ACR Meeting Abstracts

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Abstracts tagged "Animal Model"

  • Abstract Number: 0797 • ACR Convergence 2023

    Innate Lymphoid Cells Enhance Development of CD4+ T-cell Driven Autoimmune Arthritis

    Agnieszka Lastowska1, Charlotte E. van der Plas1, Anders Nguyen1, Symeon Kourmoulakis1, Miriam Bollmann1 and Mattias N.D Svensson2, 1Department of Rheumatology and Inflammation research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 2University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Innate Lymphoid cells (ILCs) are innate counterparts to T-cells that, based on their functional phenotype, can be divided into three subpopulations called Group 1…
  • Abstract Number: 0953 • ACR Convergence 2023

    Flavin-containing Monooxygenase (FMO3) Links the Gut and Fibrosis in Systemic Sclerosis

    Priyanka Verma1, Bharath Yalavarthi1, Karen Ho2, Lutfiyya Muhammad3, Seokjo Kim4, Johann Gudjonsson1, Rebecca C Schugar5, Mark Brown6, Xinmin Li6, Stanley L Hazen7, Swati Bhattacharyya1 and John Varga1, 1University of Michigan, Ann Arbor, MI, 2Northwestern University, Chicago, IL, 3Northwestern University Feinberg School of Medicine, Chicago, IL, 44SCM Lifescience Co. Ltd, South Korea, Japan, 5Stanford University, Stanford, CA, 6Department of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 7Division of Endocrinology, Department of Medicine, Stanford University, Stanford, CA

    Background/Purpose: Trimethylamine (TMA) generated by the gut microbiome is converted into trimethylamine N-oxide (TMAO) via the host enzyme FMO3. The TMA-FMO3-TMAO metaorganismal axis has been…
  • Abstract Number: 1864 • ACR Convergence 2023

    Quantifying Inflammation: A Novel In-Vivo Total Body PET Imaging Tool to Determine the Kinetics of the Degree of Changes in Inflammation in Different Time Points

    Siba Raychaudhuri1, Sanchita Raychaudhuri2, Naveen Chandrasekar3, Christine Abria3, Sneha Banerjee3, Smriti K Raychaudhuri3 and Abhijit Chaudhari2, 1UC Davis, School of Medicine/ VA Medical Center, Sacramento, Davis, CA, 2UC Davis School of Medicine, Sacramento, CA, 3VA Sacramento Medical Center, Mather, CA

    Background/Purpose: Collagen‐induced arthritis (CIA) mouse model is one of the best recognized animal model for autoimmune diseases. In this model clinical methods of evaluating inflammation…
  • Abstract Number: 0804 • ACR Convergence 2023

    Mutated NOD2 Controls IL-2 Production in Blau Syndrome Patients and Mice

    Leah M. Huey1, Emily Vance1, Holly L. Rosenzweig2, Bryce Binstadt3 and Ruth J. Napier2, 1Oregon Health & Science University, Portland, OR, 2Oregon Health & Science University, VA Portland Health Care System, Portland, OR, 3University of Minnesota, Minneapolis, MN

    Background/Purpose: Microbial sensing molecule nucleotide-binding oligomerization-domain containing protein 2 (NOD2) is expressed by CD4+ T cells and plays a novel T cell-intrinsic role within CD4+…
  • Abstract Number: 1322 • ACR Convergence 2023

    Efzofitimod, a First-in Class NRP2-targeting Immunomodulator, Ameliorates Rheumatoid Arthritis and Associated Lung Fibrosis in Preclinical Models

    Christoph Burkart, Clara Polizzi, Lisa Eide, Max Pastenes, David Siefker and Leslie Nangle, aTyr Pharma, San Diego, CA

    Background/Purpose: Efzofitimod, a novel immunomodulator, has shown clinical proof-of-concept in a Phase 1b/2a clinical trial in patients with pulmonary sarcoidosis and is currently enrolling a…
  • Abstract Number: 2437 • ACR Convergence 2023

    Translocation of Intestinal Bacteria to Axial and Peripheral Joints in a Model of Spondyloarthropathy

