Abstracts tagged "Arthritis"

Abstract Number: 914 • 2018 ACR/ARHP Annual Meeting
Increased Adverse Childhood Experiences in Children with Arthritis: An Analysis of the National Survey of Children’s Health
Tamar Rubinstein¹, Danielle R. Bullock², Kaveh Ardalan³, Wenzhu B. Mowrey⁴, Nicole Brown⁵ and Ruth E K Stein⁶, ¹Pediatric Rheumatology, Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, NY, ²Pediatrics, University of Minnesota, Minneapolis, MN, ³Division of Rheumatology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁴Albert Einstein College of Medicine, Bronx, NY, ⁵Albert Einstein College of Medicine/ Children's Hospital at Montefiore, Bronx, NY, ⁶Pediatrics, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Adverse Childhood Experiences (ACEs) are associated with increased risk of chronic disease and poorer health in children and adults. Emerging data suggest an association…
Abstract Number: 1950 • 2018 ACR/ARHP Annual Meeting
Self-Reported Depression and Anxiety Among US Adults Aged 18-44 Years with Arthritis, National Health Interview Survey 2014-2016
Dana Guglielmo¹, Jennifer M. Hootman², Louise Murphy², Michael Boring³, Kristina Theis², Charles G. Helmick², Kamil E. Barbour² and Patricia Katz⁴, ¹Oak Ridge Institute for Science and Education, Oak Ridge, TN, ²Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ³Cutting Edge Technology and Solutions, Mesa, AZ, ⁴University of California San Francisco, San Francisco, CA
Background/Purpose: Depression and anxiety are frequent comorbid conditions among adults with arthritis, and are associated with poorer quality of life, reduced adherence and efficacy of…
Abstract Number: 951 • 2018 ACR/ARHP Annual Meeting
IFN-Gamma Production in Lyme Arthritis Synovial Tissue Promotes Differentiation of Fibroblast-like Synoviocytes into Inflammatory Effector Cells
Robert Lochhead¹, David Ordonez-Del Valle¹, Sheila Arvikar², Allen C. Steere² and Klemen Strle³, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, BOSTON, MA, ²Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Department of Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, BOSTON, MA
Background/Purpose: Lyme arthritis (LA), a late-disease manifestation of Borrelia burgdorferi infection, usually responds to antibiotic therapy. However, some patients may develop a proliferative synovitis lasting…
Abstract Number: 1974 • 2018 ACR/ARHP Annual Meeting
Dynamics of Transcriptional Signatures from Synovial Macrophage Subsets during Acute and Chronic Murine Models of Inflammatory Arthritis
Philip J. Homan¹, Anna B Montgomery², Salina Dominguez³, Carla M. Cuda³, Harris Perlman³ and Deborah R. Winter³, ¹Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Macrophages play an integral role in the progression and persistence of rheumatoid arthritis (RA) through production of degradative enzymes, cytokines, and chemokines and recruitment…
Abstract Number: 250 • 2017 ACR/ARHP Annual Meeting
An Ultrasonographic Study for Investigating Relationships with the Signs of Uric Deposition and Bone Erosion in Patients with Hyperuricemia
Ikuko Tanaka¹, Takashi Kato², Motokazu Kai³, Kunikazu Ogawa³, Hisaji Oshima⁴ and Shigenori Tamaki⁵, ¹NAGOYA Rheumatology Clinic, Nagoya, Japan, ²Department of Radiology, National Center for Geratrics and Gerontology, Obu, Japan, ³Mie Rheumatology Clinic, Suzuka, Japan, ⁴Department of Connective Tissue Diseases, National Tokyo Medical Center, Tokyo, Japan, ⁵Nagoya Rheumatology Clinic, Nagoya, Japan
Background/Purpose: Joint ultrasonography (US) is a noninvasive examination that can evaluate arthritis and uric acid deposition at gout attacks. The purpose of this study was…
Abstract Number: 1323 • 2017 ACR/ARHP Annual Meeting
Crucial Roles for Toll-like Receptor 9 in the Pathogenesis of Erosive Autoimmune Arthritis and during Osteoclastogenesis
