Abstracts tagged "Arthritis"

Abstract Number: 2084 • 2015 ACR/ARHP Annual Meeting
Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Modulates Bone Resorption in Inflammatory Arthritis and Fracture Repair
Yahui Grace Chiu¹, Tzong-Ren Sheu², Jinbo Li³, Dongge Li⁴, Michael Thullen², Brendan Boyce⁵, Christopher T. Ritchlin⁶ and Javier Rangel-Moreno⁷, ¹Allergy, Immunology, and Rheumatology, University of Rochester, Rochester, NY, ²Center for Musculoskeletal Research, University of Rochester, Rochester, NY, ³Pathology, University of Rochester, Rochester, NY, ⁴Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, ⁵University of Rochester, Rochester, NY, ⁶Allergy, Immunology and Rheumatololgy Division, University of Rochester Medical Center, Rochester, NY, ⁷Allergy, Immunology & Rheumatology, University of Rochester, Rochester, NY
Background/Purpose: Osteoclasts (OC) direct pathologic bone resorption in osteoporosis and inflammatory arthritis. We previously demonstrated that DC-STAMP (Dendritic Cell-Specific Transmembrane protein), a 7-pass transmembrane protein,…
Abstract Number: 1167 • 2015 ACR/ARHP Annual Meeting
Treating Experimental Arthritis with Adenoviral Overexpression of IL-22 or with Blocking Antibodies Against Endogenous IL-22 Both Reduces Inflammation and Destruction
Marije I. Koenders¹, Debbie M. Roeleveld¹, Loreto Parga¹, Shahla Abdolahi-Roodsaz¹, Fons A.J. van de Loo¹, Jay K. Kolls² and Peter M. van der Kraan¹, ¹Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ²Richard King Mellon Foundation Institute for Pediatric Research, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA
Background/Purpose: Interleukin-22 (IL-22) is an IL-10 family cytokine member that was recently discovered to be mainly produced by Th17 cells. Previous studies have indicated the…
Abstract Number: 2090 • 2015 ACR/ARHP Annual Meeting
Gender-Specific Pathways Linking Arthritis, Activity Limitation and Incident Heart Disease: A Causal Mediation Analysis of the Canadian Longitudinal National Population Health Survey
Orit Schieir¹, Sheilah. Hogg-Johnson^1,2, Richard H Glazier^3,4,5,6 and Elizabeth M. Badley^1,7, ¹Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ²Institute for Work and Health, Toronto, ON, Canada, ³Family and Community Medicine, St. Michael's Hospital, Toronto, ON, Canada, ⁴Centre for Research on Inner City Health, St. Michael's Hospital, Toronto, ON, Canada, ⁵Family and Community Medicine, University of Toronto, Toronto, ON, Canada, ⁶Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, ⁷Division of Health Care and Outcomes Research, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
Background/Purpose: Arthritis and activity limitation are risk factors for cardiovascular (CVD) morbidity and mortality. As arthritis is a major cause of activity limitation, the objective…
Abstract Number: 1206 • 2015 ACR/ARHP Annual Meeting
Presence of ACPA in a Large (>40.000) Population Based Cohort from the Netherlands
Elisabeth Brouwer¹, Suzanne Arends², Hendrika Bootsma¹, Caroline Roozendaal³, Pieter C Limburg⁴, Fiona Maas¹, René E. M. Toes⁵, T. W. J. Huizinga⁶, LA Trouw⁷ and Annemirthe Van Zanten¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Rheumatology, Medical Center Leeuwarden, Leeuwarden, Netherlands, ³Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands, ⁴Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁵Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁶Leiden University Medical Center, Leiden, Netherlands, ⁷Rheumatology, Leiden University Medical Centre, Leiden, Netherlands
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) status provides important information regarding the diagnosis and prognosis of Rheumatoid Arthritis (RA). By using samples from blood bank donors…
