Abstracts tagged "Ankylosing spondylitis (AS)"

Abstract Number: 2347 • ACR Convergence 2025
Bimekizumab Treatment Resulted in Patients with Axial Spondyloarthritis Maintaining Their Clinical Responses Over 3 Years: Results from Two Phase 3 Studies and Their Open-Label Extension
Fabian Proft¹, Désirée Van Der Heijde², Sergio Schwartzman³, Vanessa Taieb⁴, Sarah Kavanagh⁵, Gaëlle Varkas⁶, Victoria Navarro-Compan⁷ and Xenofon Baraliakos⁸, ¹Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Weill Cornell Medical Center, New York Presbyterian Hospital, and Hospital for Special Surgery, New York, NY, ⁴UCB, Colombes, France, ⁵UCB, Morrisville, NC, ⁶Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁷Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, ⁸Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany
Background/Purpose: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease which requires optimal management.1 In clinical trials, Assessment of SpondyloArthritis international Society ≥40% improvement (ASAS40) is…
Abstract Number: 1715 • ACR Convergence 2025
Spondyloarthritis and Psoriatic Arthritis Patients Under Immunosuppressive Conventional and Biologic DMARDs: Favorable Disease Safety and Attenuated Immunogenicity Following Recombinant Herpes Zoster Vaccination
Carla Saad¹, Eduardo Borba², Fernanda Chaer³, Ana C Medeiros-Ribeiro¹, Sandra G Pasoto¹, Nadia Emi Aikawa⁴, Luisa Correia⁵, Percival Sampaio-Barros⁶, Julio Moraes⁷, Murillo Dorio¹, Claudia Goldenstein-Schainberg¹, Clovis Artur Silva⁸ and Eloisa Bonfa², ¹Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Sao Paulo, Brazil, ²Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, São Paulo, Brazil, ³Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Santos, Brazil, ⁴Rheumatology Division and Pediatric Rheumatology Unit, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Sao Paulo, São Paulo, Brazil, ⁵Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Sao Paulo, ⁶Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, Brazil, ⁷Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, Jundiai, Brazil, ⁸University of São Paulo, São Paulo, São Paulo, Brazil
Background/Purpose: Psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) patients are at increased risk for herpes zoster(HZ) due to impaired cell-mediated immunity associated with the underlying…
Abstract Number: 1428 • ACR Convergence 2025
Ankylosing Spondylitis Related Mortality Trends in USA from 1999-2020: Analysis of CDC Wonder Database
Sanjana Thimmannagari¹, Shiamak Cooper², Asim Khanfar¹ and Candrika Dini Khairani¹, ¹Rochester General Hospital, Rochester, NY, ²Rochester General Hospital, Irondequoit, NY
Background/Purpose: Ankylosing spondylitis is a significant cause of mortality and morbidity in the United States (US), with a prevalence of 0.2%–0.5%. However, trends in mortality…
Abstract Number: 0888 • ACR Convergence 2025
TargetScan Platform Identifies Targets of CD8+ T cells in Ankylosing Spondylitis and Birdshot Uveitis
Adam S. Weinheimer¹, Olivia Pryor², Catalina Burbano³, Tyler Heath³, Livio Dukaj³, Shoshana M.K. Bloom³, Jackson Lirette³, Rachel Lent³, Prachi Dhanania³, Nicole A. Ladd³, Ryan Kritzer³, Hana Husic³, Shobitha Jillella³, Alexander Cristofaro², Chandan K. Pavuluri³, Jenna LaBelle³, Laurie Barefoot³, Shrikanta Chattopadhyay³, Andrew P. Ferretti³ and Cagan Gurer³, ¹TScan Therapeutics, Boston, MA, ²TScan Therapeutics, Waltham, ³TScan Therapeutics, Waltham, MA
Background/Purpose: Antigen-specific therapies offer a promising approach to selectively modulating autoimmune responses without broad immunosuppression. Strong associations with specific Class I HLA alleles in ankylosing…
Abstract Number: 2337 • ACR Convergence 2025
A Mediation Analysis of Tofacitinib’s Effects on SF-36: The Roles of Fatigue, Pain, Stiffness, and Mobility in Ankylosing Spondylitis
Xenofon Baraliakos¹, Andrew G. Bushmakin², Joseph C. Cappelleri², Eleni Nikitopoulou³, You-Li Ling⁴, Mostafa Zayed⁵ and Jonathan Dominick Cicci⁶, ¹Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ²Pfizer Inc., Groton, CT, ³Pfizer Hellas, Athens, Greece, ⁴Pfizer Inc, New York, NY, USA, New York, NY, ⁵Pfizer Gulf FZ LLC, Dubai, United Arab Emirates, ⁶Pfizer Inc., New York, NY
Background/Purpose: Mediation modeling is used to determine mechanisms underlying the relationship between independent and dependent variables via other explanatory variables (“mediators”). Fatigue, pain, and morning…
