Abstracts tagged "Arthritis"

Abstract Number: 375 • 2018 ACR/ARHP Annual Meeting
Only a Minor Proportion of Individuals with Anti-Aminoacyl-tRNA Synthetase Autoimmunity Presents with the Clinical Picture of “Antisynthetase-Syndrome”
Johannes Knitza, Hannah Schenker, Georg Schett and Jörg Distler, Department of Internal Medicine 3, Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany
Background/Purpose: Antisynthetase Syndrome is a rare and severe autoimmune inflammatory disease that is associated with autoimmunity against aminoacyl-tRNA synthetase and clinical signs of arthritis, myositis…
Abstract Number: 1448 • 2018 ACR/ARHP Annual Meeting
Clinical Impact of Articular Ultrasound in Diagnosis and Follow-up of Patients with Polyarthritis
Justine Lafleur-Careau¹, François Taschereau¹, Artur J de Brum-Fernandes², Alessandra Bruns³, Gilles Boire⁴ and Ariel Masetto⁵, ¹Centre Hospitalier Universitaire de Sherbrooke (CHUS), Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC, Canada, ²Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke (CHUS), Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC, Canada, ³Rhumatologie, Centre Hospitalier Universitaire de Sherbrooke (CHUS), Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁴Rheumatology Division, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, ⁵Centre Hospitalier Universitaire de Sherbrooke (CHUS), Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, AB, Canada
Background/Purpose: It is well established in the literature that musculoskeletal ultrasound (MSUS) is more sensitive than clinical examination in the detection of synovitis. MSUS can…
Abstract Number: 664 • 2018 ACR/ARHP Annual Meeting
Prevalence and Factors Associated with Peripheral Manifestations in Spondyloarthritis. an Ancillary Analysis of the ASAS-Comospa Study
Clementina López-Medina¹, Anna Molto² and Maxime Dougados³, ¹Rheumatology Department, Cochin Hospital, Paris, France, ²Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, ³Department of Rheumatology, Paris Descartes University and Cochin Hospital, Paris, France
Background/Purpose: Peripheral manifestations (arthritis, enthesitis and dactylitis) can be observed in patients with Spondyloarthritis (SpA), but the factors associated with their presence are not well…
Abstract Number: 1475 • 2018 ACR/ARHP Annual Meeting
Eicosanoid Mediators of Systemic Inflammation and Arthritis in the Elderly
Roxana Coras^1,2, Rekha Narasimhan¹, Arthur Kavanaugh³, Lourdes Mateo⁴, Oswald Quehenberger⁵, Melania Martinez-Morillo⁶ and Monica Guma^1,2, ¹Medicine, University of California San Diego, La Jolla, CA, ²Medicine, Autonomous University of Barcelona, Bellatera, Spain, ³University of California, San Diego, School of Medicine, La Jolla, CA, ⁴Rheumatology, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ⁵Pharmacology, Medicine, University of California San Diego, La Jolla, CA, ⁶Rheumatology, Germans Trias i Pujol University Hospital, Barcelona, Spain
Background/Purpose: Elderly-onset RA, EORA, which is defined as rheumatoid arthritis (RA) starting at >60 years of age, has received less attention than young-onset RA. Polymyalgia rheumatica (PMR) is…
Abstract Number: 1020 • 2017 ACR/ARHP Annual Meeting
The Inflammatory and Proliferative Synovial Lesion in Post-Infectious Lyme Arthritis Results from Impaired Wound Healing
Robert Lochhead^1,2, David Ordonez-Del Valle^1,2, Klemen Strle^2,3, Sheila Arvikar^1,2, John Aversa⁴ and Allen Steere^1,2, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ²Department of Medicine, Harvard Medical School, BOSTON, MA, ³Department of Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ⁴School of Medicine, Yale University, New Haven, CT
Background/Purpose: Lyme arthritis (LA) is initially triggered by Borrelia burgdorferi infection, but in some patients, the synovitis persists despite 2-3 months of antibiotic therapy and…
Abstract Number: 2231 • 2017 ACR/ARHP Annual Meeting
