Abstracts tagged "Anti-citrullinated protein/peptide antibodies (ACPA) and rheumatoid arthritis (RA)"

Abstract Number: 567 • 2018 ACR/ARHP Annual Meeting
Non-Surgical Periodontal Therapy Plus Short-Term Antibiotic Treatment May Improve Clinical Disease Activity: A Pilot Study in Difficult to Treat Rheumatoid Arthritis
Burkhard Moeller¹, Philip Bender², Sigrun Eick², Kim Midwood³, Jan Potempa⁴, Stephan Reichenbach⁵, Anja Schwenzer³, Peter M. Villiger⁶ and Alicia Wong³, ¹Rheumatology, Immunology and Allergology, Inselspital, University Hospital of Bern, Bern, Switzerland, ²School of Dental Medicine, University of Bern, Bern, Switzerland, ³Kennedy Institute for Rheumatology, Oxford University, Oxford, United Kingdom, ⁴Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland, ⁵Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland, ⁶University of Bern, Bern, Switzerland
Background/Purpose: Autoimmunity against citrullinated peptides is a hallmark of rheumatoid arthritis (RA). Chronic periodontitis (CP) is a known major source of citrullinated peptides. Here, we…
Abstract Number: 1570 • 2016 ACR/ARHP Annual Meeting
Working in Cold Environment Is Associated with Increased Risk of Developing Rheumatoid Arthritis: Results from a Swedish Population-Based Case-Control Study
Pingling Zeng¹, Lars Klareskog², Camilla Bengtsson³ and Lars Alfredsson⁴, ¹Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden, ³Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden, ⁴Section of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: To investigate whether working in cold environment is associated with an increased risk of developing rheumatoid arthritis (RA) (overall), anti-citrullinated protein antibody (ACPA)-positive RA…
Abstract Number: 2115 • 2016 ACR/ARHP Annual Meeting
Rheumatoid Factors May Potentiate Immune Complex Formation of Anti-Citrullinated Protein Antibodies
Willem J.J. Falkenburg^1,2, Dirkjan van Schaardenburg^3,4, Jana Koers⁵, Pleuni Ooijevaar-de Heer⁵, Gertjan Wolbink^6,7, Arthur E.H. Bentlage⁸, Gestur Vidarsson⁸ and Theo Rispens⁵, ¹Rheumatology, Amsterdam Rheumatology and immunology Center | Reade, Amsterdam, Netherlands, ²Department of Immunopathology, Sanquin Research, Amsterdam, Netherlands, ³Rheumatology, Amsterdam Rheumatology and immunology Center, location Academic Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands, ⁴Rheumatology, Amsterdam Rheumatology and immunology Center, location Reade, Amsterdam, Netherlands, Amsterdam, Netherlands, ⁵Immunopathology, Sanquin Research, Amsterdam, Netherlands, ⁶Immunopathology, Sanquin Research and Landsteiner Laboratory Academic Medical Center, Amsterdam, Netherlands, ⁷Rheumatology, Amsterdam Rheumatology and immunology Center, location Reade, Amsterdam, Netherlands, ⁸Experimental Immunohematology, Sanquin Research, Amsterdam, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is a complex inflammatory disorder in which autoantibodies play a prominent role. Several types of autoantibodies, including rheumatoid factors (RFs) -…
Abstract Number: 2782 • 2014 ACR/ARHP Annual Meeting
Autoantibodies from Single Circulating Plasmablasts React with Citrullinated Antigens and Porphyromonas Gingivalis in Rheumatoid Arthritis
Song Li¹, Yangsheng Yu¹, Yinshi Yue¹, Hongyan Liao¹, Wanqin Xie¹, Jessica Thai¹, Ted R. Mikuls², Geoffrey M. Thiele³, Michael J. Duryee⁴, Jeffrey Payne⁵, Lynell W. Klassen⁶, James R. O'Dell⁷, Zhixin Zhang⁸ and Kaihong Su¹, ¹Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, ²Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ³Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁴Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ⁵College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, ⁶Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ⁷Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁸Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose Anti-citrullinated protein antibodies (ACPAs) are highly specific for rheumatoid arthritis (RA) and also believed to play a pathogenic role in RA. Porphyromonas gingivalis (P.…
