Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 2443 • 2013 ACR/ARHP Annual Meeting
Prevalence Of Coronary Heart Disease In Spondyloarthopathies may Be Increased Due To Higher Prevalence Of Risk Factors As Well As The Disease Itself- A Retrospective Analysis At Single VA Medical Center
Trayton Mains¹ and Vikas Majithia², ¹University of Mississippi Medical Center, Jackson, MS, ²G.V. "Sonny" Montogomery VA Medical Center, Jackson, MS
Background/Purpose: An increased prevalence of cardiovascular disease (CVD) and coronary heart disease (CHD) has been reported in patients with spondyloarthritides (SpA). This study investigated the…
Abstract Number: 1799 • 2013 ACR/ARHP Annual Meeting
Effect Of Certolizumab Pegol Over 48 Weeks In Patients With Axial Spondyloarthritis, Including Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthritis
Robert B. M. Landewé¹, Martin Rudwaleit², Désirée M. van der Heijde³, Maxime Dougados⁴, Philip Mease⁵, John D. Reveille⁶, Jessica Walsh⁷, Alan J. Kivitz⁸, Walter P. Maksymowych⁹, Jürgen Braun¹⁰, Atul A. Deodhar¹¹, Christian Stach¹², Bengt Hoepken¹², Pritibha Singh¹² and Joachim Sieper¹³, ¹Academic Medical Center/University of Amsterdam & Atrium Medical Center, Amsterdam, Netherlands, ²Endokrinologikum Berlin, Berlin, Germany, ³Dept of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology B Department, Paris-Descartes University, APHP, Cochin Hospital, Paris, France, ⁵Division of Rheumatology Research, Swedish Medical Center and University of Washington, Seattle, WA, ⁶Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁷Rheumatology, University of Utah Hospital, Salt Lake City, UT, ⁸Altoona Center for Clinical Research, Duncansville, PA, ⁹Medicine, University of Alberta, Edmonton, AB, Canada, ¹⁰Rheumazentrum Ruhrgebiet, Herne, Germany, ¹¹Div of Arthritis & Rheum OP-09, Oregon Health & Science University, Portland, OR, ¹²UCB Pharma, Monheim, Germany, ¹³Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany
Background/Purpose: Previous reports of RAPID-axSpA have demonstrated the efficacy and safety of certolizumab pegol (CZP), a PEGylated Fc-free anti-TNF, in patients (pts) with axial spondyloarthritis…
Abstract Number: 1506 • 2013 ACR/ARHP Annual Meeting
Total Hip Replacement Outcomes in Ankylosing Spondylitis
Susan M. Goodman¹, Rebecca Zhu², Wei-Ti Huang³, Mark P. Figgie⁴, Michael Alexiades⁵ and Lisa A. Mandl¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Clinical Research, Hospital for Special Surgery, New York, NY, ³Epidemiology and Statistics, Hospital for Special Surgery, New York, NY, ⁴Orthopedics, Hospital for Special Surgery, New York, NY, ⁵Orthopaedics, Hospital for Special Surgery, New York, NY
Background/Purpose: Historically, outcomes for total hip replacement (THR) in ankylosing spondylitis (AS) patients were poor, but contemporary outcomes are not well described. We analyzed two-year…
Abstract Number: 991 • 2013 ACR/ARHP Annual Meeting
Utilization Of An Informational Needs Assessment To Develop An Education Program For Patients With Ankylosing Spondylitis (AS) and Related Axial Spondyloarthritis (SpA)
Rita Kang¹, Rebecca Morton², Christopher Hawke³, Laura A. Passalent⁴, Robert D. Inman^5,6, Dinny Wallis⁷, Joan Blair³, Alison Lake⁸, Heather Sloman⁸, Marc Doucet⁹, Debra MacGarvie⁸ and King Wong⁹, ¹Patient Education, University Health Network- Toronto Western Hospital, Toronto, ON, Canada, ²Allied Health/Rheumatology, University Health Network- Toronto Western Hospital, Toronto, ON, Canada, ³Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁴Allied Health, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁵Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, ⁶U of Toronto, Toronto, ON, Canada, ⁷Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁸University Health Network- Toronto Western Hospital, Toronto, ON, Canada, ⁹University Health Network, Toronto, ON, Canada
Background/Purpose: The effectiveness of education programs for patients with arthritis has been well documented. Despite this, there has been minimal investigation into patient education specifically…
Abstract Number: 2776 • 2013 ACR/ARHP Annual Meeting
Ankylosing Spondylitis Is Associated With An Increased Likelihood Of Cardiovascular Disease: A Nationwide Matched Cohort Study In Primary Care
