Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 1539 • 2017 ACR/ARHP Annual Meeting
High Retention Rate and Sustained Responses with Secukinumab 150mg in Patients with Active Ankylosing Spondylitis: 3-Year Results from a Phase 3 Study
Alan J. Kivitz¹, Helena Marzo-Ortega², Clarence Legerton³, Joachim Sieper⁴, Ricardo Blanco⁵, Martin Cohen⁶, Evie Maria Delicha⁷, Susanne Rohrer⁷ and Hanno Richards⁷, ¹Altoona Center for Clinical Research, Duncansville, PA, ²NIHR LBRC, LTHT and LIRMM, UoL, Leeds, United Kingdom, ³Low Country Rheumatology, Articularis Healthcare, Charleston, SC, ⁴University Clinic Benjamin Franklin, Berlin, Germany, ⁵Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁶McGill University, Montreal, QC, Canada, ⁷Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Secukinumab provided sustained improvement in the signs and symptoms of ankylosing spondylitis (AS) over 2 years in the MEASURE 2 study (NCT01649375).1,2 Here we…
Abstract Number: 2496 • 2017 ACR/ARHP Annual Meeting
The Disease Course in Daily Clinical Practice in Radiographic and Non-Radiographic Axial Spondyloarthritis Patients; One-Year Follow-up Results of National-Subgroup of a Worldwide Observational Cohort Study
Servet Akar¹, Ilhan Sezer², Yasemin Yumusakhuylu³, Ayşen Akinci⁴, Kemal Erol⁵, Kenan Akgun⁶, Hatice Bodur⁷, Sebnem Ataman⁸, Omer Kuru⁹, Meltem Melikoglu¹⁰, Murat Karkucak¹¹, Nazli Derya Bugdayci¹², Duygu Ersozlu Bakirli¹³, Murat Birtane¹⁴, Tuncay Duruoz¹⁵, Sukran Erten¹⁶, Ediz Dalkilic¹⁷, Gülay KINIKLI¹⁸, Cemal Bes¹⁹, Ahmet Omma²⁰ and Aylin Rezvani²¹, ¹Rheumatology, Izmir Katip Celebi University, School of Medicine, Rheumatology, Izmir, Turkey, ²Physical Medicine and Rehabilitation-Rheumatology, Antalya Training and Research Hospital, Antalya, Turkey, ³Department of Physical Medicine and Rehabilitation, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey, ⁴Hacettepe University Medical School Department of Physical Medicine and Rehabilitation, Ankara, Turkey, ⁵Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Erciyes University Faculty of Medicine, Kayseri, Turkey, ⁶Department of Physical Medicine and Rehabilitation, Istanbul University, Cerrahpasa Faculty of Medicine, Istanbul, Turkey, ⁷Department of Physical Medicine and Rehabilitation, Ankara Numune Training and Research Hospital, Ankara, Turkey, ⁸Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey, ⁹Department of Physical Medicine and Rehabilitation, 19 Mayis University, Faculty of Medicine, Samsun, Turkey, ¹⁰Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Ataturk University School of Medicine, Erzurum, Turkey, ¹¹Department of Physical Medicine and Rehabilitation, Karadeniz Technical University, Faculty of Medicine, Farabi Hospital, Trabzon, Turkey, ¹²Department of Physical Medicine and Rehabilitation, Istanbul Physical Therapy and Rehabilitation Training and Research Hospital, Istanbul, Turkey, ¹³Department of Rheumatology, Adana Numune Training and Research Hospital, Adana, Turkey, ¹⁴Department of Physical Medicine and Rehabilitation, Trakya University Faculty of Medicine, Edirne, Turkey, ¹⁵Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Marmara University, Faculty of Medicine, Pendik Training and Research Hospital, Istanbul, Turkey, ¹⁶Rheumatology, Yildirim Beyazit University Faculty Of Medicine, Ankara, Turkey, ¹⁷Department of Internal Medicine, Division of Rheumatology, Uludag University, School of Medicine, Rheumatology, Bursa, Turkey, ¹⁸Department of Rheumatology, Ankara University, Faculty of Medicine, Department of Internal Medicine, Rheumatology, Ankara, Turkey, ¹⁹Rheumatology, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey, ²⁰Department of Internal Medicine, Division of Rheumatology, Ankara Numune Training and Research Hospital, Ankara, Turkey, ²¹Department of Physical Medicine and Rehabilitation, Bezmialem Vakif University, Faculty of Medicine, Istanbul, Turkey
