Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 2831 • 2014 ACR/ARHP Annual Meeting
Development of New Radiographic Vertebral Fractures in Patients with Ankylosing Spondylitis during 4 Years of TNF-α Blocking Therapy: Results from the Glas Cohort
Fiona Maas¹, Anneke Spoorenberg^1,2, Elisabeth Brouwer³, Reinhard Bos², Rizwana N. Chaudhry¹, Freke Wink², Hendrika Bootsma⁴, Eveline van der Veer⁵ and Suzanne Arends^2,4, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology, Medical Center Leeuwarden, Leeuwarden, Netherlands, ³Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁵Laboratory Medicine, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Previous studies have shown that the risk of vertebral fractures is increased in patients with ankylosing spondylitis (AS). Prospective longitudinal data about radiographic vertebral…
Abstract Number: 2562 • 2014 ACR/ARHP Annual Meeting
The Comparative One-Year Drug Survival Rate of Tumor Necrosis Factor Inhibitors in Patients with Rheumatoid arthritis and ankylosing spondylitis; results from Turkbio Registry
Ismail Sari¹, Umut Kalyoncu², Ahmet Mesut Onat³, Omer Nuri Pamuk⁴, Omer Karadag², Bunyamin Kisacik³, Niels Steen Krogh⁵, Soner Şenel⁶, Fatih Saritaş⁷, Ihsan Ertenli², Sedat Kiraz², Pinar Cetin¹, Fatos Onen¹ and Nurullah Akkoc¹, ¹Rheumatology, Dokuz Eylul University School of Medicine, Izmir, Turkey, ²Rheumatology, Hacettepe University School of Medicine, Ankara, Turkey, ³Rheumatology, Gaziantep University School of Medicine, Gaziantep, Turkey, ⁴Department of Rheumatology, Trakya University School of Medicine, Edirne, Turkey, ⁵Consultant, ZiteLab Aps, Copenhagen, Denmark, ⁶Rheumatology, Erciyes University School of Medicine, Kayseri, Turkey, ⁷Rheumatology, Trakya University School of Medicine, Edirne, Turkey
Background/Purpose Three different anti–tumor necrosis factor α (anti-TNFα) drugs (infliximab, etanercept, and adalimumab) are approved for patients with rheumatoid arthritis (RA) and particular ankylosing spondylitis…
Abstract Number: 1367 • 2014 ACR/ARHP Annual Meeting
Cardiovascular Morbidity and Associated Risk Factors in Spanish Patients with Chronic Inflammatory Rheumatic Diseases Attending Rheumatology Clinics
Santos Castañeda¹, Maria Auxiliadora Martin², Carlos González-Juanatey³, Javier Llorca⁴, María Jesús García Yébenes⁵, Sabina Pérez-Vicente⁶, Jesús Sánchez Costa², Federico Diaz-Gonzalez⁷, Miguel A. González-Gay⁸ and CARMA Project Collaborative Group⁵, ¹Rheumatology, Hospital Universitario de La Princesa, IISP, Madrid, Spain, ²Unidad de Investigación, Sociedad Española de Reumatología, Madrid, Spain, ³Hospital Universitario Lucus Augusti. Cardiology Division, Lugo, Spain, ⁴Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, ⁵Sociedad Española de Reumatología, Madrid, Spain, ⁶Unidad de Investigación de la Sociedad Española de Reumatología, Madrid, Spain, ⁷Rheumatology, Servicio de Reumatologia.Hospital Universitario de Canarias, La Laguna, Spain, ⁸Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain
Background/Purpose: The prevalence of cardiovascular disease (CVD) in chronic inflammatory rheumatic diseases (CIRD) is higher than in the general population. Recent studies have emphasized that…
Abstract Number: 591 • 2014 ACR/ARHP Annual Meeting
The Fat Spondyloarthritis Spine Score (FASSS) Independently Predicts Radiographic Progression in Patients with Ankylosing Spondylitis
Susanne Juhl Pedersen¹, Stephanie Wichuk², Praveena Chiowchanwisawakit³, Zheng Zhao⁴, Robert GW Lambert⁵ and Walter P. Maksymowych⁶, ¹Copenhagen Center for Arthritis Research, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, ²Department of Medicine, University of Alberta, Edmonton, AB, Canada, ³Mahidol University, Bangkok, Thailand, ⁴PLA General Hospital, Beijing, China, ⁵Radiology, University of Alberta, Edmonton, AB, Canada, ⁶Medicine/Rheumatic Dis Unit, University of Alberta, Edmonton, AB, Canada
The Fat Spondyloarthritis Spine Score (FASSS) independently predicts radiographic progression in patients with ankylosing spondylitis. Background/Purpose Vertebral corner fat lesions have been shown to be…
Abstract Number: 536 • 2014 ACR/ARHP Annual Meeting
Secukinumab, a Monoclonal Antibody to Interleukin-17A, Significantly Improves Signs and Symptoms of Active Ankylosing Spondylitis: Results of a Phase 3, Randomized, Placebo-Controlled Trial with Subcutaneous Loading and Maintenance Dosing
