Samuel R. Ward3, M. Kristen Demoruelle4, V. Michael Holers5, Jill M. Norris6 and Kevin D. Deane7, 1Orthopaedic Surgery, University of California, San Diego, La Jolla, CA, 2University of California, San Diego, La Jolla, CA, 3Radiology, Orthopaedic Surgery, and Bioengineering, University of California, San Diego, La Jolla, CA, 41775 Aurora Ct, 1775 Aurora Ct, Aurora, CO, 5Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, 6University of Colorado Denver, Aurora, CO, 7Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose: Osteoporosis, defined by Tscore < -2.5, is one of the main consequences of RA and it appears early in the disease. It is twice…
  • Abstract Number: 990 • 2016 ACR/ARHP Annual Meeting

    Autoimmunity to Multiple Antigens Is Expanded in at-Risk Family Members Beyond the Disease Specific Patterns of the SLE or RA Proband

    Judith A. James1, Krista M. Bean2, Hua Chen2, Kendra A. Young3, Elizabeth A. Bemis4, Jennifer Seifert5, Maria Sargent6, Kevin D. Deane7, Bill Robinson8, David A. Hafler9, Kevin O'Conner10, Jane H. Buckner11, Joel M. Guthridge12, Jill M. Norris13 and V. Michael Holers14, 1Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Epidemiology, University of Colorado Denver, Aurora, CO, 4Epidemiology, Colorado School of Public Health, Aurora, CO, 5University of Colorado, Denver, CO, 6Oklahoma Medical Research Foundation, Oklahoma City, OK, 7Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 8Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 9Neurology and Immunobiology, Yale School of Medicine, New Haven, CT, 10Yale University, New Haven, CT, 11Benaroya Research Institute at Virginia Mason, Seattle, WA, 12Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 13University of Colorado Denver, Aurora, CO, 14Rheumatology Division, University of Colorado School of Medicine, Aurora, CO

    Background/Purpose:  Certain autoantibodies (aabs) are highly disease specific, can be detected prior to the onset of clinically apparent disease and oftentimes increase in number and…
  • Abstract Number: 1095 • 2016 ACR/ARHP Annual Meeting

    Periarticular Bone Loss in Arthritis Is Induced By Autoantibodies Against Citrullinated Vimentin

    Cecilia Engdahl1, Holger Bang2, Katharina Dietel1, Stefanie C Lang1, Ulrike Harre1 and Georg Schett3, 1Department of Internal Medicine 3 and Institute for Clinical Immunology, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany, 2Orgentec Diagnostics, Mainz, Germany, 3Department of Internal Medicine III, Institute for Clinical Immunology,, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Erlangen, Germany

    Background/Purpose: Periarticular bone loss is a long known and early but yet insufficiently understood phenomenon in patients with rheumatoid arthritis. This study investigated whether autoimmunity…
  • Abstract Number: 1347 • 2016 ACR/ARHP Annual Meeting

    Steroid-Responsive Encephalopathy Associated with Autoimmune Thyroiditis: Characteristics, Treatment and Outcome in 251 Cases from the Literature

    Charlotte Laurent1, Jean Capron2, Sonia Alamowitch3, Bluenn Quillerou4, Guy Thomas4, Olivier Fain5 and Arsène Mékinian5, 1Internal Medicine, Internal Medicine, Hôpital Saint-Antoine, Paris, paris, France, 2Neurology, Neurology, Hôpital Saint-Antoine, paris, France, 3Neurology, Neurology - Hopital St Antoine, paris, France, 4Psychiatry, Psychiatry Hopital St Antoine, paris, France, 5Service de médecine interne. Hôpital Saint-Antoine., Paris, France

    Background/Purpose: Steroid-responsive encephalopathy and associated autoimmune thyroiditis (SREAT) is characterized by encephalopathy and the presence of antithyroid antibodies. We describe the clinical presentation, outcome and…
  • Abstract Number: 2114 • 2016 ACR/ARHP Annual Meeting