Linda E. Dean¹, Gary J. Macfarlane¹, Alan G. MacDonald² and Gareth T. Jones¹, ¹Musculoskeletal Research Collaboration (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, ²Department of Rheumatology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom
Background/Purpose: Cardiovascular disease (CVD) risk is well established in rheumatoid arthritis but less so in ankylosing spondylitis (AS). Due to a similar inflammatory profile, AS…
Abstract Number: 2438 • 2013 ACR/ARHP Annual Meeting
Effectiveness Of Exercise Program in Ankylosing Spondylitis: Meta-Analysis Of Randomized Controlled Trials
Virginie Pécourneau¹, Arnaud L. Constantin² and Alain G. Cantagrel³, ¹CHU Toulouse, Toulouse, France, ²Rheumatology, Purpan University Hospital, Toulouse Cedex 9, France, ³Dept of Rheumatology, Hopital Purpan, Toulouse CEDEX 9, France
Effectiveness of exercise programs in ankylosing spondylitis: meta-analysis of randomized controlled trialsVirginie PÃ©courneau1, Adeline Ruyssen-Witrand1, Thomas Barnetche2, Alain Cantagrel1, Arnaud Constantin1.1 Centre de Rhumatologie, HÃxpital…
Abstract Number: 1802 • 2013 ACR/ARHP Annual Meeting
A Major Clinical Response To Anti-Tumor Necrosis Factor Agents Is Associated With a Reduced Development Of Fatty Changes In The Spine Of Patients With Ankylosing Spondylitis
Xenofon Baraliakos¹, Frank Heldmann², Joachim Listing³, Johanna Callhoff³ and Jürgen Braun², ¹Rheumatology, Rheumazentrum Ruhrgebiet, Herne, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³German Rheumatism Research Center, Berlin, Germany
Background/Purpose: Fatty changes (FC) on T1-weighted magnetic resonance images (MRI) have been described in the spine of patients with ankylosing spondylitis (AS). Such lesions were…
Abstract Number: 1508 • 2013 ACR/ARHP Annual Meeting
How Well Are The Assessment Of Spondyloarthritis International Society (ASAS) / Outcome Measures In Rheumatology (OMERACT) Core Outcome Sets For Ankylosing Spondylitis Implemented In Randomized Clinical Trials? A Systematic Literature Review
Wilson Bautista-Molano^1,2, Victoria Navarro-Compán¹, Robert Landewé³ and Désirée van der Heijde⁴, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Rheumatology, Universidad Militar Nueva Granada, Bogotá, Colombia, ³Rheumatology, Academic Medical Center, Amsterdam, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The Assessment of SpondyloArthritis international Society (ASAS) has selected a core set of variables to include as standardized endpoints in clinical trials and clinical…
Abstract Number: 530 • 2013 ACR/ARHP Annual Meeting
Pattern Recognition Receptor Stimulated Cytokine Expression By Spondyloarthritis Patient Macrophages
Yi-Ping Liu¹, Ashley Bomkamp², Jens Eickhoff³, Jack Schneck², Mike Khan⁴ and Judith Smith⁵, ¹Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, ²University of Wisconsin-Madison, Madison, WI, ³Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, ⁴Cellular and Molecular Pathology, University of Wisconsin-Madison, Madison, WI, ⁵Pediatrics, University of Wisconsin-Madison, Madison, WI
Background/Purpose: Spondyloarthritis (SpA) encompasses a group of chronic inflammatory conditions involving axial arthritis that includes ankylosing spondylitis (AS). GWAS studies in AS have implicated multiple…
Abstract Number: 2697 • 2013 ACR/ARHP Annual Meeting
Identification Of Genetic and Epigenetic Alterations In Spondyloarthritis
Tibor A. Rauch¹, Beata Tryniszewska¹, Andras Vida¹, Timea Ocsko¹, Sandor Szanto², Holly L. Rosenzweig³, Matthew A. Brown⁴, Gethin P Thomas⁵, Katalin Mikecz¹ and Tibor T. Glant¹, ¹Orthopedic Surgery, Rush University Medical Center, Chicago, IL, ²Rheumatology, University of Debrecen, Debrecen, Hungary, ³Oregon Health & Science University, Portland, OR, ⁴Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, Australia, ⁵Translational Reserch Institute, University of Queensland Diamantina Institute, Woolloongabba, Australia
Background/Purpose: Ankylosing spondylitis (AS) is the prototypic spondyloarthritis and affects approximately 0.2-0.5% of the human population. It is estimated that genetic risk factors contribute >90%…
Abstract Number: 2440 • 2013 ACR/ARHP Annual Meeting
Is There a Role For Etoricoxib In Patients With Axial Ankylosing spondylitis Refractory To Traditional NSAID?
