Abstracts tagged "Arthritis"

Abstract Number: 2498 • 2018 ACR/ARHP Annual Meeting
The Association of Vitamin D with the Lipid Profile in Rheumatoid Arthritis: An Interplay Among Genetic Polymorphisms, DHCR7 Levels and Seasonality
Javier Rodríguez-Carrio^1,2,3, Mercedes Alperi-López⁴, Manuel Naves-Díaz^2,3, Adriana Dusso^2,3, Patricia López¹, Francisco Javier Ballina-García⁵, Jorge B. Cannata-Andía^2,3 and Ana Suárez¹, ¹Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, ²Bone and Mineral Research Unit, Instituto Reina Sofía de Investigación Nefrológica, REDinREN del ISCIII, Hospital Universitario Central de Asturias, Oviedo, Spain, ³Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain, ⁴Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain, ⁵Department of Rheumatology, Hospital Universitario Central de Asturias, Oviedo, Spain
Background/Purpose: Vitamin D deficiency is a common hallmark of rheumatic diseases, and some controversy exists about its effect on rheumatoid arthritis (RA), in particular about…
Abstract Number: 84 • 2018 ACR/ARHP Annual Meeting
ACPA-Positive Risk-RA Subject without Subclinical Arthritis Are in High Risk for Later Arthritis Onset, Especially Carriers of HLA-SE Risk-Gene
Aase Hensvold^1,2, Yogan Kisten^1,2, Monika Hansson¹, Alexandra Cîrciumaru¹, Meng Sun¹, Hamed Rezaei³, Erik af Klint¹, Guozhong Fei², Aleksandra Antovic² and Anca I. Catrina^1,2, ¹Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Stockholm Health Services, Academic Specialist Center, Center for Rheumatology, Stockholm, Sweden, ³Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) are predictive markers with pathological effects in rheumatoid arthritis (RA) development. Previous studies of ACPA-positive patients with musculoskeletal complaints (mainly…
Abstract Number: 1236 • 2018 ACR/ARHP Annual Meeting
Peripheral-Blood B-Cell Subset Disturbances in Whipple’s Disease
Maelle Le Goff¹, Divi Cornec², Dewi Guellec¹, Thierry Marhadour¹, Valérie Devauchelle-Pensec¹, Sandrine Jousse-Joulin¹, Marion Herbette¹, Jean-Michel Cauvin³, Clara Le Guillou³, Yves Renaudineau⁴, Jacques-Olivier Pers⁵ and Alain Saraux¹, ¹Rheumatology, CHU Brest, Brest, France, ²Rheumatology and UMR1227, Lymphocytes B et Autoimmunité, CHU Brest, Brest, France, ³CDC, CHU Brest, Brest, France, ⁴U1227, Université de Brest, inserm, Labex IGO, CHU de brest, Brest, France, ⁵U1227, Université de Brest, Inserm, Labex IGO, CHU de Brest, Brest, France
Background/Purpose: Whipple’s disease (WD) is a rare, systemic, disease caused by the intracellular Gram-positive bacterium Tropheryma whipplei (TW). This ubiquitous commensal organism is transmitted among…
Abstract Number: 2943 • 2018 ACR/ARHP Annual Meeting
Helping a Non-Urban Community Walk with Ease: A Feasibility Pilot Study of an Arthritis Activity Intervention
Amanda Perez¹, Brock Polnaszek², Douglas White³, Lee Walraven⁴, Chelsea Barnes⁴ and Christie M. Bartels¹, ¹Rheumatology/Medicine, University of Wisconsin - Madison, Madison, WI, ²Obstetrics and Gynecology, Washington University, St. Louis, MO, ³Gundersen Lutheran - Onalaska Clinic, Onalaska, WI, ⁴La Crosse Area Family YMCA, La Crosse, WI
Background/Purpose: An estimated 54 million US adults have arthritis, and more than half are not receiving the recommended physical activity (MMWR, 2018). Walk With Ease…
Abstract Number: 386 • 2017 ACR/ARHP Annual Meeting
Analysis of the Effectiveness of Immunization with Pneumococcal Polysaccharide Vaccine in Children with Juvenile Idiopathic Arthritis