Abstract Number: 1673 • ACR Convergence 2025
Is Transient Synovitis of the Hip preclinical Juvenile SpA ? A follow-up study
Anirudh Bandu¹, Michal Cidon² and Michael Weisman³, ¹CHLA, Los Angeles, NJ, ²Children's Hospital of Los Angeles, Los Angeles, CA, ³Cedars-Sinai Medical Center, LOS ANGELES, CA
Background/Purpose: Transient synovitis (TS) of the hip is considered a common, self-limited condition in the pediatric population. However, recurrences can occur; these may signal an…
Abstract Number: 1424 • ACR Convergence 2025
Mapping Central Nervous System Responses To Painful Stimuli In Patients With Axial Spondyloarthritis
Mohamad Bittar¹, Yvonne Lee², Atul Deodhar³, Jennifer Barton⁴ and Alexander Stevens¹, ¹Oregon Health & Science University, Portland, OR, ²Northwestern University, Chicago, IL, ³Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, Portland, OR, ⁴VA Portland Health Care System/OHSU, Portland, OR
Background/Purpose: Chronic pain is one of the common causes of disability in axial spondyloarthritis (axSpA). The mechanism behind this pain is not well understood, hindering…
Abstract Number: 0886 • ACR Convergence 2025
A First-in-Class Biologic Selectively Targeting HLA-B27-Reactive T Cells in Ankylosing Spondylitis
Patrick Holec, Megan Reitars, Nishant Singh and Isabelle Larsen, Fletcher Biosciences, Cambridge, MA
Background/Purpose: Ankylosing spondylitis (AS), a chronic autoimmune disease strongly associated with HLA-B27:05, is currently managed with therapies that broadly suppress inflammation instead of targeting disease-driving…
Abstract Number: 2335 • ACR Convergence 2025
The 14-3-3 eta AAb biomarker improves discriminative performance of CRP and HLA-B27 to differentiate people with radiographic axSpA from those with mechanical back pain.
Walter P. Maksymowych¹, Raj Sengupta², Anthony Marotta³, Stephanie Wichuk⁴, Charlotte Cavill⁵, Stephen Bleakley³ and Norma Biln⁶, ¹Department of Medicine, University of Alberta, ⁵⁶⁸ Heritage Building, Edmonton, AB, Canada, ²Royal National Hospital for Rheumatic Diseases, Bath, England, United Kingdom, ³Augurex Life Sciences Corp, Vancouver, BC, Canada, ⁴University of Alberta, Edmonton, AB, Canada, ⁵Royal United Hospitals Bath NHS Foundation Trust, Bath, England, United Kingdom, ⁶Augurex Life Sciences, Vancouver, BC, Canada
Background/Purpose: Reducing diagnostic delay for people presenting with back pain who have axial spondyloarthritis (axSpA) has become a clinical imperative since effective treatments can limit…
Abstract Number: 1642 • ACR Convergence 2025
The Impact of Secukinumab on Bone Density in Patients with Ankylosing Spondylitis: A 1-Year Retrospective Study
yifan cui¹, qingyan li², xiaoyue zhang³, qiuhao zheng⁴, tianshu chu⁵ and lemei an³, ¹Henan Provincial People's Hospital, zhengzhou, Henan, China (People's Republic), ²Henan Provincial People's Hospital, zhengzhou, China (People's Republic), ³Henan Provincial People's Hospital, zhengzhou, ⁴Henan Provincial People's Hospital, Zheng Zhou, China (People's Republic), ⁵Henan Provincial People's Hospital, Zheng Zhou Shi, Henan, China (People's Republic)
Background/Purpose: Ankylosing spondylitis (AS) is characterized by dysregulated bone remodeling, encompassing both osteolysis and heterotopic new bone formation. The differential effects of interleukin-17 (IL-17) inhibition…
Abstract Number: 1423 • ACR Convergence 2025
Genetic and Cytokine Correlates in Ankylosing Spondylitis: rs27038 polymorphism of ERAP1 gene and IL-17 Interactions : A Case-Control Study
Meghna Gavali¹, Husna Fatima², Bhavya Sirivelu³, Nishanth S³ and Noorjahan M³, ¹nizam's institute of medical sciences ,Hyderabad, Hyderabad, Telangana, India, ²Nizami Institute of Medical Sciences, Hyderabad, Telangana, India, ³Nizam’s Institute of Medical Sciences, Hyderabad, Telangana, India
Background/Purpose: Ankylosing Spondylitis (AS) is a chronic inflammatory disorder primarily affecting the axial skeleton and associated with HLA-B27. Non-HLA genes, including ERAP1 (Endoplasmic Reticulum Aminopeptidase…
Abstract Number: 0876 • ACR Convergence 2025
Effect of QX002N on Clinical and Radiographic Outcomes in Ankylosing Spondylitis: Results from a Phase III Randomized, Double-blind, Placebo-Controlled Study