    Exposure to Carbamylated Self- and Non-Self-Proteins Can Lead to a Break-of -Tolerance and the Induction of Autoimmunity

    Jacqueline Dekkers1, Marije K. Verheul2, Jeroen Stoop3, Bisheng Liu4, Peter A. van Veelen5, Martin Hegen6, Stephen Rapecki7, Tom WJ Huizinga2, Leendert A. Trouw4 and René Toes4, 1Rheumatology, Department of Rheumatology, Leiden University Medical Center (LUMC), Leiden, Netherlands, 2Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 3Leiden University Medical Center (LUMC), Leiden, Netherlands, 4Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 5Immunohematology and Bloodbank, Leiden University Medical Center, Leiden, Netherlands, 6Inflammation, Wyeth Pharmaceuticals, Cambridge, MA, 7UCB Pharma, Slough, United Kingdom

    Background/Purpose: Autoantibodies are an important hallmark of Rheumatoid Arthritis (RA). Approximately 50% of RA patients harbor anti-carbamylated protein (CarP) antibodies. These autoantibodies target proteins that…
  • Abstract Number: 2781 • 2016 ACR/ARHP Annual Meeting

    Immunization with ApoB100 Peptide Vaccine Reduces Atherosclerosis Development in a Mouse Model of Systemic Lupus Erythematosus

    Ingrid Yao-Mattisson, Maria Wigren, Gunilla Nordin Fredrikson and Jan Nilsson, Lund University, Malmö, Sweden

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by impaired self-tolerance causing damage to multiple organs including the cardiovascular system. Current therapies do…
  • Abstract Number: 3112 • 2016 ACR/ARHP Annual Meeting

    DOCK8 Associates with STAT5 and Promotes Regulatory T Cell Function

    Erin Janssen1, Mira Tohme1, Sumana Ullas2 and Raif Geha2, 1Immunology, Boston Children's Hospital, Boston, MA, 2Boston Children's Hospital, Boston, MA

    Background/Purpose: DOCK8 deficiency leads to autosomal recessive Hyper-IgE syndrome (AR-HIES). DOCK8 deficient patients develop recurrent sinopulmonary infections, chronic mucocutaneous viral infections, hyper-IgE, eosinophilia, food allergies,…
  • Abstract Number: 203 • 2015 ACR/ARHP Annual Meeting

    Rescue of Copa Syndrome Cellular Phenotype By Autophagy Modifying Drugs

    Levi Watkin1,2, Briana Burns1,2, Timothy Vece3 and Jordan S. Orange1,2, 1Baylor College of Medicine, Houston, TX, 2Center for Human Immunobiology, Texas Children's Hospital, Houston, TX, 3Pulmonology, Texas Children's Hospital, Houston, TX

    Background/Purpose: Autoimmunity is a diverse group of complex conditions that can include certain congenital genetic defects leading to loss of self-tolerance with subsequent imbalances of…
  • Abstract Number: 529 • 2015 ACR/ARHP Annual Meeting

    Immunoglobulin-a and Immunoglobulin-G Isotypes of Anti-CCP Antibodies Are Present in the Sputum of Subjects at Risk for Future Development of RA

    Kristen Demoruelle1, Linh Ho2, Michael H. Weisman3, Ryan W. Gan4, Mark C. Parish1, Marie L. Feser1, Chelsie Fleischer1, Michael Mahler5, Andrea Seaman5, Jill M. Norris4, V. Michael Holers1 and Kevin D. Deane1, 1Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 2University of Colorado School of Medicine, Aurora, CO, 3Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 4Epidemiology, Colorado School of Public Health, Aurora, CO, 5Inova Diagnostics, San Diego, CA

    Background/Purpose: Serum elevations of anti-CCP prior to inflammatory arthritis (IA) in RA suggest that anti-CCP is generated at a site outside of the joints. Data…
  • Abstract Number: 1671 • 2015 ACR/ARHP Annual Meeting

    Discovery of PRN1008, a Novel, Reversible Covalent BTK Inhibitor in Clinical Development for Rheumatoid Arthritis