MCC22, a Novel Compound That Targets Both CCR5 and Mu Opioid Receptors, Is Highly Effective in Treating Inflammatory Arthritis Pain
Raini Dutta¹, Mary Lunzer², Jennifer L. Auger³, Eyup Akgün², Philip Porthoghese² and Bryce A. Binstadt³, ¹Pediatrics, University of Minnesota, Minneapolis, MN, ²Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN, ³Center for Immunology and Department of Pediatrics, University of Minnesota, Minneapolis, MN
Background/Purpose: The pain that accompanies rheumatoid arthritis and other chronic inflammatory conditions is difficult to manage. Although opioids provide potent analgesia, chronic opioid use is…
Abstract Number: 1308 • 2017 ACR/ARHP Annual Meeting
Answering Reproductive Health Questions That Your Patients Want to Know: Impediments to Family Building and Risks of Contraception
Malithi Jayasundara¹, Amanda M. Eudy², Tayseer Haroun³, W. Benjamin Nowell⁴, Jeffrey R. Curtis⁵, Rachelle Crow-Hercher⁶, Charlotte Whitney White⁶, Seth D. Ginsberg⁷ and Megan E. B. Clowse⁸, ¹Rheumatology, Duke University, Durham, NC, ²Duke University, Durham, NC, ³Department of Medicine/Division of Rheumatology, Duke University Medical Center, Durham, NC, ⁴Global Healthy Living Foundation, Upper Nyack, NY, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Arthritis Power, Upper Nyack, NY, ⁷Global Healthy Living Foundation, CreakyJoints, Upper Nyack, NY, ⁸Duke University Medical Center, Durham, NC
Background/Purpose: Women with arthritis wonder whether they will be able to have the children they desire. They also worry that oral contraceptives may worsen their…
Abstract Number: 2239 • 2017 ACR/ARHP Annual Meeting
The Recall Program: Data from a Multicenter Educational Event on Patients with Rheumatoid Arthritis
Andrea Delle Sedie¹, Emilio Filippucci², Oscar Epis³, Pierluigi Macchioni⁴, Sebastiano Tropea⁵, Carlo Bonali⁶, Marco Canzoni⁷ and Annamaria Iagnocco⁸, ¹Department Rheumatology, University of Pisa, Pisa, Italy, ²Rheumatology Unit, Università Politecnica delle Marche, Jesi, Italy, ³Rheumatology Unit, Ospedale Niguarda, Milano, Italy, ⁴Arcispedale Santa Maria Nuova, Reggio Emilia, Italy, ⁵ASP7, Busacca Hospital, Ragusa, Italy, ⁶Rheumatology Unit,, Ospedale San Paolo, Bari, Italy, ⁷Local Health Unit (ASL) Rome 1, Rome, Italy, ⁸Academic Rheumatology Unit, Università degli Studi di Torino, Torino, Italy
Background/Purpose: ultrasound (US) is able to show subclinical synovitis in patients (pts) with rheumatoid arthritis (RA) who are in clinical remission (CR); this has been…
Abstract Number: 67 • 2017 ACR/ARHP Annual Meeting
The Oxygen Sensor PHD1 Is an Indispensable Regulator of Arthritis Development
Katelijne De Wilde¹, Peggy Jacques² and Dirk Elewaut³, ¹Inflammation Research Center - VIB UGhent, Molecular Immunology and Inflammation Unit, Ghent, Belgium, ²Ghent University Hospital, Ghent, Belgium, ³VIB Inflammation Research Center, University of Ghent, Ghent, Belgium
Background/Purpose: Oxygen supply is a fundamental requirement for all living tissues. Some tissues such as articular joints are characterized by a physiological state of hypoxia.…
Abstract Number: 1321 • 2017 ACR/ARHP Annual Meeting
Inhibition of the Mechanistic Target of Rapamycin Pathway and Glutaminolysis Facilitates the Expansion of Myeloid-Derived Suppressor Cells and Synergistically Ameliorates Arthritis in SKG Mice
Yo Ueda¹, Takaichi Okano¹, Hirotaka Yamada¹, Yoshihide Ichise¹, Ikuko Naka², Soshi Takahashi³, Sho Sendo⁴, Kengo Akashi², Akira Onishi⁵, Jun Saegusa⁴ and Akio Morinobu³, ¹Department of Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Kobe University Graduate School of Medicine, Kobe, Japan, ³Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁴Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁵Rheumaology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature cells that increase in the pathological state such as tumor or inflammation and have…
Abstract Number: 2265 • 2017 ACR/ARHP Annual Meeting
Survey on Gout-Related Knowledge and Perception in Inpatient Setting on Hospitalized Patients with Gout
