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Abstracts tagged "Ankylosing spondylitis (AS)"

  • Abstract Number: 583 • 2014 ACR/ARHP Annual Meeting

    What Is the Correlation of Individual HAQ and Basdai Questions with Disease Activity Measures in Ankylosing Spondylitis?  Implications for Instrument Reduction

    Proton Rahman1, Michel Zummer2, Wojciech Olszynski3, Majed Khraishi4, Dalton Sholter5, Rafat Faraawi6, William Bensen7, Milton Baker8, Andrew Chow9, Julie Vaillancourt10, John S. Sampalis10, Francois Nantel11, Allen J Lehman12, Susan Otawa12 and May Shawi11, 1Faculty of Medicine, Memorial University of Newfoundland, St. John's, NF, Canada, 2Université de Montréal, Montreal, QC, Canada, 3University of Saskatchewan, Saskatoon, SK, Canada, 4Nexus Clinical Research, St John's, NF, Canada, 5University of Alberta, Edmonton, AB, Canada, 6McMaster University, Hamilton, ON, Canada, 7Division of Rheumatology, McMaster University, Hamilton, ON, Canada, 8University of Victoria, Victoria, BC, Canada, 9University of Toronto, McMaster University, Credit Valley Rheumatology, Mississauga, ON, Canada, 10JSS Medical Research, Montreal, QC, Canada, 11Janssen Inc., Toronto, ON, Canada, 12Medical Affairs, Janssen Inc., Toronto, ON, Canada

    Background/Purpose Despite the importance of the Health Assessment Questionnaire (HAQ) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) in assessing patient-reported functional status and disease…
  • Abstract Number: 246 • 2014 ACR/ARHP Annual Meeting

    Neuropathic PAIN in Patients with Ankylosing Spondylitis

    Pinar Borman1, Ferda Kaygisiz2, Aysegul Yaman1 and Aynur Karagoz2, 1Department of Physical Medicine and Rehabilitation, University of Hacettepe Faculty of Medicine, Ankara, Turkey, 2Clinic of Physical Medicine and Rehabilitation, Ankara Training and Research Hospital, Ankara, Turkey

    Background/Purpose: There is only one study in the literature indicating that neuropathic pain occurs in ankylosing spondylitis (AS) (1). Methods: The aim of this cross…
  • Abstract Number: 2613 • 2014 ACR/ARHP Annual Meeting

    Positive Spine MRI for Inflammation Predicts Radiographic Progression in Patients with Ankylosing Spondylitis

    Walter P. Maksymowych1, S Wichuk2, Z Zhao3, P Chiowchanwisawakit4, RG Lambert5 and Sj Pedersen6, 1Medicine, University of Alberta, Edmonton, AB, Canada, 2Department of Medicine, University of Alberta, Edmonton, AB, Canada, 3PLA General Hospital, Beijing, China, 4Mahidol University, Bangkok, Thailand, 5Radiology, University of Alberta, Edmonton, AB, Canada, 6Dept. of Rheumatology, Copenhagen Center for Arthritis Research, Copenhagen, Denmark

    Background/Purpose: Inflammation at vertebral corners on MRI has been shown to predict development of syndesmophytes in patients with AS. However, it is unclear at a…
  • Abstract Number: 2303 • 2014 ACR/ARHP Annual Meeting

    Clinical Observation on Ankylosing Spondylitis Patients with Different Phenotypes

    Zhiming Lin1, Jun Qi2, Jieruo Gu3 and Pingping Zhang4, 1The Affiliated Third Hospital of Sun Yat-san University, Rheumatology, Guangzhou, China, 2The Third Affiliated Hospital of Sun Yat-sen University, guangzhou, China, 3Rheumatology, The Affiliated Third Hospital of Sun Yat-san University, Rheumatology, Guangzhou, China, 4Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    Background/Purpose :Juvenile and adult forms of ankylosing spondylitis (AS) have been shown different in initial symptoms,clinical presentation ,imaging manifestations and prognosis.So,according to the diagnostic criteria…
  • Abstract Number: 614 • 2014 ACR/ARHP Annual Meeting

    The Association of PPM1A with Inflammasome Activation in Ankylosing Spondylitis

    Soo Min Ahn1, Seung-Hyeon Bae1, Seokchan Hong1, Eun-Ju Lee1, Eun-Jin Lee2, Eun-Ju Chang2, Doo-Ho Lim1, Yong-Gil Kim1, Chang-Keun Lee1 and Bin Yoo1, 1Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, 2Department of Biomedical Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea

    The Association of PPM1A with Inflammasome Activation in Ankylosing SpondylitisBackground/Purpose Ankylosing spondylitis (AS) is a chronic inflammatory disorder usually affecting axial skeleton and joints. The…
  • Abstract Number: 564 • 2014 ACR/ARHP Annual Meeting

    Cardiovascular Events in Ankylosing Spondylitis. an Updated Meta-Analysis

    Sylvain Mathieu1 and Martin Soubrier2, 1Hopital Gabriel Montpied, Clermont Ferrand, France, 2Rheumatology, CHU G.-Montpied, Clermont-Ferrand, France

    Background/Purpose: Rheumatoid arthritis is associated with increased cardiovascular risk. In the guidelines, ankylosing spondylitis (AS) is considered to have an equally high cardiovascular risk. The…
  • Abstract Number: 42 • 2014 ACR/ARHP Annual Meeting

    The Prevalence of Ankylosing Spondylitis in Sweden – a Nationwide Register Study

    Sofia Exarchou1, Ulf Lindström2, Johan Askling3, Jonas Eriksson4, Helena Forsblad-d'Elia2, Lars Erik Kristensen5, Martin Neovius4, Carl Turesson1 and Lennart T. Jacobsson2, 1Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, 2Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, 3Clinical Epidemiology Unit, Rheumatology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, 4Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, 5Section of Rheumatology, Department of Clinical Sciences, Lund University, Malmö, Sweden

    Background/Purpose: Reported Ankylosing Spondylitis (AS) prevalence estimates vary considerably, and there is a lack of nationwide estimates. Previous studies by our group support the validity…
  • Abstract Number: 2612 • 2014 ACR/ARHP Annual Meeting

    Different Performance of the Major Disease Activity Measures ASDAS and Basdai in Patients with Axial Spondyloarthritis Treated with Non-Steroidal Anti-Inflammatory Agents – Results from a Prospective Study

    Xenofon Baraliakos1, Uta Kiltz1, Frank Heldmann1, Heiner Appel2, Friedrich Dybowski3, Manfred Igelmann4, Ludwig Kalthoff5, Dietmar Krause6, Hans-Jürgen Menne7, Ertan Saracbasi8, Elmar Schmitz-Bortz9 and Jürgen Braun1, 1Rheumazentrum Ruhrgebiet, Herne, Germany, 2Rheumatology and Nephrology Practice, Hamm, Germany, 3Rheumatology Practice, Herne, Germany, 4Rheumatology Practice, Bochum, Germany, 5Rheumatology practice, Herne, Germany, 6Rheumatology practice, Gladbeck, Germany, 7Rheumatology practice, Dortmund, Germany, 8Rheumatology practice, Oberhausen, Germany, 9Rheumatology practice, Hattingen, Germany

    Background/Purpose: The ASAS/EULAR recommendations for the management of patients (pts) with axial spondyloarthritis (axSpA) have established non-steroidal anti-inflammatory agents (NSAIDs) as first choice of medical…
  • Abstract Number: 2150 • 2014 ACR/ARHP Annual Meeting

    The Craniocervical Junction in Ankylosing Spondylitis: A Computed Tomography Based Study

    Gleb Slobodin1, Arsen Shpigelman2, Hanna Dawood3, Doron Rimar4, Simona Croitoru3, Nina Boulman4, Michael Rozenbaum4, Lisa Kaly1, Itzhak Rosner1 and Majed Odeh3, 1Rheumatology, Bnai Zion Medical Center, Haifa, Israel, 2Orthopedic Surgery, Bnai Zion Medical Center, Haifa, Israel, 3Bnai Zion Medical Center, Haifa, Israel, 4Rheumatology, Bnai Zion Medical Center / Technion Faculty of Medicine, Haifa, Israel

    Background/Purpose Available studies of craniocervical junction (CCJ) involvement in ankylosing spondylitis (AS) are based on conventional radiography, which has limited ability in the definition of…
  • Abstract Number: 613 • 2014 ACR/ARHP Annual Meeting

    The Amount of Free Heavy Chain and β2-Microglobulin in the Cytoplasm of B*2705 Ankylosing Spondylitis Patients Compared to B*2705 and B*2709 Healthy Subjects Does Not Support the UPR Theory. Influence of ERAP1 Polymorphisms

    Alberto Cauli, Grazia Dessole, Giovanni Porru, Matteo Piga, Alessandra Vacca and Alessandro Mathieu, Unit and Chair of Rheumatology, University Hospital of Cagliari, Cagliari, Italy

    Background/Purpose : Ankylosing Spondylitis (AS) is a chronic inflammatory disease of the spine strongly associated with the majority of HLA-B27 alleles, with the exception of…
  • Abstract Number: 563 • 2014 ACR/ARHP Annual Meeting