Joachim Sieper¹, Jürgen Braun², Xenofon Baraliakos², Dominique L. Baeten³, Maxime Dougados⁴, Paul Emery⁵, Atul A. Deodhar⁶, Brian Porter⁷, Mats Andersson⁸, Shephard Mpofu⁸ and Hanno Richards⁹, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, ⁴INSERM (U1153): Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France., Paris, France, ⁵University of Leeds, Leeds, United Kingdom, ⁶Oregon Health and Sciences University, Portland, OR, ⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁸Novartis Pharma AG, Basel, Switzerland, ⁹Clinical Immunology / Dermatology, Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Previous data indicate that interleukin (IL)-17, a key pro-inflammatory cytokine, might play a role in the pathogenesis of ankylosing spondylitis (AS). We assessed the…
Abstract Number: 2832 • 2014 ACR/ARHP Annual Meeting
The Effect of Co-Medication with Conventional Synthetic Disease Modifying Anti-Rheumatic Drugs on TNF Inhibitor Drug Survival in Patients with Ankylosing Spondylitis: Results from a Nationwide Prospective Study
Elisabeth Lie^1,2, Lars Erik Kristensen³, Helena Forsblad-d'Elia¹, Johan Askling⁴ and Lennart T. Jacobsson¹, ¹Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ²Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Section of Rheumatology, Department of Clinical Sciences, Lund University, Malmö, Sweden, ⁴Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
Background/Purpose For rheumatoid arthritis it is well established that co-medication (co-med) with methotrexate (MTX) increases the efficacy and drug survival of TNF inhibitors (TNFi), while…
Abstract Number: 2564 • 2014 ACR/ARHP Annual Meeting
Ileocolonoscopic Findings in the Korean Patients with Ankylosing Spondylitis
Soo Min Ahn, Bin Yoo, Chang-Keun Lee, Yong-Gil Kim, Seokchan Hong, Seung-Hyeon Bae and Doo-Ho Lim, Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
Background/Purpose: The prevalence of concurrent Ankylosing spondylitis (AS) and inflammatory bowel disease, either Crohn's disease (CD) or Ulcerative colitis (UC), is estimated at 5-10%. Up…
Abstract Number: 1285 • 2014 ACR/ARHP Annual Meeting
Prevalence of Risk Factors for Gastrointestinal Side Effects of Drugs for the Treatment of Pain in Rheumatic Diseases and the Provision of Gastroprotective Treatment – Results of a Large Non-Intervention Study
Gustavo Citera¹, Edgardo Smecuol², Alberto Millán³, Manuel Robles⁴ and Ruben Mantilla⁵, ¹Universidad de Buenos Aires, Buenos Aires, Argentina, ²Hospital Municipal de Gastroenterología, Buenos Aires, Argentina, ³Hospital Universitario de Caracas, Caracas, Venezuela, ⁴Centro Médico Toluca, Toluca, Mexico, ⁵Clínica de Artritis y Rehabilitación (CAYRE), Bogota, Colombia
Background/Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) are the long established first-line treatment for the management of pain associated with rheumatic diseases but carry a risk of…
Abstract Number: 589 • 2014 ACR/ARHP Annual Meeting
Patients with Nr-Axspa Show a Statistically Higher Disease Burden in Clinical Practice Compared with Patients with Radiographic Axial Spa
Lennart TH Jacobsson¹, Tomas Husmark², Elke Theander³, Kenneth Henriksson⁴, Katharina Büsch⁵ and Martin Johansson⁵, ¹Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ²Rheumatology, Falu Hospital, Falun, Sweden, ³Skane University Hospital Malmö, Lund University, Malmö, Sweden, ⁴Rheumatology city clinic, Stockholm, Sweden, Stockholm, Sweden, ⁵AbbVie AB, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose The ASAS axial SpA classification criteria was published in 2009 but so far there has been limited research on axial SpA patients in clinical…
Abstract Number: 463 • 2014 ACR/ARHP Annual Meeting
Golimumab 5-Year Safety: an Analysis of Pooled Data from the Long Term Extensions of Randomized, Double-Blind, Placebo-Controlled Studies in Rheumatoid Arthritis, Psoriatic Arthritis, and Ankylosing Spondylitis
Jonathan Kay¹, Roy Fleischmann², Edward C. Keystone³, Elizabeth C. Hsia^4,5, Neil Goldstein⁴, Benjamin Hsu⁴, Yiying Zhou⁴, Jürgen Braun⁶ and Arthur Kavanaugh⁷, ¹UMass Memorial Medical Center, Worcester, MA, ²Southwestern Medical Center, Department of Medicine, Metroplex Clinical Research Center, University of Texas, Dallas, TX, ³University of Toronto, Mount Sinai Hospital, Toronto, ON, Canada, ⁴Janssen Research & Development, LLC., Spring House, PA, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Rheumazentrum Ruhrgebiet, Herne, Germany, ⁷University of California San Diego, La Jolla, CA