Abstract Number: 437 • 2014 ACR/ARHP Annual Meeting
Anti-Citrullinated Heat Shock Protein 90 Antibodies Identified in Bronchoalveolar Lavage Fluid Are a Marker of Lung-Specific Immune Responses
Lisa Harlow¹, Bernadette Gochuico², Ivan Rosas³, Tracy Doyle⁴, Juan Osorio⁴, Timothy Travers⁵, Carlos Camacho⁶, Chester V. Oddis⁷ and Dana P. Ascherman⁸, ¹Rheumatology and Clinical Immunology, University of Miami Miller School of Medicine, Miami, FL, ²Medical Genetics Branch, National Institutes of Health, Bethesda, MD, ³Medicine/Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, ⁴Medicine/Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, ⁵Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, ⁶Compuational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, ⁷Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁸Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL
Background/Purpose . Previous work has demonstrated an association between serum anti-citrullinated HSP90 antibodies and rheumatoid arthritis-associated interstitial lung disease (RA-ILD). To further investigate this potential…
Abstract Number: 2291 • 2013 ACR/ARHP Annual Meeting
Only Rheumatoid Factor-Positive Subset Of Anti-Citrullinated Peptide/Protein Antibody-Negative Rheumatoid Arthritis Seroconverts To Anti-Citrullinated Peptide/Protein Antibody-Positive
Ryosuke Hiwa¹, Koichiro Ohmura¹, Shuichiro Nakabo¹, Chikashi Terao², Ran Nakashima¹, Yoshitaka Imura³, Naoichiro Yukawa⁴, Hajime Yoshifuji¹, Motomu Hashimoto⁵, Moritoshi Furu⁶, Hiromu Ito⁶, Takao Fujii⁶ and Tsuneyo Mimori^1,6, ¹Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Center for Genomic Medicine, Kyoto University, Kyoto, Japan, ³Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁴Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁵The Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ⁶Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Background/Purpose: 216 (17.3%) out of 1,246 RA patients were negative for ACPA. In 149 cases of the ACPA-negative RA whose ACPA were measured more than…
Abstract Number: 2303 • 2013 ACR/ARHP Annual Meeting
Clinical Characteristics Of Rheumatoid Factor-Positive Or Negative Subsets Of Anti-Citrullinated Peptide/Protein Antibody-Negative Rheumatoid Arthritis
Ryosuke Hiwa¹, Koichiro Ohmura¹, Noriyuki Yamakawa¹, Moritoshi Furu², Chikashi Terao³, Ran Nakashima¹, Yoshitaka Imura⁴, Naoichiro Yukawa⁵, Hajime Yoshifuji¹, Motomu Hashimoto⁶, Hiromu Ito², Takao Fujii² and Tsuneyo Mimori^1,2, ¹Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ³Center for Genomic Medicine, Kyoto University, Kyoto, Japan, ⁴Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁵Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁶The Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Background/Purpose: Although anti-citrullinated peptide/protein antibody (ACPA) is a specific autoantibody for rheumatoid arthritis (RA), ~20% of RA are ACPA negative. It has been reported that…
Abstract Number: 183 • 2013 ACR/ARHP Annual Meeting
The Performance Of a Point Of Care Test For Detection Of Anti-Mutated Citrullinated Vimentin and Rheumatoid Factor In Early Rheumatoid Arthritis
Preeda Rojanasantikul¹, Prapa Pattrapornpisut², Kulvara Anuruckparadorn³ and Wanruchada Katchamart¹, ¹Division of Rheumatology, Department of Internal Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, ²Department of Internal Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, ³Department of Transfusion Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
Background/Purpose: Besides rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (ACPA), a newer serologic marker, was added to the new American College of Rheumatology (ACR)/European League…
Abstract Number: 2127 • 2012 ACR/ARHP Annual Meeting
