Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 1373 • 2012 ACR/ARHP Annual Meeting
Influence of Early Onset On the Clinical Characteristics and Prognosis of Ankylosing Spondylitis
Maria Aparicio¹, Jesús Rodríguez-Moreno¹, Paula Estrada¹, Irene Martín-Esteve², Laura López-Vives¹, Vicenç Torrente³, Jordi Anton⁴, Joan Miquel Nolla⁵ and Xavier Juanola⁶, ¹Rheumatology, Hospital Universitari de Bellvitge, Barcelona, Spain, ²Rheumatology Service, Hospital Universitari de Bellvitge - IDIBELL, Barcelona, Spain, ³Rheumatology, Hospital Sant Joan de Déu, Barcelona, Spain, ⁴Rheumatology, Hospital Sant Joan de Deu, Barcelona, Spain, ⁵Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, ⁶Rheumatology, University Hospital Bellvitge, Barcelona, Spain
Background/Purpose: To determine the influence of early onset (≤ 16 years) on the clinical characteristics and prognosis of ankylosing spondylitis (AS). Methods: We revised patients…
Abstract Number: 584 • 2012 ACR/ARHP Annual Meeting
Association of Platelet Endothelial Cell Adhesion Molecule-1 and â1 Integrin Gene Polymorphisms with Uveitis Development in Ankylosing Spondylitis
Seung Cheol Shim¹, Donghyuk Sheen², Mi Kyoung Lim¹ and Hyo Park¹, ¹Medicine, Eulji University Hospital, Daejeon, South Korea, ²Rheumatology, Eulji University Hospital, Daejeon, South Korea
Background/Purpose: Genetic factors provide over 90% of the susceptibility to ankylosing spondylitis (AS) and recent studies have focused on non-major histocompatibility complex genes. The etiology…
Abstract Number: 1825 • 2012 ACR/ARHP Annual Meeting
Work Disability and Work Limitations in Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Are Equal and Increase with Comorbidities
Chanseok Rhee¹, Janet E. Pope², Andrew E. Thompson³, Nicole G. H. Le Riche⁴, Gina Rohekar⁵ and Sherry Rohekar⁵, ¹School of Medicine and Dentistry, Schulich School of Medicine and Dentisty, Western University, London, ON, Canada, ²Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ³Rheumatology, St. Josephs Health Ctr, London, ON, Canada, ⁴Department of Medicine, St. Joseph's Hospital, London, ON, Canada, ⁵Rheumatology, St. Joseph's Hospital, London, ON, Canada
Background/Purpose: Few studies directly compare work disability (WD) and work productivity losses in different forms of inflammatory arthritis (IA) such as rheumatoid arthritis (RA), psoriatic…
Abstract Number: 1349 • 2012 ACR/ARHP Annual Meeting
Trends in Incidence and Clinical Features of Ankylosing Spondylitis in Olmsted County (1980-2009): A Population Based Study
Kerry Wright¹, Cynthia S. Crowson², Clement J. Michet¹ and Eric L. Matteson¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Department of Health Sciences Research, Mayo Clinic, Rochester, MN
Background/Purpose: To determine trends in the incidence and clinical presentation of ankylosing spondylitis (AS) among residents of a geographically defined area first diagnosed 1980-2009 and…
Abstract Number: 586 • 2012 ACR/ARHP Annual Meeting
High Prevalence of Anti-CD-74 Antibodies with Specificity for the Class II-Associated Invariant Chain Peptide in Patients with Axial Spondyloarthritis but Not in Controls
Xenofon Baraliakos¹, Niklas T. Baerlecken², Frank Heldmann³, Torsten Witte⁴ and Jürgen Braun³, ¹Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, ²Clinical Immunology and Rheumatology, Medical University Hannover, Hannover, Germany, ³Rheumazentrum Ruhrgebiet, Herne, Germany, ⁴Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany
Background/Purpose: The pathogenesis of axial spondyloarthritis (axSpA) is still unclear. Based on the strong association with HLA-B27 and ERAP-1, T cells are believed to play…
Abstract Number: 1835 • 2012 ACR/ARHP Annual Meeting