Background/Purpose: The natural history of axial spondyloarthritis (axSpA) has not been clearly established yet. The aim of this study is to evaluate the natural course…
Abstract Number: 1234 • 2017 ACR/ARHP Annual Meeting
How Machine Learning Statistics Can Change the Game of Data Analysis in Rheumatology: The Example a Study with 170 Patients with Rheumatoid Arthritis (ra) or Axial Spondyloarthritis (axspa)
Frédéric Guyard¹, Laure Gossec², Didier Leroy³, Thomas Lafargue¹, Michel Seiler³, Charlotte Jacquemin⁴, Anna Molto⁵, Jeremie Sellam⁶, Violaine Foltz⁴, Frédérique Gandjbakhch⁴, Christophe Hudry⁷, Stéphane Mitrovic⁴, Bruno Fautrel⁴ and Herve Servy⁸, ¹IMT, Orange, Nice, France, ²UPMC, University Paris 06, Pitié-Salpétrière Hospital, Paris, France, ³Healthcare, Orange, Paris, France, ⁴UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France, ⁵Hôpital Cochin, Department of Rheumatology, Paris Descartes University, Paris, France, ⁶Rheumatology, Saint-Antoine Hospital, Paris, France, ⁷AP-HP Hôpital Cochin, Paris, France, ⁸e-health services, Sanoia, Gemenos, France
Background/Purpose: A link between flares and physical activity would confirm the objective consequences of flares. In the ActConnect study of patients with RA or axSpA,…
Abstract Number: 1540 • 2017 ACR/ARHP Annual Meeting
Comparison of Radiologic Parameters of Ankylosing Spondylitis Treated with Anti-TNF-α Versus Non-Steroidal Anti-Inflammatory Drugs and Sulfasalazine
Seung Min Son, Orthopaedic surgery, Pusan National University Yangsan Hospital, Yangsan, Korea, Republic of (South)
Background/Purpose: There are many studies about impact of TNF-inhibitors on radiographic progression but little data are available on the relationship between treatment agents and sagittal…
Abstract Number: 2503 • 2017 ACR/ARHP Annual Meeting
Does Maastricht Ankylosing Spondylitis Enthesitis Scores Differ between Ankylosing Spondylitis, Psoriatic Arthritis and Rheumatoid Arthritis Patients?
Steffan Robstad Nilssen¹, Jintana B: Andersen¹, Hanne K. Vestaby¹, Glenn Haugeberg² and Brigitte Michelsen³, ¹Dept. of Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, ²Martina Hansens Hospital, Bærum, Norway, ³Dept. of Rheumatology, Hospital of Southern Norway Trust, kristiansand, Norway
Background/Purpose: The Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) is an enthesitis index developed and validated as an outcome measure in ankylosing spondylitis (AS), but is…
Abstract Number: 68 • 2016 ACR/ARHP Annual Meeting
Epigenetic and Expression Analysis of Ankylosing Spondylitis Association Loci Point to Key Cell Types Driving Disease
Zhixiu Li¹, Katelin Haynes², Gethin P. Thomas³, Tony J. Kenna¹, Paul Leo¹ and Matthew A. Brown¹, ¹Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ²University of Queensland Diamantina Institute, Brisbane, Australia, Brisbane, Australia, ³Research Office, Charles Sturt University, Wagga, Australia, Wagga, Australia
Background/Purpose: Susceptibility to ankylosing spondylitis (AS) is primarily genetic; thus far 113 susceptibility variants for AS have been identified. However, most of the AS associated…
Abstract Number: 713 • 2016 ACR/ARHP Annual Meeting
Predictors of Treatment Retention Among Patients with Rheumatoid Arthritis or Ankylosing Spondylitis Treated with Remicade® (Infliximab) for Long-Term in Canadian Real-World