Rheumatoid Arthritis (RA) Patients Discordant for Rheumatoid Factor and Anti-CCP Positivity Have Different Clinical and Laboratory Features Than RA Patients Seropositive or Seronegative for Both Markers
Swati Modi¹, Yona Cloonan², Danielle Goudeau³, Donald M. Jones⁴, Christine L. Amity⁵, Lynne M. Frydrych⁴, Kelly A. Reckley⁶, Heather Eng⁷, Stephen R. Wisniewski⁸, Larry W. Moreland⁹ and Marc C. Levesque³, ¹Rheumatology, University of Pittsburgh, Pittsburgh, PA, ²Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁴Rheumatology & Clinical Immun, Univ of Pittsburgh Med Ctr, Pittsburgh, PA, ⁵Rheumatology & Clinical Immun, Univ of Pittsburgh, Pittsburgh, PA, ⁶Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁷Epidemiology Data Center, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, ⁸Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, ⁹Division of Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) positive rheumatoid arthritis (RA) patients develop more extra-articular disease manifestations and erosions, and have a worse…
Abstract Number: 1769 • 2012 ACR/ARHP Annual Meeting
Affinity Purification and Characterisation of Anti-CCP Antibodies From Plasma and Synovial Fluids of Patients with Rheumatoid Arthritis
Elena Ossipova¹, Catia Cerqueira², Evan Reed², Nastya Kharlamova², Lena Israelsson², Rikard Holmdahl³, Anca Catrina², Vivianne Malmström², Yngve Sommarin⁴, Lars Klareskog², Per Johan Jakobsson² and Karin Lundberg², ¹Rheumatology unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ³Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden, ⁴Euro-Diagnostica AB, Malmö, Sweden
Background/Purpose: Autoimmunity in rheumatoid arthritis (RA) is characterized by autoantibodies to citrullinated proteins/peptides (ACPA). These antibodies (present in 60-70% of patients) antedate clinical onset and…
Abstract Number: 1605 • 2012 ACR/ARHP Annual Meeting
Anti-Citrullinated Peptide Autoantibodies to Rheumatoid Synovium Epitopes in Women and Risk of Future Rheumatoid Arthritis
Elizabeth V. Arkema¹, Barbara L. Goldstein², William H. Robinson³, Catriona Cramb⁴, Jeremy Sokolove⁵, Jing Cui⁶, Susan Malspeis⁷, Elizabeth W. Karlson⁸ and Karen H. Costenbader⁷, ¹Epidemiology, Harvard School of Public Health, Boston, MA, ²Rheumatology & Immunology, Brigham and Women's Hospital, Boston, MA, ³Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴VA Palo Alto Heatlh Care System and Stanford University, Palo Alto, CA, ⁵Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁶Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁷Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁸Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Recent studies have shown that anti-citrullinated protein antibodies (ACPA) are detectable years before rheumatoid arthritis (RA) diagnosis, representing a potential early marker of RA…
Abstract Number: 1607 • 2012 ACR/ARHP Annual Meeting
The Association Between Thyroxin Substitution and Rheumatoid Arthritis; Results From the Swedish EIRA Study
Camilla Bengtsson¹, Henrik Källberg¹, Leonid Padyukov² and Saedis Saevarsdottir³, ¹Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, ³Rheumatology Unit, Dept. of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Hypothyroidism is usually of autoimmune nature, in areas with sufficient iodine, and leads to chronic substitution treatment with thyroxin. The disease shares some risk…
Abstract Number: 64 • 2012 ACR/ARHP Annual Meeting
Use of Moist Snuff and the Risk of Developing Rheumatoid Arthritis; Results From the Swedish Epidemiological Investigation of Rheumatoid Arthritis Study
Lars Alfredsson¹, Lars Klareskog² and Camilla Bengtsson¹, ¹Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden
Background/Purpose: Smoking is the major known environmental risk factor for RA, and notably this risk factor is exclusively seen in ACPA-positive RA. Whether this increased…

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