Anita Fischer¹, Brigitte Meyer¹, Birgit Niederreiter², Erik Lönnblom³, Rikard Holmdahl⁴ and Günter Steiner², ¹Internal Medicine III, Division of Rheumatology, Medical University Vienna, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Medical Biochemistry & Biophysics, Karolinska Institute, Stockholm, Sweden, ⁴Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
Background/Purpose: Release and insufficient removal of endogenous nucleic acids may be involved in triggering harmful autoimmune reactions important in the initiation of systemic autoimmune diseases…
Abstract Number: 2840 • 2017 ACR/ARHP Annual Meeting
Clinical Presentation and Outcomes in Patients with Prosthetic Joint Septic Arthritis Who Had One-Stage Versus Two-Stage Joint Replacement
Mary Louise Fowler¹, Kevin Byrne², Sarah Lieber³, Robert Shmerling⁴ and Ziv Paz³, ¹2Boston University School of Medicine, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Beth Israel Deaconess Medical Center, Boston, MA, ⁴Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA
Background/Purpose: Prosthetic joint septic arthritis (PJSA) complicates about 1 to 2 percent of joint replacement surgeries. The management of PJSA usually includes a combination of…
Abstract Number: 277 • 2017 ACR/ARHP Annual Meeting
Rheumatic Conditions Appearing De Novo after Infection with Chikungunya Virus in Venezuelan Patients
Yurilis Fuentes-Silva¹, Carlota Acosta², Luisa Ortega³, Martin A Rodriguez⁴, Soham Al Snih⁵, Ivan Amaya⁶ and Irama Maldonado³, ¹Division of Rheumatology/Internal Medicine Department, 1Unidad de Reumatología adscrita al Centro Nacional de Enfermedades Reumáticas. Complejo Hospitalario Universitario Ruiz y Páez, Ciudad Bolivar, Venezuela (Bolivarian Republic of), ²1Unidad de Reumatología adscrita al Centro Nacional de Enfermedades Reumáticas. Complejo Hospitalario Universitario Ruiz y Páez, Ciudad Bolivar, Venezuela (Bolivarian Republic of), ³Internal Medicine, 1Unidad de Reumatología adscrita al Centro Nacional de Enfermedades Reumáticas. Complejo Hospitalario Universitario Ruiz y Páez, Ciudad Bolivar, Venezuela (Bolivarian Republic of), ⁴Division of Rheumatology/Internal Medicine Department, Centro Nacional de Enfermedades Reumaticas. Hospital Universitario de Caracas, Caracas, Venezuela (Bolivarian Republic of), ⁵University of Texas Medical Branch, Galveston, TX, ⁶Facultad de Bioanálisis. Universidad de Oriente, Cudad Bolivar, Venezuela (Bolivarian Republic of)
Background/Purpose: It is well known that viral infections can trigger autoimmune rheumatic diseases. In 2,014 there was an outbreak of Chikungunya (CHIK) virus infection in…
Abstract Number: 1330 • 2017 ACR/ARHP Annual Meeting
Rhesus Theta Defensin 1 (RTD-1) Suppresses Disease-Associated Genes and Induces Anti-Inflammatory Expression Signature in Synovial Tissues of Rat Model of Rheumatoid Arthritis
Prasad Tongaonkar¹, Vasu Punj², Akshay Subramanian³, Dat Tran³, Katie Trinh⁴, Justin Schaal¹, Percio S. Gulko⁵, Andre Oullette³ and Michael Selsted³, ¹Pathology and Laboratory Medicine, Keck School of Medicine University of Southern California, Los Angeles, CA, ²Medicine, Keck School of Medicine University of Southern California, Los Angeles, CA, ³Keck School of Medicine University of Southern California, Los Angeles, CA, ⁴Pathology, Keck School of Medicine University of Southern California, Los Angeles, CA, ⁵Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Theta (θ) defensins are the only known macrocyclic peptides found in the Animal kingdom and are exclusively expressed in Old World monkeys. θ-defensins were…
Abstract Number: 2842 • 2017 ACR/ARHP Annual Meeting
Usefulness of Polymerase Chain Reaction for Diagnosing Whipple’S Disease in Rheumatology