Abstract Number: 2111 • 2015 ACR/ARHP Annual Meeting
A Study to Evaluate the Efficacy and Safety of Arhalofenate for Preventing Flares and Reducing Serum Uric Acid in Gout Patients
Alexandra Steinberg¹, Harinder Chera¹, Yun-Jung Choi¹, Robert Martin¹, Charles McWherter¹, Yunbin Zhang², Pol Boudes¹ and on behalf of the Arhalofenate Anti-Flare Therapy Study Group, ¹Cymabay Therapeutics, Newark, CA, ²INC Research, Raleigh, NC
Background/Purpose: Arhalofenate is a novel Urate-Lowering Anti-Flare Therapy (ULAFT) to treat gout. It lowers serum uric acid (sUA) by blocking URAT1, a tubular UA transporter, and…
Abstract Number: 1244 • 2015 ACR/ARHP Annual Meeting
Extracellular MicroRNAs in Synovial Fluid Reveal a Marked Proliferative Signature in Patients with Antibiotic-Refractory Lyme Arthritis
Robert B. Lochhead, Nancy D. Kim, Sheila Arvikar, Klemen Strle and Allen C. Steere, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Lyme arthritis (LA), caused by a tick-borne spirochete Borrelia burgdorferi, usually resolves appropriately with antibiotic treatment, called antibiotic-responsive LA. However, in some patients, arthritis…
Abstract Number: 2162 • 2015 ACR/ARHP Annual Meeting
Associations Between Education and Health Status Among Hispanics with Self-Reported Arthritis and/or Joint Pain
Leigha Vilen¹, Rebecca J. Cleveland², Alfredo Rivadeneira¹, Mary Altpeter³, Betsy Hackney⁴, Victoria Sepulveda² and Leigh F. Callahan⁴, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Institute on Aging, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC
Background/Purpose: Understanding the associations between education and health status among Hispanics with arthritis and/or joint pain is crucial in adapting existing arthritis interventions for this…
Abstract Number: 1345 • 2015 ACR/ARHP Annual Meeting
The Impact of Prior Antibiotic Treatment on Culture Results of Patients with Septic Arthritis
Ziv Paz¹, Sarah B. Lieber¹, Andrew Moore², Clara Zhu³, Mary Louise Fowler⁴ and Robert H. Shmerling⁵, ¹Beth Israel Deaconess Medical Center, Boston, MA, ²Medicine, Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, ³Medical School, Boston University School of Medicine, Boston, MA, ⁴School of Medicine, Boston University School of Medicine, Boston, MA, ⁵Medicine, Beth Israel Deaconess Medical Center, Boston, MA
Background/Purpose: Synovial fluid culture and gram stain offer the most compelling proof of septic arthritis (SA); these tests are indicated in every suspected case. However,…
Abstract Number: 2259 • 2015 ACR/ARHP Annual Meeting
Incidence of Obesity, Diabetes and High Blood Pressure Associated with Arthritis: Analysis of the Canadian Longitudinal National Population Health Survey
Orit Schieir¹, Sheilah. Hogg-Johnson^1,2, Richard H Glazier^3,4,5,6 and Elizabeth M. Badley^1,7, ¹Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ²Institute for Work and Health, Toronto, ON, Canada, ³Family and Community Medicine, St. Michael's Hospital, Toronto, ON, Canada, ⁴Centre for Research on Inner City Health, St. Michael's Hospital, Toronto, ON, Canada, ⁵Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, ⁶Family and Community Medicine, University of Toronto, Toronto, ON, Canada, ⁷Health Care & Outcomes Research, Toronto Western Res. Institute, Toronto, ON, Canada
Background/Purpose: While cross-sectional evidence points to a higher prevalence of cardiovascular (CVD) risk factors in persons with arthritis, longitudinal population based studies are lacking. The…
Abstract Number: 1346 • 2015 ACR/ARHP Annual Meeting
The Presentation and Outcomes of Surgically Treated Septic Arthritis: the Impact of Culture Results
