Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 2985 • 2014 ACR/ARHP Annual Meeting
Autoantibodies to 14-3-3η Are Novel Biomarkers Associated with Inflammation and Radiographic Progression in Ankylosing Spondylitis
Walter P. Maksymowych¹, Stephanie Wichuk¹, RG Lambert², Mairead Murphy³ and Anthony Marotta⁴, ¹Medicine, University of Alberta, Edmonton, AB, Canada, ²Radiology, University of Alberta, Edmonton, AB, Canada, ³Augurex Life Sciences Corp., North Vancouver, BC, Canada, ⁴1423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada
Background/Purpose 14-3-3η is a ubiquitous intracellular chaperone protein that is expressed extracellularly in rheumatoid arthritis and mediates inflammatory cascades that result in expression of inflammatory…
Abstract Number: 2582 • 2014 ACR/ARHP Annual Meeting
Serum Levels of Bone Morphogenetic Protein-7 and Sclerostin Are Elevated in Ankylosing Spondylitis, but Not Linked with Structural Damage
Weiping Kong¹, Xiaotong WANG¹, Tongliang Zhou², Yue Jin³, Qingwen TAO¹, Yuan Xu¹, Yingze Zhang¹, Jianming WANG¹ and Xiaoping Yan¹, ¹Department of TCM Rheumatology, China-Japan Friendship Hospital, BEIJING, China, ²CLINICAL RESEARCH INSTITUTE OF IMMUNOLOGY, China-Japan Friendship Hospital, BEIJING, China, ³COMBINATION OF WESTERN AND CHINESE MEDICINE, Beijing University of Chinese Medicine, BEIJING, China
Background/Purpose Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by new bone formation that progressively leads to ankylosis and functional disability. The mechanisms of…
Abstract Number: 1913 • 2014 ACR/ARHP Annual Meeting
Rosuvastatin Induced Carotid Plaque Regression in Patients with Inflammatory Joint Diseases
Silvia Rollefstad¹, Eirik Ikdahl¹, Jonny Hisdal², Inge C. Olsen³, Ingar Holme⁴, Hilde Berner Hammer⁵, Knut T. Smerud⁶, G Kitas⁷, Terje R. Pedersen⁸, Tore K. Kvien⁹ and Anne Grete Semb¹, ¹Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Section of Vascular Investigations, Uslo University Hospital-Aker, Oslo, Norway, ³Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁴Department of biostatistics, epidemiology and health economics, Oslo University Hospital, Oslo, Norway, ⁵Postboks 23 Vinderen, Diakonhjemmet Hospital, Oslo, Norway, ⁶Smerud Medical Research International AS, Oslo, Norway, ⁷The Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom, ⁸Faculty of Medicine, University of Oslo, Oslo, Norway, ⁹PsAID taskforce, EULAR, Zurich, Switzerland
Background/Purpose Patients with rheumatoid arthritis (RA) and carotid artery plaques (CP) have increased risk of acute coronary syndromes. Statin treatment with low density lipoprotein cholesterol…
Abstract Number: 619 • 2014 ACR/ARHP Annual Meeting
Effect of ERAP1 Knockdown on Conformation of HLA-B27 and Other HLA Class I Molecules in Human Monocytic Cells
Tri M. Tran¹, Sohee Hong¹, Jehad H. Edwan² and Robert A. Colbert¹, ¹NIAMS/NIH, Bethesda, MD, ²NIAMS NIH, Bethesda, MD
Background/Purpose Polymorphisms in endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) are associated with ankylosing spondylitis, Behcet’s disease, and psoriasis/psoriatic arthritis, where HLA class I alleles are…
Abstract Number: 573 • 2014 ACR/ARHP Annual Meeting
Three-Year Course and Prediction of Physical Functioning in Ankylosing Spondylitis Patients Treated with TNF-Inhibitors
Salima F.E. van Weely¹, Eva L. Kneepkens¹, Mike T. Nurmohamed¹, Joost Dekker^1,2 and Irene E. van der Horst-Bruinsma³, ¹Reade, centre for Rehabilitation and Rheumatology, Amsterdam, Netherlands, ²Rehabilitation Medicine, Psychiatry and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands, ³Rheumatology, VU University Medical Centre, Amsterdam, Netherlands
Background/Purpose: Currently, only limited information is available on the long-term course of limitations in physical functioning and spinal mobility in Ankylosing Spondylitis (AS) patients receiving…
Abstract Number: 2986 • 2014 ACR/ARHP Annual Meeting
Fat Metaplasia on MRI of the Sacroiliac Joints Is a Lead Indicator of Radiographic Progression in the Spine of Patients with Ankylosing Spondylitis
