Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 1377 • 2012 ACR/ARHP Annual Meeting
Prevalence of Spondyloarthritis-Related Comorbidities, Osteoporosis and Fractures in Ankylosing Spondylitis: a Systematic Literature Review
Carmen Stolwijk¹, A.M. Van Tubergen², Jose Dionisio Castillo-Ortiz³ and Annelies Boonen⁴, ¹Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ²Department of Medicine, Maastricht University Medical Center, Maastricht, Netherlands, ³Unidad de Investigacion en Enfermedades Cronico-Degenerativas, Guadalajara, Mexico, ⁴Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands
Background/Purpose: Comorbidities, both related and unrelated to the concept of spondyloarthritis (SpA), are common in patients with ankylosing spondylitis (AS) and may have substantial influence…
Abstract Number: 725 • 2012 ACR/ARHP Annual Meeting
The Role of Interleukin-23 in Spondyloarthropathy
Jonathan Sherlock¹, Barbara Joyce-Shaikh¹, Scott Turner¹, Cheng-Chi Chao², Manjiri Sathe¹, Jeff Grein¹, Dan Gorman¹, Eddie P. Bowman², Terrill McClanahan¹, Jennifer Yearley¹, Gerard Eberl³, Christopher D. Buckley⁴, Robert Kastelein¹, Robert Pierce¹, Drake LaFace¹ and Daniel Cua⁵, ¹Merck, Palo Alto, CA, ²Drug Discovery, Merck, Palo Alto, CA, ³Institut Pasteur, Paris, France, ⁴Center for Translational Inflammation Research, School of Immunity and Infection, MRC Center for Immune Regulation, Birmingham, United Kingdom, ⁵Discovery Research, Merck Research Laboratory, Palo Alto, CA
Background/Purpose: Spondyloarthropathy is characterized by inflammation and bony pathology at the entheseal insertion of tendons to bone. Recent investigations have converged upon interleukin(IL)-23, demonstrating firstly…
Abstract Number: 538 • 2012 ACR/ARHP Annual Meeting
Association Between Biomarkers (Metalloproteinase-3, Dikkopf-1 and Sclerostin) with Disease Activity and Prediction of Anti-TNFá Therapy Response in Patients with Ankylosing Spondylitis
Victoria Navarro-Compán¹, Rafael Ariza², Rufino Mondéjar-García³, Virginia Moreira-Navarrete⁴, Enrique Melguizo-Madrid³, Blanca Hernández-Cruz⁴, Concepción González-Rodríguez³ and Federico Navarro-Sarabia⁵, ¹Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, University Hospital Virgen Macarena.Sevilla, Sevilla, Spain, ³Biochemistry, University Hospital Virgen Macarena, Sevilla, Spain, ⁴Rheumatology, University Hospital Virgen Macarena, Sevilla, Spain, ⁵Rheumatology, Hospital Virgen Macarena, Serv. de Reumatología, Sevilla, Spain
Background/Purpose: Better objectives measures for evaluating disease activity and anti-TNFα response in patients with ankylosing spondylitis (AS) are needed. MMP-3 seems to be the most…
Abstract Number: 2224 • 2012 ACR/ARHP Annual Meeting
Oral Contraceptive Pill Use in Women with Ankylosing Spondylitis Is Associated with a Younger Age At Diagnosis
Dharini Mahendira¹, Arane Thavaneswaran², Adele Carty³, Nigil Haroon⁴, Ammepa Anton⁵, Laura A. Passalent⁶, Khalid A. Alnaqbi³, Laurie M. Savage⁷, Elin Aslanyan⁷ and Robert D. Inman⁸, ¹Rheumatology, St Michael's Hospital, Toronto, ON, Canada, ²Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ³Rheumatology, Toronto Western Hospital, Toronto, ON, Canada, ⁴Medicine/Rheumatology, University Health Network, Toronto Western Research Institute, University of Toronto, Toronto, ON, Canada, ⁵Rheumatology, University Health Network, Toronto, ON, Canada, ⁶Allied Health, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁷Spondylitis Association of America, Van Nuys, CA, ⁸Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada
Background/Purpose: While AS is traditionally recognized as a predominantly male disease, the impact of gender differences on AS pathogenesis has not been clearly established. Specifically,…
Abstract Number: 1381 • 2012 ACR/ARHP Annual Meeting
Non-Radiographic Spondyloarthritis Has Greater Work Instability Than Other Spondyloarthritis Subtypes in a National Database
Sherry Rohekar¹, Robert D. Inman², Renise Ayearst³, Proton Rahman⁴, Walter P. Maksymowych⁵ and Dafna D. Gladman⁶, ¹Rheumatology, St. Joseph's Hospital, London, ON, Canada, ²Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, ³Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, ⁵Department of Medicine, University of Alberta, Edmonton, AB, Canada, ⁶Centre for Prognosis Studies in The Rheumatic Diseases, Toronto Western Research Institute, University of Toronto, University Health Network, Toronto, ON, Canada
Background/Purpose: Clinical subsets of spondyloarthritis (SpA), such as ankylosing spondylitis (AS) and psoriatic arthritis (PsA) can be associated with significant impact on work performance and…
Abstract Number: 591 • 2012 ACR/ARHP Annual Meeting
Structural Progression of Ankylosing Spondylitis Associated with Elevation in Two NOVEL, Inflammatory Biomarkers; Matrix Metalloproteinase and Cathepsin-Derived
Anne C. Bay-Jensen¹, Morten Asser Karsdal², Stephanie Wichuk³, Zheng Zhao⁴, Robert GW Lambert⁵, Per Qvist⁶ and Walter P. Maksymowych⁷, ¹Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience A/S, Herlev, Denmark, ³Medicine, University of Alberta, Edmonton, AB, Canada, ⁴Department of Rheumatology, University of Alberta and PLA General Hospital, Beijing, PR China, Beijing, AB, China, ⁵Radiology, University of Alberta, Edmonton, AB, Canada, ⁶Nordic Bioscience, Herlev, Denmark, ⁷Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Current inflammatory biomarkers, such as CRP, have insufficient sensitivity and specificity to be broadly accepted for diagnosis and prognosis of AS. We hypothesized, that…
Abstract Number: 493 • 2012 ACR/ARHP Annual Meeting
Effect of Infliximab On Employment Status in Patients with Rheumatoid Arthritis or Ankylosing Spondylitis
W. Bensen¹, J. Carter Thorne², Saeed A. Shaikh³, Maqbool K. Sheriff⁴, Susan M. Otawa⁵, Allen J. Lehman⁵ and Hayssam Khalil⁶, ¹St. Joseph's Hospital and McMaster University, Hamilton, ON, Canada, ²Southlake Regional Health Centre, Newmarket, ON, Canada, ³Medicine, McMaster University, St Catharines, ON, Canada, ⁴Nanaimo Regional General Hospital, Nanaimo, BC, Canada, ⁵Medical Affairs, Janssen Inc., Toronto, ON, Canada, ⁶Medical Affairs, Janssen Canada Inc, Toronto, ON, Canada
Background/Purpose: Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are associated with significant functional impairment and work disability. In the absence of treatment, approximately 80% of…
Abstract Number: 2225 • 2012 ACR/ARHP Annual Meeting
Improvement in Signs and Symptoms of Active Ankylosing Spondylitis Following Treatment with Anti-Interleukin (IL)-17A Monoclonal Antibody Secukinumab Are Paralleled by Reductions in Acute Phase Markers and Inflammatory Markers S100A8 and A9 (Calgranulin A and B)