Roshanak Habibi¹, David T Liss², Sreelakshmi Panginikkod¹, Alvaro Altamirano Ufion³, Ehsan Rajabirostami¹ and Manish Jain⁴, ¹Internal Medicine, Presence Saint Francis Hospital, Evanston, IL, ²Northwestern University, Chicago, IL, ³Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, IL, ⁴Rheumatology, Presence Saint Francis Hospital, Evanston, IL
Background/Purpose: The increasing global burden of gout disease and its impact on the patient’s quality of life calls for new strategies in management. Even though…
Abstract Number: 234 • 2017 ACR/ARHP Annual Meeting
Impact of Arthritis Among Populations with Chronic Health Conditions in Rural Counties of the United States – 2015
Michael Boring¹, Louise Murphy², Jennifer M. Hootman³ and Yong Liu², ¹Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ²Division of Population Health, Centers for Disease Control and Prevention, Atlanta, GA, ³Centers for Disease Control and Prevention, Kennesaw, GA
Background/Purpose: US rural populations have well documented health disparities, including higher prevalence of chronic health conditions; however, arthritis prevalence among those with other chronic conditions…
Abstract Number: 1322 • 2017 ACR/ARHP Annual Meeting
Tissue Folate Dysregulation Is Associated with Disease Activity and Methotrexate Response in Collagen-Induced Arthritis
Leon van Haandel¹, Rakesh Singh², Paul Kiptoo³, Teruna Siahaan³, Mara L Becker⁴ and Ryan Funk⁵, ¹2401 Gillham Road, Children's Mercy, Kansas City, MO, ²Department of Pharmacy Practice, University of Kansas Medical Center, Kansas City, KS, ³Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS, ⁴Rheumatology, Children's Mercy Kansas City, Kansas City, MO, ⁵University of Kansas Medical Center, Kansas City, KS
Background/Purpose: Methotrexate (MTX) is an anti-metabolite inhibitor of folate-dependent biochemical pathways and is effective in reducing disease activity in autoimmune arthritis. This work seeks to…
Abstract Number: 2709 • 2017 ACR/ARHP Annual Meeting
Histone Deacetylase 1 (HDAC1): A Novel Therapeutic Target for Patients with Rheumatoid Arthritis
Lisa Goschl^1,2, Michael Bonelli³, Victoria Saferding⁴, Teresa Peglej², Sylvia Knapp⁵, Johan Bäcklund⁶, Christoph Bock⁵, Patrick Matthias⁷, Kiyoshi Hirahara⁸, Clemens Scheinecker¹, Günter Steiner⁹, Josef S. Smolen¹ and Wilfried Ellmeier², ¹Medical University of Vienna, Devision of Rheumatology, Vienna, Austria, ²Medical University of Vienna,Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Vienna, Austria, ³Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Medical University of Vienna, Austria, Vienna, Austria, ⁵CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria, ⁶Karolinska Institute,Department of Medical Biochemistry and Biophysics, Stockholm, Sweden, ⁷Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, ⁸Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan, ⁹Medical University of Vienna, Dvision of Rheumatology, Vienna, Austria
Background/Purpose: Autoreactive T cells drive the inflammatory process, which leads to an irreversible destruction of the joints. Gene transcription and regulation of proinflammatory cytokine production…
Abstract Number: 250 • 2017 ACR/ARHP Annual Meeting
An Ultrasonographic Study for Investigating Relationships with the Signs of Uric Deposition and Bone Erosion in Patients with Hyperuricemia
Ikuko Tanaka¹, Takashi Kato², Motokazu Kai³, Kunikazu Ogawa³, Hisaji Oshima⁴ and Shigenori Tamaki⁵, ¹NAGOYA Rheumatology Clinic, Nagoya, Japan, ²Department of Radiology, National Center for Geratrics and Gerontology, Obu, Japan, ³Mie Rheumatology Clinic, Suzuka, Japan, ⁴Department of Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan, ⁵Nagoya Rheumatology Clinic, Nagoya, Japan
Background/Purpose: Joint ultrasonography (US) is a noninvasive examination that can evaluate arthritis and uric acid deposition at gout attacks. The purpose of this study was…

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