ACR Meeting Abstracts

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Abstracts tagged "Animal Model"

  • Abstract Number: 2182 • ACR Convergence 2022

    mRNA Vaccine Against Fibroblast Activation Protein Ameliorates Murine Models of Inflammatory Arthritis

    Xiaowei Zhang1, Antony Jozic1, Pingfang Song1, Qiang Xu2, Xiaofei Shi3, Hong Wang4, Lindsey Bishop1, Hillary Struthers1, John Rutledge5, Shuang Chen1, Fei Xu1, Meaghan Hancock1, Daocheng Zhu6, Gaurav Sahay1 and Cong-Qiu Chu1, 1Oregon Health & Science University, Portland, OR, 2Guangzhou University of Chinese Medicine, Guangzhou, China, 3Henan University of Science and Technology, Luoyang, China, 4Wenzhou Medical University, Wenzhou, China, 5Portland VA Research Foundation, Portland, 6Shanghai Kexin Biotechnology, Shanghai, China

    Background/Purpose: Synovial fibroblasts in patients with rheumatoid arthritis (RA) contribute substantially to the perpetuation of synovitis and invasion to cartilage and bone, and have been…
  • Abstract Number: 0049 • ACR Convergence 2022

    IL-18 Receptor-α Signaling Pathway Contributes to Autoantibody-induced Arthritis via Neutrophil Recruitment

    Shinjiro Kaieda and Tomoaki Hoshino, Kurume University School of Medicine, Kurume, Japan

    Background/Purpose: We have previously reported that IL-18 levels in the lungs, serum and bronchoalveolar lavage fluid (BALF) were increased in patients with idiopathic pulmonary lung…
  • Abstract Number: 1664 • ACR Convergence 2022

    TRIM21 as a Regulator of UVB-Driven IFN Responses in Lupus

    Richard Moore, Gantsetseg Tumurkhuu, Daniel Wallace and Caroline Jefferies, Cedars-Sinai Medical Center, Los Angeles, CA

    Background/Purpose: Patients with systemic lupus erythematosus (SLE) experience photosensitivity where exposure to ultraviolet light B (UVB) drives lupus flares and systemic symptoms. Although the mechanisms…
  • Abstract Number: 2240 • ACR Convergence 2022

    Autoimmunity Against Melanoma Differentiation-Associated Protein 5 Advances Acute Lung Injury to Interstitial Lung Disease in Mice

    Yuki Ichimura1, Risa Konishi1, Toshifumi Nomura2, Manabu Fujimoto3 and Naoko Okiyama1, 1Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan, 2University of Tsukuba, Tsukuba, Ibaraki, Japan, 3Osaka University, Suita, Japan

    Background/Purpose: Anti-melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (DM) is characterized by amyopathic DM with interstitial lung disease (ILD). Patients with anti-MDA5 antibody-associated DM sometimes…
  • Abstract Number: 0050 • ACR Convergence 2022

    Effect of Disease-modifying Anti-rheumatic Drugs on Lung Microenvironment of SKG Mice

    Sung Hae Chang1, Jeongjun Choe2, Seon Uk Kim3, Jeong Yeon Kim4, Sung Won Lee5, Jeong Seok Lee6 and Eun Young Lee4, 1Soonchunhyang University College of Medicine, Bongmyeong-dong, Dongnam-gu, Cheonan-si, Republic of Korea, 2Sungkyunkwan University, Seoul, Republic of Korea, 3Seoul National University College of Medicine, Jongno-gu, Seoul, Republic of Korea, 4Seoul National University College of Medicine, Seoul, Republic of Korea, 5Sooncheonhyang University College of Medicine, Seoul, Republic of Korea, 6Korea Advanced Institute of Science and Technology, KAIST, Graduate school of Medical Science and Engineering, Daejeon, Republic of Korea

    Background/Purpose: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is one of the pivotal extrapulmonary conditions. However, the pathophysiology of RA-ILD, including the effect of disease-modifying anti-rheumatoid…
  • Abstract Number: 1703 • ACR Convergence 2022