Ekaterina Alexeeva^1,2, Tatiana Dvoryakovskaya¹, Rina Denisova¹, Olga Lomakina¹, Ksenia Isaeva¹, Margarita Soloshenko¹, Anna Karaseva¹, Nikolay Mayansky³, Irina Zubkova³, Darija Novikova⁴, Anna Gayvoronskaya⁴, Natalia Tkachenko⁴, Marika Ivardava⁴, Firuza Shakhtakhtinskaya⁴ and Marina Fedoseenko⁴, ¹Reumatology department, Federal State Autonomous Institution"National Scientific and Practical Center of Children's Health"Of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, ²Pediatrics, The Federal State Autonomous Educational Institution of Higher Education The First Moscow State Medical University named after I.M. Sechenov Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation, ³Clinical laboratory, Federal State Autonomous Institution"National Scientific and Practical Center of Children's Health"Of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, ⁴Department of Vaccine Prevention, Federal State Autonomous Institution"National Scientific and Practical Center of Children's Health"Of the Ministry of Health of the Russian Federation, Moscow, Russian Federation
Background/Purpose: Juvenile idiopathic arthritis (JIA) is one of the most frequent and most disabling rheumatic diseases in childhood. Children suffering from JIA receiving immunosuppressive and…
Abstract Number: 2124 • 2017 ACR/ARHP Annual Meeting
Mixed Connective Tissue Disorder Has Higher Prevalence of Arthritis and Use of Methotrexate Than Systemic Lupus Erythematosus
Gunasekaran Sambandam^1,2, Dr. Varun Dhir³, Dr. Mahesh Prakash⁴, Ranjana Minz⁵, Shefali Sharma⁶ and Aman Sharma⁷, ¹Internal Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), chandigarh, India, ²Internal medicine, Post graduate Institute of medical education and research, chandigarh, India, ³Internal Medicine ( Clinical Rheumatology), Post Graduate Institute of Medical Education and Research, chandigarh, India, ⁴Radio Diagnosis, Post Graduate Institute of Medical Education and Research, chandigarh, India, ⁵Department of Immunopathology,, PGIMER,, Chandigarh, India, ⁶Department of Medicine, All India Institute of Medical Sciences, New Delhi, New Delhi, India, ⁷Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Background/Purpose: Mixed connective disease is a multi-system disorder with overlapping features of SLE, rheumatoid arthritis, scleroderma and polymyositis/dermatomyositis with high titres of U1 RNP. Arthritis…
Abstract Number: 387 • 2017 ACR/ARHP Annual Meeting
F4/80hi Synovial Macrophages in the Pathogeneses of Spontaneous Inflammatory Arthritis in CD11c-Flip-KO (HUPO) Mice
Qi Quan Huang^1,2, Renee E. Doyle², Philip J. Homan¹, Harris Perlman³, Deborah R. WInter⁴ and Richard M. Pope², ¹Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Synovial tissue macrophages (STMs) are critical in the pathogenesis of rheumatoid arthritis (RA). During homeostasis, the majority of murine synovial tissue resident macrophages (TRMs)…
Abstract Number: 2130 • 2017 ACR/ARHP Annual Meeting
Joint Manifestations in Patients Diagnosed with Idiopathic Inflammatory Myopathy: Multicenter Registry on Inflammatory Myositis from the Rheumatology Society in Madrid, Spain
