Abstracts tagged "Atherosclerosis"

Abstract Number: 374 • 2014 ACR/ARHP Annual Meeting
IL-33 and Soluble ST2 Levels As Novel Predictors for Remission and Progression of Carotid Plaque in Early Rheumatoid Arthritis: A Prospective Study
Jiayun Shen¹, Qing Shang¹, Ying Ying Leung², Shui Lian Yu¹, Chun-Kwok Wong³, Edmund Li¹, Tracy Y. Zhu¹ and Lai-Shan Tam¹, ¹Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore, ³Department of Chemical Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose Clinical remission is achievable for patients with early rheumatoid arthritis (ERA). Identification of predictors for response of treatment may provide risk estimation and help…
Abstract Number: 1443 • 2014 ACR/ARHP Annual Meeting
Increased Occurence of Carotid and Femoral Plaques, but Not Increased Arterial Stiffness of Hypertrophy, in Classical Risk Factor-Free Patients with Rheumatoid Arthritis
Aikaterini I. Arida¹, Evaggelia Zampeli¹, George Konstantonis¹, Kalliopi Fragkiadaki¹, George D. Kitas², Athanasios D. Protogerou¹ and Petros P. Sfikakis¹, ¹First Department of Propedeutic Internal Medicine, Laikon Hospital, Athens University Medical School, Athens, Greece, ²The Dudley Group of Hospitals NHS Foundation Trust, Dudley, and Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, United Kingdom
Background/Purpose Several lines of evidence indicate that classical cardiovascular disease (CVD) risk factors, such as arterial hypertension, diabetes mellitus, smoking and dyslipidemia, are significantly increased…
Abstract Number: 373 • 2014 ACR/ARHP Annual Meeting
Biomarkers of Cardiac Dysfunction and Inflammation in Plasma Predict Occult Coronary Plaque Burden and Composition in Rheumatoid Arthritis
George A. Karpouzas¹, Joel Estis², John Todd² and Matthew Budoff³, ¹Rheumatology, Harbor-UCLA Medical Center, Torrance, CA, ²Singulex, Alameda, California, Alameda, CA, ³Cardiology, Harbor-UCLA Medical Center, Torrance, CA
Background/Purpose Rheumatoid arthritis (RA) is associated with accelerated coronary atherogenesis, myocardial infarction, and mortality. We previously reported a higher prevalence, severity, and different composition of…
Abstract Number: 1440 • 2014 ACR/ARHP Annual Meeting
Asymptomatic Carotid Plaques in RA Patients Are Associated with Increased HDL Function
Silvia Rollefstad¹, Bente Halvorsen², Tonje Skarpengland², Sella Provan³, Tore K. Kvien⁴ and Anne Grete Semb¹, ¹Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway, ³Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴PsAID taskforce, EULAR, Zurich, Switzerland
Background/Purpose Reverse cholesterol transport (RCT) is a major anti atherogenic function of high density lipoprotein cholesterol (HDL) and has been shown to be related to…
Abstract Number: 334 • 2014 ACR/ARHP Annual Meeting
Inflammatory Arthritis in K/BxN Mice Is Associated with Abnormal HDL Function
C. Charles-Schoeman¹, Ani Shahbazian¹, Yuen Yin Lee¹ and Srinivasa T. Reddy², ¹Medicine-Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ²Medicine-Cardiology, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose Patients with rheumatoid arthritis (RA) have significantly increased cardiovascular (CV) morbidity and mortality. Abnormal function of high density lipoprotein (HDL) has been implicated as…
Abstract Number: 1437 • 2014 ACR/ARHP Annual Meeting
Cholesterol Efflux Capacity of HDL and Coronary Atherosclerosis in Rheumatoid Arthritis
Michelle J. Ormseth¹, Patricia Yancey², Suguru Yamamoto², Annette M. Oeser¹, Tebeb Gebretsadik³, Ayumi Shintani¹, MacRae F. Linton¹, Sergio Fazio¹, Sean Davies¹, L Jackson Roberts II¹, Kasey C. Vickers¹, Paolo Raggi⁴, Valentina Kon¹ and C Michael Stein¹, ¹Vanderbilt University, Nashville, TN, ²Medicine, Vanderbilt University, Nashville, TN, ³Biostatistics, Vanderbilt University, Nashville, TN, ⁴Emory University, Atlanta, GA
Background/Purpose: Cardiovascular (CV) risk is increased in patients with rheumatoid arthritis (RA), but not fully explained by traditional risk factors such as LDL and HDL…
Abstract Number: 79 • 2014 ACR/ARHP Annual Meeting
PECAM-1 GENE Polymorphisms and Soluble PECAM-1 LEVEL in Rheumatoid Arthritis and Systemic LUPUS Erythematosus Patients Is There a Link with Clinical Atherosclerotic Events?
