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Abstracts tagged "Ankylosing spondylitis (AS)"

  • Abstract Number: 561 • 2012 ACR/ARHP Annual Meeting

    Performance of Magnetic Resonance Imaging in Detection of Chronic Structural Changes in Sacroiliac Joints As Compared to Conventional X-Rays in Axial Spondyloarthritis

    Denis Poddubnyy1, Inna Gaydukova2, Hildrun Haibel1, In-Ho Song1 and Joachim Sieper1, 1Medical Department I, Rheumatology, Charité Medical University, Campus Benjamin Franklin, Berlin, Germany, 2Hospital Therapy, Saratov State Medical University, Saratov, Russia

    Background/Purpose: Conventional x-rays of the sacroiliac joints (SIJ) remains the first imaging method in case of suspicion of axial spondyloarthritis (SpA). Moreover, a diagnosis of…
  • Abstract Number: 1704 • 2012 ACR/ARHP Annual Meeting

    New Threshold Values for Spinal Mobility Measures Based On a Large Nationally Representative Sample of U.S. Adults  Ages 20-69 Years

    Shervin Assassi1, Michael H. Weisman2, Zhongxue Chen3, Mohammad Rahbar3 and John D. Reveille4, 1Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, 2Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 3Univ of Texas Health Science Center at Houston, Houston, TX, 4Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX

    Background/Purpose: Spinal mobility measures are widely utilized for diagnosis and assessment of disease severity in patients with Ankylosing Spondylitis.  The previously proposed threshold values for…
  • Abstract Number: 781 • 2012 ACR/ARHP Annual Meeting

    Ankylosing Spondylitis Is Associated with an Increased Risk of Osteoporotic Fractures: A Population-Based Cohort Study

    Juan Muñoz-Ortego1, Peter Vestergaard2, Josep Blanch3, Paul Wordsworth4, Andrew Judge5, M. Kassim Javaid6, Nigel K. Arden7, Cyrus Cooper8, Adolfo Díez-Pérez9 and Daniel Prieto-Alhambra10, 1Rheumatology, Hospital Sagrat Cor, Barcelona (Spain), Barcelona, Spain, 2Endocrinology and Internal Medicine (MEA), Aarhus University Hospital THG, Aarhus (Denmark), Aarhus, Denmark, 3Rheumatology, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain, 4Ndorms, Nuffield Orthopaedic Centre, Oxford, United Kingdom, 5Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, 6Rheumatology, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK, Oxford, United Kingdom, 7NDORMS; MRC Lifecourse Epidemiology Unit, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, 8NDORMS; MRC Lifecourse Epidemiology Unit, University of Oxford; Southampton General Hospital, Southampton, United Kingdom, 9Internal Medicine, Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Barcelona; and RETICEF, ISCIII Madrid; Spain, Barcelona, Spain, 10Internal Medicine; Primary Care; NDORMS Dept; MRC Lifecourse Epidemiology Unit, URFOA-IMIM, Parc de Salut Mar; Idiap Jordi Gol; University of Oxford; University of Southampton, Barcelona, Spain

    TITLE: "Ankylosing Spondylitis is associated with an increased risk of osteoporotic fractures: a population-based cohort study."Background/Purpose: Patients with Ankylosing Spondylitis (AS) have reduced bone mass,…
  • Abstract Number: 532 • 2012 ACR/ARHP Annual Meeting

