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Abstracts tagged "antiphospholipid syndrome"

  • Abstract Number: 0525 • ACR Convergence 2020

    Epidemiology of Thromboembolic Complications Among Hospitalized Patients with Antiphospholipid Syndrome in the United States

    Lauren Mathias1, Aditya Mantha2, Kristen Mathias3 and Glenn Ehresmann1, 1University of Southern California, Division of Rheumatology, Los Angeles, CA, 2University of Southern California, Department of Medicine, Los Angeles, CA, 3University of Chicago, Department of Medicine, Chicago, IL

    Background/Purpose: Antiphospholipid syndrome (APLS) is characterized by arterial and venous thrombosis, often in the setting of an underlying systemic disease. Few studies have described the…
  • Abstract Number: 1775 • ACR Convergence 2020

    Risk Factors for Adverse Pregnancy Outcomes of Women with Positive for Antiphospholipid Antibodies Treated with Conventional Therapies

    Hiromi Shimada1, Risa Wakiya2, Mai Mahmound Fahmy Mansour1, Shusaku Nakashima1, Mikiya Kato1, Koichi Sugihara1, Yusuke Ushio1, Tomohiro Kameda1 and Hiroaki Dobashi3, 1Department of Internal Medicine, Division of Haematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University., Kita-gun, Kagawa, Japan, 2Department of Internal Medicine, Division of Haematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University., Kagawa, Kagawa, Japan, 3Department of Internal Medicine, Division of Haematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan

    Background/Purpose: Antiphospholipid antibodies induce several obstetric complications including recurrent spontaneous abortion, preterm birth, intrauterine fetal death. EULAR recommendations for antiphospholipid syndrome (APS) indicates low dose…
  • Abstract Number: 0526 • ACR Convergence 2020

    Patient-Reported Outcomes in Antiphospholipid Syndrome

    Julia Weiner1, Kelsey Gockman1, Jacqueline Madison1, Yu Zuo2, Emily Briceño1, Vivek Nagaraja3 and Jason Knight2, 1University of Michigan, Ann Arbor, 2Division of Rheumatology, University of Michigan, Ann Arbor, MI, 3University of Michigan, Ann Arbor, MI

    Background/Purpose: PROMIS® (Patient-Reported Outcome Measurement Information System) is a set of person-centered measures that evaluates and monitors the physical, emotional, and social aspects of health.…
  • Abstract Number: 1792 • ACR Convergence 2020

    Platelet-bound C4d Is Associated with an Increased Risk of Arterial and Venous Thromboses in SLE

    Yevgeniya Gartshteyn1, Roberta Vezza Alexander2, John Conklin3, Thierry Dervieux4 and Anca Askanase5, 1Columbia University College of Physicians and Surgeons, Glen Rock, NJ, 2Exagen Inc, Vista, CA, 3Exagen Inc., Vista, CA, 4Prometheus Biosciences Inc, San Diego, CA, 5Columbia University College of Physicians and Surgeons, New York, NY

    Background/Purpose: Platelet-bound complement activation products (PC4d), defined as PC4d20 net mean fluorescent intensity [MFI], or a thrombotic risk score that includes PC4d, C3 and anti-phosphatidylserine/prothrombin…
  • Abstract Number: 0527 • ACR Convergence 2020

    Rituximab for Refractory Manifestations of the Antiphospholipid Syndrome: A Multicenter Israeli Experience

    Nancy Agmon-Levin1, Mark Berman2, Liora Harel3, Merav Lidar4, Soad Hajyahia1 and Daphna Paran5, 1Clinical Immunology, Angioedema and Allergy Unit, Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel, 2Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 3Scheider Children's Medical Center of Israel, Tel Aviv University, Tel Aviv, Israel, Petach Tikva, Israel, 4Rheumatology unit, Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Hod Hasharon, Israel, 5Department of Rheumatology, Tel Aviv Medical Center, Tel Aviv, Israel

    Background/Purpose: The clinical manifestations of the antiphospholipid syndrome (APS) are heterogeneous and related to anti-phospholipid antibodies (aPL). There is some evidence that B cells are…
  • Abstract Number: 0528 • ACR Convergence 2020

    The Complex Relationship Between C4b Binding Protein, Warfarin and Antiphospholipid Antibodies

    Giorgia Grosso1, Kerstin Sandholm2, Aleksandra Antovic1, Iva Gunnarsson1, Agneta Zickert1, Anna Vikerfors3, Lennart Truedsson4, Maria Bruzelius1, Bo Nilsson5, Kristina Nilsson Ekdahl5 and Elisabet Svenungsson1, 1Karolinska University Hospital, Stockholm, Sweden, 2Linnaeus Center for Biomaterials Chemistry, Linnaeus University, Kalmar, Sweden, 3Swedish Medical Products Agency, Uppsala, Sweden, 4Lunds University, Lund, Sweden, 5Uppsala University, Uppsala, Sweden