Ziv Paz¹, Mary Louise Fowler², Clara Zhu³, Sarah B. Lieber¹, Andrew Moore⁴ and Robert H. Shmerling⁵, ¹Beth Israel Deaconess Medical Center, Boston, MA, ²School of Medicine, Boston University School of Medicine, Boston, MA, ³Medical School, Boston University School of Medicine, Boston, MA, ⁴Medicine, Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, ⁵Medicine, Beth Israel Deaconess Medical Center, Boston, MA
Background/Purpose: Clinically-suspected septic arthritis is culture-negative in 18-43% of cases. These patients are often treated surgically with associated morbidity, prolonged hospital stays and high medical…
Abstract Number: 2283 • 2015 ACR/ARHP Annual Meeting
Current and Lifetime Smoking Among US Adults with Arthritis: A Serious Clinical and Public Health Issue
Louise Murphy¹, Miriam G. Cisternas² and Teresa J. Brady¹, ¹Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, ²MGC Data Services, Carlsbad, CA
Background/Purpose: Smoking's adverse effects include increased risk of joint replacement failure and decreased medication effectiveness (e.g., methotrexate, TNF blockers). Because little is known about the…
Abstract Number: 1347 • 2015 ACR/ARHP Annual Meeting
The Presentations and Outcomes of Prosthetic Joint Septic Arthritis: a Comparison of Culture-Positive and Culture-Negative Disease
Ziv Paz¹, Sarah B. Lieber¹, Andrew Moore², Clara Zhu³, Robert H. Shmerling⁴ and Mary Louise Fowler⁵, ¹Beth Israel Deaconess Medical Center, Boston, MA, ²Medicine, Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, ³Medical School, Boston University School of Medicine, Boston, MA, ⁴Medicine, Beth Israel Deaconess Medical Center, Boston, MA, ⁵School of Medicine, Boston University School of Medicine, Boston, MA
Background/Purpose: Prosthetic joint septic arthritis (PJSA) may complicate joint replacement in approximately 1-2% of cases. Synovial fluid cultures are negative in up to 25% of…
Abstract Number: 2372 • 2015 ACR/ARHP Annual Meeting
Timing of Onset and Cluster with Other Manifestations Influence the Spectrum of Arthritis in Anti Jo-1 Positive Antisynthetase Syndrome: Results from a Multicenter, International, Retrospective Study
Alberto Sifuentes Giraldo¹, Carlo Alberto Scirè², Santos Castañeda³, Laura Nuño⁴, Francisco Javier Lopez Longo⁵, Julia Martínez-Barrio⁵, Franco Franceschini⁶, Ilaria Cavazzana⁶, Paolo Airò⁷, Elena Bartoloni Bocci⁸, Javier Bachiller Corral⁹, Rossella Neri¹⁰, Simone Barsotti¹¹, Roberto Caporali¹², Carlomaurizio Montecucco¹³, Marcello Govoni¹⁴, Renato La Corte¹⁴, Federica Furini¹⁴, Florenzo Iannone¹⁵, Margherita Giannini¹⁶, Enrico Fusaro¹⁷, Simone Parisi¹⁸, Giuseppe Paolazzi¹⁹, Giovanni Barausse¹⁹, Raffaele Pellerito²⁰, Alessandra Russo²⁰, Lesley Ann Saketkoo²¹, Norberto Ortego-Centeno²², Luca Quartuccio²³, Christof Specker²⁴, Andreas Schwarting²⁵, Kostantinos Triantafyllias²⁶, Carlo Selmi²⁷, Fausto Salaffi²⁸, Marco Amedeo Cimmino²⁹, Annamaria Iuliano³⁰, Fabrizio Conti³¹, Gianluigi Baiocchi³², Elena Bravi³³, Veronica Codullo¹², Anna Ghirardello³⁴, Trinitario Pina³⁵, Miguel Angel Gonzalez-Gay³⁵, Lorenzo Cavagna¹³ and AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group, ¹Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, ²Epidemiology Unit – Italian Society for Rheumatology (SIR), Milano, Italy, ³Rheumatology, H.U. La Princesa, Madrid, Spain, ⁴Servicio de Reumatologia, Hospital Universitario La Paz, Madrid, Spain, ⁵Servicio de Reumatologia, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ⁶Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ⁷Rheumatology Unit, Spedali Civili of Brescia, Brescia, Italy, ⁸Rheumatology Unit, Department of Clinical & Experimental Medicine, University of