    The Prevalance of Autoimmune Thyroid Disfunction in Ankylosing Spondylitis

    Hakan Emmungil1, Mehmet Erdogan2, Melike Kalfa1, Gonca Karabulut1, Hayriye Kocanaogullari1, Vedat Inal1, Yasemin Kabasakal3, Fahrettin Oksel4, Kenan Aksu5 and Gokhan Keser6, 1Dept. of Internal Medicine, Division of Rheumatology, Ege University, Dept. of Internal Medicine, Division of Rheumatology, Ege University, Izmir, Turkey, 2Dept. of Internal Medicine, Division of Endocrinolgy, Ege University, Dept. of Internal Medicine, Division of Endocrinolgy, Ege University, Izmir, Turkey, 3Dept. of Internal Medicine, Division of Rheumatology, Ege University, Izmir, Turkey, 4Division of Rheumatology, Ege University, Izmir, Turkey, 5Dept. Of Internal Medicine, Division of Rheumatology, Ege University, Dept. Of Internal Medicine, Division of Rheumatology, Ege University, Izmir, Turkey, 6Dept. of Internal Medicine, Division of Rheumatology, Dept. of Internal Medicine, Division of Rheumatology, Ege University, Izmir, Turkey

    Background/Purpose: Although the association of autoimmune thyroid dysfunction and primary Sjögren's syndrome (SjS) is well known, it is less clear whether a similar relationship also…
  • Abstract Number: 2615 • 2012 ACR/ARHP Annual Meeting

    Circulating Levels of Citrullinated Vimentin Fragments Are Diagnostic and Prognostic in Ankylosing Spondylitis; Evidence for Disease-Related Citrullination

    Anne C. Bay-Jensen1, Morten Asser Karsdal2, Efstathios Vassiliadis3, Stephanie Wichuk4, Zheng Zhao5, Robert GW Lambert6, Rik Lories7, Claus Christiansen8 and Walter P. Maksymowych9, 1Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 2Nordic Bioscience A/S, Herlev, Denmark, 3Nordic Bioscience, Herlev, Denmark, 4Medicine, University of Alberta, Edmonton, AB, Canada, 5Department of Rheumatology, University of Alberta and PLA General Hospital, Beijing, PR China, Beijing, AB, China, 6Radiology, University of Alberta, Edmonton, AB, Canada, 7Laboratory of Tissue Homeostasis and Disease - SBE Research Center, KU Leuven, Leuven, Belgium, 8CCBR, Ballerup, Denmark, 9Department of Medicine, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Rheumatoid arthritis (RA) is considered an anti-CCP positive disease whereas ankylosing spondylitis (AS) is considered an anti-CCP negative disease. Anti-CCP has prognostic capacity in…
  • Abstract Number: 1619 • 2012 ACR/ARHP Annual Meeting

    Quantification of Bone Marrow Edema by Using Magnetic Resonance Imaging for the Assessment of Neck Pain Only Marginally Reflects Clinical Evaluation in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis

    Xenofon Baraliakos1, Frank Heldmann2, Ravi Suppiah3, Fiona M. McQueen4 and Jürgen Braun2, 1Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, 2Rheumazentrum Ruhrgebiet, Herne, Germany, 3Department of Rheumatology, Auckland District Health Board, Auckland, New Zealand, 4Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand

    Background/Purpose: Despite the differences in the pathogenesis of rheumatoid arthritis (RA) and ankylosing spondylitis (AS), neck pain is a frequent clinical symptom in both diseases…
  • Abstract Number: 746 • 2012 ACR/ARHP Annual Meeting

    Increased Risk of Acute and Chronic Renal Comorbidity in Ankylosing Spondylitis: Results From a Population-Based Study

    Walter P. Maksymowych1, Shelagh Szabo2, Sumati Rao3, Mary A. Cifaldi3 and Adrian R. Levy4, 1Department of Medicine, University of Alberta, Edmonton, AB, Canada, 2Oxford Outcomes, Oxford Outcomes, Vancouver, BC, Canada, 3Abbott Laboratories, Abbott Park, IL, 4Oxford Outcomes Ltd, Vancouver, BC, Canada

    Background/Purpose: Clinical evidence points to an increased risk of renal comorbidity in ankylosing spondylitis (AS) compared to the general population.  However, there are no population-based…
  • Abstract Number: 533 • 2012 ACR/ARHP Annual Meeting

    NT-Probnp and Inflammation in Active Ankylosing Spondylitis Receiving TNF Blockers: Is There a Link?

