ACR Meeting Abstracts

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Abstracts tagged "animal models and rheumatoid arthritis"

  • Abstract Number: 985 • 2019 ACR/ARP Annual Meeting

    Inhibition of Calcium/calmodulin-dependent Protein Kinase IV in Rheumatoid Arthritis: Dual Effect on Th17 Cell Activation and Osteoclastogenesis

    Tomohiro Koga1, Tomohito Sato 2, Yushiro Endo 1, Sosuke Tsuji 1, Ayuko Takatani 1, Toshimasa Shimizu 1, Remi Sumiyoshi 1, Takashi Igawa 1, Shin-ya Kawashiri 1, Naoki Iwamoto 1, Kunihiro Ichinose 1, Mami Tamai 1, Hideki Nakamura 1, Tomoki Origuchi 3, Nobuya Yoshida 4, Masataka Umeda 5, George Tsokos 4 and Atsushi Kawakami 6, 1Nagasaki University Graduate School of Biomedical Sciences, Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki, Japan, 2Nagasaki University, Nagasaki, Japan, 3Nagasaki University School of health sciences, Division of physical therapy, Nagasaki, Japan, 4Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 5Beth Israel Deaconess Medical Center, Boston, MA, 6Nagasaki University Graduate School of Biomedical Sciences, Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki

    Background/Purpose: Background: CD4 + T cells are important in the pathogenesis of rheumatoid arthritis (RA), and therapies targeting the differentiation of osteoclasts are attracting attention. Calcium/calmodulin-dependent…
  • Abstract Number: 2900 • 2018 ACR/ARHP Annual Meeting

    Impaired TCR Signaling Paves the Way for Cytokine Hyper-Responsiveness in Arthritogenic T Cells

    Judith Ashouri1, Lih-Yun Hsu1, Dmitry Rychkov2, Marina Sirota2, Lisa Lattanza3, Eric Hansen3, Julie Zikherman1 and Arthur Weiss1, 1Rosalind Russell and Ephraim P. Engleman Rheumatology Research Center, Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, CA, 2Pediatrics, Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA, 3Orthopedic Surgery, University of California, San Francisco, San Francisco, CA

    Background/Purpose: The inability to identify relevant arthritogenic CD4 T cells in patients and in murine disease models has limited our understanding of disease initiating events…
  • Abstract Number: 179 • 2016 ACR/ARHP Annual Meeting

    CD11b+Gr1dimcells, Which Are Induced By GM-CSF Produced By Th17 and Group3 Innate Lymphoid Cell, May Facilitate the Progression of Pneumonitis in SKG Mice

    Sho Sendo1, Jun Saegusa1, Takaichi Okano2, Soshi Takahashi3 and Akio Morinobu1, 1Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 2Rheumatology and Clinical immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 3Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: Rheumatoid lung disease is a prognostic factors of rheumatoid arthritis in human. The pathogenesis and the mechanism of rheumatoid lung disease is unclear. Zymosan…
  • Abstract Number: 2705 • 2015 ACR/ARHP Annual Meeting

    AAA-Atpase p97-HDAC6 Controlled Poly-Ubiquitin Turnover Regulates Apoptotic and Autophagy-Associated Cell Death in Arthritis

    Masaru Kato1, Kerstin Klein2, Caroline Ospelt2, Christoph Kolling3, Michihito Kono1, Shinsuke Yasuda1, Renate E. Gay4, Steffen Gay5 and Tatsuya Atsumi1, 1Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3Schulthess Clinic, Zurich, Switzerland, 4Center of Experimental Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, 5Center of Experimental Rheumatology, University Hospital Zurich, University Zurich, Zurich, Switzerland

    Background/Purpose: The AAA-ATPase valosin containing protein (p97) and histone deacetylase 6 (HDAC6) interact with each other and are implicated in the degradation of ubiquitin-labelled proteins.…
  • Abstract Number: 2165 • 2014 ACR/ARHP Annual Meeting

    Myeloid-Derived Suppressor Cells in Rheumatoid Arthritis: Friend or Foe?