    Potential Regulation of NK Cells by CD1c+ Dendritic Cells Through RIG-I/DDX60 Pathway Involved in Th17 Responses in Primary Sjögren Syndrome

    Ildefonso Sánchez Cerrillo1, Marta Calvet Mirabent1, Ana Triguero2, Diego Calzada Fraile3, Mariel Valdivia1, Marta Ramírez3, Enrique Vázquez de Luis3, Alberto Benguría Filippini3, Roberto Moreno3, María Magdalena Adrados de llano1, Hortensia de la Fuente1, Ilya Tsukalov4, Emilia Roy Vallejo5, Almudena Ramiro3, Salvador Iborra6, Francisco Sánchez Madrid1, Ana Dopazo3, Isidoro Gonzalez7, Santos Castañeda8 and Enrique Martín Gayo4, 1Hospital La Princesa, Madrid, Spain, 2Hospital Universitario La Princesa, Madrid, Spain, 3Centro de Investigaciones Cardiovasculares, Madrid, Spain, 4Universidad Autónoma de Madrid, Madrid, Spain, 5Internal Medicine Department, Hospital Universitario La Princesa, Instituto de Investigación Sanitaria La Princesa (IIS-IP), Madrid, Spain, 6Universidad Complutense de Madrid, Madrid, Spain, 7Hospital Universitario de La Princesa, Madrid, Spain, 8Division of Rheumatology, Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain

    Background/Purpose: Altered Th17, CD8+ T cell and B cell adaptative immune responses in patients with primary Sjögren syndrome (pSS) have been characterized in salivary glands…
  • Abstract Number: 2260 • ACR Convergence 2022

    Transcutaneous Vagal Nerve Stimulation Improves Destabilized Medial Meniscus-Induced Osteoarthritis Pain Associated with Significant Serum Biomarker Changes

    Shivmurat Yadav1, Monika Niewiadomska1, Lynsie Morris2, Taylor Conner2, Jessica Lumry2, Sanique South3, Emmaline Prinz2, Matlock Jeffries2, Timothy Griffin2, Stavros Stavrakis1 and Mary Beth Humphrey1, 1University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma CIty, OK, 3Oklahoma Medical Research Foundation, Okahoma City, OK

    Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis, affecting over 32.5 million US adults and characterized by pain, stiffness, swelling and functional disability.…
  • Abstract Number: 0055 • ACR Convergence 2022

    Protective Role for Mast Cells in TNF-induced Inflammatory-Erosive Arthritis and Its Associated Lymphatic Dysfunction in Mice

    Yue Peng1, H. Mark Kenney2, Karen Bentley3, Lianping Xing4, Christopher Ritchlin5 and Edward Schwarz1, 1University of Rochester Medical Center, Rochester, NY, 2University of Rochester Medical Center, Henrietta, NY, 3University of Rochester, Rochester, 4University of Rochester Medical Center, Webster, NY, 5Allergy, Immunology and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY

    Background/Purpose: Inflammatory-erosive arthritis is exacerbated by lymphatic dysfunction (1). Mast cells (MCs) regulate lymphatic vessels by releasing inflammatory and vasoactive mediators (e.g. histamine) (2). Previous…
  • Abstract Number: 1704 • ACR Convergence 2022

    Interaction of Macrophages and Natural Killer Cells in Pathogenesis of HIV-1-Associated Inflammatory Arthritis

    Can Sungur1, Gao Hongbo1, Li-ping Yang2, Liang Shan1 and Wayne Yokoyama3, 1Washington University, St. Louis, MO, 2Washington University in St. Louis, St. Louis, MO, 3Washington University School of Medicine, St. Louis, MO

    Background/Purpose: Human immunodeficiency virus (HIV) remains a significant life-threatening agent and burden on public health. Lesser studied and understood aspects of HIV infections include HIV-associated…
  • Abstract Number: 2264 • ACR Convergence 2022

