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Abstracts tagged "Ankylosing spondylitis (AS)"

  • Abstract Number: 2431 • 2018 ACR/ARHP Annual Meeting

    Birth Outcomes and Disease Activity during Pregnancy in a Prospective Cohort of Women with Psoriatic Arthritis and Ankylosing Spondylitis

    Chelsey J F Smith1, Arthur Kavanaugh2 and Christina D Chambers3, 1Rheumatology, University of California San Diego, La Jolla, CA, 2University of California, San Diego, School of Medicine, La Jolla, CA, 3University of California San Diego Department of Pediatrics, La Jolla, CA

    Background/Purpose: The goal of this prospective cohort study is to add to the limited data on birth outcomes in psoriatic arthritis (PsA) and ankylosing spondylitis…
  • Abstract Number: 450 • 2018 ACR/ARHP Annual Meeting

    Injection Site Reaction Associated with Subcutaneous Biologic Agents and Methotrexate. Analysis from the Rhumadata® Clinical Database and Registry

    Denis Choquette1, Louis Bessette2, Jacques Brown2, Boulos Haraoui1, Frédéric Massicotte1, Jean-Pierre Pelletier1, Jean-Pierre Raynauld1, Marie-Anaïs Rémillard1, Diane Sauvageau1, Angèle Turcotte2, Édith Villeneuve1 and Louis Coupal1, 1Rheumatology, Institut de Recherche en Rhumatologie de Montréal (IRRM), Montréal, QC, Canada, 2Rheumatology, Centre de l'Ostéoporose et de Rhumatologie de Québec (CORQ), Québec, QC, Canada

    Background/Purpose: Injection Site Reaction (ISRs) are associated with the subcutaneous (SC) route of administration of all biologic agents, and 3% to 15% of patients reports…
  • Abstract Number: 894 • 2018 ACR/ARHP Annual Meeting

    Cancer Risk in Ankylosing Spondylitis in United States Medicare Beneficiaries: Detection of a Chronic Non Steroidal Anti-Inflammatory Drug Use Signature

    Sara Alehashemi1 and Michael Ward2, 1Rheumatology, National Institutes of Health, Bethesda, MD, 2National Institutes of Health, Bethesda, MD, USA, Bethesda, MD

    Background/Purpose:  Few studies have examined risk of cancer in ankylosing spondylitis (AS) since the end of the radiation therapy era. With greater use of biologics,…
  • Abstract Number: 1629 • 2018 ACR/ARHP Annual Meeting

    Hyperlipoproteinemia (a) in Patients with Spondyloarthritis. Results of the CARMA Study

    María Carmen García-Gómez1, Maria Auxiliadora Martin2, Cristina Fernández-Carballido3, Santos Castañeda4, Carlos González-Juanatey5, Fernando Sánchez-Alonso6, María José González-Fernández7, Raimon Sanmarti8, Alberto Garcia-Vadillo9, Benjamin Fernandez Gutierrez10, Miriam García-Arias11, Javier Manero12, José Miguel Senabre13, Amalia Rueda Cid14, Sergio Ros Expósito15, José Manuel Pina Salvador16, Alba Erra Durán17, Ingrid Moller18, Javier Llorca19 and Miguel Angel González-Gay20, 1Rheumatology Division, Consorci Sanitari de Terrassa, Terrassa (Barcelona), Spain, 2Research Unit of Spanish Society of Rheumatology,, Madrid, Spain, 3Rheumatology Division, Hospital General Universitario de Elda, Elda, Spain, 4Rheumatology, Hospital La Princesa. Madrid. Spain, Madrid, Spain, 5Division of Cardiology, Hospital Universitario Lucus Augusti, Lugo, Spain, 6Unidad de Investigación, Spanish Society of Rheumatology, Madrid, Spain, 7Rheumatology, Institut Dexeus, Barcelona, Spain, 8Rheumatology Service, Hospital Clinic, Barcelona, Spain, 9Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 10Rheumatology Department, Hospital Clínico San Carlos, Madrid, Spain, 11Hospital Universitario de la Princesa. Madrid. Spain, Madrid, Spain, 12Ophthalmology and Rheumatology, Hospital Miguel Servet. Zaragoza. Spain, Zaragoza, Spain, 13Rheumatology, Hospital Marina Baixa, Alicante, Spain, 14Rheumatology, Hospital General de Valencia, Valencia, Spain, 15Rheumatology, Hospital de Viladecans, Barcelona, Spain, 16Rheumatology, Hospital de Barbastro, Huesca, Spain, 17Rheumatology, Hospital de Sant Rafael, Barcelona, Spain, 18Instituto de Poal, Barcelona, Spain, 19Division of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, Santander, Spain, 20School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain

    Background/Purpose: Cardiovascular disease (CVD) is one of the main cause of mortality and morbidity in patients with spondyloarthritis (SpA), partially explained by traditional CV risk…
  • Abstract Number: 2556 • 2018 ACR/ARHP Annual Meeting

    Secukinumab 150mg Provides Sustained Improvements in the Signs and Symptoms of Active Ankylosing Spondylitis with Consistent Safety Profile and High Retention Rate: 4-Year Results from a Phase III Trial

    Helena Marzo-Ortega1, Joachim Sieper2, Alan J. Kivitz3, Ricardo Blanco4, Martin Cohen5, Evie Maria Delicha6, Susanne Rohrer6 and Hanno Richards6, 1NIHR LBRC, LTHT and LIRMM, University of Leeds, Leeds, United Kingdom, 2University Clinic Benjamin Franklin, Berlin, Germany, 3Altoona Center for Clinical Research, Duncansville, PA, 4Hospital Universitario Marqués de Valdecilla, Santander, Spain, 5McGill University, Montreal, QC, Canada, 6Novartis Pharma AG, Basel, Switzerland

    Background/Purpose: Secukinumab, a fully human monoclonal IgG1 antibody that neutralizes IL-17A, has shown significant and sustained improvement in the signs and symptoms of active ankylosing…
  • Abstract Number: 512 • 2018 ACR/ARHP Annual Meeting

    Incidence of First Cardiovascular Event in Spanish Patients with Chronic Inflammatory Rheumatic Diseases: Prospective Data from an Observational Multicentric Study

    Maria Auxiliadora Martin1, Santos Castañeda2, Carlos González-Juanatey3, Fernando Sánchez-Alonso4, María Carmen García-Gómez5, R López-González6, Jesus Babio7, Antonio Juan-Mas8, María P Moreno-Gil9, Olga Sanchez-González10, Montserrat Romera11, Jose A Pinto-Tasende12, Jose A Piqueras13, Dolores Fábregas14, Javier Llorca15 and Miguel Angel González-Gay16, 1Research Unit of Spanish Society of Rheumatology,, Madrid, Spain, 2Hospital Universitario La Princesa, IIS-Princesa, Madrid, Spain, 3Cardiology Division, Hospital Xeral-Calde, Lugo, Spain, 4Unidad de Investigación, Spanish Society of Rheumatology, Madrid, Spain, 5Rheumatology Division, Consorci Sanitari de Terrassa, Terrassa (Barcelona), Spain, 6Rheumatology, Complejo Hospitalario de Zamora. Spain, Zamora, Spain, 7Rhaumatology, H General de Cabueñes, Gijon, Spain, 8Division of Rheumatology, Hospital Son Llatzer, Palma de Mallorca, Spain, Spain, 9Division of Rheumatology, Hospital San Pedro de Alcántara, Cáceres, Spain, 10Division of Rheumatology, Hospital del Sureste, Madrid, Spain, 11Division of Rheumatology, Hospital de Bellvitge, Barcelona, Spain, 12Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain, 13Division of Rheumatology, Hospital Universitario de Guadalajara, Guadalajara, Spain, 14Division of Rheumatology, Hospital de Barbastro, Huesca, Spain, 15Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, Santander, Spain, 16School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain

    Background/Purpose: To determine the incidence and risk factors implicated in the development of first cardiovascular event (CVE) in patients with chronic inflammatory rheumatic diseases (CIRD)…
  • Abstract Number: 895 • 2018 ACR/ARHP Annual Meeting

    Associations of Statin Usage with Disease Activity in Ankylosing Spondylitis

    Jonathan Dau1, Lianne S. Gensler2, MinJae Lee3, Michael Ward4, Matthew Brown5, Laura A. Diekman6, Mohammad H. Rahbar7, Mariko Ishimori8, Michael Weisman9 and John D. Reveille10, 1McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, 2University of California San Francisco, San Francisco, CA, 3Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, 4National Institutes of Health, Bethesda, MD, USA, Bethesda, MD, 5Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, 6Rheumatology, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, 7Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, 8Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 9Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 10McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX

    Background/Purpose: Recent studies have shown possible anti-inflammatory effects and a survival benefit with statin usage in ankylosing spondylitis (AS). The purpose of this study was…
  • Abstract Number: 1630 • 2018 ACR/ARHP Annual Meeting

    Do Symptoms of Depression and Anxiety Influence Treatment Response and Long-Term Physical Health Outcomes in Ankylosing Spondylitis?