Marion Herbette¹, Jean Baptiste Cren², Laurie Joffres³, charlotte lucas⁴, Emilie Ricard⁵, Carine Salliot⁶, Jerome Guinard⁷, Aleth Perdriger⁸, Elisabeth Solau-Gervais⁹, Béatrice Bouvard¹⁰ and Alain Saraux¹¹, ¹Rheumatology, University Hospital, Brest, France, ²Rheumatology, University Hospital of Angers, Angers, France, ³University Hospital de Poitiers, Poitiers, France, ⁴Rheumatology, University Hospital, Rennes, France, ⁵Rheumatology, University Hospital, Orléans, France, ⁶department of Rheumatology, Orleans, France, ⁷Microbiology, CHU Angers, Angers, France, ⁸Service de Rhumatologie, CHRU de Rennes, Rennes, France, ⁹Rhumatologie, University Hospital, Poitiers, France, ¹⁰rheumatology, CHU Angers, Angers, France, ¹¹Rheumatology, Brest University Medical School Hospital, Brest, France
Background/Purpose: Whipple's disease should be considered in patients with recurrent episodes of seronegative arthritis in the large limb, various symptoms (fever, uveitis,...) or biological abnormalities…
Abstract Number: 302 • 2017 ACR/ARHP Annual Meeting
From Monocytes to Macrophages: the Pathogeneses of Spontaneous Inflammatory Arthritis in CD11c-Flip-KO (HUPO) Mice
Qi Quan Huang¹, Renee E. Doyle², Philip J. Homan¹, Harris Perlman³, Deborah R. WInter³ and Richard M. Pope², ¹Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: We have generated a CD11c-Flip-KO mouse line (HUPO) that spontaneously develops erosive arthritis with incidence 70-80% at age ≥ 20 weeks. This study aimed…
Abstract Number: 1339 • 2017 ACR/ARHP Annual Meeting
Role of Hexokinase-2 in Synovial Lining Hypertrophy in Murine Arthritis
Marta Fernandez Bustmanate¹, Jeffrey Smith², Adam Paul Croft³, Gary S. Firestein⁴, Chris Buckley⁵, Shigeki Miyamoto² and Monica Guma⁶, ¹Medicine, UCSD, San Diego, CA, ²Pharmacology, UCSD, La Jolla, CA, ³Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ⁴Medicine, University of California San Diego, La Jolla, CA, ⁵University of Birmingham, Birmingham, United Kingdom, ⁶Medicine, UCSD, La Jolla, CA
Background/Purpose: Recent studies indicate that fibroblast-like synoviocyte (FLS) glucose metabolism is altered in rheumatoid arthritis (RA). Hexokinases (HKs) catalyze the first step in glucose metabolism.…
Abstract Number: 2902 • 2017 ACR/ARHP Annual Meeting
Inflammatory Arthritis Due to Immune Checkpoint Inhibitors: A Persistent Problem Requiring Immunosuppression
Laura Cappelli¹, Clifton O. Bingham III² and Ami A. Shah³, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University, Baltimore, MD, ³Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Immune checkpoint inhibitors (ICIs) have emerged as an important treatment for advanced malignancies. ICIs are a form of immunotherapy which block negative co-stimulation of…
Abstract Number: 314 • 2017 ACR/ARHP Annual Meeting
Effects of Exercise on Anxiety in Adults with Arthritis: A Systematic Review with Meta-Analysis
George Kelley¹, Kristi Kelley¹ and Leigh F. Callahan², ¹Biostatistics, West Virginia University, Morgantown, WV, ²Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Previous randomized controlled trials have led to conflicting findings regarding the effects of exercise on anxiety in adults with arthritis and other rheumatic diseases…
Abstract Number: 1742 • 2017 ACR/ARHP Annual Meeting
Involvement of T Helper 17 Cells in Inflammatory Arthritis Depends on the Host Intestinal Microbiota
Heather Evans-Marin¹, Rebecca Rogier², Jose U. Scher³, Debbie M. Roeleveld², Marije I. Koenders⁴ and Shahla Abdollahi-Roodsaz^5,6, ¹Division of Rheumatology, New York University School of Medicine, New York, NY, ²Experimental Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands, ³New York University School of Medicine, New York, NY, ⁴Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁵Department of Medicine, Division of Rheumatoogy, New York University School of Medicine, New York, NY, ⁶Rheumatology, Radboud University Medical Center, Nijmegen, Netherlands
Background/Purpose: The intestinal microbiota has been associated with psoriatic and rheumatoid arthritis. One of the major effects of microbiota is the induction of mucosal T…

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