Abstracts tagged "Arthritis"

Abstract Number: 934 • 2015 ACR/ARHP Annual Meeting
Platelet-Independent Role of Megakaryocytes in Antibody-Mediated Murine Arthritis
Pierre Cunin¹, Loka Penke², Jonathan Thon³, Paul A. Monach⁴, Tatiana Jones⁵, Mary Chen², Yoichiro Iwakura⁶, Jerry Ware⁷, Michael Gurish², Joseph Italiano³, Eric Boilard⁸ and Peter A. Nigrovic^2,9, ¹Rheumatology, Immunology and Allergy, Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ²Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ³Department of Medicine, Hematology Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Rheumatology, Boston University School of Medicine, Boston, MA, ⁵Department of Clinical Laboratory and Nutritional Science, University of Massachusetts Lowell, Lowel, MA, ⁶Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan, ⁷Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, ⁸Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Faculté de Médecine de l’Université Laval, Quebec, QC, Canada, ⁹Department of Medicine, Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Mice bearing mutations affecting Kit (stem cell factor receptor) exhibit multiple hematologic phenotypes, including mast cell deficiency, and have been used to assess the…
Abstract Number: 1531 • 2015 ACR/ARHP Annual Meeting
The Changing Face of Septic Arthritis Complicating Rheumatoid Arthritis in the Era of Biotherapies. Retrospective Single-Center Study over 35 Years
Jean-Jacques Dubost¹, Bruno Pereira², Anne Tournadre³, Zuzana Tatar¹, Marion Couderc¹ and Martin Soubrier¹, ¹Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, ²Biostatistics unit (DRCI), CHU Clermont-Ferrand, Clermont-Ferrand, France, ³Rheumatology, UNH-UMR 1019 INRA University of Auvergne and Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France
Background/Purpose: Rheumatoid arthritis (RA) is a risk factor for septic arthritis (SA), and anti-TNF therapy doubles the risk of SA. The purpose of this study…
Abstract Number: 3244 • 2015 ACR/ARHP Annual Meeting
Evaluation of a Self-Directed Walking Program in Hispanics with Arthritis
Leigh F. Callahan¹, Alfredo Rivadeneira², Mary Altpeter³, Rebecca J. Cleveland⁴, Betsy Hackney¹, Leigha Vilen², Victoria Sepulveda⁴, Daniel S Reuland⁵ and Claudia Rojas⁴, ¹Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ²Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Institute on Aging, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Department of Internal Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Walk with Ease (WWE) is the Arthritis Foundation's (AF) 6-week evidence-based walking program for adults with arthritis that can be offered in 2 formats:…
Abstract Number: 1037 • 2015 ACR/ARHP Annual Meeting
Impaired Regulatory T Cell Survival in the Pathogenesis of Autoreactive Arthritis Mediated By CD11c-Deletion of Flip
Qi Quan Huang¹, Renee E. Doyle¹, Robert Birkett², Deyu Fang³, Syamal K. Datta¹ and Richard M. Pope¹, ¹Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: We have generated a mouse line with Flip conditionally deleted in CD11c-cre expressing cells (CD11c-Flip-KO, named HUPO), which spontaneously develops erosive arthritis resembling rheumatoid…
Abstract Number: 1874 • 2015 ACR/ARHP Annual Meeting
Impact of Socioeconomic Status on Survival in Connective Tissue Disease Associated and Idiopathic Pulmonary Arterial Hypertension
Helen Jin¹, John T. Granton², John Thenganatt³, Jakov Moric³, Ambika Gupta¹, Amie T. Kron¹, Cathy Chau¹ and Sindhu R. Johnson¹, ¹Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, University Health Network Pulmonary Hypertension Programme, Toronto, ON, Canada, ²Medicine, Univeristiy Health Network Pulmonary Hypertension Programme, Toronto General Hospital and University of Toronto, Toronto, ON, Canada, ³Univeristiy Health Network Pulmonary Hypertension Programme, Toronto General Hospital and University of Toronto, Toronto, ON, Canada