Background/Purpose: To present an analysis of pooled data through approx 5yrs of follow-up from 5 completed golimumab(GLM) Ph3 SC trials across rheumatological indications. Methods: SC…
Abstract Number: 2618 • 2014 ACR/ARHP Annual Meeting
Impact of Ustekinumab on Active Inflammation and Post-Inflammatory Structural Changes As Detected By Magnetic Resonance Imaging in Patients with Active Ankylosing Spondylitis: Results of a 28-Week, Prospective, Open-Label, Proof-of-Concept Study
Denis Poddubnyy¹, Kay-Geert Hermann¹, Johanna Callhoff², Joachim Listing² and Joachim Sieper¹, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²German Rheumatism Research Center, Berlin, Germany
Background/Purpose Ustekinumab – a fully human monoclonal antibody against interleukins 12 and 23 – has been shown to be effective in reduction of symptoms of…
Abstract Number: 2561 • 2014 ACR/ARHP Annual Meeting
Low Cardio-Respiratory Fitness Is Associated with Increased Arterial Stiffness in Patients with Ankylosing Spondylitis
Inger Jorid Berg¹, Anne Grete Semb², Silje H. Sveaas^3,4, Camilla Fongen³, Désirée van der Heijde^3,5, Tore K. Kvien³, Hanne Dagfinrud³ and Sella A. Provan³, ¹Dep of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ³Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Health Sience, University of Oslo, Oslo, Norway, ⁵Leiden University Medical Center, Leiden, Netherlands
Background/Purpose We have previously shown that patients with ankylosing spondylitis (AS) have lower cardio-respiratory fitness (CRF) than population controls. CRF is inversely associated to risk…
Abstract Number: 1159 • 2014 ACR/ARHP Annual Meeting
Long-Term Quality of Life, Productivity Impairment, Disease Severity and Health Care Costs in Relation to Functional Impairment in Ankylosing Spondylitis Patients in the Czech Republic
Liliana Sedova^1,2, Monika Urbanova³, Jiri Stolfa^2,3, David Suchy⁴, Andrea Smrzova⁵, Tomas Mlcoch⁶, Jiri Klimes⁷ and Tomas Dolezal⁷, ¹rheumatology, Institute of Rheumatology, Prague, Czech Republic, ²Clinic of Rheumatology, Charles University Prague, Prague, Czech Republic, ³Inpatients´ Clinic, Institute of Rheumatology Prague, Prague, Czech Republic, ⁴Department of Clinical Pharmacology, Rheumatology, University hospital Plzen, Plzen, Czech Republic, ⁵3rd internal clinic, University hospital Olomouc, Olomouc, Czech Republic, ⁶Institute of Health Economics and Technology Assessment, Prague, Dominica, ⁷Institute of Health Economics and Technology Assessment, Charles University, Prague, Czech Republic
Background/Purpose To describe the quality-of-life (QoL), productivity impairment, clinical indicators and health care costs in relationship to functional status described by Bath Ankylosing Spondylitis Functional…
Abstract Number: 588 • 2014 ACR/ARHP Annual Meeting
Blacks with As Have Greater Disease Severity Than Whites
Farokh Jamalyaria¹, Michael M. Ward², MinJae Lee³, Lianne S. Gensler⁴, Laura A. Diekman⁵, Mohammad H. Rahbar⁶, Amirali Tahanan⁶, Shervin Assassi⁷, Michael H. Weisman⁸ and John D. Reveille^9,10, ¹University of Texas Health Science Center at Houston, Houston, TX, ²Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, ³Medicine, University of Texas Health Science Center at Houston, Houston, TX, ⁴Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁵Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX, ⁶The University of Texas Health Science Center at Houston, Houston, TX, ⁷Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁸Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁹Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ¹⁰Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX
Background/Purpose : To compare clinical parameters in African American (AA) patients with ankylosing spondylitis (AS) to white patients. Methods: 539 AS patients (47 B, 492…
Abstract Number: 318 • 2014 ACR/ARHP Annual Meeting
HLA-B27 Subtypes in Enthesitis Related Arthritis Category of Juvenile Idiopathic Arthritis
Rajni Srivastava¹, Shikha Agnihotry², Rakesh Aggarwal³ and Amita Aggarwal¹, ¹Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ²Bioinformatics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ³Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: HLA-B27 has a high degree of genetic polymorphism, with more than 105 known subtypes. Enthesitis Related Arthritis (ERA) is most common form of Juvenile Idiopathic Arthritis…

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