    Julio C. B. Moraes1, Ana C. M. Ribeiro2, Carla G.S. Saad3, Alessandro C. Lianza4, Nadia E. Aikawa5, Clovis Artur Silva6 and Eloisa Bonfa7, 1Reumatologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 2Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, 3Rheumatology Division, University of Sao Paulo, Sao Paulo, Brazil, 4Radiology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 5Rheumatology, University of São Paulo, Sao Paulo, Brazil, 6Paediatric Rheumatology International Trials Organization (PRINTO), Istituto Giannina Gaslini, Genova, Italy, 7Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: Cardiovascular disease plays a central role in morbidity and mortality in rheumatic patients. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a strong marker of cardiovascular…
  • Abstract Number: 2496 • 2012 ACR/ARHP Annual Meeting

    Elevated Serum Level of the Vascular Endothelial Growth Factor Is Highly Predictive for New Syndesmophytes Formation in Patients with Ankylosing Spondylitis

    Denis Poddubnyy1, Kristina Conrad2, Uta Syrbe2, Hildrun Haibel3, Heiner Appel2, Martin Rudwaleit4 and Joachim Sieper5, 1Charité Universitätsmedizin Berlin, Berlin, Germany, 2Charité Medical University, Campus Benjamin Franklin, Berlin, Germany, 3Medical Department I, Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany, 4Endokrinologikum Berlin, Berlin, Germany, 5Medical Department I, Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany

    Background/Purpose: In the recent years several predictors of radiographic spinal progression/syndesmophyte formation in ankylosing spondylitis (AS) were identified: syndesmophytes at baseline (the strongest predictor so…
  • Abstract Number: 1377 • 2012 ACR/ARHP Annual Meeting

    Prevalence of Spondyloarthritis-Related Comorbidities, Osteoporosis and Fractures in Ankylosing Spondylitis:  a Systematic Literature Review

    Carmen Stolwijk1, A.M. Van Tubergen2, Jose Dionisio Castillo-Ortiz3 and Annelies Boonen4, 1Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, 2Department of Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 3Unidad de Investigacion en Enfermedades Cronico-Degenerativas, Guadalajara, Mexico, 4Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands

    Background/Purpose: Comorbidities, both related and unrelated to the concept of spondyloarthritis (SpA), are common in patients with ankylosing spondylitis (AS) and may have substantial influence…
  • Abstract Number: 725 • 2012 ACR/ARHP Annual Meeting

    The Role of Interleukin-23 in Spondyloarthropathy

    Jonathan Sherlock1, Barbara Joyce-Shaikh1, Scott Turner1, Cheng-Chi Chao2, Manjiri Sathe1, Jeff Grein1, Dan Gorman1, Eddie P. Bowman2, Terrill McClanahan1, Jennifer Yearley1, Gerard Eberl3, Christopher D. Buckley4, Robert Kastelein1, Robert Pierce1, Drake LaFace1 and Daniel Cua5, 1Merck, Palo Alto, CA, 2Drug Discovery, Merck, Palo Alto, CA, 3Institut Pasteur, Paris, France, 4Center for Translational Inflammation Research, School of Immunity and Infection, MRC Center for Immune Regulation, Birmingham, United Kingdom, 5Discovery Research, Merck Research Laboratory, Palo Alto, CA

    Background/Purpose: Spondyloarthropathy is characterized by inflammation and bony pathology at the entheseal insertion of tendons to bone.  Recent investigations have converged upon interleukin(IL)-23, demonstrating firstly…
  • Abstract Number: 538 • 2012 ACR/ARHP Annual Meeting

    Association Between Biomarkers (Metalloproteinase-3, Dikkopf-1 and Sclerostin) with Disease Activity and Prediction of Anti-TNFá Therapy Response in Patients with Ankylosing Spondylitis