Perugia, Perugia, Italy, ⁹Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain, ¹⁰Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, ¹¹Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, ¹²Division of Rheumatology, University of Pavia, IRCCS Foundation Policlinico S. Matteo, Pavia, Italy, ¹³Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy, ¹⁴UOC Reumatologia, Azienda Ospedaliera Universitaria S. Anna, Ferrara, Italy, ¹⁵Interdisciplinary Department of Medicine (DIM), Rheumatology Unit, University of Bari, Bari, Italy, ¹⁶DIM, Rheumatology Unit, Bari, Italy, ¹⁷Department of Rheumatology, Città della Salute e della Scienza, Torino, Italy, ¹⁸Department of Rheumatology, Città Della Salute e della Scienza, Torino, Italy, ¹⁹Rheumatology Unit, Santa Chiara Hospital, Trento, Italy, ²⁰Division of Rheumatology, Mauriziano Hospital, Turin, Italy, ²¹Tulane University Lung Center, New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, ²²Systemic Autoimmune Diseases Unit, Hospital Universitario San Cecilio, Granada, Spain, ²³Clinic of Rheumatology, Department of Medical and Biological Sciences (DSMB), Santa Maria della Misericordia Hospital, University of Udine, Udine, Italy, ²⁴Department for Rheumatology and Clinical Immunology, St. Josef Krankenhaus, University Clinic, Essen, Germany, ²⁵Department of Internal Medicine, Rheumatology and Clinical Immunology, University Hospital Johannes-Gutenberg, Mainz, Germany, ²⁶ACURA Rheumatology Center, Bad Kreuznach, Germany, ²⁷Internal Medicine- Unit of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center, Rozzano, Italy, ²⁸Rheumatology Department, Polytechnic University of Marche, C. Urbani Hospital, Jesi,, Ancona, Italy, ²⁹Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genoa, Genoa, Italy, ³⁰Osp. San Camillo, Roma, Italy, ³¹Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy, ³²Rheumatology Unit, Department of Internal Medicine, S.Maria Hospital –IRCCS, Reggio Emilia, Italy, ³³Internal Medicine, Rheumatology Unit, Ospedale Guglielmo da Saliceto, Piacenza, Italy, ³⁴Department of Medicine-DIMED, University of Padova, Padova, Italy, ³⁵Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain
Background/Purpose: arthritis, myositis and interstitial lung disease (ILD) are reported in up to 90% of patients affected by antisynthetase syndrome (ASSD) and thus represent the…
Abstract Number: 2050 • 2014 ACR/ARHP Annual Meeting
Knee Arthritis Is Positively Associated with Physical Impairment: Conclusion Based on Physical Examinations from a Cross-Sectional Study of 17708 Chinese Residents
Qiang Liu¹, Xu Tang Sr.², Xu Wu³, Zhengming Cao² and Jianhao Lin², ¹Arthritis Clinical and Reserch Center, Peking University People's Hospital, Peking University Health Science Center, Beijing, China, ²Peking University Health Science Center, Beijing, China, ³Peking University People's Hospital Arthritis Clinic & Research Center, Peking University Health Science Center, Beijing, China
Background/Purpose The prevalence of knee arthritis is high in both urban and rural China. Although the association between knee arthritis and limitation of daily activity…
Abstract Number: 67 • 2014 ACR/ARHP Annual Meeting
Effects of Exercise on Depressive Symptoms in Adults with Arthritis: A Systematic Review with Meta-Analysis
George A. Kelley¹, Kristi S. Kelley¹ and Jennifer Hootman², ¹Biostatistics, West Virginia University, Morgantown, WV, ²Population Health, Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Previous randomized controlled trials have led to conflicting findings regarding the effects of exercise on depressive symptoms in adults with arthritis and other rheumatic…

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