Omer Nuri Pamuk¹, Hilmi Tozkir², Mehmet Sevki Uyanik³, Hakan Gurkan⁴, Julide Duymaz⁴, Salim Donmez⁵, Metin Yazar² and Gulsum Pamuk³, ¹Rheumatology, Trakya University Medical Faculty, Edirne, Turkey, ²Genetics, Trakya University Medical Faculty, EDIRNE, Turkey, ³Hematology, Trakya University Medical Faculty, Edirne, Turkey, ⁴Trakya University Medical Faculty, EDIRNE, Turkey, ⁵Department of Rheumatology, Trakya University School of Medicine, Edirne, Turkey
Background/Purpose: Platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) which plays a role in the transmigration of leucocytes into tissues is a member of the immunoglobulin (Ig) superfamily.…
Abstract Number: 1218 • 2014 ACR/ARHP Annual Meeting
The Reduction of Serum Uric Acid Level Might Prevent Atherosclerosis in Mice
Yoshitaka Kimura^1,2, Tamiko Yanagida³, Akiko Onda⁴, Hajime Kono², Maki Takayama², Kurumi Asako², Akiko Okamoto², Hirotoshi Kikuchi² and Toshihiro Nanki⁵, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ³Depart ment of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁴Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁵Department of Clinical Research Medicine, Teikyo University, Tokyo, Japan
Background/Purpose: Excess amount of uric acid in human body causes acute inflammation, gout. In addition, uric acid is identified as a danger signal and is…
Abstract Number: 1182 • 2014 ACR/ARHP Annual Meeting
Do Patients with Active RA Also Have Inflamed Atherosclerotic Plaques on PET-MRI?
Sarah Skeoch¹, Heather Williams², Penny Cristanacce³, Jacqueline James⁴, Paul Hockings⁵, Yvonne Alexander⁶, John Waterton^7,8 and Ian N. Bruce⁹, ¹University of Manchester, Manchester, United Kingdom, ²Centre for Imaging Sciences Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom, ³Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom, ⁴Department of Nuclear Medicine, Central Manchester University Hospitals Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom, ⁵MedTech West, Chalmers University of Technology, Gottenburg, Sweden, ⁶Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁷R&D Personalised Healthcare & Biomarkers, Astra Zeneca, MACCLESFIELD, United Kingdom, ⁸Bioimaging Institute, University of Manchester, Manchester, United Kingdom, ⁹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Inflammation plays a key role in the progression and destabilisation of atherosclerotic plaque in the general population. In RA, inflammation is thought to accelerate…
Abstract Number: 840 • 2014 ACR/ARHP Annual Meeting
Vascular Calcifications on Hand and Wrist Radiographs Are Associated with Cardiovascular Risk Factors, Antigen-Specific Anti-Citrullinated Protein Antibodies, and Mortality in Rheumatoid Arthritis
E. Blair Solow¹, Fang Yu², Geoffrey M. Thiele³, Jeremy Sokolove^4,5, William H. Robinson^6,7, Zachary M. Pruhs³, Kaleb Michaud^8,9, Alan R. Erickson⁹, Harlan Sayles⁹, Gail S. Kerr¹⁰, Angelo L. Gaffo¹¹, Liron Caplan¹², Lisa A. Davis¹³, Grant W. Cannon¹⁴, Andreas M. Reimold¹⁵, Joshua Baker¹⁶, Pascale Schwab^17,18, Daniel Anderson⁹ and Ted R. Mikuls⁹, ¹Internal Medicine, Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX, ²University of Nebraska Medical Center, Omaha, NE, ³Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁴VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ⁵Stanford University School of Medicine, Stanford, CA, ⁶VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁷Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁸National Data Bank for Rheumatic Diseases, Wichita, KS, ⁹Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ¹⁰Rheumatology, Washington DC VAMC, Georgetown and Howard University, Washington, DC, ¹¹Medicine, Birmingham VA Medical Center and University of Alabama at Birmingham, Birmingham, AL, ¹²Div of Rheumatology, Denver VAMC and Univ of Colorado School of Medicine, Aurora, CO, ¹³Denver VAMC and Univ of Colorado School of Medicine, Aurora, CO, ¹⁴Division of Rheumatology, Salt Lake City VA and University of Utah, Salt Lake City, UT, ¹⁵Rheumatology, Dallas VA and University of Texas Southwestern, Dallas, TX, ¹⁶Medicine/Rheumatology, University of Pennsylvania and Philadelphia VAMC, Philadelphia, PA, ¹⁷Department of Internal Medicine, Division of Rheumatology, Portland VA Medical Center, Portland, OR, ¹⁸Internal Medicine, Division of Arthritis & Rheumatic Diseases, Oregon Health & Science University, Portland, OR