Dominique L. Baeten¹, Stephan Bek², Jiawei Wei³, Arndt Brachat⁴, Joachim Sieper⁵, Paul Emery⁶, Jürgen Braun⁷, Desiree M. van der Heijde⁸, Iain B. McInnes⁹, Jacob M. van Laar¹⁰, R. Landewe¹¹, Paul Wordsworth¹², Jurgen Wollenhaupt¹³, Herbert Kellner¹⁴, Jacqueline E. Paramarta¹⁵, Arthur Bertolino¹⁶, Andrew Wright¹⁷ and Hueber Wolfgang², ¹Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Novartis Institutes for BioMedical Research, Basel, Switzerland, ³Integrated Information Sciences (IIS), Beijing Novartis Pharma Co. Ltd., Shanghai,, China, ⁴Novartis Pharma AG, Novartis Pharma AG, Basel, Switzerland, ⁵Medical Department I, Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, ⁶Medicine, Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, ⁷Rheumazentrum Ruhrgebiet, Herne, Germany, ⁸Dept of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁹Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, ¹⁰Newcastle University, Musculoskeletal Research Group, Newcastle, United Kingdom, ¹¹Division of Clinical Immunology and Rheumatology, Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, ¹²Nuffield Orthopaedic Centre, Oxford, United Kingdom, ¹³Division of Reheumatology, Schoen-Klinik Hamburg-Eilbek Teaching Hospital of the University of Hamburg, Hamburg, Germany, ¹⁴Centre for Inflammatory Joint Diseases, Munich, Germany, ¹⁵Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ¹⁶Translational Medicine- 3rd Floor, Novartis Institutes for BioMedical Research, Basel, Switzerland, ¹⁷Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Secukinumab has shown to be well tolerated and effective in active ankylosing spondylitis (AS) patients in a proof-of-concept trial1. Briefly, at Week (Wk) 6,…
Abstract Number: 1383 • 2012 ACR/ARHP Annual Meeting
The Burden of Ankylosing Spondylitis and the Cost-Effectiveness of Anti-Tumor Necrosis Factor α Agents in Romania
Ioan Ancuta¹, Catalin Codreanu², Ruxandra Ionescu³, Magda Parvu⁴ and Mihai Bojinca¹, ¹Internal Medicine, “Dr. I. Cantacuzino” Hospital, Bucharest, Romania, ²Rheumatology, “Dr. I. Stoia” Center for Rheumatic Diseases, Bucharest, Romania, ³Internal Medicine, Clinic Hospital Sf. Maria, Bucharest, Romania, ⁴Internal Medicine, “N.Gh. Lupu” Clinical Hospital, Bucharest, Romania
Background/Purpose: Ankylosing Spondylitis (AS) usually affects young males, severely impairing their quality of life. Chronic treatment of AS using anti-TNF α agents is costly and…
Abstract Number: 592 • 2012 ACR/ARHP Annual Meeting
Two Novel Diagnostic Biomarkers of Cartilage Degradation and Connective Tissue Inflammation Are Predictive of Disease Progression in Ankylosing Spondylitis
Anne C. Bay-Jensen¹, Stephanie Wichuk², Inger Byrjalsen³, Zheng Zhao⁴, Robert GW Lambert⁵, Morten Asser Karsdal⁶ and Walter P. Maksymowych⁷, ¹Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Medicine, University of Alberta, Edmonton, AB, Canada, ³Research & Development, Nordic Bioscience, Herlev, Denmark, ⁴Department of Rheumatology, University of Alberta and PLA General Hospital, Beijing, PR China, Beijing, AB, China, ⁵Radiology, University of Alberta, Edmonton, AB, Canada, ⁶Nordic Bioscience A/S, Herlev, Denmark, ⁷Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Cartilage degradation and inflammation of synovial and connective tissue are key events in inflammatory arthropathies such as SpA. Presently there are no prognostic tools…
Abstract Number: 2652 • 2012 ACR/ARHP Annual Meeting
Benefits of Aerobic Training in Patients with Ankylosing Spondylitis Are Not Coupled by Effects On Cytokines: A Randomized Controlled Trial
Fabio Jennings¹, Hilda A. Oliveira², Marcelo C. Sousa¹, Vaneska G. Cruz¹, Fabio S. Lira³ and Jamil Natour¹, ¹Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ²Rheumatology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ³Psicobiology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
Background/Purpose: Ankylosing Spondylitis (AS) is a systemic inflammatory disease that causes deterioration of physical capacity. Although exercises remain essential in the treatment, the literature lacks…
Abstract Number: 2233 • 2012 ACR/ARHP Annual Meeting