Xiaofeng Zeng¹, Shangzhu Zhang², SHENGYUN LIU³, Fengju Li⁴, xuebin wang⁵, LINGYUN SUN⁶, Hongwei Du⁷, Guixiu Shi⁸, yanling li⁹, hongwei zhang¹⁰, Liyun Zhang¹¹, Jian Wu¹², mingxuan zhou¹³, zhanqing gu¹⁴, yi zhao¹⁵, min fang¹⁶, Qingyi Song¹⁷ and ting wang¹⁷, ¹Department of Rheumatology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China (People's Republic), ²Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China (People's Republic), ³The First Affiliated Hospital Of Zhengzhou University, zhengzhou, China (People's Republic), ⁴Puyang Olifield General Hospital, puyang, Henan, China (People's Republic), ⁵Binzhou Medical University Hospital, binzhou, Shandong, China (People's Republic), ⁶Nanjing Drum Tower Hospital, NANJING, China (People's Republic), ⁷Jinhua Municipal Central Hospital, Jinhua, China (People's Republic), ⁸The First Affiliated Hospital of Xiamen University, xiamen, Fujian, China (People's Republic), ⁹Hospital of Traditional Chinese Medicine of Zhongshan, 中山, Guangdong, China (People's Republic), ¹⁰The First People's Hospital of Foshan, foshan, Guangdong, China (People's Republic), ¹¹Shanxi Bethune Hosptial, Taiyuan, China (People's Republic), ¹²The First Affiliated Hospital of soochow University, Suzhou, China (People's Republic), ¹³The Second Affiliated Hospital of Fujian Medical University, quanzhou, Fujian, China (People's Republic), ¹⁴The First Hospital of Hebei Medical University, shijiazhuang, Hebei, China (People's Republic), ¹⁵Xuanwu Hospital, Capital Medical University, beijing, Beijing, China (People's Republic), ¹⁶Qyuns Therapeutics Co., Ltd., Shanghai, Shanghai, China (People's Republic), ¹⁷Qyuns Therapeutics CO., Ltd., Shanghai, China (People's Republic)
Background/Purpose: QX002N is a novel high-affinity monoclonal antibody (mAb) that selectively targets IL-17A.In the phase II clinical study, QX002N was well tolerated and rapidly reduced…
Abstract Number: 2334 • ACR Convergence 2025
Development and validation analysis of a Corrected Axial Spondyloarthritis Metrology Index
Dafne capelusnik¹, Philip Gardiner², Elena Nikiphorou³, Désirée Van Der Heijde⁴, Robert Landewé⁵, Astrid Van Tubergen⁶, Annelies Boonen⁷ and Sofia Ramiro⁸, ¹Tel Aviv Sourasky Medical Center, Ramat Gan, Israel, ²Altnagelvin Hospital, Londonderry, United Kingdom, ³King’s College London, London, United Kingdom, ⁴Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Department of Rheumatology, Amsterdam University Medical Center, Amsterdam, Netherlands; and Zuyderland Medical Center, Heerlen, Netherlands, ⁶Maastricht university, Maastricht, Netherlands, ⁷Maastricht University Medical Centre+ & Maastricht University, Maastricht, Limburg, Netherlands, ⁸Leiden University Medical Center, Bunde, Netherlands
Background/Purpose: The MOBILITY study, a study on spinal mobility measures in healthy individuals, showed that the Bath Ankylosing Spondylitis Metrology Index (BASMI) often overestimates spinal…
Abstract Number: 1466 • ACR Convergence 2025
Impact of Bimekizumab on Spinal MRI Inflammation and Structural Lesions in Patients with Radiographic Axial Spondyloarthritis: 2-Year CANDEN Scoring Results from a Phase 3 Study and Its Open-Label Extension
Walter P. Maksymowych¹, Robert G. W. Lambert², Victoria Navarro-Compan³, Xenofon Baraliakos⁴, Jason Coarse⁵, Natasha de Peyrecave⁶ and Mikkel Ostergaard⁷, ¹Department of Medicine, University of Alberta, ⁵⁶⁸ Heritage Building, Edmonton, AB, Canada, ²University of Alberta, Department of Radiology & Diagnostic Imaging, Edmonton, AB, Canada, ³Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, ⁴Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ⁵UCB, Morrisville, NC, ⁶UCB, Brussels, Belgium, ⁷Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, and Copenhagen Center for Arthritis Research, Center for Rheumatology, Rigshospitalet, Glostrup, Denmark
Background/Purpose: Spinal inflammation and structural progression are key features of radiographic axial spondyloarthritis (r-axSpA).1 Canada-Denmark (CANDEN) scoring enables anatomical-based assessments of MRI inflammatory and structural…
Abstract Number: 1420 • ACR Convergence 2025
A Nationwide Analysis of In-Hospital Mortality in Adult Ankylosing Spondylitis
Isadora Small¹, Anuya Natu² and Augustine Manadan³, ¹The Latin School of Chicago, Chicago, IL, ²John H Stroger, Jr. Hospital of Cook County, Chicago, IL, ³Rush University Medical Center, Chicago, IL
Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory disease with systemic complications that may contribute to increased mortality risk. This study examines the characteristics and…

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