Background/Purpose: Poorer health outcomes for persons with chronic diseases have been reported in association with lower socioeconomic status (SES). No such evaluation exists for patients…
Abstract Number: 1142 • 2015 ACR/ARHP Annual Meeting
Joint Specific Function of Synovial Fibroblasts – Integrating Positional Transcriptomes and Anatomic Patterns of Arthritis
Mojca Frank Bertoncelj¹, Michelle Trenkmann¹, Kerstin Klein¹, Emmanuel Karouzakis¹, Christoph Kolling², Andrew Filer³, Christopher Buckley⁴, Beat A. Michel¹, Renate E. Gay¹, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, University Zurich, Zurich, Switzerland, ²Upper Extremity Dept., Schulthess Clinic Zurich, Zurich, Switzerland, ³University of Birmingham, Birmingham, United Kingdom, ⁴University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom
Background/Purpose: Synovial fibroblasts (SF) profoundly influence physiological and pathological processes in the joint such as reaction to inflammatory stimuli and production of extracellular matrix. We…
Abstract Number: 1888 • 2015 ACR/ARHP Annual Meeting
There Is a Need for New Systemic Sclerosis Subset Criteria: A Content Analytic Approach
Sindhu Johnson¹, Medha Soowamber², Jaap Fransen³, Dinesh Khanna⁴, Frank H.J. van den Hoogen⁵, Murray Baron⁶, Marco Matucci Cerinic⁷, Christopher P. Denton⁸, Thomas A. Medsger Jr.⁹, Patricia E. Carreira¹⁰, Gabriela Riemekasten¹¹, Jorg HW. Distler¹², Armando Gabrielli¹³, Virginia D. Steen¹⁴, Lorinda Chung¹⁵, Richard Silver¹⁶, John Varga¹⁷, Ulf Müller-Ladner¹⁸, Madelon C. Vonk¹⁹, Ulrich A. Walker²⁰, Frank Wollheim²¹, Ariane L. Herrick²², Daniel E. Furst²³, Lazlo Czirjak²⁴, Otylia Kowal-Bielecka²⁵, Francesco Del Galdo²⁶, Maurizio Cutolo²⁷, Nicolas Hunzelmann²⁸, Charles Murray²⁹, Ivan Foeldvari³⁰, Luc Mouthon³¹, Nemanja Damjanov³², Bashar Kahaleh³³, Tracy M. Frech³⁴, Shervin Assassi³⁵, Lesley Ann Saketkoo³⁶ and Janet E. Pope³⁷, ¹Toronto Scleroderma Program, Toronto Western Hospital, Mount Sinai Hospital, University of Toronto, University Health Network Pulmonary Hypertension Programme, Toronto, ON, Canada, ²Rheumatology, University of Toronto/ Toronto Western Hospital, Toronto, ON, Canada, ³Rheumatology, Radboud University Medical Centre, Nijmegen, Netherlands, ⁴Medicine, University of Michigan, Ann Arbor, MI, ⁵Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ⁶Pavillion A, Rm 216, Jewish General Hospital, Montreal, QC, Canada, ⁷Department of BioMedicine, Division of Rheumatology, Transition Unit, University of Florence, Firenze, Italy, ⁸Centre for Rheumatology, Royal Free Hospital, London, United Kingdom, ⁹Medicine/Rheumatology, Univ of Pittsburgh, Pittsburgh, PA, ¹⁰Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹¹Rheumatology, Human medicine, BERLIN, Germany, ¹²Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany, ¹³Clinica Medica, Università Politecnica delle Marche, Ancona, Italy, ¹⁴Rheumatology, Georgetown University Medical Center, Washington, DC, ¹⁵Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ¹⁶Div Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ¹⁷Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹⁸Rheumatology, Internal Medicine, Bad Nauheim, Germany, ¹⁹Rheumatology, Rheumatology, Nijmegen, Netherlands, ²⁰Rheumatology, Systemic Sclerosis, Basel, Switzerland, ²¹Rheumatology, Lund University Hospital, Lund, Sweden, ²²Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, ²³Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ²⁴University