Maria García Manrique¹, Pilar Font², Joan Calvet³, María Cruz Fernandez⁴, Carlos Montilla⁵, Luis Linares⁶, Elia Brito⁷, Xavier Juanola⁸, Juan Mulero⁹, Rubén Queiro¹⁰, Rosa M. Morla¹¹, Rosario Garcia-Vicuña¹², Alba Erra¹³, Mireia Moreno¹⁴, Marta Larrosa¹⁵, Eduardo Collantes¹⁶ and Jordi Gratacos¹⁷, ¹Rheumatology, Hospital Parc Taulí, Sabadell, Spain, ²Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain, ³Rheumatology, Corporació Sanitària Parc Taulí, Sabadell, Spain, ⁴Rheumatology, Hospital General de Móstoles, Mostoles, Spain, ⁵Rheumatology Service, Hospital Universitario de Salamanca, Salamanca, Spain, ⁶Rheumatology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain, ⁷Rheumatology, Hospital Ramón y Cajal, Madrid, Spain, ⁸Rheumatology, University Hospital Bellvitge, Barcelona, Spain, ⁹Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda (Madrid), Spain, ¹⁰Rheumatology Department. Hospital Universitario Central de Asturias, Oviedo, Spain, ¹¹Rheumatology, Hospital Sta Tecla, Tarragona, Spain, ¹²Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ¹³Hospital de Sant Rafael, Barcelona, Spain, ¹⁴Rheumatology, Hospital Universitari Parc Taulí, Sabadell, Spain, ¹⁵Rheumatology, Hospital Universitari Parc Tauli, Sabadell, Spain, ¹⁶Rheumatology, Hospital Reina Sofia, Cordoba, Spain, ¹⁷Rheumatology Service, Hospital Universitari Parc Taulí, Sabadell (Barcelona), Spain
Background/Purpose: Anti-TNF treatment has demonstrated its effectiveness in axial ankylosing spondylitis (AS) patients with inadecuate response to traditional NSAIDs (tNSAIDs) therapy (>=2 tNSAIDs), but also aspects…
Abstract Number: 1706 • 2013 ACR/ARHP Annual Meeting
Fine-Mapping Major Histocompatibility Complex Variation Associated With Ankylosing Spondylitis Susceptibility
Adrian Cortes¹, International Genetics of Ankylosing Spondylitis Consortium (IGAS)², Paul de Bakker³ and Matthew A. Brown⁴, ¹Human Genetics Group, The University of Queensland Diamantina Insititute, Brisbane, Australia, ²University of Queensland Diamantina Institute, brisbane, Australia, ³Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, ⁴University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose: Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis. Thus far, 27 susceptibility loci have been identified in and outside the MHC in…
Abstract Number: 1510 • 2013 ACR/ARHP Annual Meeting
Disease Activity In Male Smokers Has A >10-Fold Amplified Effect On Radiographic Damage In Comparison With Female NON-Smokers In Ankylosing Spondylitis
Sofia Ramiro^1,2, A.M. van Tubergen³, Robert Landewé⁴, Carmen Stolwijk⁵, Maxime Dougados⁶, Filip Van den Bosch⁷ and Désirée van der Heijde⁸, ¹Clinical Immunology & Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Rheumatology, Hospital Garcia de Orta, Almada, Portugal, ³Department of Internal Medicine, Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ⁴Academic Medical Center Amsterdam & Atrium Medical Center, Heerlen, Netherlands, ⁵Rheumatology, Maastricht University Medical Center, Maastricht, Netherlands, ⁶Rheumatology B Department, Paris-Descartes University, Cochin Hospital, Paris, France, ⁷Ghent University Hospital, Ghent, Belgium, ⁸Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: We have shown that disease activity has an effect on radiographic progression over the long-term and that gender and symptom duration are effect modifiers.…
Abstract Number: 535 • 2013 ACR/ARHP Annual Meeting
Death Receptor 3 Increases Region-Specific, Osteoblast-Dependent Aberrant New Bone Formation In The Axial Skeleton Of Mice In a Spontaneous Model Of Ankylosing Enthesopathy
Fraser L. Collins¹, Jessica O Williams², Anja C. Bloom¹, Michael D. Stone³, Ernest Choy¹, Edward C. Wang⁴ and Anwen S. Williams⁵, ¹Section of Rheumatology, Cardiff University, Institute of Infection and Immunity, Cardiff, United Kingdom, ²Institute of Molecular and Experimental Medicine, Cardiff University School of Medicine, Cardiff, United Kingdom, ³University Hospital Llandough, Cardiff & Vale University Health Board, Cardiff, United Kingdom, ⁴Cardiff University, Institute of Infection and Immunity, Cardiff, United Kingdom, ⁵Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom
Background/Purpose: Clinical management of localised bone formation and joint ankylosis constitute major challenges in patients with seronegative inflammatory spondyloarthropathies (SpAs). Whether TNF receptor superfamily members,…
Abstract Number: 2493 • 2013 ACR/ARHP Annual Meeting
Interleukin-17 Serum Levels Are Associated With Markers Of Systemic Inflammation In Patients With Active Ankylosing Spondylitis
Denis Poddubnyy¹, Alain Vicari², Hildrun Haibel¹, Jürgen Braun³, Martin Rudwaleit⁴ and Joachim Sieper¹, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²EMD Serono, Geneva, Switzerland, ³Rheumazentrum Ruhrgebiet, Herne, Germany, ⁴Endokrinologikum, Berlin, Germany
Background/Purpose: There is accumulating evidence that the Th17-signaling axis, particularly interleukin-17 (IL-17), plays an important role in the pathogenesis of ankylosing spondylitis (AS). Furthermore, biologics…

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