Assessing the Clinical and Economic Burden of U.S. Veteran Ankylosing Spondylitis Patients
Lin Xie¹, Onur Baser², Ahong Huang³, Lu Li³, Elyse K. Fritschel³ and Li Wang⁴, ¹Director, Health Economics & Outcomes Research, STATinMED Research, Ann Arbor, MI, ²President/Adjunct Professor of Internal Medicine, STATinMED Research/The University of Michigan, Ann Arbor, MI, ³STATinMED Research, Dallas, TX, ⁴Director, Analytic Research, STATinMED Research, Dallas, TX
Background/Purpose: To examine the economic burden, demographic and clinical characteristics of ankylosing spondylitis (AS) in the U.S. veteran population. Methods: A retrospective database analysis…
Abstract Number: 1384 • 2012 ACR/ARHP Annual Meeting
The Frequency of Non-Radiographic Axial Spondyloarthritis in Relation to Symptom Duration in Patients Referred Because of Chronic Back Pain: Results From the Berlin Early Spondyloarthritis Clinic
Denis Poddubnyy¹, Henning Brandt², Janis Vahldiek³, Inge Spiller², In-Ho Song⁴, Martin Rudwaleit⁵ and Joachim Sieper⁶, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Medical Department I, Rheumatology, Charité Medical University, Campus Benjamin Franklin, Berlin, Germany, ³Charité Medical University, Campus Benjamin Franklin, Berlin, Germany, ⁴Medical Department I, Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany, ⁵Endokrinologikum Berlin, Berlin, Germany, ⁶Medical Department I, Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany
Background/Purpose: Non-radiographic axial spondyloarthritis (nr-axSpA) and radiographic axial SpA (=ankylosing spondylitis – AS) are considered currently as two stages of axial SpA. We reported recently…
Abstract Number: 597 • 2012 ACR/ARHP Annual Meeting
Investigating the Genetic Association Between ERAP1 and Spondyloarthritis
Amir Kadi¹, Brigitte Izac², Roula Said-Nahal³, Ariane Leboime⁴, Kurt L. de Vlam⁵, Dirk Elewaut⁶, Gilles Chiocchia² and Maxime A. Breban³, ¹Institut Cochin - Université Paris Descartes - INSERM U1016 - CNRS (UMR 8104), Paris, France, ²Immunology and Hematology Department, Institut Cochin - INSERM U1016 - CNRS (UMR 8104), Paris, France, ³Rheumatology Division, Ambroise Paré Hospital (AP-HP), and Versailles Saint Quentin en Yvelines University, Boulogne-Billancourt, France, ⁴Rheumatology Division, Ambroise-Paré Hospital AP-HP, Boulogne-Billancourt, France, ⁵Rheumatology, University Hospitals Leuven, Leuven, Belgium, ⁶Rheumatology, Department of Rheumatology Ghent University Hospital, Ghent, Belgium
Background/Purpose: A robust association was recently identified between polymorphisms in the non-major histocompatibility complex gene ERAP1 and ankylosing spondylitis (AS) in several populations. The aim…
Abstract Number: 2235 • 2012 ACR/ARHP Annual Meeting
How Important Is the Assessment of ASDAS in the Long-Term Evaluation of Disease Activity in Ankylosing Spondylitis? A Comparison with Currently Used Clinical Parameters
Xenofon Baraliakos¹, Claudia Fritz², Joachim Listing³, Hildrun Haibel⁴, Joachim Sieper⁵ and Jürgen Braun⁶, ¹Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, ²German Rheumatism Research Centre, Berlin, Germany, ³German Rheumatism Research Center, Berlin, Germany, ⁴Medical Department I, Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany, ⁵Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany, ⁶PsAID taskforce, EULAR, Zurich, Switzerland
Background/Purpose: Measures for disease activity (BASDAI) or response to therapy (ASAS partial remission (PR)) are widely used in the assessment of patients with ankylosing spondylitis…

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