Abstracts tagged "Arthritis"

Abstract Number: 1295 • 2016 ACR/ARHP Annual Meeting
The Prevalence of Inflammatory and Structural Lesions on MRI of the Sacroiliac Joints in Patients with Very Early Peripheral Spondyloarthritis
Gaëlle Varkas¹, Philippe Carron², Heleen Cypers¹, Dirk Elewaut¹, Lennart Jans³ and Filip van Den Bosch⁴, ¹Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, VIB, Ghent University and Ghent University Hospital, Ghent, Belgium, ²Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ³Department of Radiology, Ghent University Hospital, Ghent, Belgium, ⁴Rheumatology, Ghent University Hospital, Ghent, Belgium
Background/Purpose: To assess the prevalence of inflammatory and structural lesions on MRI of the sacroiliac joints (SIJ) in patients with peripheral spondyloarthritis (PSpA) in a…
Abstract Number: 2739 • 2016 ACR/ARHP Annual Meeting
Subclinical Ungueal Distrophy in Patients with Psoriasis without Joint Involvement: Is There Any Role for Nail Ultrasound?
Barbara Nascimento de Carvalho Klemz¹, Karine Luz², Eugenia Maria Damasio Ohe³, Adriana Maria Porro⁴, Polianna de Oliveira Matos Soares⁵, Helder Henrique da Costa Pinheiro⁶ and Marcelo Pinheiro⁷, ¹Rheumatology Division, Federal University of Sao Paulo (Unifesp/ EPM), Sao Paulo, Brazil, ²Rheumatology Division, Universidade Federal de São Paulo, São Paulo, Brazil, ³Dermatology Division, Federal University of Sao Paulo, (UNIFESP/EPM), Sao Paulo, Brazil, ⁴Dermatology Division, Federal University of Sao Paulo (UNIFESP/EPM), Sao Paulo, Brazil, ⁵Federal University of Sao Paulo (UNIFESP/EPM), Sao Paulo, Brazil, ⁶Federal University of Para (UFPA), Belem, Brazil, ⁷Federal University of São Paulo, São Paulo, Brazil
Background/Purpose: The joint involvement is observed in approximately 30% of patients with psoriasis (Ps). However, no clinical, lab or by imaging strategy is well established…
Abstract Number: 1318 • 2016 ACR/ARHP Annual Meeting
Profile of Macrophage-Derived Cytokines and Chemokines of Patients with Chikungunya-Induced Chronic Arthralgia/Arthritis
Idali Martinez¹, Edwin Lopez¹, Zelma L. Rios¹ and Luis M. Vilá², ¹Department of Microbiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, ²Department of Medicine, Division of Rheumatology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico
Background/Purpose: Chikungunya virus (CHIKV) caused a large epidemic in Puerto Rico in 2014 with more than 30,000 reported cases. Many of the affected individuals developed…
Abstract Number: 2923 • 2016 ACR/ARHP Annual Meeting
T-Cell Receptor Signaling Inhibition By CC-90005, a Selective Protein Kinase C Theta Antagonist, Reduces Antigen Mediated T-Cell Activation and Arthritis Pathology in the Mouse CIA Model
Garth Ringheim¹, Jolanta Kosek¹, Lori Capone², Eun Mi Hur¹ and Peter H. Schafer³, ¹Inflammation and Immunology Translational Development, Celgene Corporation, Summit, NJ, ²Celgene Corporation, Summit, NJ, ³Department of Translational Development, Celgene Corporation, Summit, NJ
Background/Purpose: PKC-θ is a member of the Ca2+-independent novel PKC subfamily, most abundantly expressed in T-cells, and mediates early antigen recognition signal transduction and cell…
Abstract Number: 3L • 2015 ACR/ARHP Annual Meeting
A Randomised Controlled Trial of the Clinical Effectiveness, Safety and Cost-Effectiveness of Adalimumab in Combination with Methotrexate for the Treatment of Juvenile Idiopathic Arthritis Associated Uveitis
Athimalaipet V Ramanan¹, Andrew D. Dick², Andrew McKay³, Ashley Jones⁴, Paula Williamson⁴, Sandrine Compeyrot-Lacassagne⁵, Ben Hardwick⁴, Helen Hickey⁴, Dyfrig Hughes⁶, Patricia Woo⁵, Diana Benton¹, Clive Edelsten⁵ and Michael W. Beresford⁷, ¹University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom, ²University of Bristol, Bristol Eye Hospital, Bristol, United Kingdom, ³Biostatistics, Clinical Trials Research Centre, University of Liverpool, Liverpool, United Kingdom, ⁴Clinical Trials Research Centre, University of Liverpool, Liverpool, United Kingdom, ⁵Great Ormond Street Hospital, London, United Kingdom, ⁶Bangor University, Bangor, United Kingdom, ⁷University of Liverpool, Liverpool, United Kingdom
Background/Purpose: Uveitis associated with Juvenile Idiopathic Arthritis (JIA) is a major cause of morbidity with potentially sight-threatening complications. Despite current screening and (pre-biologic) therapeutic options,…