Michael Starr¹, Edward Keystone², Rafat Faraawi³, Louis Bessette⁴, Boulos Haraoui⁵, Wojciech Olszynski⁶, John Kelsall⁷, Raman Joshi⁸, Andrew Chow⁹, Algis Jovaisas¹⁰, J Carter Thorne¹¹, Emmanouil Rampakakis¹², Eliofotisti Psaradellis¹³, Marilise Marrache¹⁴, Brendan Osborne¹⁵, Karina Maslova¹⁶, Francois Nantel¹⁷, Allen J Lehman¹⁶ and Cathy Tkaczyk¹⁵, ¹Rheumatology, Mcgill University, Pointe-Claire,, QC, Canada, ²Mt. Sinai Hospital, University of Toronto, Toronto, ON, Canada, ³McMaster University, Hamilton, ON, Canada, ⁴Rheumatology, CHUL de Quebec, Quebec, QC, Canada, ⁵Centre hospitalier de l'Université de Montréal, Montreal, QC, Canada, ⁶103 Midtown Professional Center, Rheumatology Associates of Saskatoon, Saskatoon, SK, Canada, ⁷Mary Pack Arthritis Centre, Vancouver, Vancouver, BC, Canada, ⁸William Osler Health Centre-Brampton Civic Hospital, Brampton, ON, Canada, ⁹Credit Valley Rheumatology, Mississauga, ON, Canada, ¹⁰Capital North Therapeutics & Research, Ottawa, ON, Canada, ¹¹Southlake Regional Health Centre, Newmarket, ON, Canada, ¹²JSS Medical Research, St-Laurent, QC, Canada, ¹³JSS Medical Research, Montreal, QC, Canada, ¹⁴Medical Affairs, Janssen Inc, Toronto, ON, Canada, ¹⁵Medical Affairs, Janssen Inc., Toronto, ON, Canada, ¹⁶Janssen Inc., Toronto, ON, Canada, ¹⁷19 Green belt Dr, Janssen Inc., Toronto, ON, Canada
Background/Purpose: Remission has become a target to achieve in rheumatic diseases and it also could be linked to treatment retention. The aim of this analysis…
Abstract Number: 1281 • 2016 ACR/ARHP Annual Meeting
Feasibility and Reliability of the Spondyloarthritis Research Consortium of Canada Sacroiliac Joint Inflammation Score for Children with Spondyloarthritis
Nancy A. Chauvin¹, Walter P. Maksymowych^2,3, Robert G. Lambert⁴, Jacob Jaremko⁵, David M. Biko¹, Timothy G. Brandon⁶, Joel Paschke² and Pamela F. Weiss^7,8, ¹Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, ²CaRE Arthritis, Edmonton, AB, Canada, ³Medicine, University of Alberta, Edmonton, AB, Canada, ⁴Radiology, University of Alberta, Edmonton, AB, Canada, ⁵Radiology, Radiology, University of Alberta, Edmonton, AB, Canada, ⁶Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, ⁷Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ⁸Division of Rheumatology, Center for Pediatric Clincial Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: We lack a method to quantify severity of inflammation in the pediatric sacroiliac joint. We evaluated the reliability and construct validity of the Spondyloarthritis…
Abstract Number: 2006 • 2016 ACR/ARHP Annual Meeting
Tuberculosis Incidence in Ankylosing Spondylitis, Psoriatic Arthritis, and Other Spondyloarthropathies in Sweden: A Population-Based Cohort Study
Mirjam K. de Vries¹, Elizabeth V. Arkema¹, Jerker Jonsson², Judith Bruchfeld³, Lennart TH Jacobsson⁴ and Johan Askling^1,5, ¹Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, ²Infectious Diseases Unit, Karolinska University Hospital, The Public Health Agency of Sweden, Stockholm, Sweden, ³Department of Medicine, Infectious Diseases Unit, Karolinska Institutet, Stockholm, Sweden, ⁴Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden, ⁵Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Patients with rheumatoid arthritis (RA) are at a well-documented increased risk of tuberculosis (TB) compared to the general population, both with and without treatment…
Abstract Number: 3038 • 2016 ACR/ARHP Annual Meeting
Enumeration and Preliminary Characterisation of Peri-Entheseal Bone Type 3 Innate Lymphoid Cells
Richard Cuthbert¹, Yasser El-Sherbiny¹, Evangelos M. Fragkakis¹, Robert Dunsmuir², Helena Marzo-Ortega³, Elena Jones¹ and Dennis McGonagle¹, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Department of Spinal Surgery, National Health Service, Leeds, United Kingdom, ³NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals and University of Leeds, Leeds, United Kingdom
Background/Purpose: In an IL-23 overexpression animal model of spondyloarthropathy (SpA), primary entheseal disease is driven by innate like lymphocytes at peripheral and spinal enthesis with…
Abstract Number: 61 • 2016 ACR/ARHP Annual Meeting
Killer Immunoglobulin-like Receptors Are Associated with Ankylosing Spondylitis