    Victoria Navarro-Compán1, Rafael Ariza2, Rufino Mondéjar-García3, Virginia Moreira-Navarrete4, Enrique Melguizo-Madrid3, Blanca Hernández-Cruz4, Concepción González-Rodríguez3 and Federico Navarro-Sarabia5, 1Leiden University Medical Center, Leiden, Netherlands, 2Rheumatology, University Hospital Virgen Macarena.Sevilla, Sevilla, Spain, 3Biochemistry, University Hospital Virgen Macarena, Sevilla, Spain, 4Rheumatology, University Hospital Virgen Macarena, Sevilla, Spain, 5Rheumatology, Hospital Virgen Macarena, Serv. de Reumatología, Sevilla, Spain

    Background/Purpose: Better objectives measures for evaluating disease activity and anti-TNFα response in patients with ankylosing spondylitis (AS) are needed. MMP-3 seems to be the most…
  • Abstract Number: 2224 • 2012 ACR/ARHP Annual Meeting

    Oral Contraceptive Pill Use in Women with Ankylosing Spondylitis Is Associated with a Younger Age At Diagnosis

    Dharini Mahendira1, Arane Thavaneswaran2, Adele Carty3, Nigil Haroon4, Ammepa Anton5, Laura A. Passalent6, Khalid A. Alnaqbi3, Laurie M. Savage7, Elin Aslanyan7 and Robert D. Inman8, 1Rheumatology, St Michael's Hospital, Toronto, ON, Canada, 2Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, 3Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, 4Medicine/Rheumatology, University Health Network, Toronto Western Research Institute, University of Toronto, Toronto, ON, Canada, 5Rheumatology, University Health Network, Toronto, ON, Canada, 6Allied Health, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 7Spondylitis Association of America, Van Nuys, CA, 8Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada

    Background/Purpose: While AS is traditionally recognized as a predominantly male disease, the impact of gender differences on AS pathogenesis has not been clearly established. Specifically,…
  • Abstract Number: 1381 • 2012 ACR/ARHP Annual Meeting

    Non-Radiographic  Spondyloarthritis Has Greater Work Instability Than Other Spondyloarthritis Subtypes in a National Database

    Sherry Rohekar1, Robert D. Inman2, Renise Ayearst3, Proton Rahman4, Walter P. Maksymowych5 and Dafna D. Gladman6, 1Rheumatology, St. Joseph's Hospital, London, ON, Canada, 2Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 3Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 4Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, 5Department of Medicine, University of Alberta, Edmonton, AB, Canada, 6Centre for Prognosis Studies in The Rheumatic Diseases, Toronto Western Research Institute, University of Toronto, University Health Network, Toronto, ON, Canada

    Background/Purpose: Clinical subsets of spondyloarthritis (SpA), such as ankylosing spondylitis (AS) and psoriatic arthritis (PsA) can be associated with significant impact on work performance and…
  • Abstract Number: 591 • 2012 ACR/ARHP Annual Meeting

    Structural Progression of Ankylosing Spondylitis Associated with Elevation in Two NOVEL, Inflammatory Biomarkers; Matrix Metalloproteinase and Cathepsin-Derived

    Anne C. Bay-Jensen1, Morten Asser Karsdal2, Stephanie Wichuk3, Zheng Zhao4, Robert GW Lambert5, Per Qvist6 and Walter P. Maksymowych7, 1Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 2Nordic Bioscience A/S, Herlev, Denmark, 3Medicine, University of Alberta, Edmonton, AB, Canada, 4Department of Rheumatology, University of Alberta and PLA General Hospital, Beijing, PR China, Beijing, AB, China, 5Radiology, University of Alberta, Edmonton, AB, Canada, 6Nordic Bioscience, Herlev, Denmark, 7Department of Medicine, University of Alberta, Edmonton, AB, Canada

    Background/Purpose: Current inflammatory biomarkers, such as CRP, have insufficient sensitivity and specificity to be broadly accepted for diagnosis and prognosis of AS. We hypothesized, that…
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