Walter P. Maksymowych¹, S Wichuk², P Chiowchanwisawakit³, RG Lambert⁴ and Sj Pedersen⁵, ¹Medicine, University of Alberta, Edmonton, AB, Canada, ²Department of Medicine, University of Alberta, Edmonton, AB, Canada, ³Mahidol University, Bangkok, Thailand, ⁴Radiology, University of Alberta, Edmonton, AB, Canada, ⁵Dept. of Rheumatology, Copenhagen Center for Arthritis Research, Copenhagen, Denmark
Fat Metaplasia on MRI of the Sacroiliac joints is a Lead Indicator of Radiographic Progression in the Spine of Patients with Ankylosing SpondylitisMaksymowych WP, Wichuk…
Abstract Number: 2580 • 2014 ACR/ARHP Annual Meeting
A Comparison of Baseline Characteristics and Real-Life Effectiveness of Anti-TNF Therapy in Non-Radiographic Axial Spondyloarthritis Versus Ankylosing Spondylitis – a Single Center Cohort Study
Sarka Forejtova¹, Jakub Zavada², Michal Uher³, Karel Hejduk³ and Karel Pavelka⁴, ¹Rheumatology, Institute of Rheumatology, Prague, Czech Republic, ²Charles University, Prague, Czech Republic, ³Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic, ⁴Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
Background/Purpose: The recent Assessment of SpondyloArthritis international Society (ASAS) classification criteria proposed the concept of axial spondylarthritis (axSpA) to enable earlier treatment not only for…
Abstract Number: 1804 • 2014 ACR/ARHP Annual Meeting
Increased Mortality in Ankylosing Spondylitis – Results from a National Population Based Study
Sofia Exarchou¹, Elisabeth Lie², Johan Askling³, Helena Forsblad-d'Elia², Carl Turesson¹, Lars Erik Kristensen⁴ and Lennart T. Jacobsson², ¹Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ³Clinical Epidemiology Unit, Rheumatology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Section of Rheumatology, Department of Clinical Sciences, Lund University, Malmö, Sweden
Background/Purpose: Ankylosing spondylitis (AS) is characterized both by inflammation of the axial skeleton and systemic inflammation, and may also involve joints, entheses and other organs.…
Abstract Number: 617 • 2014 ACR/ARHP Annual Meeting
Shared HLA Class I and II Alleles in Susceptibility to Ankylosing Spondylitis Among Three Ethnic Groups
Mark Hwang¹, Xiaodong Zhou², Michael H. Weisman³, Michael M. Ward⁴, Jiucun Wang⁵, Lianne S. Gensler⁶, Hejian Zou⁵, Dongyi He⁷, Matthew A. Brown⁸, Paul Scheet⁹ and John D. Reveille^10,11, ¹Medicine, University of Texas Health Science Center at Houston, Houston, TX, ²Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ³Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁴Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, ⁵Rheumatology, Huashan Hospital, Shanghai, China, ⁶Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁷No.540 xinhua Road .Shanghai, Shanghai Guanghua Hospital, Shanghai, China, ⁸University of Queensland Diamantina Institute, Brisbane, Australia, ⁹MD Anderson Cancer Center, Houston, TX, ¹⁰Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ¹¹Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX
Background/Purpose : The purpose of this study is to examine associations of HLA class I and class II alleles with AS in different patients populations of…
Abstract Number: 571 • 2014 ACR/ARHP Annual Meeting
Unraveling the Familial Tendency for Ankylosing Spondylitis in Korea
Hye Won Kim¹, Hye Rim Choe², Won Ik Chang³, Yong-Gil Kim⁴, Bin Yoo⁴, Jin Wook Hur¹, Tae-Hwan Kim⁵, Sungim Lee⁶ and Eun Young Lee⁷, ¹Division of Rheumatology, Department of Internal Medicine, Eulji University of Medicine, Eulji General Hospital, Seoul, South Korea, ²Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, ³Seoul National University College of Medicine, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁶Department of Applied Statistics, Dankook University, Yongin, South Korea, ⁷Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Background/Purpose : Despite of the evidence of familial aggregation of ankylosing spondylitis (AS), familial tendencies are not fully explored. The purpose of this study was…
Abstract Number: 2939 • 2014 ACR/ARHP Annual Meeting
Increased Diagnosis of Spondyloarthritis in Female Patients Started in the Early Biologic Era
