Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 1510 • 2013 ACR/ARHP Annual Meeting
Disease Activity In Male Smokers Has A >10-Fold Amplified Effect On Radiographic Damage In Comparison With Female NON-Smokers In Ankylosing Spondylitis
Sofia Ramiro^1,2, A.M. van Tubergen³, Robert Landewé⁴, Carmen Stolwijk⁵, Maxime Dougados⁶, Filip Van den Bosch⁷ and Désirée van der Heijde⁸, ¹Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Rheumatology, Hospital Garcia de Orta, Almada, Portugal, ³Department of Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ⁴Academic Medical Center Amsterdam & Atrium Medical Center, Heerlen, Netherlands, ⁵Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ⁶Rheumatology B Department, Paris-Descartes University, Cochin Hospital, Paris, France, ⁷Ghent University Hospital, Ghent, Belgium, ⁸Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: We have shown that disease activity has an effect on radiographic progression over the long-term and that gender and symptom duration are effect modifiers.…
Abstract Number: 535 • 2013 ACR/ARHP Annual Meeting
Death Receptor 3 Increases Region-Specific, Osteoblast-Dependent Aberrant New Bone Formation In The Axial Skeleton Of Mice In a Spontaneous Model Of Ankylosing Enthesopathy
Fraser L. Collins¹, Jessica O Williams², Anja C. Bloom¹, Michael D. Stone³, Ernest Choy¹, Edward C. Wang⁴ and Anwen S. Williams⁵, ¹Section of Rheumatology, Cardiff University, Institute of Infection and Immunity, Cardiff, United Kingdom, ²Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom, ³University Hospital Llandough, Cardiff & Vale University Health Board, Cardiff, United Kingdom, ⁴Cardiff University, Institute of Infection and Immunity, Cardiff, United Kingdom, ⁵Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom
Background/Purpose: Clinical management of localised bone formation and joint ankylosis constitute major challenges in patients with seronegative inflammatory spondyloarthropathies (SpAs). Whether TNF receptor superfamily members,…
Abstract Number: 2495 • 2013 ACR/ARHP Annual Meeting
Ankylosing Spondylitis Protective Endoplasmic Reticulum Aminopeptidase 1 Variants Lead To Decreased Natural Killer Cell Conjugation and Activation
Hasan Abdullah¹, Zhenbo Zhang², Robert Inman³ and Nigil Haroon⁴, ¹IMS, University of Toronto, Toronto, ON, Canada, ²Toronto Western Research Institute, Toronto, ON, Canada, ³Immunlogy and Institute of Medical Science, University of Toronto and Toronto Western Hospital, Toronto, ON, Canada, ⁴Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada
Background/Purpose: Ankylosing Spondylitis (AS) is an inflammatory arthritis affecting the axial and peripheral joints. Human Leukocyte Antigen (HLA)-B27 and Endoplasmic Reticulum Aminopeptidase (ERAP) 1 genes…
Abstract Number: 2448 • 2013 ACR/ARHP Annual Meeting
Cardiovascular Disease Is Associated With Worse Functional Outcomes In Ankylosing Spondylitis
Lianne S. Gensler¹, Michael M. Ward², MinJae Lee³, Mohammad Rahbar⁴, Matthew A. Brown⁵, John D. Reveille⁶ and Michael H. Weisman⁷, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, ³Medicine, University of Texas Health Science Center at Houston, Houston, TX, ⁴The University of Texas Health Science Center at Houston, Houston, TX, ⁵Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, Australia, ⁶Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁷Rheumatology, Cedars-Sinai Med Ctr, Los Angeles, CA
Background/Purpose: Cardiovascular disease is an important comorbidity in inflammatory arthritis. There is evidence that AS patients have a significant burden of cardiovascular comorbidity. This appears…
Abstract Number: 1542 • 2013 ACR/ARHP Annual Meeting
Regular Exercise Is Associated With Better Functional Outcomes In Ankylosing Spondylitis
Lianne S. Gensler¹, John D. Reveille², MinJae Lee³, Mohammad Rahbar⁴, Manouchehr Ardjomand-Hessabi⁵, Matthew A. Brown⁶, Michael H. Weisman⁷ and Michael M. Ward⁸, ¹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ²Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ³Medicine, University of Texas Health Science Center at Houston, Houston, TX, ⁴The University of Texas Health Science Center at Houston, Houston, TX, ⁵Medicine, The University of Texas, Health Science Center at Houston, Houston, TX, ⁶Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, Australia, ⁷Rheumatology, Cedars-Sinai Med Ctr, Los Angeles, CA, ⁸Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD
Background/Purpose: Exercise and physical therapy are the cornerstones of non-pharmacologic therapy in Ankylosing Spondylitis. The long-term association of exercise on function has not been evaluated.…
Abstract Number: 1511 • 2013 ACR/ARHP Annual Meeting
What Impairs Balance In Ankylosing Spondylitis? Posture Or Disease Activity?