    Evaluation of Clinical Parameters and Quality of Life in Smokers with Ankylosing Spondylitis: Results from the Scotland Registry for Ankylosing Spondylitis

    Linda E. Dean1, Fabiola Azeni1,2, Tiara Ratz1, Alan G. MacDonald3, Roger D. Sturrock1,4, John Hunter5, David Marshall6, Gary J. Macfarlane1 and Gareth T. Jones1, 1Musculoskeletal Research Collaboration (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, 2Rheumatology Unit, L.Sacco University Hospital, Milan, Italy, 3Department of Rheumatology, Aberdeen Royal Infirmary, Aberdeen, United Kingdom, 4Centre for Rheumatic Diseases, Glasgow Royal Infirmary, Glasgow, United Kingdom, 5Department of Rheumatology, Gartnavel General Hospital, Glasgow, United Kingdom, 6Department of Rheumatology, Inverclyde Royal Hospital, Greenock, United Kingdom

    Background/Purpose: Several studies have shown that smoking is associated with increased disease activity, worse physical function and poor quality of life in ankylosing spondylitis (AS). …
  • Abstract Number: L21 • 2014 ACR/ARHP Annual Meeting

    Striking Discrepancy in the Development of Anti-Drug Antibodies (ADA) in Patients with Rheumatoid Arthritis (RA) and Ankylosing Spondylitis (AS) in Response to Infliximab (INF) and Its Biosimilar CT-P13

    Jürgen Braun1, Xenofon Baraliakos1, Alex Kudrin2, H. Kim3 and Sang Joon Lee2, 1Rheumazentrum Ruhrgebiet, Herne, Germany, 2CELLTRION, Inc., Incheon, South Korea, 3CELLTRION, Inc, Incheon, Republic of Korea, Incheon, South Korea

    Background/Purpose: The differences between RA and AS have been recently highlighted (1). There is evidence that there are major clinical, pathophysiological and genetic differences. In…
  • Abstract Number: 2610 • 2014 ACR/ARHP Annual Meeting

    The Role of IL-20 in the Pathogenesis of Ankylosing Spondylitis with Peripheral Joint Involvement

    Göksal Keskin1, Baris Mavi2, Lale Ozisik3, Rahsan Ilikci4 and Mehmet Yildiz2, 1Immunology, Medical School of Ankara, Ankara, Turkey, 2Internal Medicine, Diskapi Training and Research Hospital, Ankara, Turkey, 3Internal Medicine, MD, Ankara, Turkey, 4Basic Immunology, BC, Ankara, Turkey

    Background/Purpose The interleukin-20 (IL-20) is a pro-inflammatory cytokine of the IL-10 family and sequence amino acid is very similar. It has been reported to be…
  • Abstract Number: 2149 • 2014 ACR/ARHP Annual Meeting

    Relationship Between the Magnitude of Bone Formation in the Anterior Vertebral Corners, As Assessed through 18F-Fluoride Uptake, and Lumbar Spine Bone Mineral Density in Patients with Ankylosing Spondylitis

    Seung-Geun Lee1, Eun-Kyoung Park1, Geun-Tae Kim2, Sang-Yeob Lee3 and Joung-Wokk Lee4, 1Divsion of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Kosin University College of Medicine, Busan, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, South Korea, 4Divsion of Rheumatology, Department of Internal Medicine, Busan St. Marys center, Busan, South Korea

    Background/Purpose: 18F-fluoride uptake represents active osteoblastic bone synthesis. We investigated the relationship between the magnitude of bone formation in anterior vertebral corners, as assessed through…
  • Abstract Number: 612 • 2014 ACR/ARHP Annual Meeting

    Association of Platelet Endothelial Cell Adhesion Molecule-1 and beta1 Integrin Gene Polymorphisms with Uveitis Development in Ankylosing Spondylitis

    Seong-Wook Kang1, Seung-Taek Song1, Su-Jin Yoo2, Mi-Kyoung Lim3, Dong-Hyuk Sheen4, In-Seol Yoo2, Jinhyun Kim1 and Seung-Cheol Shim1, 1Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea, 2Departmen of Internal medicine, Chungnam National University School of Medicine, Daejeon, South Korea, 3Rheumatology, Eulji University Hospital, Daejeon, South Korea, 4Department of Internal Medicine, Eulji University Hospital, Daejeon, South Korea

    Background/Purpose Genetic factors provide over 90% of the overall susceptibility to ankylosing spondylitis (AS) and recent studies have focused on non-major histocompatibility complex genes. The…
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