    Background/Purpose: C4b Binding Protein (C4BP) is the main inhibitor of the classical complement pathway. Both β2glycoprotein-I (β2GPI), the main antigen in the antiphospholipid syndrome (APS),…
  • Abstract Number: 0529 • ACR Convergence 2020

    A Prospective Study on the Incidence of a First Thrombo-embolic Event in Patients with Systemic Lupus Erythematosus and Anti-phosphatidylserine/prothrombin Antibodies

    Savino Sciascia1, Massimo Radin1, Irene Cecchi1, Daniela Rossi1 and Dario Roccatello2, 1University of Torino, Torino, Italy, 2S Giovanni Hospital, Univ of Turin, Turin, Italy

    Background/Purpose: Prospective data confirming the role of anti-phosphatidylserine/prothrombin antibodies (aPS/PT) in the absence of other aPL tested by β2–glycoprotein I-depend assays are missing.Methods: Since 2015 aPSPT…
  • Abstract Number: 0530 • ACR Convergence 2020

    Pediatric APS: Clinical Features, Therapeutic Interventions, and Damage in a Series of 22 Cases

    Jacqueline Madison1, Kelsey Gockman1 and Jason Knight2, 1University of Michigan, Ann Arbor, 2Division of Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Pediatric antiphospholipid syndrome (APS) is a thromboinflammatory disease classically defined by the presence of circulating antiphospholipid antibodies and either thrombotic events or pregnancy morbidity.…
  • Abstract Number: 0847 • ACR Convergence 2020

    Impact of Hydroxychloroquine Treatment on Immunologic Markers in SLE Depends on Ethnicity

    Laurence Magder1, Daniel Goldman2 and Michelle Petri2, 1University of Maryland, Baltimore, Baltimore, MD, 2Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: SLE patients with certain immunological markers (i.e., anti-DNA, low complement) are at higher risk of lupus nephritis and those with antiphospholipid antibodies are at…
  • Abstract Number: 0938 • ACR Convergence 2020

    Low Preconceptional Complement Level Is Related with an Adverse Obstetric Outcome in a Multicentric Cohort of Pregnancy in Patients with APS and aPL Positivity

    Cecilia Nalli1, Daniele Lini2, Laura Andreoli2, Francesca Crisafulli2, Micaela Fredi2, Maria Grazia Lazzaroni2, Victoria Bitsadze3, Antonia Calligaro4, Valentina Canti5, Roberto Caporali6, Francesco Carubbi7, Cecilia Chighizola8, Paola Conigliaro9, Caterina De Carolis10, Teresa Del Ross4, Maria Favaro4, Maria Gerosa11, Annamaria Iuliano12, Jamilya Khizroeva3, Alexander Makatsariya3, Pierlugi Meroni13, Marta Mosca14, Melissa Padovan15, Roberto Perricone9, Patrizia Rovere-Querini16, Gian Domenico Sebastiani12, Chiara Tani14, Marta Tonello4, Dina Zucchi14, Franco Franceschini17 and Angela Tincani2, 1Rheumatology and Clinical Immunology Unit, ASST Spedali Civili of Brescia, Brescia, Lombardia, Italy, 2Rheumatology and Clinical Immunology Unit, Spedali Civili and University of Brescia, Brescia, Lombardia, Italy, 3Department of Obstetrics and Gynecology of I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia, 4Rheumatology Unit, Department of Medicine, University Hospital of Padua, Padua, Italy, 5Immunology, Rheumatology, Allergology and Rare Disease-IRCCS San Raffaele Hospital, Laboratory of Autoimmunity and vascular inflammation San Raffaele, Milan, Italy, 6Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy, 7Department of Biotechnological and Applied Clinical Science, Rheumatology Unit, School of Medicine, University of L'Aquila, L'Aquila, Italy, 8Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy; Experimental Laboratory of Immunorheumatological Researches, Istituto Auxologico Italiano, Milan, Italy, 9Rheumatology, Allergology and Clinical Immunology, Department of "Medicina dei Sistemi", University of Rome Tor Vergata, Rome, Italy, 10Polymedical Center for Prevention of Recurrent Spontaneous Abortion, Rome, Italy, 11Division of Rheumatology, Department of Clinical Sciences and Community Health, Ospedale Gaetano Pini, University of Milan, Milan, Italy, 12Rheumatology Unit, Azienda Ospedaliera San Camillo-Forlanini, Rome, Italy, 13Division of Rheumatology, ASST.G Pini, Department of Clinical Sciences and Community Health, University of Milan and Istituto Auxologico Italiano, Milan, Italy, 14Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 15UO e Sezione di Reumatologia, Dipartimento di Scienze Mediche, Universita' degli Studi di Ferrara, Ferrara, Italy, 16Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Università Vita-Salute San Raffaele - IRCCS Ospedale San Raffaele, Milan, Italy, 17Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy

    Background/Purpose: The role of complement in the aPL related pathology has been widely studied in animal models. aPL can induce fetal loss in experimental animals but…
  • Abstract Number: 1261 • ACR Convergence 2020

    Antiphospholipid Patterns Predict the Risk of Thrombosis in Systemic Lupus Erythematosus

    Selcan Demir1, Jessica Li2, Laurence Magder3 and Michelle Petri4, 1Hacettepe University Faculty of Medicine, Ankara, Ankara, Turkey, 2Johns Hopkins University, Baltimore, MD, 3University of Maryland, Baltimore, Baltimore, MD, 4Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose: Antiphospholipid syndrome (APS) has been classified as the development of venous and/or arterial thromboses, and/or pregnancy morbidity, in the presence of persistently raised levels…
  • Abstract Number: 0429 • ACR Convergence 2020

    Prothrombotic Antiphospholipid Antibodies in COVID-19

    Yu Zuo1, Shanea Estes2, Alex Ghandi3, Srilakshmi Yalavarthi3, Ramadan Ali3, Shi Hui3, Gautam Sule3, Kelsey Gockman3, Jacqueline Madison3, Melanie Zuo3, Wrenn Woodard3, Sean Lezak3, Njira Lugogo3, Yogendra Kanthi4 and Jason Knight1, 1Division of Rheumatology, University of Michigan, Ann Arbor, MI, 2University of Michigan, Ann Arbor, MI, 3University of Michigan, Ann Arbor, 4Division of Cardiovascular Medicine, Ann Arbor

    Background/Purpose: Patients with coronavirus disease 19 (COVID-19) are at high risk for thrombosis of arteries and veins. At the same time, COVID-19 lung histopathology has…
  • Abstract Number: 1262 • ACR Convergence 2020

    Single LAC Positivity versus Double and Triple Positivity for Thrombosis in SLE

    Selcan Demir1, Jessica Li2, Laurence Magder3 and Michelle Petri4, 1Hacettepe University Faculty of Medicine, Ankara, Ankara, Turkey, 2Johns Hopkins University, Baltimore, MD, 3University of Maryland, Baltimore, Baltimore, MD, 4Johns Hopkins University School of Medicine, Timonium, MD

    Background/Purpose:Antiphospholipid syndrome (APS) is classified as the development of venous and/or arterial thromboses, and pregnancy morbidity, in the presence of antiphospholipid antibodies (aPL); lupus anticoagulant,…
  • Abstract Number: 0519 • ACR Convergence 2020

    Thrombotic and Obstetric Associations of Non-Criteria Antiphospholipid Immunoassays That Detect Antibodies to Neutral and Negatively-Charged Phospholipid

    Rohan Willis1, E Nigel Harris2, Vijaya Murthy3, Zurina Romay-Penabad1, Alvaro Schleh4, Monica Smikle2, Karel De Ceulaer2, Anne Tebo5, Troy Jaskowski6, Marta Guerra7, David Ware Branch8, Jane Salmon7, Michelle Petri9 and Emilio Gonzalez1, 1University of Texas Medical Branch, Galveston, TX, 2University of the West Indies, Kingston, Jamaica, 3University of Texas Medical Branch, League City, TX, 4Antiphospholipid Standardization Laboratory, GALVESTON, TX, 5Department of Pathology, University of Utah, Salt Lake City, 6ARUP Laboratories, Salt Lake City, UT, 7Hospital for Special Surgery, New York, NY, 8University of Utah, Salt Lake City, 9Johns Hopkins University School of Medicine, Baltimore

    Background/Purpose: Criteria antiphospholipid (aPL) antibodies that identify antiphospholipid syndrome (APS) patients, anticardiolipin (aCL) and anti-β2glycoprotein-I (anti-β2GPI), have demonstrated inconsistent specificity and sensitivity in this regard…
  • Abstract Number: 1447 • ACR Convergence 2020

    Vitamin D Deficiency Enhances Antiphospholipid Antibody-Mediated Thrombosis in a Passive Immunization Mouse Model

    Rohan Willis1, Karen Roye-Green2, Zurina Romay-Penabad1, Elizabeth Papalardo1, Alvaro Schleh3, Vijaya Murthy4, Monica Smikle2 and Emilio Gonzalez1, 1University of Texas Medical Branch, Galveston, TX, 2University of the West Indies, Kingston, Jamaica, 3Antiphospholipid Standardization Laboratory, GALVESTON, TX, 4University of Texas Medical Branch, League City, TX

    Background/Purpose: Abnormal vitamin D levels occur frequently in antiphospholipid (APS) patients and are correlated with thrombosis. It remains unclear however if vitamin D deficiency observed…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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