Osman Hakan Gunduz¹, Emel Ece Ozcan¹, Esra Giray¹ and Ilker Yagci², ¹Physical Medicine and Rehabilitation, Marmara University School of Medicine, Istanbul, Turkey, ²Department of Physical Medicine and Rehabilitation, Marmara University School of Medicine, Istanbul, Turkey
Background/Purpose: To compare ankylosing spondylitis (AS) patients and healthy individuals in terms of posture and balance and to identify the factors affecting balance among patients…
Abstract Number: 538 • 2013 ACR/ARHP Annual Meeting
Ankylosing Spondylitis Associated Endoplasmic Reticulum Aminopeptidase 1 Variants Alter The Unfolded Protein Response
Nigil Haroon^1,2,3 and Zhenbo Zhang³, ¹Rheumatology, University Health Network, Toronto, ON, Canada, ²Medicine, Rheumatology, University of Toronto, Toronto, ON, Canada, ³Toronto Western Research Institute, Toronto, ON, Canada
Background/Purpose: Endoplasmic reticulum aminopeptidase 1 (ERAP1) has recently been identified to be strongly associated with HLA-B27 positive AS. We have shown that ERAP1 variants cause…
Abstract Number: 1704 • 2012 ACR/ARHP Annual Meeting
New Threshold Values for Spinal Mobility Measures Based On a Large Nationally Representative Sample of U.S. Adults Ages 20-69 Years
Shervin Assassi¹, Michael H. Weisman², Zhongxue Chen³, Mohammad Rahbar³ and John D. Reveille⁴, ¹Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ²Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ³Univ of Texas Health Science Center at Houston, Houston, TX, ⁴Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: Spinal mobility measures are widely utilized for diagnosis and assessment of disease severity in patients with Ankylosing Spondylitis. The previously proposed threshold values for…
Abstract Number: 781 • 2012 ACR/ARHP Annual Meeting
Ankylosing Spondylitis Is Associated with an Increased Risk of Osteoporotic Fractures: A Population-Based Cohort Study
Juan Muñoz-Ortego¹, Peter Vestergaard², Josep Blanch³, Paul Wordsworth⁴, Andrew Judge⁵, M. Kassim Javaid⁶, Nigel K. Arden⁷, Cyrus Cooper⁸, Adolfo Díez-Pérez⁹ and Daniel Prieto-Alhambra¹⁰, ¹Rheumatology, Hospital Sagrat Cor, Barcelona (Spain), Barcelona, Spain, ²Endocrinology and Internal Medicine (MEA), Aarhus University Hospital THG, Aarhus (Denmark), Aarhus, Denmark, ³Rheumatology, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain, ⁴Ndorms, Nuffield Orthopaedic Centre, Oxford, United Kingdom, ⁵Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, ⁶Rheumatology, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK, Oxford, United Kingdom, ⁷NDORMS; MRC Lifecourse Epidemiology Unit, Oxford NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, United Kingdom, ⁸NDORMS; MRC Lifecourse Epidemiology Unit, University of Oxford; Southampton General Hospital, Southampton, United Kingdom, ⁹Internal Medicine, Hospital del Mar-IMIM, Universitat Autònoma de Barcelona, Barcelona; and RETICEF, ISCIII Madrid; Spain, Barcelona, Spain, ¹⁰Internal Medicine; Primary Care; NDORMS Dept; MRC Lifecourse Epidemiology Unit, URFOA-IMIM, Parc de Salut Mar; Idiap Jordi Gol; University of Oxford; University of Southampton, Barcelona, Spain
TITLE: "Ankylosing Spondylitis is associated with an increased risk of osteoporotic fractures: a population-based cohort study."Background/Purpose: Patients with Ankylosing Spondylitis (AS) have reduced bone mass,…
Abstract Number: 532 • 2012 ACR/ARHP Annual Meeting
The Prevalance of Autoimmune Thyroid Disfunction in Ankylosing Spondylitis
Hakan Emmungil¹, Mehmet Erdogan², Melike Kalfa¹, Gonca Karabulut¹, Hayriye Kocanaogullari¹, Vedat Inal¹, Yasemin Kabasakal³, Fahrettin Oksel⁴, Kenan Aksu⁵ and Gokhan Keser⁶, ¹Dept. of Internal Medicine, Division of Rheumatology, Ege University, Dept. of Internal Medicine, Division of Rheumatology, Ege University, Izmir, Turkey, ²Dept. of Internal Medicine, Division of Endocrinolgy, Ege University, Dept. of Internal Medicine, Division of Endocrinolgy, Ege University, Izmir, Turkey, ³Dept. of Internal Medicine, Division of Rheumatology, Ege University, Izmir, Turkey, ⁴Division of Rheumatology, Ege University, Izmir, Turkey, ⁵Dept. Of Internal Medicine, Division of Rheumatology, Ege University, Dept. Of Internal Medicine, Division of Rheumatology, Ege University, Izmir, Turkey, ⁶Dept. of Internal Medicine, Division of Rheumatology, Dept. of Internal Medicine, Division of Rheumatology, Ege University, Izmir, Turkey
