ACR Meeting Abstracts

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Abstracts tagged "Anti-TNF therapy and psoriatic arthritis"

  • Abstract Number: 598 • 2017 ACR/ARHP Annual Meeting

    Efficacy of Ustekinumab in Psoriatic Arthritis Patients By Prior Treatment Exposure and Disease Duration

    Arthur Kavanaugh1, Soumya D. Chakravarty2,3, G. James Morgan4, M. Isabel Apaolaza5, Shelly Kafka2, Elizabeth C. Hsia6,7, Michael Song7, Yin You7 and Iain B. McInnes8, 1Medicine, University of California, San Diego, La Jolla, CA, 2Janssen Scientific Affairs, LLC, Horsham, PA, 3Drexel University College of Medicine, Philadelphia, PA, 4Janssen Scientific Affairs, LLC, Spring House, PA, 5Janssen Biologics BV, Leiden, Netherlands, 6University of Pennsylvania School of Medicine, Philadelphia, PA, 7Janssen Research & Development, LLC, Spring House, PA, 8University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: To evaluate the efficacy of ustekinumab (UST) by prior treatment exposure and disease duration in adult PsA patients (pts) in the Phase 3 trials…
  • Abstract Number: 599 • 2017 ACR/ARHP Annual Meeting

    Intravenous Golimumab in Adult Patients with Active Psoriatic Arthritis: Efficacy and Safety through Week 24

    Arthur Kavanaugh1, M. Elaine Husni2, Diane D. Harrison3, Lilianne Kim3, Kim Hung Lo3 and Elizabeth C. Hsia4, 1Medicine, University of California, San Diego, La Jolla, CA, 2Rheumatology, Cleveland Clinic, Cleveland, OH, 3Janssen Research & Development, LLC, Spring House, PA, 4Janssen Research & Development, LLC/University of Pennsylvania, Spring House/Philadelphia, PA

    Background/Purpose: The GO-VIBRANT study was designed to evaluate the safety and efficacy of intravenous (IV) golimumab (GLM) in adult patients (pts) with active PsA (biologic-naïve).…
  • Abstract Number: 632 • 2017 ACR/ARHP Annual Meeting

    Long-Term Golimumab Retention Rate in Patients with Psoriatic Arthritis. Is Concomitant DMARD Important?

    Belen Serrano1, Carlos M Gonzalez2, Roberto González3, Juan Gabriel Ovalles-Bonilla4, Juan Carlos Nieto2, Julia Martínez-Barrio5, Iustina Janta2, Larissa Valor3, Indalecio Monteagudo2 and Francisco Javier López Longo6, 1Rheumatology, Hospital General Universitario Gregorio Marañón, Genoa, Italy, 2Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, 3Rheumatology, Hospital general Universitario Gregorio Marañón, Madrid, Spain, 4Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain, 5Servicio de Reumatologia, Hospital General Universitario Gregorio Marañón, Madrid, Spain, 6Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain

    Background/Purpose: The efficacy of Golimumab (GLM) treatment in psoriatic arthritis (PsA) patients has been widely documented. The aim of this study was to analyze the…
  • Abstract Number: 1525 • 2017 ACR/ARHP Annual Meeting

    Characteristics and Treatment Patterns Among Patients with Psoriatic Arthritis Initiating Subcutaneously Administered Biologics: Descriptive Analyses from a US Claims Database

    Kurt R. Oelke1, Rahul Garg2, Peter Hur3, Olivier Chambenoit3, Amar Q. Majjhoo4, Stephani Gray5, Kate Higgins5 and Jacqueline B. Palmer3, 1Rheumatic Disease Center, Glendale, WI, 2PRO Unlimited, Inc, East Hanover, NJ, 3Novartis Pharmaceuticals Corporation, East Hanover, NJ, 4Shores Rheumatology, St. Clair Shores, MI, 5Truven Health Analytics, Cambridge, MA

    Background/Purpose: To better understand the real-world efficacy of biologics for the treatment of psoriatic arthritis (PsA), there is a need to evaluate the persistence and…
  • Abstract Number: 2767 • 2016 ACR/ARHP Annual Meeting

    Minimal Disease Activity Among Psoriatic Arthritis Patients in Canada: Evaluation of Modified Minimal Disease Activity upon Elimination of Each Component

    Boulos Haraoui1, Proton Rahman2, Louis Bessette3, Philip Baer4, Suneil Kapur5, J. Antonio Avina-Zubieta6, Regan Arendse7, Emmanouil Rampakakis8, Eliofotisti Psaradellis9, Karina Maslova10, Allen J Lehman10, Francois Nantel11, Brendan Osborne12 and Cathy Tkaczyk12, 1University of Montreal, Montreal, QC, Canada, 2Rheumatology, St Claires Mercy Hospital, St Johns, NF, Canada, 3Rheumatology, CHUL de Quebec, Quebec, QC, Canada, 4Independent Rheumatology Practice, Scarborough, ON, Canada, 5University of Ottawa, 139 Greenbank Rd, Suite 203, ON, Canada, 6Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada, 7University of Saskatchewan, Saskatoon, SK, Canada, 8JSS Medical Research, St-Laurent, QC, Canada, 9JSS Medical Research, Montreal, QC, Canada, 10Janssen Inc., Toronto, ON, Canada, 1119 Green belt Dr, Janssen Inc., Toronto, ON, Canada, 12Medical Affairs, Janssen Inc., Toronto, ON, Canada