    Benjamin Cai1, Rabina Giri2, Helen Benham3, Linda Rehaume1, Geoffery Strutton3, Anne-Sophie Bergot1 and Ranjeny Thomas4, 1Frazer Institute, The University of Queensland, Woolloongabba, Australia, 2Mater Research Institute-UQ, Woolloongabba, Australia, 3Princess Alexandra Hospital, Woolloongabba, Australia, 4Frazer Institute, The University of Queensland, Brisbane, Australia

    Background/Purpose: In spondylarthropathy (SpA), such as psoriatic arthritis (PsA) and ankylosing spondylitis (AS), arthritis is often associated with gut inflammation. After systemic β-1,3-glucan (curdlan) injection,…
  • Abstract Number: 0860 • ACR Convergence 2023

    Vagus Nerve Stimulation Enhances Bone Morphology in a Rodent Model of Central Nervous System Inflammation

    Chandramohan Natarajan1, Julia Lucchino1, David Chenoff2 and Yaakov Levine1, 1SetPoint Medical, Valencia, CA, 2SetPoint Medical, Sausalito, CA

    Background/Purpose: Electrical stimulation of the vagus nerve activates the inflammatory reflex to inhibit cytokines and decrease clinical signs and symptoms of chronic inflammatory disease such…
  • Abstract Number: 1342 • ACR Convergence 2023

    The Delivery of the Super-repressor IκBα by Exosomes Has the Potential to Alleviate Inflammation Associated with Rheumatoid Arthritis

    Ki-Jeong Park1, Ji-Hyoun Kang1, Hae-In Lee2, Yu Jeong Lee1, Moon-Ju Kim1, So-Hee Ahn3, Jae-Kwang Yoo3, Chulhee Choi3 and Tae-jong Kim4, 1Chonnam National University Hospital, Gwangju, South Korea, 2Chonnam National University, Gwangju, South Korea, 3ILIAS Biologics, Daejeon, South Korea, 4Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwang-Ju, South Korea

    Background/Purpose: Rheumatoid arthritis (RA) is a persistent inflammatory disease primarily affecting the diarthrodial joints. Nuclear factor-κB (NF-κB) is a family of inducible transcription factors responsible…
  • Abstract Number: 2444 • ACR Convergence 2023

    Development of Engineered Smith-Specific Regulatory T Cells to Treat Lupus Nephritis

    Eric Morand1, Rachel Cheong2, Peter Eggenhuizen2, Janet Chang2, Ashraf Broury2, Boaz Ng2, Khai Loh2, Elean Tay2, Chanjuan Shen3, Julie Monk2, Yong Zhong4, Steven Lim2, Jia Xi Chung2, Rangi Kandane-Rathnayake5, Rachel Koelmeyer2, Alberta Hoi6, Sarah Snelgrove2, Yi Tian Ting2 and Joshua Ooi2, 1Monash University, Centre for Inflammatory Diseases, Melbourne, Australia, 2Monash University, Clayton, Australia, 3Central South University, Changsha, China, 4Xiangya Hospital, Central South University, Changsha, China, 5Monash University, Department of Medicine, Sub-faculty of Clinical and Molecular Medicine, Clayton, Australia, 6Monash University, Department of Medicine, Sub-faculty of Clinical and Molecular Medicine, Melbourne, Australia

    Background/Purpose: Regulatory T cells (Tregs) play an important role in maintaining immune system homeostasis. Antigen-specific Tregs potently and specifically suppress autoreactivity, suggesting their potential to…
  • Abstract Number: 0861 • ACR Convergence 2023

    The Analgesic Effect of RC-0165, a TRPV1 Antagonist, for Osteoarthritis Pain

    Donghui kim, Juil park, Minjung kim and Yongho kim, RudaCure, Seoul, South Korea

    Background/Purpose: Osteoarthritis (OA), the most common form of arthritis, arises from the deterioration of cartilage within joint bones, resulting in pain and functional disability with…
  • Abstract Number: 1370 • ACR Convergence 2023

    Synthetic Glabridin Derivatives Improves Sjogren’s Syndrome by Inducing Salivary Secretion and Salivary Gland Regeneration