of Pécs Medical Center, Pécs, Hungary, ²⁵Department of Rheumatology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland, ²⁶University of Leeds, Leeds, United Kingdom, ²⁷Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ²⁸Department of Dermatology, University of Cologne, Cologne, Germany, ²⁹Department of Gastroenterology, Royal Free Hospital, London, United Kingdom, ³⁰Rheumatology, Hamburg, Germany, ³¹Department of Internal Medicine, Department of Internal Medicine, Cochin Hospital, Referent Center for Necrotizing Vasculitis and Systemic Sclerosis, Paris-Descartes University, AP-HP, Paris, France, ³²Resavska 69, Institute of Rheumatology, Belgrade, Serbia, ³³Medicine/Rheumatology, The University of Toledo, Toledo, OH, ³⁴Div of Rheumatology, University of Utah Medical Ctr, Salt Lake City, UT, ³⁵Rheumatology, University of Texas Medical School at Houston, Houston, TX, ³⁶Tulane University Lung Center, New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, ³⁷University of Western Ontario, London, ON, Canada
Background/Purpose: Systemic sclerosis (SSc) is a family of diseases unified by the presence of immune activation, vasculopathy and fibrosis. The concept of SSc subsets cannot…
Abstract Number: 1157 • 2015 ACR/ARHP Annual Meeting
Specific Profile of Serum Free Fatty Acids Is Found in Rheumatoid Arthritis Patients
Javier Rodríguez-Carrio¹, Mercedes Alperi-López², Patricia López¹, Javier Ballina-García² and Ana Suárez¹, ¹Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, ²Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain
Background/Purpose: Lipidomics is an emerging field in biomedical research. Free Fatty Acids (FFA) are important mediators of the lipid metabolism which can play a role…
Abstract Number: 2084 • 2015 ACR/ARHP Annual Meeting
Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Modulates Bone Resorption in Inflammatory Arthritis and Fracture Repair
Yahui Grace Chiu¹, Tzong-Ren Sheu², Jinbo Li³, Dongge Li⁴, Michael Thullen², Brendan Boyce⁵, Christopher T. Ritchlin⁶ and Javier Rangel-Moreno⁷, ¹Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY, ²Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ³Pathology, University of Rochester, Rochester, NY, ⁴Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁵University of Rochester, Rochester, NY, ⁶Allergy, Immunology and Rheumatololgy Division, University of Rochester Medical Center, Rochester, NY, ⁷Allergy, Immunology & Rheumatology, University of Rochester, Rochester, NY
Background/Purpose: Osteoclasts (OC) direct pathologic bone resorption in osteoporosis and inflammatory arthritis. We previously demonstrated that DC-STAMP (Dendritic Cell-Specific Transmembrane protein), a 7-pass transmembrane protein,…
Abstract Number: 1167 • 2015 ACR/ARHP Annual Meeting
Treating Experimental Arthritis with Adenoviral Overexpression of IL-22 or with Blocking Antibodies Against Endogenous IL-22 Both Reduces Inflammation and Destruction
Marije I. Koenders¹, Debbie M. Roeleveld¹, Loreto Parga¹, Shahla Abdolahi-Roodsaz¹, Fons A.J. van de Loo¹, Jay K. Kolls² and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA
Background/Purpose: Interleukin-22 (IL-22) is an IL-10 family cytokine member that was recently discovered to be mainly produced by Th17 cells. Previous studies have indicated the…
Abstract Number: 2090 • 2015 ACR/ARHP Annual Meeting
Gender-Specific Pathways Linking Arthritis, Activity Limitation and Incident Heart Disease: A Causal Mediation Analysis of the Canadian Longitudinal National Population Health Survey