    Carina Lopes1,2, Mónica Eusébio3, Miguel Bernardes4, Patrícia Pinto5, Helena Santos6, João Lagoas Gomes1,2, José Tavares Costa7, Joao Madruga Dias8, Alexandra Bernardo9, Lúcia Domingues2, Carolina Crespo2, Sara Maia2, Fernando Martins10, Jaime Cunha Branco1,2 and Fernando Pimentel-Santos1,2, 1Rheumatology, Hospital de Egas Moniz - Centro Hospitalar Lisboa Ocidental, EPE, Lisbon, Portugal, 2CEDOC, NOVA Medical School, Lisbon, Portugal, 3Sociedade Portuguesa de Reumatologia, Lisboa, Portugal, LIsboa, Portugal, 4Rheumatology, Centro Hospitalar de São João, Oporto, Portugal, 5Centro Hospitalar Vila Nova de Gaia/Espinho, Gaia, Portugal, 6Rheumatology, Instituto Português de Reumatologia, Lisbon, Portugal, 7Rheumatology, Unidade Local de Saúde do Alto Minho, Ponte de Lima, Portugal, 8Centro Hospitalar Médio Tejo, Torres Novas, Portugal, 9Centro Hospitalar de São João, Porto, Portugal, 10Portuguese Society of Rheumatology, Lisbon, Portugal

    Background/Purpose: Psychological disturbances, frequently observed in inflammatory rheumatic diseases, seem to negatively influence patient’s clinical status and treatment response. The aim of this study was to examine…
  • Abstract Number: 2575 • 2018 ACR/ARHP Annual Meeting

    Long-Term Effects of TNF-Alpha Inhibitors on Bone Mineral Density and the Incidence of Vertebral Fractures in Patients with Ankylosing Spondylitis

    Kim Beek1, Tamara Rusman2, Mignon van der Weijden3, Willem F. Lems4, Christiaan van Denderen5, Michael T. Nurmohamed6 and Irene van der Horst-Bruinsma7, 1Rheumatology, Amsterdam Rheumatology immunology Centre/VUmc and Reade, Amsterdam, Netherlands, 2Rheumatology, VU University medical centre, Amsterdam, Netherlands, 3Rheumatology, Groene Hart Ziekenhuis, Gouda, Netherlands, 4Department of Rheumatology, VU Medical Center, Amsterdam, Netherlands, 5Rheumatology, Jan van Breemen Research Institute | Reade, Amsterdam, Netherlands, 6Rheumatology, Amsterdam Rheumatology and immunology Center, VU University Medical Center, Amsterdam, Netherlands, 7Rheumatology, VU University Medical Center, Amsterdam, Netherlands

    Background/Purpose: Ankylosing Spondylitis (AS) is not only characterized by pathological bone formation leading to ankylosis, but also by bone loss which may lead to vertebral…
  • Abstract Number: 605 • 2018 ACR/ARHP Annual Meeting

    Clinical Outcomes of Golimumab As Second Line TNF Inhibitor Treatment in Patients with Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA) or Ankylosing Spondylitis (AS) – Subanalysis of a Non-Interventional Study in Germany

    Klaus Krüger1, Gerd R. Burmester2, Siegfried Wassenberg3, Astrid Thiele4 and Matthias H. Thomas5, 1Medical Centre of Rheumatology, Munich, Germany, 2Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Berlin, Germany, 3Rheumazentrum Ratingen, Ratingen, Germany, 4Krankenhaus St. Josef Wuppertal, Wuppertal, Germany, 5Medical Affairs, MSD Sharp & Dohme GmbH, Bünde, Germany

    Background/Purpose: Golimumab (GLM) has demonstrated efficacy and safety in patients (pts.) with active RA after treatment with at least one TNFi in a RCT. However,…
  • Abstract Number: 897 • 2018 ACR/ARHP Annual Meeting

    Prevalence of Inflammatory and Chronic Changes Suggestive of Axial Spondyloarthritis in Magnetic Resonance Images of the Axial Skeleton in Individuals < 45 Years in the General Populationas Part of a Large Community Study (SHIP)

    Xenofon Baraliakos1, Daniel Feldmann2, Anne Ott2, Carsten Oliver Schmidt3, Martin Albers3, Adrian Richter3 and Jürgen Braun1, 1Ruhr-University Bochum, Herne, Germany, 2Rheumazentrum Ruhrgebiet, Herne, Germany, 3Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

    Background/Purpose: Magnetic resonance imaging (MRI) is crucial for classification and diagnosis of axial spondyloarthritis (axSpA). Characteristic MRI lesions of axSpA are bone marrow edema (BME)…
  • Abstract Number: 1634 • 2018 ACR/ARHP Annual Meeting

    The Impact of Comorbidities on Physical Function in Patients with Ankylosing Spondylitis and Psoriatic Arthritis Attending Rheumatology Clinics. Results of a National Study