Prescription of Biologics in Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA) and Ankylosing Spondylitis (AS) in 4 Norwegian Regions 2002-2011: A Study of Prescription Rates and Baseline Disease Activity
Elisabeth Lie¹, Karen M. Fagerli², Knut Mikkelsen³, Åse S. Lexberg⁴, Erik Rødevand⁵, Till Uhlig¹ and Tore K. Kvien¹, ¹Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Department of Rheumatology, Diakonhjemmet Hospital, Department of Rheumatology, Oslo, Norway, Oslo, Norway, ³Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway, ⁴Dept. of Rheumatology, Vestre Viken Hospital, Drammen, Norway, ⁵Dept. of Rheumatology, St. Olavs Hospital, Trondheim, Norway
Background/Purpose: Biologics have constituted a major advance in the treatment of RA, PsA and AS. In Norway access to these therapies has been good since…
Abstract Number: 1352 • 2012 ACR/ARHP Annual Meeting
Adalimumab Significantly Reduces Recurrence Rate of Anterior Uveitis in Patients with Ankylosing Spondylitis
J. Christiaan van Denderen¹, Ingrid M. Visman¹, M. T. Nurmohamed², Maria S.A. Suttorp-Schulten³ and Irene E. van der Horst-Bruinsma⁴, ¹Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ²VU University Medical Center/Jan van Bremen Research Institute, Amsterdam, Netherlands, ³Ophtalmology, Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands, ⁴Rheumatology, VU University Medical Centre, Amsterdam, Netherlands
Background/Purpose : A high percentage (30-40%) of patients with Ankylosing Spondylitis (AS) suffer from acute anterior uveitis (AAU) attacks. Local treatment with corticosteroids is a…
Abstract Number: 587 • 2012 ACR/ARHP Annual Meeting
Brain MRI and Psychophysics Analysis Demonstrate Neuropathic Pain to Be a Component of Back Pain in Ankylosing Spondylitis
Q. Wu¹, Robert D. Inman² and Karen Davis³, ¹Research, Toronto Western Research Institute, Toronto, ON, Canada, ²Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, ³Department of Surgery, Toronto Western Research Institute, Toronto, ON, Canada
Background/Purpose: The mechanisms underlying pain in ankylosing spondylitis (AS) are unclear. The aim of this study was to investigate whether there is a neuropathic component…
Abstract Number: 1702 • 2012 ACR/ARHP Annual Meeting
Tumor Necrosis Factor Blocking Agents Inhibit the Progression of Preclinical Atherosclerosis in Patients with Ankylosing Spondylitis
Alper M. van Sijl¹, Izhar C. van Eijk², Mike J.L. Peters³, Erik H. Serne³, Yvo M. Smulders⁴ and Mike T. Nurmohamed¹, ¹Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, ²Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ³Internal medicine, VU University Medical Center, Amsterdam, Netherlands, ⁴Internal Medicine, VU University Medical Center, Amsterdam, Netherlands
Background/Purpose: Ankylosing spondylitis (AS) is associated with an increased cardiovascular (CV) risk that might be due to the chronic underlying inflammatory process. It is still…
Abstract Number: 987 • 2012 ACR/ARHP Annual Meeting
Autoimmune Susceptibility Genes Are Regulators of Gene Expression Response to ER Stress
William E. Bernal¹, Michael P. Morley² and Vivian G. Cheung³, ¹Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Pediatrics & Genetics, Howard Hughes Medical Institute, Chevy Chase, MD; University of Pennsylvania, Philadelphia, PA
Background/Purpose: Endoplasmic recticulum (ER) stress is caused by excessive demands on the protein-processing capacity of the ER; inefficiencies in response to ER stress lead to…
Abstract Number: 553 • 2012 ACR/ARHP Annual Meeting
Identification of Axial Spondyloarthritis Among Patients with Chronic Back Pain in Primary Care – How Does Determination of HLA B27 Influence the Performance of Clinical Assessments of Inflammatory Back Pain?
