Abstracts tagged "anti-dsDNA"

Abstract Number: 0879 • ACR Convergence 2021
Anti-dsDNA Antibodies Increase Systemic Lupus Erythematosus Cardiovascular Risk Impairing the Immune and Cardiovascular Systems
Carlos Pérez-Sánchez¹, Alejandra Patiño-Trives², Maria Angeles Aguirre³, Laura Perez-Sanchez³, Chary Lopez-Pedrera³, Maria Luque-Tevar², Maria del Carmen Ábalos-Aguilera³, Iván Arias de la Rosa⁴, Cristobal Román-Rodriguez³, Pedro Segui³, Mario Espinosa³, Pilar Font³, Nuria Barbarroja⁴, alejandro Escudero³, Eduardo Collantes-Estevez³, Jose Antonio Gonzalez-Reyes⁵, Jose Manuel Villalba⁵ and Chary lopez-pedrera³, ¹IMIBIC, Córdoba, Spain, ²Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, ³IMIBIC/Reina Sofia Hospital/University of Córdoba, Córdoba, Spain, ⁴University of Cordoba/IMIBIC/Reina Sofia Hospital, Cordoba, Spain, ⁵Department of Cell Biology, Physiology and Immunology, University of Córdoba, Campus de Excelencia Internacional Agroalimentario, ceiA3, Cordoba, Spain
Background/Purpose: This study aimed to delineate the role of anti-dsDNA antibodies on the alterations observed in the gene profile and the activity of immune and…
Abstract Number: 0243 • ACR Convergence 2020
The Role of Anti-dsDNA Antibodies in Predicting Incident Lupus Nephritis in Newly Diagnosed Lupus
Pooja Kumari¹, Viswanathan Ramakrishnan², Jihad Obeid², Diane Kamen³ and Jim Oates⁴, ¹The university of Tennesse Health Science center, Memphis, TN, ²medical university of south carolina, south carolina, ³Medical University of South Carolina, Charleston, SC, ⁴Medical University of South Carolina, Charleston, SC, Charleston, SC
Background/Purpose: Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) that leads to significant morbidity and mortality. Therefore, it is essential to…
Abstract Number: 034 • 2020 Pediatric Rheumatology Symposium
Chest Computed Tomography Manifestations in Childhood-Onset Systemic Lupus Erythematosus: A Single-Center Cohort Study
Pooja Patel¹, Gunes Orman ², Manuel Silva Carmona ³, Maria Pereira ⁴, Marietta De Guzman ⁵, Danielle Guffey ⁶, Scott Wenderfer ⁷ and R. Paul Guillerman ⁸, ¹Baylor College of Medicine, Houston, Texas, ²Edward B. Singleton Department of Radiology, Texas Children's Hospital, Houston, Texas, ³Section of Pulmonology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, ⁴Assistant Professor, Section of Rheumatology, Division of Pediatrics, Baylor College of Medicine, Houston, Texas, ⁵Section of Rheumatology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, ⁶Dan L. Duncan Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, ⁷Section of Nephrology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, ⁸Edward B. Singleton Department of Radiology, Texas Children's Hospital, Houston, Texas
Background/Purpose: Intrathoracic involvement in adults with systemic lupus erythematosus (SLE) is relatively common, particularly pleural disease. The prevalence of intrathoracic involvement in childhood-onset SLE (cSLE)…
Abstract Number: 265 • 2019 ACR/ARP Annual Meeting
Frequency of Performing Anti dsDNA Antibody in an ANA Negative Patient with Clinical Suspicion of SLE in a Single Centre Trial Before and After the Publication of National Guideline
Pamela Anjara ¹, David Liew², Victor Yang ³, Christopher McMaster ² and Russell Buchanan ³, ¹Austin Hospital, Melbourne, Victoria, Australia, ²Austin Health, Melbourne, Victoria, Australia, ³Austin Health, Heidelberg, Victoria, Australia
Background/Purpose: In October 2017, the Australian Rheumatology Association widely promoted a list of five recommendations on low-value practices to general clinicians and patients as part…
Abstract Number: 1020 • 2019 ACR/ARP Annual Meeting
NLRP12 Regulates Interferon-α Expression and Is a Biomarker for Disease Activity of Systemic Lupus Erythematosus
Ming-Han Chen¹, Yen-Po Tsao ¹ and Szu-Ting Chen ², ¹Division of Allergy, Immunology & Rheumatology/Taipei Veterans General Hospital, Taipei, Taiwan (Republic of China), ²Institutes of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan (Republic of China)
Background/Purpose: Systemic lupus erythematous (SLE) is a systemic autoimmune disease with diverse etiological factors. It was well recognized that interferon (IFN) signature did the perpetration…
Abstract Number: 2896 • 2019 ACR/ARP Annual Meeting
The Role of Alterations in the Splicing Machinery in the Pathogenesis of Lupus: Does It Impact Lupus Nephritis?