Aimee Hanson¹, International Genetics of Ankylosing Spondylitis Consortium (IGAS)², Kim-Anh Lê Cao³, Tony J. Kenna⁴ and Matthew A. Brown², ¹The University of Queensland Diamantina Institute, Translational Research Instiute, Brisbane, Australia, Brisbane, Australia, ²Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ³Translational Research Instiute, The University of Queensland Diamantina Institute, Brisbane, Australia, ⁴Translational Research Institute, Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
Background/Purpose: Killer immunoglobulin-like receptors (KIRs) are expressed predominantly on the surface of natural killer (NK) cells and some T-cells and are important in regulating the…
Abstract Number: 80 • 2016 ACR/ARHP Annual Meeting
Impact of a Patient Support Program on Abandonment of Adalimumab Treatment Initiation in Patients with Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis
Philip Mease¹, Manish Mittal², Martha Skup², Matthew Davis³, Arijit Ganguli², Scott Johnson³ and Michael Schiff⁴, ¹Swedish Medical Center and University of Washington, Seattle, WA, ²AbbVie Inc., North Chicago, IL, ³Medicus Economics, LLC, Milton, MA, ⁴University of Colorado, Greenwood Village, CO
Background/Purpose: Treatment abandonment (failure to start therapy after prescription) is common among patients (pts) prescribed specialty pharmaceuticals. AbbVie offers a pt support program (PSP) for…
Abstract Number: 714 • 2016 ACR/ARHP Annual Meeting
Functional Relevance of Structural Damage in the Sacroiliac Joints in Patients with Axial Spondyloarthritis – Results from the German Spondyloarthritis Inception Cohort
Mikhail Protopopov¹, Hildrun Haibel¹, Jürgen Braun², Martin Rudwaleit³, Joachim Sieper¹ and Denis Poddubnyy¹, ¹Charité Medical University, Berlin, Germany, ²Rheumazentrum Ruhrgebiet, Herne, Germany, ³Klinikum Bielefeld Rosenhöhe, Bielefeld, Germany
Background/Purpose: To analyze the association between the presence of structural damage in the sacroiliac joints and physical function / spinal mobility in patients with axial…
Abstract Number: 1282 • 2016 ACR/ARHP Annual Meeting
Feasibility and Reliability of the Spondyloarthritis Research Consortium of Canada Sacroiliac Joint Structural Score for Children with Spondyloarthritis
Nancy A. Chauvin¹, Walter P. Maksymowych^2,3, Robert G. Lambert⁴, Jacob Jaremko⁵, David M. Biko¹, Timothy G. Brandon⁶, Joel Paschke³ and Pamela F. Weiss^7,8, ¹Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Medicine, University of Alberta, Edmonton, AB, Canada, ³CaRE Arthritis, Edmonton, AB, Canada, ⁴Radiology, University of Alberta, Edmonton, AB, Canada, ⁵Radiology, Radiology, University of Alberta, Edmonton, AB, Canada, ⁶Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, ⁷Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ⁸Division of Rheumatology, Center for Pediatric Clincial Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: There is a critical need for measures to evaluate structural progression in the pediatric sacroiliac joint. We aimed to evaluate the precision and construct…
Abstract Number: 2169 • 2016 ACR/ARHP Annual Meeting
Presence of Cardiovascular Risk Factors Across Different Inflammatory Joint Disease Entities: Results from a Norwegian, Multi-Centre Project
Grunde Wibetoe¹, Eirik Ikdahl², Silvia Rollefstad², Anne Salberg³, Dag Magnar Soldal⁴, Tore K Kvien⁵, Glenn Haugeberg⁶ and Anne Grete Semb⁷, ¹Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Diakonhjemmet Hospital, Oslo, Norway, ³Hospital for Rheumatic Diseases, Lillehammer, Norway, ⁴Rheumatology, Hospital of Southern Norway, Kristiansand, Norway, ⁵Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ⁶Martina Hansens Hospital, Bærum, Norway, ⁷Preventive Cardio-Rheuma clinic, Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: EULAR recommendations for cardiovascular disease (CVD) risk management in inflammatory joint diseases (IJD) advocates annual CVD risk assessments to reduce the increased CVD risk.…

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