Annalina Braun¹, Holger Gnann², Ertan Saracbasi¹, Joachim Grifka³, Uta Kiltz¹, Jürgen Braun⁴, Katrin Letschert⁵ and Jürgen Braun⁴, ¹Rheumazentrum Ruhrgebiet, Herne, Germany, ²Abteilung Biostatistik, GKM Gesellschaft für Therapieforschung mbH, München, Germany, ³Orthopedic Surgery, University of Regensburg, Bad Abbach, Germany, ⁴Institut für angewandte Statistik Dr. Jörg Schnitker GmbH, Bielefeld, Germany, ⁵Abbott Inc., Wiesbaden, Germany
Background/Purpose: The value of a combination of items defining inflammatory back pain (IBP) to screen for axial spondyloarthritis (axSpA) in primary care has recently been…
Abstract Number: 1703 • 2012 ACR/ARHP Annual Meeting
Relationship Between Tobacco Smoking and Radiographic Spinal Progression in Axial Spondyloarthritis: The Role of Inflammatory Activity
Denis Poddubnyy¹, Hildrun Haibel², Joachim Listing³, Elisabeth Märker-Hermann⁴, Henning Zeidler⁵, Jürgen Braun⁶, Martin Rudwaleit⁷ and Joachim Sieper⁸, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Medical Department I, Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany, ³German Rheumatism Research Center, Berlin, Germany, ⁴Dr. Horst Schmidt Kliniken, Wiesbaden, Germany, ⁵Medizinische Hochschule, Hannover, Germany, ⁶PsAID taskforce, EULAR, Zurich, Switzerland, ⁷Endokrinologikum Berlin, Berlin, Germany, ⁸Medical Department I, Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany
Background/Purpose: Cigarette smoking is associated with functional impairment [1, 2] and radiographic severity of ankylosing spondylitis (AS) [3, 4]. Moreover, smoking status at baseline was…
Abstract Number: 777 • 2012 ACR/ARHP Annual Meeting
Effect of Certolizumab Pegol On Signs and Symptoms of Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis: 24 Week Results of a Double Blind Randomized Placebo-Controlled Phase 3 Axial Spondyloarthritis Study
Robert B. M. Landewé¹, Martin Rudwaleit², Désirée van der Heijde³, Maxime Dougados⁴, Walter P. Maksymowych⁵, Jürgen Braun⁶, Atul A. Deodhar⁷, Christian Stach⁸, Bengt Hoepken⁸, Geoffroy Coteur⁹, Danuta Kielar⁹, Andreas Fichtner⁸, Terri Arledge¹⁰ and Joachim Sieper¹¹, ¹Academic Medical Center/University of Amsterdam & Atrium Medical Center, Amsterdam, Netherlands, ²Endokrinologikum Berlin, Berlin, Germany, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology B Department, Paris-Descartes University, APHP, Cochin Hospital, Paris, France, ⁵Department of Medicine, University of Alberta, Edmonton, AB, Canada, ⁶Rheumazentrum Ruhrgebiet, Herne, Germany, ⁷Oregon Health & Science University, Portland, OR, ⁸UCB Pharma, Monheim am Rheim, Germany, ⁹UCB Pharma, Brussels, Belgium, ¹⁰UCB Pharma, Rtp, NC, ¹¹Medical Department I, Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany
Background/Purpose: Axial spondyloarthritis (axSpA ) includes both ankylosing spondylitis (AS) and non-radiographic axSpA (nr-axSpA), as defined by the ASAS criteria.1 RAPID-axSpA (NCT01087762) is the first…
Abstract Number: 561 • 2012 ACR/ARHP Annual Meeting
Performance of Magnetic Resonance Imaging in Detection of Chronic Structural Changes in Sacroiliac Joints As Compared to Conventional X-Rays in Axial Spondyloarthritis
Denis Poddubnyy¹, Inna Gaydukova², Hildrun Haibel¹, In-Ho Song¹ and Joachim Sieper¹, ¹Medical Department I, Rheumatology, Charité Medical University, Campus Benjamin Franklin, Berlin, Germany, ²Hospital Therapy, Saratov State Medical University, Saratov, Russia
Background/Purpose: Conventional x-rays of the sacroiliac joints (SIJ) remains the first imaging method in case of suspicion of axial spondyloarthritis (SpA). Moreover, a diagnosis of…
Abstract Number: 1704 • 2012 ACR/ARHP Annual Meeting
New Threshold Values for Spinal Mobility Measures Based On a Large Nationally Representative Sample of U.S. Adults Ages 20-69 Years
Shervin Assassi¹, Michael H. Weisman², Zhongxue Chen³, Mohammad Rahbar³ and John D. Reveille⁴, ¹Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ²Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ³Univ of Texas Health Science Center at Houston, Houston, TX, ⁴Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: Spinal mobility measures are widely utilized for diagnosis and assessment of disease severity in patients with Ankylosing Spondylitis. The previously proposed threshold values for…

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