Chary Lopez-Pedrera¹, Alejandro Ibañez-Costa ¹, Mª Ángeles Aguirre-Zamorano ², Laura Pérez-Sanchez ³, Alejandra Patiño-Trives ¹, Maria Luque-Tevar ¹, Maria del Carmen Abalos-Aguilera ¹, Ivan Arias de la Rosa ⁴, Nuria Barbarroja ⁵, Mario Espinosa ⁶, Eduardo Collantes-Estevez ⁴, Justo Castaño ⁷, Raúl Luque ⁷ and Carlos Perez-Sanchez ⁸, ¹IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ³MIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ⁴University of Cordoba/IMIBIC/Reina Sofia Hospital, Cordoba, Spain, ⁵University of Cordoba/IMIBIC/Reina Sofia Hospital and CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain, ⁶UGC de Nefrología. Hospital Universitario Reina Sofía, Cordoba, Spain, ⁷Maimónides Institute for Biomedical Research at Córdoba, Cordoba, Spain, ⁸Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, Cordoba, Spain
Background/Purpose: The aim of this study was to evaluate whether alterations in the splicing machinery of immune cells could influence the development and activity of…
Abstract Number: 2129 • 2018 ACR/ARHP Annual Meeting
Precipitating Anti-dsDNA Peptide Repertoires in Lupus
Jing Jing Wang¹, Alexander Colella¹, Dimitra Beroukas², Tim Chataway³ and Tom Gordon^1,4, ¹Immunology, Flinders University, Adelaide, Australia, ²Immunology, SA Pathology, Adelaide, AR, Australia, ³Proteomic Facility, Flinders University, Adelaide, Australia, ⁴Immunology, SA Pathology, Adelaide, Australia
Background/Purpose: Anti-double-stranded (ds)DNA autoantibodies are prototypic serological markers of systemic lupus erythematosus (SLE) but little is known about their immunoglobulin variable (IgV) region composition at…
Abstract Number: 693 • 2017 ACR/ARHP Annual Meeting
The Utility of a Rise in Anti – Double Stranded DNA Antibodies for Predicting Disease Flares in Systemic Lupus Erythematosus. a Meta-Analysis
Margrét Arna Viktorsdóttir¹, Sæmundur Rögnvaldsson¹, Þórunn Jónsdóttir² and Gunnar Tomasson³, ¹University of Iceland, Faculty of Medicine, Reykjavík, Iceland, ²Landspítali University Hospital, Reykjavík, Iceland, ³University of Iceland, Faculty of Medicine, Reykjavik, IS
Background/Purpose: The ability of predicting disease flares in systemic lupus erythematosus (SLE) by serial measurements of antibodies to double stranded DNA (anti-dsDNA) remains uncertain. Previous…
Abstract Number: 703 • 2017 ACR/ARHP Annual Meeting
Clinical Value of Autoantibodies for Lupus Myelitis and Its Subtypes: A Systematic Review
Hiroshi Oiwa¹, Akira Kuriyama², Tomoyasu Matsubara³ and Eiji Sugiyama⁴, ¹Rheumatology, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan, ²General Medicine, Kurashiki Central Hospital, Kurashiki, Japan, ³Neurology, Hiroshima University Hospital, Hiroshima, Japan, ⁴Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan
Background/Purpose: We conducted a systematic review to investigate the clinical value of clinical characteristics and autoantibodies, especially lupus-specific antibodies, for lupus myelitis and its subtypes.…
Abstract Number: 704 • 2017 ACR/ARHP Annual Meeting
Detection of dsDNA Antibodies By New Fluoroimmunoassay with Comparable Diagnostic Sensitivity and Specificity to Farr-Ria
Katja Lakota^1,2, Tanja Kveder², Tinka Svec², Polona Žigon², Ales Ambrozic³, Borut Božič^2,4, Matija Tomšič^2,5, Saša Čučnik^2,4 and Snezna Sodin Semrl^1,2, ¹Faculty of Mathematics, Natural Science and Information Technology, University of Primorska, Koper, Slovenia, ²Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ³Department of Rheumatology, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia, ⁴Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia, ⁵University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia
Background/Purpose: Antibodies against double-stranded deoxyribonucleic acid (anti-dsDNA) are a useful and valuable serological marker for diagnosis of systemic lupus erythematosus (SLE). Studies suggest strong correlation…
Abstract Number: 833 • 2017 ACR/ARHP Annual Meeting