Nisha Nigil Haroon¹, Ping Li², Michael Paterson² and Nigil Haroon³, ¹Department of Medicine, University of Toronto, Toronto, ON, Canada, ²Institute of Clinical Evaluative Sciences, Toronto, ON, Canada, ³Toronto Western Research Institute, Toronto, ON, Canada
Background/Purpose The health and economic impact of spondyloarthritis is considerable and growing. Over the past decade or more, there have been two major changes in…
Abstract Number: 2579 • 2014 ACR/ARHP Annual Meeting
How Should We Calculate the ASDAS If the Conventional C-Reactive Protein Is below the Limit of Detection? – an Analysis in the DESIR Cohort
Pedro Machado^1,2, Victoria Navarro-Compán^1,3, Robert Landewé^4,5, Floris van Gaalen¹, Christian Roux⁶ and Desirée van der Heijde¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²University College London, London, United Kingdom, ³University Hospital La Paz, Madrid, Spain, ⁴Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Atrium Medical Center, Heerlen, Netherlands, ⁶Paris Descartes University, Cochin Hospital, Paris, France
Background/Purpose: The Ankylosing Spondylitis Disease Activity Score (ASDAS) is a composite measure of disease activity in axial spondyloarthritis. It was suggested that when the conventional …
Abstract Number: 1598 • 2014 ACR/ARHP Annual Meeting
Serum Fetuin-a, Intercellular Adhesion Molecule -1 and Interleukin -18 Levels in Ankylosing Spondylitis and Psoriatic Arthritis
Hanna Przepiera-Bedzak¹, Katarzyna Fischer² and Marek Brzosko¹, ¹Department of Rheumatology and Internal Diseases, Department of Rheumatology and Internal Diseases Pomeranian Medical University in Szczecin, Szczecin, Poland, ²Independent Laboratory of Rheumatic Diagnostics, Pomeranian Medical University in Szczecin, Szczecin, Poland
Background/Purpose In recent years, increased incidences of metabolic disorders have been observed in patients with systemic inflammatory rheumatic diseases. Fetuin-A, Intercellular Adhesion Molecule -1(ICAM-1) and…
Abstract Number: 606 • 2014 ACR/ARHP Annual Meeting
The Immunological Basis of the Sex-Bias in Ankylosing Spondylitis: Th17 Expansion Is Restricted to Male Patients and Correlates with Sex-Related Alteration in Vitamin D Metabolism
Eric Gracey^1,2, Blerta Green², Paul Yip³, Renise Ayearst⁴, Ammepa Anton⁵, Aifeng Lin² and Robert D. Inman⁶, ¹Immunology, University of Toronto, Toronto, ON, Canada, ²Genetics and Development, University Health Network, Toronto, ON, Canada, ³Clinical Biochemistry, University Health Network, Toronto, ON, Canada, ⁴University Health Network, Toronto, ON, Canada, ⁵Rheumatology, University Health Network, Toronto, ON, Canada, ⁶Immunlogy and Institute of Medical Science, University of Toronto and Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose : Ankylosing spondylitis (AS) is an inflammatory arthritis of the spine, which has a major impact on function and quality of life. AS is…
Abstract Number: 569 • 2014 ACR/ARHP Annual Meeting
Better Outcomes in Ankylosing Spondylitis: The Synergistic Association Between Exercise and Tumor Necrosis Factor Inhibitors
Sarah L. Patterson¹, John D. Reveille^2,3, MinJae Lee⁴, Michael M. Ward⁵, Mohammad H. Rahbar⁶, Matthew A. Brown⁷, Michael H. Weisman⁸ and Lianne S. Gensler⁹, ¹Internal Medicine, University of California, San Francisco, San Francisco, CA, ²Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ³Internal Medicine/Rheumatology, Univ of Texas Health Science Center at Houston, Houston, TX, ⁴Medicine, University of Texas Health Science Center at Houston, Houston, TX, ⁵Bldg 10 CRC Rm 4-1339, NIAMS/NIH, Bethesda, MD, ⁶The University of Texas Health Science Center at Houston, Houston, TX, ⁷University of Queensland Diamantina Institute, Brisbane, Australia, ⁸Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁹Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA
Background/Purpose: Exercise is an important component of Ankylosing Spondylitis (AS) management. The purpose of this study was to determine if the amount patients exercise associates…

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