Orit Schieir¹, Sheilah. Hogg-Johnson^1,2, Richard H Glazier^3,4,5,6 and Elizabeth M. Badley^1,7, ¹Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ²Institute for Work and Health, Toronto, ON, Canada, ³Family and Community Medicine, St. Michael's Hospital, Toronto, ON, Canada, ⁴Centre for Research on Inner City Health, St. Michael's Hospital, Toronto, ON, Canada, ⁵Family and Community Medicine, University of Toronto, Toronto, ON, Canada, ⁶Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, ⁷Division of Health Care and Outcomes Research, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Arthritis and activity limitation are risk factors for cardiovascular (CVD) morbidity and mortality. As arthritis is a major cause of activity limitation, the objective…
Abstract Number: 1206 • 2015 ACR/ARHP Annual Meeting
Presence of ACPA in a Large (>40.000) Population Based Cohort from the Netherlands
Elisabeth Brouwer¹, Suzanne Arends², Hendrika Bootsma¹, Caroline Roozendaal³, Pieter C Limburg⁴, Fiona Maas¹, René E. M. Toes⁵, T. W. J. Huizinga⁶, LA Trouw⁷ and Annemirthe Van Zanten¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Rheumatology, Medical Center Leeuwarden, Leeuwarden, Netherlands, ³Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands, ⁴Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁵Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁶Leiden University Medical Center, Leiden, Netherlands, ⁷Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) status provides important information regarding the diagnosis and prognosis of Rheumatoid Arthritis (RA). By using samples from blood bank donors…
Abstract Number: 2111 • 2015 ACR/ARHP Annual Meeting
A Study to Evaluate the Efficacy and Safety of Arhalofenate for Preventing Flares and Reducing Serum Uric Acid in Gout Patients
Alexandra Steinberg¹, Harinder Chera¹, Yun-Jung Choi¹, Robert Martin¹, Charles McWherter¹, Yunbin Zhang², Pol Boudes¹ and on behalf of the Arhalofenate Anti-Flare Therapy Study Group, ¹Cymabay Therapeutics, Newark, CA, ²INC Research, Raleigh, NC
Background/Purpose: Arhalofenate is a novel Urate-Lowering Anti-Flare Therapy (ULAFT) to treat gout. It lowers serum uric acid (sUA) by blocking URAT1, a tubular UA transporter, and…
Abstract Number: 2198 • 2014 ACR/ARHP Annual Meeting
The Aromatase Inhibitor Induced Musculoskeletal Syndrome: Is There a Potential Role of Osteoporosis Therapy and Menopause Timing?
Zsolt Kulcsar¹, Clinton Morgan², Peter Kaufman³, Jonathan Jones⁴ and William Rigby⁵, ¹Rheumatology/Leadership Preventive Medicine Residency, Dartmouth Hitchcock Medical Center, lebanon, NH, ²Hematology/Oncology, Dartmouth Hitchcock Medical Center, Lebanon, NH, ³Hematology/Oncology, Dartmouth Hitchcock Medical Center, lebanon, NH, ⁴Rheumatology Clinic, Dartmouth-Hitchcock Medical Center, Lebanon, NH, ⁵Dartmouth-Hitchcock Medical Center and Dartmouth Medical School, Lebanon, NH
Background/Purpose: Aromatase Inhibitor (AI) therapy is the most effective hormonal treatment in post-menopausal estrogen receptor (ER) positive breast cancer. These patients may be seen by…
Abstract Number: 927 • 2014 ACR/ARHP Annual Meeting
Urate Crystal Induced Inflammation and Joint Pain Are Reduced in Transient Receptor Potential Ankyrin 1 (TRPA1) Deficient Mice – a New Potential Role for TRPA1 in Gout
Lauri J Moilanen, Mari Hämäläinen, Lauri Lehtimäki, Riina Nieminen and Eeva Moilanen, The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland
Background/Purpose: In the gout, monosodium urate (MSU) crystals deposit intra-articularly and cause painful arthritis. In the present study we tested the hypothesis that Transient Receptor…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].