Chronic Cutaneous Lupus Erythematosus Patients Have a Breakdown in Autoreactive VH4.34 Antibody Tolerance While Maintaining Tolerance to dsDNA and Chromatin
Scott Jenks¹, Regina Bugrovsky¹, Xiaoqian Wang^1,2, Aisha Hill³, Chungwen Wei⁴, S. Sam Lim⁵, Ignacio Sanz⁶ and Cristina Drenkard⁵, ¹Emory University School of Medicine and Lowance Center for Human Immunology, Atlanta, GA, ²Division of Rheumatology and Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA, ³Medicine, Emory University School of Medicine, atlanta, GA, ⁴Medicine, Emory University School of Medicine, Atlanta, GA, ⁵Division of Rheumatology, Emory University School of Medicine, Atlanta, GA, ⁶Rheumatology and Lowance Center for Human Immunology, Emory University School of Medicine and Lowance Center for Human Immunology, Atlanta, GA
Background/Purpose: While the contribution of humoral immunity to SLE is well established, the role it plays in chronic cutaneous lupus erythematosus (CCLE) is less clear.…
Abstract Number: 1811 • 2016 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus: Detailed Anatomy of a Cohort (follow-up for more than 35 years).
Borja Del Carmelo Gracio Tello¹, Alexis Jones¹, Charles Raine¹ and David Isenberg², ¹Rheumatology, University College Hospital, London, London, United Kingdom, ²University College Hospital, London, London, United Kingdom
Background/Purpose: Very long-term follow-up has rarely been reported in lupus patients. We report on the follow up of (up to 37 years) of our lupus…
Abstract Number: 2066 • 2016 ACR/ARHP Annual Meeting
Anti-Ds-DNA Antibodies Regulate Atherothrombosis in Systemic Lupus Erythematosus through the Induction of Netosis, the Prothrombotic and Proinflammatory Activities of Monocytes and the Endothelial Activation
Carlos Perez-Sanchez¹, Maria Ángeles Aguirre Zamorano¹, María Galindo², Patricia Ruiz-Limon³, Ivan Arias de la Rosa³, Nuria Barbarroja¹, Yolanda Jiménez-Gómez¹, Pedro Segui¹, Eduardo Collantes-Estévez¹, Maria Jose Cuadrado⁴ and Chary Lopez-Pedrera¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, ³Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁴St Thomas Hospital, Lupus Research Unit, London, United Kingdom
Background/Purpose: The role of anti-dsDNA in the pathogenesis of the systemic lupus erythematosus (SLE) has been clearly established. However, the influence of these autoantibodies in…
Abstract Number: 2937 • 2016 ACR/ARHP Annual Meeting
Regulation of Follicular Helper T (TFH) Cells By ROCK2 (Rho-associated coiled-coil containing protein kinase 2)
Woelsung Yi¹, Sanjay Gupta², Chien-Huan Weng³, Yurii Chinenov⁴, James K. Liao⁵ and Alessandra B. Pernis⁶, ¹Hospital for Special Surgery, New York, NY, ²Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY, ³Weill Cornell Medical College, New York, NY, ⁴Arthritis & Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, ⁵Cardiology Section, University of Chicago Medical Center, Chicago, IL, ⁶David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Follicular helper T (TFH) cells promote humoral responses and serve as a limiting factor for the selection of high affinity germinal center B cells.…
Abstract Number: 578 • 2015 ACR/ARHP Annual Meeting
Study of the Production of Antinuclear Antibodies and Anti-Ds DNA Antibodies in Rheumatoid Arthritis Patients Treated with TNF Inhibitors
Ran Matsudaira^1,2, Naoto Tamura³, Yoshichika Sugisaki², Tomoko Ito⁴, Kentaro Minowa², Michihiro Ogasawara², Ken Yamaji², Yoshinori Kanai¹, Kenjiro Yamanaka¹ and Yoshinari Takasaki², ¹Division of Internal Medicine and Rheumatology, Sasaki institute Kyoundo Hospital, Tokyo, Japan, ²Department of Internal Medicine and Rheumatology, Juntendo University, School of Medicine, Tokyo, Japan, ³Department of Internal Medicien and Rheumatology, Juntendo University, School of Medicine, Tokyo, Japan, ⁴Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: The production of autoantibodies, such as anti-nuclear antibodies (ANA) and anti-ds DNA antibodies (anti-DNA), is commonly observed in patients who have been treated with…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].