Abstract Number: 832 • 2015 ACR/ARHP Annual Meeting
The Validity and Reliability of Online Obituaries As a Source of Mortality Data
Medha Soowamber¹, John T. Granton², Fatemeh Bavaghar-Zaeimi³ and Sindhu R. Johnson^4,5, ¹Rheumatology, University of Toronto/ Toronto Western Hospital, Toronto, ON, Canada, ²Medicine, Univeristiy Health Network Pulmonary Hypertension Programme, Toronto General Hospital and University of Toronto, Toronto, ON, Canada, ³Rheumatology, Toronto Scleroderma Program, Toronto Western Hospital and Mount Sinai Hospital, Toronto, ON, Canada, ⁴Toronto Scleroderma Program, Division of Rheumatology, Toronto Western Hospital, Mount Sinai Hospital, Institue of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, ⁵Institute of Health Policy, Management and Evaluation,, University of Toronto, Toronto, ON, Canada
Background/Purpose: Loss to follow-up is a major threat to the conduct of chronic disease cohort research. Tracking the survival status of patients who are lost…
Abstract Number: 1428 • 2015 ACR/ARHP Annual Meeting
Subchondral Bone Structure and Pain Behaviors in Complete Freund’s Adjuvant (CFA) Monoarthritis in Mice Treated with Intra-Articular (IA) Neurotoxin
Hollis E. Krug^1,2, Joseph Bert³, Fakhar Abbass⁴, Christopher W. Dorman⁵, Sandra Frizelle⁵ and Maren L. Mahowald^1,2, ¹Medicine, Minneapolis VA Health Care System, Minneapolis, MN, ²Medicine, University of Minnesota, Minneapolis, MN, ³Internal Medicine, Division of Rheumatology, University of Minnesota, Minneapolis, MN, ⁴Minneapolis VA Health Care System, Minneapolis, MN, ⁵Research, Minneapolis VA Health Care System, Minneapolis, MN
Background/Purpose: Bone histomorphometry can define OA changes in rodents and in Antigen-Induced arthritis (AIA) in rats. We produced painful inflammatory monoarthritis in mouse knees with IA…
Abstract Number: 2724 • 2015 ACR/ARHP Annual Meeting
Methotrexate Treatment Could Modulate the Abnormal CD4+T Lymphocyte Subset Distribution in NaÏve Rheumatoid Arthritis Patients
Cristina Bohórquez Heras¹, Lucía Ruiz Gutiérrez¹, Carolina Garcia Torrijos², Ana Turrión Nieves¹, Ana Pérez Gómez¹, Ana Sánchez Atrio¹, Eduardo Cuende¹, Atusa Movasat¹, Fernando Albarrán Hernández¹, Henry Moruno¹, M José León¹, David Diaz², Jorge Monserrat² and Melchor Álvarez de Mon^1,2, ¹University Hospital Príncipe de Asturias, Immune System Diseases, Rheumatology department, Alcalá de Henares, Madrid, Spain, ²Laboratory of Immune System Diseases, Department of Medicine, University of Alcalá, Alcalá de Henares, Madrid, Spain
Background/Purpose: Mechanisms regulating the chronic autoimmune response in rheumatoid arthritis (RA) are not well understood. However, activated T CD4+ play a pivotal role initiating and…
Abstract Number: 834 • 2015 ACR/ARHP Annual Meeting
The Efficacy of Rituximab in Systemic Sclerosis Joint Disease: A Pilot Study
Helena Borrell Paños¹, Javier Narváez², Juan José Alegre³, Ivan Castellvi⁴, Gloria Albert Espi³, Sergi Heredia¹, Elide Toniolo⁴ and Joan Miquel Nolla¹, ¹Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ²Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ³Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, ⁴Rheumatology Unit. Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
Background/Purpose: Between 16 and 20% of patients with systemic sclerosis (SS) have arthritis, which is occasionally erosive. In addition, between 1 and 5% of patients…
Abstract Number: 1441 • 2015 ACR/ARHP Annual Meeting
Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials
Ninna Karsbæk Senftleber^1,2, Sabrina Mai Nielsen^3,4, Jens Rikardt Andersen⁴, Henning Bliddal⁵, Simon Tarp³, Lotte Lauritzen⁴, Daniel E. Furst⁶, Maria E. Suarez-Almazor⁷, Anne Lyddiatt⁸ and Robin Christensen⁵, ¹Musculoskeletal Statistics Unit, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Frederiksberg and Bispebjerg, Denmark, ²Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark, ³Musculoskeletal Statistics Unit, The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, ⁴Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark, ⁵The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark, ⁶Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁷General Internal Medicine, The University of Texas, MD Anderson Cancer Center, Houston, TX, ⁸Musculoskeletal Group, Cochrane Collaboration, Ottawa, ON, Canada