    Background/Purpose: Minimal disease activity (MDA) is now considered an attainable target in psoriatic arthritis (PsA) reflecting a desired state of comprehensive disease control. MDA is…
  • Abstract Number: 2514 • 2016 ACR/ARHP Annual Meeting

    Does Combination of Conventional Synthetic Disease Modifying Antirheumatic Drug with Anti-TNF Influence the Long Term Retention Compared to Anti-TNF Monotherapy in Psoriatic Arthritis? an Analysis from Rhumadata® over 12 Years

    Isabelle Ferdinand1, Louis Bessette2, Josiane Bourré-Tessier3, Boulos Haraoui4, Jacques Brown5, Frédéric Massicotte3, Jean-Pierre Pelletier3, Jean-Pierre Raynauld4, Marie-Anaïs Rémillard6, Diane Sauvageau3, Angèle Turcotte5, Édith Villeneuve3 and Louis Coupal3, 1University of Montreal, Montreal, QC, Canada, 2Rhumatology, Centre d’Ostéoporose et de Rhumatologie de Québec (CORQ), Québec, QC, Canada, 3Rheumatology, Institut de Recherche en Rhumatologie de Montréal (IRRM), Montréal, QC, Canada, 41551, Ontario Street East, Institut de Recherche en Rhumatologie de Montréal (IRRM), Montreal, QC, Canada, 5Rheumatology, Centre d’Ostéoporose et de Rhumatologie de Québec (CORQ), Québec, QC, Canada, 6Rhumatology, Institut de Recherche en Rhumatologie de Montréal (IRRM), Montréal, QC, Canada

    Background/Purpose: In rheumatoid arthritis, it has been shown that anti-TNF therapy (TNFi) in combination with a conventional synthetic disease-modifying antirheumatic drug (csDMARD), often methotrexate (MTX),…
  • Abstract Number: 2146 • 2015 ACR/ARHP Annual Meeting

    Secukinumab Provides Sustained Improvements in the Signs and Symptoms of Active Psoriatic Arthritis in Anti-TNF-Naive Patients and Those Previously Exposed to Anti-TNF Therapy: 52-Week Results from a Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial with Subcutaneous Dosing

    Arthur Kavanaugh1, Iain B. McInnes2, Philip J. Mease3, Stephan Hall4, Hector Chinoy5, Alan J Kivitz6, Manmath Patekar7, Zailong Wang8 and Shephard Mpofu9, 1University of California, San Diego School of Medicine, LaJolla, CA, 2Immunology, Infection and Inflammation, University of Glasgow, Glasgow, United Kingdom, 3Rheumatology Research, Swedish Medical Center, Seattle, WA, 4Monash University, Melbourne, Australia, 5University of Manchester, Manchester, United Kingdom, 6Altoona Center for Clinical Research, Duncansville, PA, 7Novartis Healthcare Pvt. Ltd., Hyderabad, India, 8Novartis Pharmaceuticals Corporation, East Hanover, NJ, 9Novartis Pharma AG, Basel, Switzerland

    Background/Purpose: There remains an unmet need for additional treatment options for patients (pts) with psoriatic arthritis (PsA) who have had an inadequate response to or…
  • Abstract Number: 333 • 2013 ACR/ARHP Annual Meeting

    Changes In Weight Associated With Tumour Necrosis Factor Inhibition In Psoriatic Arthritis

    Barry J. Sheane1, Arane Thavaneswaran2, Dafna D. Gladman1 and Vinod Chandran1, 1Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with progressive joint damage and disability. In the last 15 years, tumour necrosis factor inhibitors…
  • Abstract Number: 1357 • 2012 ACR/ARHP Annual Meeting

    Psoriatic Arthritis and Biologic Therapy: Treatment Response, Drug Survival and Outcome After Switching

    Dinny Wallis1, Deepak Jadon2, William Tillett2, Nicola Waldron2, Charlotte Cavill3, Neil McHugh4 and Eleanor Korendowych2, 1Rheumatology, Royal National Hospital for Rheumatic Diseases NHS Foundation Trust, Bath, United Kingdom, 2Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 3Rheumatology, Bath Institute for Rheumatic Disease, Bath, United Kingdom, 4Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom

    Background/Purpose: Data on longer term efficacy and tolerance of biologic therapies in psoriatic arthritis (PsA) are emerging.  Persistence with the first TNF inhibitor (TNFi) at…
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