Background/Purpose: Rheumatoid arthritis (RA) is associated with increased mortality due to cardiovascular disease (CVD). Select antigen-specific anti-citrullinated protein antibodies (ACPA) are associated with atherosclerotic…
Abstract Number: 829 • 2014 ACR/ARHP Annual Meeting
Asymptomatic Deposit of Monosodium Urate Crystals Associates to a More Severe Coronary Calcification in Hyperuricemic Patients with Acute Coronary Syndrome
Mariano Andrés¹, María Amparo Quintanilla², Francisca Sivera¹, Paloma Vela^3,4 and Juan Miguel Ruiz-Nodar⁵, ¹Sección de Reumatología, Hospital General Universitario de Elda, Alicante, Spain, ²Sección de Cardiología, Hospital General Universitario de Elda, Alicante, Spain, ³Departamento de Medicina Clínica, Universidad Miguel Hernández, Alicante, Spain, ⁴Sección de Reumatología, Hospital General Universitario de Alicante, Alicante, Spain, ⁵Servicio de Cardiología, Hospital General Universitario de Alicante, Alicante, Spain
Background/Purpose: Increased cardiovascular (CV) risk in gout relates to crystal-driven inflammation. Monosodium urate (MSU) crystals are found in ~25% of patients with asymptomatic hyperuricemia (AH)…
Abstract Number: 799 • 2014 ACR/ARHP Annual Meeting
Peripheral Arterial Disease in Patients with Giant Cell Arteritis: A Systematic Review and Meta-Analysis
Patompong Ungprasert¹, Praveen Ratanasrimetha², Charat Thongprayoon³, Wisit Cheungpasitporn³ and Promporn Suksaranjit⁴, ¹Department of Internal medicine, Bassett medical center, Cooperstown, NY, ²Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, ³Department of Medicine, Mayo clinic, Rochester, MN, ⁴Department of Cardiology, University of Utah School of Medicine, Salt Lake City, UT
Peripheral Arterial Disease in Patients with Giant Cell Arteritis: A Systematic Review and Meta-analysisBackground/Purpose: Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus…
Abstract Number: 726 • 2014 ACR/ARHP Annual Meeting
Risk of Ischemic Stroke in Patients with Systemic Sclerosis: A Systematic Review and Meta-Analysis
Patompong Ungprasert¹, Praveen Ratanasrimetha², Charat Thongprayoon³, Wisit Cheungpasitporn³ and Promporn Suksaranjit⁴, ¹Department of Internal medicine, Bassett medical center, Cooperstown, NY, ²Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, ³Department of Medicine, Mayo clinic, Rochester, MN, ⁴Department of Cardiology, University of Utah School of Medicine, Salt Lake City, UT
Risk of Ischemic Stroke in Patients with Systemic Sclerosis: A Systematic Review and Meta-analysisBackground/Purpose: Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus…
Abstract Number: 1277 • 2013 ACR/ARHP Annual Meeting
A Pilot Study Of Young Adults With Juvenile Dermatomyositis With Decreased Nailfold Capillary End Row Loops: Brachial Artery Reactivity and Oxidized Lipids
Lauren M. Pachman^1,2, Maureen A. McMahon³, Tamar Polonsky⁴, Gabrielle A. Morgan¹, Maria Amoruso⁵ and Chiang-Ching Huang⁶, ¹Cure JM Myositis Center, Ann & Robert H. Lurie Children's Hospital of Chicago Research Center, Chicago, IL, ²Division of Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Division of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA, ⁴Cardiology, University of Chicago Medicine, Chicago, IL, ⁵Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Cure JM Myositis Center, Chicago, IL, ⁶Zilber School of Public Health, University of Wisconsin at Milwaukee, Milwaukee, WI
Background/Purpose: Our center previously reported increased carotid intima media thickness, and lower high-density lipoprotein (HDL) levels in young or middle-age adults with a history of…
Abstract Number: 1267 • 2013 ACR/ARHP Annual Meeting
Impact Of Disease Duration On Vascular Surrogates Of Early Atherosclerosis In Childhood-Onset Systemic Lupus Erythematosus
Julie Barsalou¹, Timothy J. Bradley², Cameron Slorach², Lawrence W.K. Ng³, Deborah M. Levy⁴ and Earl D. Silverman¹, ¹Rheumatology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ²Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada, ³Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada
Background/Purpose: Cardiovascular disease is a leading cause of morbidity and mortality in adults with systemic lupus erythematosus. Exposure to atherogenic risk factors in childhood-onset SLE…

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