Background/Purpose: Marine oil supplements (MOS) are suggested to have anti-inflammatory properties, but there is no consensus regarding the efficacy of MOS in the management of…
Abstract Number: 2856 • 2015 ACR/ARHP Annual Meeting
Efficacy and Safety of Ustekinumab in Psoriatic Arthritis Patients with Spondylarthritis As Well As Peripheral Arthritis: Results from 2 Phase 3, Multicenter, Double-Blind, Placebo-Controlled Study
Arthur Kavanaugh¹, Luis Puig², Alice B. Gottlieb³, Christopher T. Ritchlin⁴, Yin You⁵, Shu Li⁵, Michael Song⁵, Bruce Randazzo⁵, Proton Rahman⁶ and Iain. B. McInnes⁷, ¹University of California San Diego, La Jolla, CA, ²Universitat Autònoma de Barcelona, Barcelona, Spain, ³Tufts Medical Center, Boston, MA, ⁴Allergy, Immunology and Rheumatololgy Division, University of Rochester Medical Center, Rochester, NY, ⁵Janssen Research & Development, LLC, Spring House, PA, ⁶Rheumatology, Memorial University of Newfoundland, St Johns, NF, Canada, ⁷Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: To evaluate ustekinumab(UST) in a subgroup of psoriatic arthritis (PsA) pts with physician diagnosed spondylarthritis, as well as peripheral arthritis, from the PSUMMIT 1…
Abstract Number: 934 • 2015 ACR/ARHP Annual Meeting
Platelet-Independent Role of Megakaryocytes in Antibody-Mediated Murine Arthritis
Pierre Cunin¹, Loka Penke², Jonathan Thon³, Paul A. Monach⁴, Tatiana Jones⁵, Mary Chen², Yoichiro Iwakura⁶, Jerry Ware⁷, Michael Gurish², Joseph Italiano³, Eric Boilard⁸ and Peter A. Nigrovic^2,9, ¹Rheumatology, Immunology and Allergy, Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ²Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ³Department of Medicine, Hematology Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Rheumatology, Boston University School of Medicine, Boston, MA, ⁵Department of Clinical Laboratory and Nutritional Science, University of Massachusetts Lowell, Lowel, MA, ⁶Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan, ⁷Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, ⁸Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Faculté de Médecine de l’Université Laval, Quebec, QC, Canada, ⁹Department of Medicine, Division of Immunology, Boston Children’s Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Mice bearing mutations affecting Kit (stem cell factor receptor) exhibit multiple hematologic phenotypes, including mast cell deficiency, and have been used to assess the…
Abstract Number: 1531 • 2015 ACR/ARHP Annual Meeting
The Changing Face of Septic Arthritis Complicating Rheumatoid Arthritis in the Era of Biotherapies. Retrospective Single-Center Study over 35 Years
Jean-Jacques Dubost¹, Bruno Pereira², Anne Tournadre³, Zuzana Tatar¹, Marion Couderc¹ and Martin Soubrier¹, ¹Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, ²Biostatistics unit (DRCI), CHU Clermont-Ferrand, Clermont-Ferrand, France, ³Rheumatology, UNH-UMR 1019 INRA University of Auvergne and Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France
Background/Purpose: Rheumatoid arthritis (RA) is a risk factor for septic arthritis (SA), and anti-TNF therapy doubles the risk of SA. The purpose of this study…
Abstract Number: 3244 • 2015 ACR/ARHP Annual Meeting
Evaluation of a Self-Directed Walking Program in Hispanics with Arthritis
Leigh F. Callahan¹, Alfredo Rivadeneira², Mary Altpeter³, Rebecca J. Cleveland⁴, Betsy Hackney¹, Leigha Vilen², Victoria Sepulveda⁴, Daniel S Reuland⁵ and Claudia Rojas⁴, ¹Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ²Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³Institute on Aging, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁵Department of Internal Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Walk with Ease (WWE) is the Arthritis Foundation's (AF) 6-week evidence-based walking program for adults with arthritis that can be offered in 2 formats:…
Abstract Number: 1037 • 2015 ACR/ARHP Annual Meeting
Impaired Regulatory T Cell Survival in the Pathogenesis of Autoreactive Arthritis Mediated By CD11c-Deletion of Flip
Qi Quan Huang¹, Renee E. Doyle¹, Robert Birkett², Deyu Fang³, Syamal K. Datta¹ and Richard M. Pope¹, ¹Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: We have generated a mouse line with Flip conditionally deleted in CD11c-cre expressing cells (CD11c-Flip-KO, named HUPO), which spontaneously develops erosive arthritis resembling rheumatoid…

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