    Ronald J. Hill1, Patrick Smith2, Janakan Krishnarajah3, J. Michael Bradshaw1, Mohammad Masjedizadeh1, Angelina Bisconte1, Dane Karr1, Timothy D. Owens1, Ken Brameld1, Jens Oliver Funk1, David M. Goldstein1, Philip A. Nunn1 and Steven G. Gourlay1, 1Principia Biopharma, South San Francisco, CA, 2d3 Medicine, Parsippany, NJ, 3Linear Research Pty Ltd, Perth, Australia

    Background/Purpose: There is strong pre-clinical validation for Bruton’s Tyrosine Kinase (BTK) as a therapeutic target for autoimmune diseases based on multiple animal models. Principia discovered…
  • Abstract Number: 1776 • 2015 ACR/ARHP Annual Meeting

    Significantly Reduced Lymphadenopathy, Salivary Gland Infiltrates and Proteinuria in MRL-Lpr/Lpr Mice Treated with Ultrasoluble Curcumin/Turmeric: Increased Survival with Curcumin Treatment

    Biji T Kurien1,2,3, Valerie M Harris1,4, Syed MS Quadri1,4, Patricia Coutinho-de Souza1, Joshua Cavett5,6, Amanda Moyer4, Bilal Ittiq7, Angela Metcalf6, Husayn Ramji8, Dat Truong8, Kristi A. Koelsch4,9,10, Mike Centola11, Adam Payne12, D. Danda13 and R. Hal Scofield1,14, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, 3College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4University of Oklahoma Health Sciences Center, Oklahoma City, OK, 5Allergy and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 7University of Oklahoma Health Sciences Center, Oklahoma, OK, 8University of Oklahoma, Oklahoma City, OK, 9Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Okalahoma City, OK, 10Department Veterans Affairs Medical Center, Oklahoma City, OK, 11Haus Bioceuticals, Oklahoma City, OK, 12Arthritis and Immunology, Oklahoma Medical Research Foun, Oklahoma City, OK, 13Christian Medical College, Vellore, India, 14US Department of Veterans Affairs Medical Center, Oklahoma City, OK

    Background/Purpose: Commercial curcumin (CU), derived from food spice turmeric, has been widely studied as a potential therapeutic for a variety of oncological and inflammatory conditions.…
  • Abstract Number: 2548 • 2015 ACR/ARHP Annual Meeting

    M-CSF-R Is a Critical Determinant for the Differentiation of Classical to Non-Classical Monocytes

    Philip J. Homan1, Alexander Misharin1, Carla Cuda2, Salina Dominguez2, Rana Saber2, Fu-Nien Tsai3 and Harris R. Perlman4, 1Medicine-Rheumatology, Northwestern University, Chicago, IL, 2Northwestern University, Chicago, IL, 3Medicine, Rhuematology, Northwestern University, Chicago, IL, 4Feinberg School of Medicine, Northwestern University, Chicago, IL

    Background/Purpose: Colony-stimulating factors (CSF) are simply defined as haemotopoitec growth factors. However, CSFs have been implicated to have additional functions in various autoimmune diseases. Specifically…
  • Abstract Number: 2713 • 2015 ACR/ARHP Annual Meeting

    A Novel Paradigm in the Clinical Context of Rheumatoid Arthritis: Role of Tfh and Th17 Cells in Autoimmunity

    Magdalena Budziakowska1, Arif Shahzad1, Jerry Pounds1, Shikha Singla1, Jerald M. Zakem1,2, Kismet Collins1, Tamika Webb-Detiege1, William E. Davis1,2, Zongbing You3, Robert Quinet1,2 and Xin Zhang4, 1Rheumatology, Ochsner Medical Center, New Orleans, LA, 2University of Queensland School of Medicine, Brisbane, Australia, 3Tulane University Health Science Center, New Orleans, LA, 4Laboratory of Cellular Immunology, Institution of Translational Research, Ochsner Medical Center, New Orleans, LA

    Background/Purpose: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovium, which causes progressive joint destruction and reduction in quality of life…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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