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Abstracts tagged "Anti-centromere antibodies (ACA)"

  • Abstract Number: 2595 • 2019 ACR/ARP Annual Meeting

    Asymptomatic Scleroderma Antibody Positivity and Progression to Systemic Sclerosis

    Derek Jones 1, Marissa Mangini 1, Sydney Wearing 1 and Victoria Shanmugam2, 1The George Washington University School of Medicine and Health Sciences, Washington, DC, 2George Washington University, Georgetown, DC

    Background/Purpose: Systemic sclerosis is an autoimmune disease characterized by inflammation, vasculopathy and fibrosis of the skin, vasculature and internal organs along with disease specific autoantibody…
  • Abstract Number: 1962 • 2018 ACR/ARHP Annual Meeting

    HLA Contributions to Risk and Protection for Anti-Centromere Autoantibody-Positive Scleroderma

    Elaine F. Remmers1, Theresa Alexander2, Nadia D. Morgan3, Ami A. Shah4, Maureen D. Mayes5, Adebowale Adeyemo1, Ayo Doumatey1, Amy Bentley1, Daniel Shriner6, Settara C Chandrasekharappa1, Mary A. Carns7, Lorinda Chung8, Lindsey A. Criswell9, Chris T. Derk10, Robyn T. Domsic11, Heather Gladue12, Avram Goldberg13, Jessica K. Gordon14, Vivien Hsu15, Reem Jan16, Dinesh Khanna17, Thomas A. Medsger Jr.18, Paula S. Ramos19, Marcin A. Trojanowski20, Lesley Ann Saketkoo21, Elena Schiopu22, Victoria Shanmugam23, Benjamin D. Korman24, Brynn Kron9, S. Louis Bridges Jr.25, Kathleen D. Kolstad26, Elana J. Bernstein27, Suzanne Kafaja28, Kathleen Maksimowicz-McKinnon29, Rick Silver30, Virginia D. Steen31, John Varga32, Charles Rotimi1, Francesco Boin33, Fredrick M. Wigley34, Daniel L. Kastner35 and Pravitt Gourh36, 1National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 2National Institutes of Health, Bethesda, MD, 3Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 4Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 5Rheumatology, University of Texas McGovern Medical School, Houston, TX, 6National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, MD, 7Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, 8Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, 9University of California San Francisco, San Francisco, CA, 10Rheumatology, University of Pennsylvania, Philadelphia, PA, 11Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 12Rheumatology, Arthritis and Osteoporosis Consultants of the Carolinas, Charlotte, NC, 13NYU Langone Medical Center, New York, NY, 14Rheumatology, Hospital for Special Surgery, New York, NY, 15Rheumatology, Robert Wood Johnson University Scleroderma Program, New Brunswick, NJ, 16Medicine, Rheumatology, University of Chicago, Chicago, IL, 17Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, 18University of Pittsburgh, Pittsburgh, PA, 19Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, 20Boston University School of Medicine, Boston, MA, 21Rheumatology, Tulane University School of Medicine, New Orleans, LA, 22University of Michigan, Ann Arbor, MI, 23Rheumatology, The George Washington University, Washington, DC, 24Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, 25Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, 26Rheumatology, Stanford University Medical Center, Stanford, CA, 27Rheumatology, Columbia University, New York, NY, 28David Geffen School of Medicine, UCLA, Los Angeles, CA, 29Rheumatology, Henry Ford Hospital, Detroit, MI, 30Rheumatology, Medical University of SC, Charleston, SC, 31Rheumatology, MedStar Georgetown University Hospital, Washington, DC, 32Northwestern University, Chicago, IL, 33Rheumatology, University California, San Francisco, San Francisco, CA, 34Rheum Div/Mason F Lord, Johns Hopkins University, Baltimore, MD, 35Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 36Rheumatology, NIAMS, National Institutes of Health, Bethesda, MD

    Background/Purpose:  Anti-nuclear autoantibodies are a hallmark of scleroderma with anti-centromere antibody (ACA) recognizing centromeric antigens.  ACA-positive patients have longstanding Raynaud’s, limited cutaneous disease and increased…
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