    Eui-Jong Kwon1, Jin-Sil Park2, Ha Yeon Jeong3, Hye Yeon Kang4, JeongWon Choi3, Mi-La Cho3 and Sung-Hwan Park5, 1Division of Rheumatology, Department of Internal Medicine, The Catholic University of Korea Seoul St. Mary's Hospital, Seocho-gu, South Korea, 2The Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seocho-gu, South Korea, 3Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seoul, South Korea, 4Rheumatism Research Center, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, Seocho-gu, South Korea, 5Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Background/Purpose: Sjogren’s syndrome (SS) is a systemic autoimmune disease characterized by infiltration of lymphocytes into the exocrine gland resulting in progressive lacrimal and salivary estruction…
  • Abstract Number: 2445 • ACR Convergence 2023

    Targeting of Endothelial Dysfunction in Lupus Nephritis: Effect on Human Renal Endothelial Cell Gene Expression and Outcomes in Murine Lupus Nephritis

    Dayvia Russell1, Sandra Sanchez2, Evelyn Bruner2 and Jim Oates2, 1Ralph H. Johnson VA Medical Center, Charleston, SC, 2Medical University of South Carolina, Charleston, SC

    Background/Purpose: Lupus nephritis (LN) constitutes one of the most severe manifestations of systemic lupus erythematosus (SLE). Evidence points to endothelial nitric oxide synthase (eNOS) uncoupling,…
  • Abstract Number: 0867 • ACR Convergence 2023

    Pentosan Polysulfate Sodium, a Glycosaminoglycan Mimetic Demonstrates Durable Effects on Pain, Function and Joint Structure in Canine Naturally Occurring Osteoarthritis

    Ravi Krishnan1, Catherine Stapledon2, Christian Reiter2, Stewart Ryan3, Sebastien Bauquier3 and Thierry Beths3, 1Paradigm Biopharmaceuticals, Adelaide, Australia, 2Paradigm Biopharmaceuticals, Melbourne, Australia, 3U-Vet Werribee Animal Hospital, University of Melbourne, Melbourne, Australia

    Background/Purpose: Pentosan Polysulfate sodium (PPS) is a semi-synthetic polysaccharide and a glycosaminoglycan mimetic. The multiple actions of PPS involve anti-inflammatory effects via inhibition of NF-κB;…
  • Abstract Number: 1594 • ACR Convergence 2023

    Oral Delivery of Δ9-Tetrahydrocannabinol Provides Symptom and Disease Modification in a Mouse Model of Knee Osteoarthritis

    Jason rockel1, Anca Maglaviceanu2, Helena Fetter Filippini3, Ewa Wasilewski4, Melissa M. Lewis-Bakker4, Sarah Gabrial1, Evgeny Rossomacha1, Johana Garcia1, Nizar Mahomed5, Timothy Leroux5, Hance Clarke6, Robert P. Bonin3, Lakshmi P. Kotra7 and Mohit Kapoor1, 1Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network, Toronto, ON, Canada, 2Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, 3Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada, 4Krembil Research Institute, and Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 5Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, Krembil Research Institute, and Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 6Krembil Research Institute, and Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, Toronto, ON, Canada, 7Krembil Research Institute, University Health Network; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Osteoarthritis (OA) results in joint pain, cartilage degeneration, and synovitis. Recent studies suggest that some OA patients are self-medicating with cannabis. Δ9-tetrahydrocannabinol (THC) is…
  • Abstract Number: 0870 • ACR Convergence 2023

    Targeting Peroxisome Proliferator-Activated Receptor α Is a Disease-Modifying Therapy for Osteoarthritis

    Uxía nogueira Recalde1, Patricia Díaz rodríguez2, Francisco J. Blanco3, Eduardo Dominguez Medina4 and Beatriz Carames5, 1Unidad de Biología del Cartílago, Grupo de Reumatología, Instituto de Investigación Biomedica de A Coruña (iNIBIC), A Coruña, Spain, 2Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Pharmacy School, Santiago de Compostela, Spain, 3Rheumatology department, Complexo Hospitalario Universitario A Coruña (CHUAC). Instituto de Investigación Biomédica A Coruña (INIBIC), A Coruña, Spain, 4Center for Research in Molecular Medicine and Chronic Diseases, Santiago de Compostela, Spain, 5Unidad de Biología del Cartílago, Grupo de Reumatología, Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain

    Background/Purpose: Disease-modifying therapeutic agents to prevent progression of Osteoarthritis (OA) are an urgent clinical need. Targeting senescence and autophagy in chondrocytes with small molecules is…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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