    Dysregulated Interferon Gamma Signals Promote Systemic Autoimmunity in STAT1 Gain of Function Syndrome

    Andrea Largent1, Jane Buckner2, David Rawlings1 and Shaun Jackson1, 1Seattle Children's Research Institute, Seattle, WA, 2Benaroya Research Institute at Virginia Mason, Seattle, WA

    Background/Purpose: Heterozygous gain-of-function mutations in STAT1 promote a complex disorder of immune dysregulation including chronic mucocutaneous candidiasis (CMC) and systemic autoimmunity. However, given widespread expression…
  • Abstract Number: 0316 • ACR Convergence 2022

    Targeting Oxidized Macrophage Migration Inhibitory Factor (oxMIF) – a Novel Treatment Approach for Rheumatoid Arthritis

    Christine Landlinger1, Maroua Ferhat1, ferdinando Nicoletti2 and Michael Thiele1, 1OncoOne R&D, Vienna, Austria, 2University of Catania, Catania, Italy

    Background/Purpose: Macrophage migration inhibitory factor (MIF) is a primary mediator of adaptive and innate immune responses, as well as a primary counter-regulator of glucocorticoids (GCs),…
  • Abstract Number: 1709 • ACR Convergence 2022

    Role of Corneal Langerhans Dendritic Cells in Lupus Keratitis

    Ram Singh1 and Angel Gutierrez2, 1UCLA David Geffen School of Medicine, Los Angeles, CA, 2University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Patients with lupus and other systemic autoimmune diseases develop ocular surface inflammation that is sometimes severe and debilitating. Pathogenesis of autoimmune keratitis remains unclear.…
  • Abstract Number: 0586 • ACR Convergence 2022

    Transcription Factor Fli-1 Impacts CXCL13 Expression and Renal Inflammation in Lupus-like Nephritis of Adult MRL/lpr Mouse

    Shuzo Sato1, Xian Zhang2, Naoki Matsuoka1, Yuya Sumichika1, Kenji Saito1, Shuhei Yoshida1, Haruki Matsumoto1, Jumpei Temmoku1, Yuya Fujita1, Tomoyuki Asano1, Hiroshi Watanabe1 and Kiyoshi Migita1, 1Fukushima Medical University, Fukushima, Japan, 2Medical University of South Carolina, Charleston, SC

    Background/Purpose: Friend leukemia virus integration 1 (Fli-1) belongs to the Ets family of transcription factors and plays an important role in the development of lupus…
  • Abstract Number: 1713 • ACR Convergence 2022

    Bank1 Signaling Shapes the Gut Microbiota Composition by Controlling the Gut Mucosal B-cell Response in Lupus

    Georgina Galicia-Rosas, María Botía Sánchez, Daniel Toro-Domínguez, Lorena Albadalejo and Marta Alarcon-Riquelme, Center for Genomics and Oncological Research (GENYO), Granada, Spain

    Background/Purpose: Mucosa-associated commensal bacteria have been shown to be involved in the pathogenesis of systemic lupus erythematosus (SLE). However, its exact role remains to be…
  • Abstract Number: 0654 • ACR Convergence 2022

    Lymphatic Dysfunction and Immune Activation in Lupus

    william ambler1, Madhavi Somaraju1, JiHyun Sim1, Ethan Seltzer1, Noa Schwartz2, Ecem Sevim3, Doruk Erkan1, Jinyeon Shin4, Rahgu Kataru4, Babak Mehrara5 and theresa Lu1, 1Hospital for Special Surgery, New York, NY, 2Albert Einstein College of Medicine, New York, NY, 3Montefiore Medical Center - Wakefield Campus, New York, NY, 4Memorial Sloan Kettering, New York, NY, 5Department of Surgery, Division of Plastic and Reconstructive Surgery, Memorial Sloan Kettering, New York, NY

    Background/Purpose: Systemic lupus erythematosus is a prototypic autoimmune disease in which patients frequently have photosensitivity. Exposure to ultraviolet radiation (UVR) causes the eruption of cutaneous…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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