Background/Purpose: Although the association of autoimmune thyroid dysfunction and primary Sjögren's syndrome (SjS) is well known, it is less clear whether a similar relationship also…
Abstract Number: 2615 • 2012 ACR/ARHP Annual Meeting
Circulating Levels of Citrullinated Vimentin Fragments Are Diagnostic and Prognostic in Ankylosing Spondylitis; Evidence for Disease-Related Citrullination
Anne C. Bay-Jensen¹, Morten Asser Karsdal², Efstathios Vassiliadis³, Stephanie Wichuk⁴, Zheng Zhao⁵, Robert GW Lambert⁶, Rik Lories⁷, Claus Christiansen⁸ and Walter P. Maksymowych⁹, ¹Cartilage Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience A/S, Herlev, Denmark, ³Nordic Bioscience, Herlev, Denmark, ⁴Medicine, University of Alberta, Edmonton, AB, Canada, ⁵Department of Rheumatology, University of Alberta and PLA General Hospital, Beijing, PR China, Beijing, AB, China, ⁶Radiology, University of Alberta, Edmonton, AB, Canada, ⁷Laboratory of Tissue Homeostasis and Disease - SBE Research Center, KU Leuven, Leuven, Belgium, ⁸CCBR, Ballerup, Denmark, ⁹Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Rheumatoid arthritis (RA) is considered an anti-CCP positive disease whereas ankylosing spondylitis (AS) is considered an anti-CCP negative disease. Anti-CCP has prognostic capacity in…
Abstract Number: 1619 • 2012 ACR/ARHP Annual Meeting
Quantification of Bone Marrow Edema by Using Magnetic Resonance Imaging for the Assessment of Neck Pain Only Marginally Reflects Clinical Evaluation in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis
Xenofon Baraliakos¹, Frank Heldmann², Ravi Suppiah³, Fiona M. McQueen⁴ and Jürgen Braun², ¹Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Department of Rheumatology, Auckland District Health Board, Auckland, New Zealand, ⁴Molecular Medicine and Pathology, University of Auckland, Auckland, New Zealand
Background/Purpose: Despite the differences in the pathogenesis of rheumatoid arthritis (RA) and ankylosing spondylitis (AS), neck pain is a frequent clinical symptom in both diseases…
Abstract Number: 746 • 2012 ACR/ARHP Annual Meeting
Increased Risk of Acute and Chronic Renal Comorbidity in Ankylosing Spondylitis: Results From a Population-Based Study
Walter P. Maksymowych¹, Shelagh Szabo², Sumati Rao³, Mary A. Cifaldi³ and Adrian R. Levy⁴, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Oxford Outcomes, Oxford Outcomes, Vancouver, BC, Canada, ³Abbott Laboratories, Abbott Park, IL, ⁴Oxford Outcomes Ltd, Vancouver, BC, Canada
Background/Purpose: Clinical evidence points to an increased risk of renal comorbidity in ankylosing spondylitis (AS) compared to the general population. However, there are no population-based…
Abstract Number: 533 • 2012 ACR/ARHP Annual Meeting
NT-Probnp and Inflammation in Active Ankylosing Spondylitis Receiving TNF Blockers: Is There a Link?
Julio C. B. Moraes¹, Ana C. M. Ribeiro², Carla G.S. Saad³, Alessandro C. Lianza⁴, Nadia E. Aikawa⁵, Clovis Artur Silva⁶ and Eloisa Bonfa⁷, ¹Reumatologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ³Rheumatology Division, University of Sao Paulo, Sao Paulo, Brazil, ⁴Radiology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁵Rheumatology, University of São Paulo, Sao Paulo, Brazil, ⁶Paediatric Rheumatology International Trials Organization (PRINTO), Istituto Giannina Gaslini, Genova, Italy, ⁷Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Cardiovascular disease plays a central role in morbidity and mortality in rheumatic patients. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a strong marker of cardiovascular…
Abstract Number: 2496 • 2012 ACR/ARHP Annual Meeting
Elevated Serum Level of the Vascular Endothelial Growth Factor Is Highly Predictive for New Syndesmophytes Formation in Patients with Ankylosing Spondylitis
Denis Poddubnyy¹, Kristina Conrad², Uta Syrbe², Hildrun Haibel³, Heiner Appel², Martin Rudwaleit⁴ and Joachim Sieper⁵, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Charité Medical University, Campus Benjamin Franklin, Berlin, Germany, ³Medical Department I, Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany, ⁴Endokrinologikum Berlin, Berlin, Germany, ⁵Medical Department I, Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany
Background/Purpose: In the recent years several predictors of radiographic spinal progression/syndesmophyte formation in ankylosing spondylitis (AS) were identified: syndesmophytes at baseline (the strongest predictor so…

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