    Fanlei Hu1, Chunqing Guo2, Xiang-Yang Wang2 and Zhanguo Li1, 1Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 2Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA

    Background/Purpose Although myeloid-derived suppressor cells (MDSCs) have been linked to T-cell tolerance, their role in rheumatoid arthritis (RA) remains exclusive. Here, we investigated the potential…
  • Abstract Number: 1512 • 2014 ACR/ARHP Annual Meeting

    Therapeutic Efficacy of a Novel Oral Small Molecule Macrophage Migration Inhibitory Factor [MIF] Inhibitor: A Promising Safe & Efficacious Treatment for Rheumatoid Arthritis

    Anderson Gaweco1,2, Samantha Palmer2, Rambon Shamilov2, Caroline Stremnitzer2, Michael Fisher2, Gregg Crichlow2, William Windsor2, Ellen M. Ginzler3 and Jefferson Tilley2, 1SUNY-Downstate Medical Center, Brooklyn, NY, 2Innovimmune Biotherapeutics, Brooklyn, NY, 3Rheumatology, SUNY-Downstate Medical Center, Brooklyn, NY

    Background/Purpose: Macrophage migration inhibitory factor [MIF] is a cytokine secreted by activated T cells and macrophages that plays an important role in RA and autoimmune…
  • Abstract Number: 338 • 2014 ACR/ARHP Annual Meeting

    Bombina Variegate peptide8/Prokineticin 2: A Novel Arthritis-Inducible Chemokine

    Haruyasu Ito, Ken Yoshida, Kentaro Noda and Daitaro Kurosaka, Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

    Background/Purpose Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by the joint destruction. Chemokines play important roles as monocyte and neutrophil recruiters in RA.…
  • Abstract Number: 2817 • 2014 ACR/ARHP Annual Meeting

    Histone Deacetylase One Contributes to the Auto-Aggressive Phenotype of Rheumatoid Arthritis

    Sarah Hawtree1, Munitta Muthana1, J. Mark Wilkinson2, Anthony G. Wilson1 and Mohammed Akil3, 1Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, 2Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, United Kingdom, 3Rheumatology Department, Sheffield South Yorkshire, United Kingdom

    Background/Purpose Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease that affects synovial joints. A key characteristic of RA is hyperplasia of fibroblast-like synoviocytes (FLS)…
  • Abstract Number: 1792 • 2013 ACR/ARHP Annual Meeting

    Inhibition Of Chemokine Receptors CCR1 and CCR6 As Promising Therapies For Autoimmune Diseases Such As Rheumatoid Arthritis and Psoriasis

    Daniel Dairaghi1, Penglie Zhang2, Manmohan Leleti2, Robert Berahovich3, Karen Ebsworth3, Linda Ertl3, Shichang Miao4, Zhenhua Miao3, Lisa Seitz3, Joanne Tan3, Matthew Walters3, Yu Wang3, Jay Powers5, Thomas J. Schall6 and Juan C. Jaen7, 1Biology, ChemoCentryx, Inc., Mountain View, CA, 2Chemistry, ChemoCentryx, Mountain View, CA, 3Biology, ChemoCentryx, Mountain View, CA, 4Pharmacokinetics, ChemoCentryx, Inc., Mountain View, CA, 5ChemoCentryx, Mountain View, CA, 6ChemoCentryx, Inc., Mountain View, CA, 7Discovery and Preclinical Development, ChemoCentryx, Inc., Mountain View, CA

    Background/Purpose:  Chemokines are key regulators of leukocyte activation and recruitment to sites of inflammation. Of particular relevance in rheumatoid arthritis (RA), the chemokine receptors CCR1…
  • Abstract Number: 1302 • 2013 ACR/ARHP Annual Meeting

    Application of Cytostatic Agent Kinesin Eg5 Inhibitor Litronesib (KF89617) On Rat Adjuvant-Induced Arthritis and Mouse Type II Collagen-Induced Arthritis

    Ichiro Miki1 and Masako Uchii2, 1Fuji Research Park, Kyowa Hakko Kirin, Co., Ltd., Shizuoka, Japan, 2Fuji Research Park, Kyowa Hakko Kirin Co., Ltd., Shizuoka, Japan

    Background/Purpose:   Kinesins are family of motor proteins that are involved in mitosis and intracellular transport of vesicles and organelles. The mitotic kinesin, Eg5, acts…
  • Abstract Number: 943 • 2013 ACR/ARHP Annual Meeting

