Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 2513 • 2017 ACR/ARHP Annual Meeting
The Effect of Alcohol on Disease Activity in Axial Spondyloarthritis
Sizheng Zhao^1,2, Daniel Thong³, Stephen Duffield¹, David Hughes³ and Nicola Goodson^1,2, ¹Musculoskeletal Biology 1 Department, University of Liverpool, Liverpool, United Kingdom, ²Aintree University Hospital, Liverpool, United Kingdom, ³University of Liverpool, Liverpool, United Kingdom
Background/Purpose: There has been much interest in smoking as a modifiable risk factor for increased disease severity in rheumatic diseases. However, the effects of alcohol…
Abstract Number: 74 • 2017 ACR/ARHP Annual Meeting
IL-17 Blockade Attenuates Osteoblastic Activity and Differentiation in Ankylosing Spondylitis
Sungsin Jo¹, Ye-Soo Park², Il-Hoon Sung³ and Tae-Hwan Kim¹, ¹Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ²Orthopaedic, Hanyang University Guri Hospital, Guri, Korea, Republic of (South), ³Orthopaedic, Hanyang University Seoul Hospital, Seoul, Korea, Republic of (South)
Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory bone disease mediated by proinflammatory cytokine secreted by specialized T cells population. The mechanism by which the…
Abstract Number: 1521 • 2017 ACR/ARHP Annual Meeting
Impact of Time Since Diagnosis, Age, and Number of Prior Non-Steroidal Anti-Inflammatory Drugs on 52-Week Clinical Response to Adalimumab in Patients with Ankylosing Spondylitis
Joachim Sieper¹, Atul A. Deodhar², Maja Hojnik³, Ying Zhang⁴ and Maxime Dougados⁵, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Oregon Health & Science University, Portland, OR, ³AbbVie, Ljubljana, Slovenia, ⁴AbbVie Inc., North Chicago, IL, ⁵René Descartes University and Hôpital Cochin, Paris, France
Background/Purpose : Ankylosing spondylitis (AS) patients (pts) were found to respond better to TNF inhibitors (TNFi) if treated early in the disease course.1 The actual…
Abstract Number: 1549 • 2017 ACR/ARHP Annual Meeting
A Non-Medical Switch from Originator Infliximab to Biosimilar CT-P13 in 36 Patients with Ankylosing Spondylitis: 6 – Months Clinical Outcomes from the Czech Biologic Registry Attra
Šárka Forejtová¹, Jakub Zavada¹, Lenka Szczukova², Katerina Jarosova¹, Tom Philipp³ and Karel Pavelka⁴, ¹Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Czech Republic, Prague, Czech Republic, ²Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Brno, Czech Republic, ³Department of Rheumatology and Physiotherapy, Thomayer Hospital, Prague, Praha 4, Czech Republic, ⁴Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: A non-medical switch from originator (INX, Remicade) to biosimilar infliximab (CT-P13, Remsima) was conducted in 36 patients with ankylosing spondylitis (AS) in one clinical…
Abstract Number: 2514 • 2017 ACR/ARHP Annual Meeting
When Should Lateral Dexa be Used to Measure Spine Bone Mineral Density in Axial Spondyloarthritis Patients: A Cross-Sectional Study
Sizheng Zhao^1,2, Daniel Thong³, Eleanor Quilliam², Stephen Duffield¹, Kai-Wei Yin³ and Nicola Goodson^1,2, ¹Musculoskeletal Biology 1 Department, University of Liverpool, Liverpool, United Kingdom, ²Aintree University Hospital, Liverpool, United Kingdom, ³University of Liverpool, Liverpool, United Kingdom
Background/Purpose: Osteoporosis and vertebral fractures are recognized complications in axial spondyloarthritis (axSpA). Anteroposterior (AP) DEXA is commonly used to assess spinal bone mineral density (BMD)…
Abstract Number: 629 • 2016 ACR/ARHP Annual Meeting
Golimumab Improves Patient-Reported Outcomes and Socio- and Health-Economic Parameters in Patients with Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), and Ankylosing Spondylitis (AS): Results from a Non-Interventional Clinical Evaluation in Germany
Klaus Krüger¹, GR Burmester², Siegfried Wassenberg³, Martin Bohl-Buehler⁴ and Matthias H. Thomas⁵, ¹Praxiszentrum St. Bonifatius, München, Germany, ²Charité – University Medicine Berlin, Berlin, Germany, ³Rheumazentrum, Ratingen, Germany, ⁴Friedrich-Ebert-Str. 35, Rheumahaus, Potsdam, Germany, ⁵Medical Affairs, MSD Sharp & Dohme GmbH, Bünde, Germany
Background/Purpose: Golimumab (GLM) has shown its efficacy and safety in various randomized clinical trials with patients eligible for clinical studies. Data from patient-reported outcomes (PROs)…
Abstract Number: 717 • 2016 ACR/ARHP Annual Meeting
NSAID Use and Functional Impairment in Ankylosing Spondylitis
Mark Hwang¹, Seth Eisen¹, MinJae Lee², Michael Ward³, Lianne S. Gensler⁴, Prabha Ranganathan⁵, Johnathan Jia⁶, Amirali Tahanan², Matthew A. Brown⁷, Mohammad H. Rahbar², Michael Weisman⁸ and John D. Reveille⁹, ¹Internal Medicine-Rheumatology, Washington University in Saint Louis, School of Medicine, Saint Louis, MO, ²Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, ³NIH/NIAMS, Bethesda, MD, ⁴Medicine/Rheumatology, UCSF, San Francisco, CA, ⁵Washington University in Saint Louis, School of Medicine, Saint Louis, MO, ⁶University of Texas-McGovern Medical School, Houston, TX, ⁷The University of Queensland Diamantina Institute, Brisbane, Australia, ⁸Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁹Rheumatology, University of Texas-McGovern Medical School, Houston, TX
Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory disease with significant burden to patients and society. NSAIDs are the first line pharmacologic therapy in…
Abstract Number: 1429 • 2016 ACR/ARHP Annual Meeting
Patient-Reported Outcomes Measures and Economical Burden of Patients with Ankylosing Spondylitis in a Chinese Prospective Cohort with Smart Management System for Spondyloarthritis
Qiongfang Wen, Xiaojian Ji, Jinshui Yang, Jian Zhu, Jianglin Zhang and Feng Huang, Rheumatology, Chinese PLA General Hospital, Beijing, China
Background/Purpose: Ankylosing Spondylitis (AS) is characterized by relatively young onset age, easily causing spinal deformity and stiffness, and seriously influencing the health related Quality of…
Abstract Number: 2458 • 2016 ACR/ARHP Annual Meeting
Erectile Dysfunction in Men with Rheumatic Diseases: A Systematic Review
Omid Zahedi Niaki¹, Christian A. Pineau², Sasha Bernatsky^3,4 and Evelyne Vinet³, ¹Université de Montréal, Montreal, QC, Canada, ²McGill University Health Centre, Montreal, QC, Canada, ³Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ⁴Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: Given the obvious female predominance of rheumatic diseases, significant attention has already been drawn to the impact of these conditions on female sexual function.…
Abstract Number: 676 • 2016 ACR/ARHP Annual Meeting
Syndesmophytes in the Thoracic Spine in Ankylosing Spondylitis As Detected By Computed Tomography and Association with Lumbar Radiographic Involvement
Sovira Tan and Michael Ward, NIAMS/NIH, Bethesda, MD
Background/Purpose: Because the thoracic spine has traditionally been excluded from radiographic examinations of spinal damage in ankylosing spondylitis (AS) due to poor visualization, little is…
Abstract Number: 718 • 2016 ACR/ARHP Annual Meeting
Radiographic Progression of Hip Arthritis in Patients with Ankylosing Spondylitis Treated with TNF Inhibitors
Maria Konsta¹, Michael Nurmohamed², J.C. van Denderen³, Ingrid Visman⁴ and I.E. Van der Horst - Bruinsma⁵, ¹Amsterdam Rheumatology and Immunology Center,VUmc and Reade, Amsterdam, Netherlands, ²Rheumatology, Amsterdam Rheumatology and immunology Center | Reade, Amsterdam, Netherlands, ³Center for Rheumatology and Rehabilitation, Jan van Breemen Institute, Amsterdam, Netherlands, ⁴Amsterdam Rheumatology and Immunology Center, VUmc and Reade, Amsterdam, Netherlands, ⁵GENRA Consortium, Amsterdam, Netherlands
Background/Purpose: Although current evidence suggests that anti-TNF treatment may not inhibit spinal radiographic progression, its effect on hip involvement in AS is not known. The…
Abstract Number: 1481 • 2016 ACR/ARHP Annual Meeting
Success Rate of Blood Pressure Goal Achievement in Patients with Inflammatory Joint Diseases
Silvia Rollefstad, Pia Norheim, Eirik Ikdahl and Anne Grete Semb, Preventive Cardio-Rheuma clinic, Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: The excess risk of cardiovascular disease (CVD) in patients with inflammatory joint diseases (IJD) is attributable to several risk factors, including a high prevalence…
Abstract Number: 2695 • 2016 ACR/ARHP Annual Meeting
Genetic Association of Ankylosing Spondylitis with TBX21 Influences T-Bet and Pro-Inflammatory Cytokine Expression in Humans and SKG Mice As a Model of Spondyloarthritis and Alters Host Microbiome and Response to Microbial Stimuli
Max Lau¹, Patricia Keith¹, Madeline McCready¹, Mary-Ellen Costello¹, Linda Bradbury¹, Kelly Holiis¹, Ranjeny Thomas², Gethin P. Thomas³, Matthew A. Brown¹ and Tony J. Kenna¹, ¹Translational Research Institute, Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia, ²Translational Research Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, ³Translational Reserch Institute, The University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose: TBX21 encodes the transcription factor T-bet and is genome-wide significant associated with ankylosing spondylitis (AS). T-bet is implicated in innate and adaptive immunity. However,…
Abstract Number: 677 • 2016 ACR/ARHP Annual Meeting
Low Functional Relevance of Radiographic Spinal Progression in Patients with Early Axial Spondyloarthritis
Denis Poddubnyy¹, Hildrun Haibel¹, Jürgen Braun², Martin Rudwaleit³ and Joachim Sieper¹, ¹Charité Medical University, Berlin, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany
Background/Purpose: It has been shown in the past that radiographic spinal progression is an important determinant of the functional outcome in patients with advanced axial…
Abstract Number: 724 • 2016 ACR/ARHP Annual Meeting
Diminished Spinal Radiographic Progression during Long-Term Treatment with TNF-α Inhibitors in Ankylosing Spondylitis Patients at Risk of Poor Radiographic Outcome
Fiona Maas¹, Suzanne Arends^1,2, Freke Wink², Reinhard Bos², Hendrika Bootsma³, Elisabeth Brouwer¹ and Anneke Spoorenberg^1,2, ¹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology, Medical Center Leeuwarden, Leeuwarden, Netherlands, ³Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, The Netherlands, Groningen, Netherlands
Background/Purpose: In AS, spinal radiographic progression shows a very heterogeneous course. Our aim was to investigate which patient characteristics are of influence on the…

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