    Cristina Fernández-Carballido1, Maria Auxiliadora Martin2, María Carmen García-Gómez3, Santos Castañeda4, Carlos González-Juanatey5, Fernando Sánchez-Alonso6, Rosario García-Vicuña7, Celia Erausquin8, Francisco J Lopez-Longo9, María D Sanchez-Gonzalez10, Alfonso Corrales11, Estefania Quesda-Masachs12, Eugenio Chamizo Carmona13, Carmen Barbadillo14, Javier Bachiller15, Tatiana Cobo-Ibáñez16, Ana Turrión Nieves17, Emilio Giner Serret18, Javier Llorca19 and Miguel Angel González-Gay11, 1Rheumatology Division, Hospital General Universitario de Elda, Elda, Spain, 2Research Unit of Spanish Society of Rheumatology,, Madrid, Spain, 3Rheumatology Division, Consorci Sanitari de Terrassa, Terrassa (Barcelona), Spain, 4Hospital Universitario La Princesa, IIS-Princesa, Madrid, Spain, 5Division of Cardiology, Hospital Universitario Lucus Augusti, Lugo, Spain, 6Unidad de Investigación, Spanish Society of Rheumatology, Madrid, Spain, 7Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 8Rheumatology, Hospital de Gran Canaria Dr Negrin, Las Palmas GC, Spain, 9Rheumatology Department, Hospital Gregorio Marañón, Madrid, Spain, 10Rheumatology, Hospital Clínico, Salamanca, Spain, 11Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 12Rheumatology Division, Hospital Vall Hebrón, Barcelona, Spain, 13Rheumatology, Hospital de Mérida, Merida, Spain, 14Hospital Universitario Puerta de Hierro, Madrid, Spain, 15Immuno-Rheumatology research group, IRYCIS. Ramón y Cajal University Hospital, Madrid, Spain, 16Hospital Universitario Reina Sofía, Universidad Europea de Madrid, Madrid, Spain, 17Rheumatology, Hospital Universitario de Salamanca. Spain, Salamanca, Spain, 18Rheumatology, H Obispo Polanco, Teruel, Spain, 19Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, Santander, Spain

    Background/Purpose: Functional status gets worse with comorbidities regardless of disease activity in patients with rheumatoid arthritis (RA). However, the impact of comorbidities on physical function…
  • Abstract Number: 2580 • 2018 ACR/ARHP Annual Meeting

    Predicting Treatment Persistence and Non-Persistence of Newly Initiated TNF Inhibitor Therapy in Ankylosing Spondylitis Patients: A Gender Comparison

    Theresa Hunter1, Atul A. Deodhar2, Rebecca Bolce1, Krista Schroeder1 and David Sandoval Calderon1, 1Eli Lilly and Company, Indianapolis, IN, 2Oregon Health & Science U, Portland, OR

    Background/Purpose: The purpose of this study was to compare treatment patterns in the 2 years following the initiation of TNF inhibitor (TNFi) in AS patients.Methods:…
  • Abstract Number: 645 • 2018 ACR/ARHP Annual Meeting

    Real World Secukinumab Study in Ankylosing Spondylitis and Psoriatic Arthritis – Comorbidities and Extraarticular Manifestations: Incidence and Status throughout a Non-Interventional Study in Germany

    Uta Kiltz1, Peter Kaestner2, Holger Krauel2, Ilka Schwarze3, Jan Brandt-Juergens4, Monika Maier-Peuschel5, Carolin Legeler5, Justyna Veit5 and Hans-Peter Tony6, 1Rheumazentrum Ruhrgebiet, Herne, Germany, 2Rheumatology, Ambulantes Rheumazentrum, Erfurt, Germany, 3Praxis internistische Rheumatologie, Leipzig, Germany, 4Rheumatology, Rheumatologische Schwerpunktpraxis, Berlin, Germany, 5Novartis Pharma GmbH, Nürnberg, Germany, 6Rheumatology/Immunology, Medizinische Klinik II, Universitätsklinik, Würzburg, Germany

    Background/Purpose: Patients with psoriatic arthritis (PsA) or ankylosing spondylitis (AS) may suffer from extraarticular (EA) manifestations (uveitis, psoriasis) and have higher rates of comorbidities like…
  • Abstract Number: 1143 • 2018 ACR/ARHP Annual Meeting

    Periodontal Disease Is Associated with an Increased Risk of Ankylosing Spondylitis: A Systematic Review and Meta-Analysis

    Patompong Ungprasert1, Karn Wijarnpreecha2 and Wisit Cheungpasitporn3, 1Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, 2Internal medicine, Bassett medical center, cooperstown, NY, 3Medicine, University of Mississippi Medical center, Jackson, MS

    Periodontal Disease is Associated with an Increased Risk of Ankylosing Spondylitis: A Systematic Review and Meta-analysisAbstractBackground/Purpose: The association between periodontal disease and rheumatoid arthritis is…
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