    Synergism Between Granulocyte-Macrophage Colony Stimulating Factor and Interleukin-17 Causes Joint Damage Via The Production Of Interleukin-23, Receptor Activator Of NF-κB Ligand and S100A8

    Annemarie E.M. Van Nieuwenhuijze1, Fons A.J. Van de Loo2, Birgitte Walgreen3, Miranda B. Bennink4, Monique M. Helsen3, Liduine Van den Bersselaar1, Ian P. Wicks5,6, Wim B. Van den Berg7 and Marije I. Koenders7, 1Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology Research and Advanced Therapeutics, Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 3Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 4Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 5Inflammation Division, Walter & Eliza Hall Institute of Medical Research, Melbourne, Australia, 6Department of Rheumatology, The Royal Melbourne Hospital, Melbourne, Australia, 7Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands

    Background/Purpose: T helper-17 (Th17) cells are important mediators of inflammatory diseases, and are the main pathogenic cell type in many animal models of autoimmunity. Recent…
  • Abstract Number: 1636 • 2012 ACR/ARHP Annual Meeting

    Commensal Gut-Derived Bacteria As Therapy for Systemic Autoimmune Disease

    David Luckey1, Eric Marietta1, Harvinder S. Luthra2, Robin Patel3, Joseph A. Murray4, Ashutosh Mangalam1 and Veena Taneja1, 1Immunology, Mayo Clinic, Rochester, MN, 2Medicine/Division of Rheum, Mayo Clinic, Rochester, MN, 3Medicine, Mayo Clinic, Rochester, MN, 4Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease that leads to destruction of joints. Although etiology of RA is unknown, both genetic and environmental factors…
  • Abstract Number: 901 • 2012 ACR/ARHP Annual Meeting

    Colony-Stimulating Factor (CSF) Receptor 1 Blockade Overcomes Overlapping Effects of M-CSF and Interleukin-34 On Myeloid Differentiation and Gene Expression to Reduce Inflammation in Human and Murine Models of Rheumatoid Arthritis

    Samuel Garcia1, Linda M. Hartkamp2, Inge E. van Es2, Haishan Lin3, Li Long3, Emma L. Masteller3, Brian R. Wong3, Paul P. Tak4 and Kris A. Reedquist2, 1Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 2Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3Five Prime Therapeutics, Inc., South San Francisco, CA, 4Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands

    Background/Purpose: Disease activity and response to therapy in RA correlates with changes in synovial macrophage numbers and their products. M-CSF or IL-34 stimulation of their…
  • Abstract Number: 336 • 2012 ACR/ARHP Annual Meeting

    Preclinical Development of ALX-0061, an Anti-IL-6R Nanobody® For Therapeutic Use in Rheumatoid Arthritis with a High in Vitro Affinity and Potency and a Competitive in Vivo Pharmacological Profile

    Maarten Van Roy1, Hans Ulrichts2, Stefaan Rossenu2, Sandy Jacobs2, Sofie Poelmans3, Gert Verheyden2, Michel Vierboom4, Bert 't Hart4, Judith Baumeister1 and Josefin-Beate Holz5, 1Department of Pharmacology, Ablynx N.V., Zwijnaarde, Belgium, 2Pharmacology, Ablynx N.V., Zwijnaarde, Belgium, 3Pharmacology, Ablynx NV, Gent, Belgium, 4Department of Immunobiology, Biomedical Primate Research Centre, Rijswijk, Netherlands, 5Chief Medical Officer, Ablynx N.V., Zwijnaarde, Belgium

    Background/Purpose: Interleukin-6 (IL-6) is a pleiotropic cytokine inducing a wide range of biological activities via its receptor IL-6R. IL-6 plays an important role in the…
  • Abstract Number: 327 • 2012 ACR/ARHP Annual Meeting

    Tolerogenic Dendritic Cells Ameliorates the Disease Severity of Murine Collagen-Induced Arthritis

    Bin Ning1, Shang-You Yang2, Jianlu Wei1, Weiming Gong1 and Paul H. Wooley2, 1Orthopaedic Surgery, Shandong University Jinan Central Hospital, Jinan, China, 2Orthopaedic Research Institute, Via Christi Wichita Hospitals, Wichita, KS

    Background/Purpose: Rheumatoid arthritis (RA) is a common autoimmune disease characterized by synovial inflammation, cartilage breakdown and bone destruction with the involvement of various types of…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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