Larissa Valor¹, Diana Hernández-Flórez², Julia Martínez-Barrio³, Beatriz E. Joven⁴, Laura Nuño⁵, Carmen Larena⁶, Irene Llorente⁷, Carmen Barbadillo⁸, Paloma Garcia De La Peña⁹, Lucía Ruíz Gutiérrez¹⁰, Henry Moruno Cruz¹¹, Tatiana Cobo-Ibáñez¹², Raquel Almodóvar González¹³, Leticia Lojo¹⁴, MARIA JESUS GARCIA DE YEBENES Y PROUS¹⁵ and Francisco Javier López Longo¹⁶, ¹Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ²Rheumatology, Gregorio Marañón University General Hospital, Madrid, Spain, ³Servicio de Reumatologia, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ⁴Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ⁵Servicio de Reumatologia, Hospital Universitario La Paz, Madrid, Spain, ⁶Hospital Gregorio Marañón, Madrid, Spain, ⁷Rheumatology, H.U. La Princesa, Madrid, Spain, ⁸Hospital Universitario Puerta de Hierro, Madrid, Spain, ⁹Rheumatology, Hospital Madrid Norte Sanchinarro, Madrid, Spain, ¹⁰Pediatric Rheumathology Unit, University Children's Hospital Niño Jesús, Madrid, Spain, ¹¹University Hospital Príncipe de Asturias, Immune System Diseases, Rheumatology department, Alcalá de Henares, Madrid, Spain, ¹²Hospital Universitario Reina Sofía, Universidad Europea de Madrid, Madrid, Spain, ¹³Rheumatology Unit, Hospital Universitario Fundación Alcorcón, Madrid, Spain, ¹⁴Rheumatology, Hospital Universitario La Paz, Spain, Spain, ¹⁵Institute for Musculoskeletal Health, Madrid, Spain, ¹⁶Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain
Background/Purpose: Idiopathic inflammatory myopathies (IIM) comprise a heterogeneous group of autoimmune conditions characterized by muscle non-suppurative inflammation, progressive muscle weakness and a variety of extra-muscular…
Abstract Number: 402 • 2017 ACR/ARHP Annual Meeting
Alteration of the Intestinal Microbiome in the Preclinical Phase of Experimental Arthritis and the Efficacy of Microbiota Modulation in Established Arthritis in Mice
Rebecca Rogier¹, Heather Evans-Marin², Julia Manasson³, Peter M. van der Kraan⁴, Wim B. van den Berg⁵, Marije I. Koenders⁴, Jose U. Scher⁶ and Shahla Abdollahi-Roodsaz^7,8, ¹Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ²Division of Rheumatology, New York University School of Medicine, New York, NY, ³Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁵Rheumatology Research and Advanced Therapeutics, Radboud University Medical Center, Nijmegen, Netherlands, ⁶New York University School of Medicine, New York, NY, ⁷Department of Medicine, Division of Rheumatoogy, New York University School of Medicine, New York, NY, ⁸Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands
Background/Purpose: The composition of intestinal microbiota is perturbed in patients with new-onset and chronic rheumatoid arthritis (RA). However, it is not known whether the changes…
Abstract Number: 2221 • 2017 ACR/ARHP Annual Meeting
Eradication of Hepatitis C Among US Veterans: Examination of Changes in Pain Severity and Prescription Opioid Use Following Treatment
Anand Kumthekar¹, Sarah Shull², Benjamin Morasco^3,4, Travis Lovejoy^3,4, Michael Chang² and Jennifer Barton³, ¹Rheumatology, Oregon Health & Science University, Portland, OR, ²Gastroenterology, VA Portland Health Care System, Portland, OR, ³VA Portland Health Care System, Portland, OR, ⁴Oregon Health & Science University, Portland, OR
Background/Purpose: Hepatitis C virus (HCV) is associated with chronic wide spread pain, fatigue, myalgia, arthritis, sicca symptoms and vasculitis. Data regarding prior interferon-based treatment of…
Abstract Number: 731 • 2017 ACR/ARHP Annual Meeting
Prediction of Progression of Interstitial Lung Disease in Patients with Systemic Sclerosis
Wanlong Wu¹, Suzana Jordan², Mike Oliver Becker³, Rucsandra Dobrota³, Shuang Ye⁴, Britta Maurer⁵ and Oliver Distler², ¹Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich; Department of Rheumatology, Renji Hospital South Campus, Shanghai Jiao Tong University School of Medicine, Zurich, Switzerland, ²Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ³Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Department of Rheumatology, Renji Hospital South Campus, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ⁵Department of Rheumatology, Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: No data are available to distinguish between progressive and stable patients when mild lung fibrosis is diagnosed in systemic sclerosis (SSc) patients. This study…
Abstract Number: 2229 • 2017 ACR/ARHP Annual Meeting
The Effect of Intra-Articular Neurotoxin on Arthritis Pain and Substance P Expression in the Dorsal Root Ganglion: Results from Murine Arthritis Models
Hollis Krug^1,2, Sandra Frizelle³, Nicole Blanshan⁴, Christopher W. Dorman³ and Maren Mahowald^2,5, ¹Medicine, Minneapolis VAHCS, Minneapolis, MN, ²Medicine, University of Minnesota Medical School, Minneapolis, MN, ³Research, Minneapolis VA Health Care System, Minneapolis, MN, ⁴Research, Minneapolis VAHCS, Minneapolis, MN, ⁵Rheumatology/ Dept of Medicine, Minneapolis VA and Univ MN Med School, SAINT PAUL, MN
Background/Purpose : Substance P (SP) release and binding to NK-1 produces pain transmission. Neurotoxins (NT) that prevent release of SP, such as onabotulinum toxin (BoNT/A),…
Abstract Number: 1020 • 2017 ACR/ARHP Annual Meeting
The Inflammatory and Proliferative Synovial Lesion in Post-Infectious Lyme Arthritis Results from Impaired Wound Healing
Robert Lochhead^1,2, David Ordonez-Del Valle^1,2, Klemen Strle^2,3, Sheila Arvikar^1,2, John Aversa⁴ and Allen Steere^1,2, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ²Department of Medicine, Harvard Medical School, BOSTON, MA, ³Department of Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ⁴School of Medicine, Yale University, New Haven, CT
Background/Purpose: Lyme arthritis (LA) is initially triggered by Borrelia burgdorferi infection, but in some patients, the synovitis persists despite 2-3 months of antibiotic therapy and…
Abstract Number: 2231 • 2017 ACR/ARHP Annual Meeting
MCC22, a Novel Compound That Targets Both CCR5 and Mu Opioid Receptors, Is Highly Effective in Treating Inflammatory Arthritis Pain
Raini Dutta¹, Mary Lunzer², Jennifer L. Auger³, Eyup Akgün², Philip Porthoghese² and Bryce A. Binstadt³, ¹Pediatrics, University of Minnesota, Minneapolis, MN, ²Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN, ³Center for Immunology and Department of Pediatrics, University of Minnesota, Minneapolis, MN
Background/Purpose: The pain that accompanies rheumatoid arthritis and other chronic inflammatory conditions is difficult to manage. Although opioids provide potent analgesia, chronic opioid use is…
Abstract Number: 1308 • 2017 ACR/ARHP Annual Meeting
Answering Reproductive Health Questions That Your Patients Want to Know: Impediments to Family Building and Risks of Contraception
Malithi Jayasundara¹, Amanda M. Eudy², Tayseer Haroun³, W. Benjamin Nowell⁴, Jeffrey R. Curtis⁵, Rachelle Crow-Hercher⁶, Charlotte Whitney White⁶, Seth D. Ginsberg⁷ and Megan E. B. Clowse⁸, ¹Rheumatology, Duke University, Durham, NC, ²Duke University, Durham, NC, ³Department of Medicine/Division of Rheumatology, Duke University Medical Center, Durham, NC, ⁴Global Healthy Living Foundation, Upper Nyack, NY, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Arthritis Power, Upper Nyack, NY, ⁷Global Healthy Living Foundation, CreakyJoints, Upper Nyack, NY, ⁸Duke University Medical Center, Durham, NC
Background/Purpose: Women with arthritis wonder whether they will be able to have the children they desire. They also worry that oral contraceptives may worsen their…

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