ACR Meeting Abstracts

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Abstracts tagged "Animal Model"

  • Abstract Number: 0877 • ACR Convergence 2023

    Loss of Transient Receptor Potential Channel 1 (TRPC1) Links Regulation of Intracellular Calcium to Cellular Senescence and Leads to Development of Osteoarthritis

    Meike Sambale1, starlee lively2, Osvaldo Espin-Garcia2, Pratibha Potla2, Chiara Pastrello3, Alexandra Schaefer1, Jessica Bertrand4, Mohit Kapoor5, Thomas Pap1 and Joanna Sherwood1, 1University Hospital Münster, Münster, Germany, 2University Health Network, Toronto, ON, Canada, 3Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, 4Department of Orthopaedic Surgery, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany, 5Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network, Toronto, ON, Canada

    Background/Purpose: Transient receptor potential channel 1 (TRPC1) is a widely expressed mechanosensitive ion channel located within the endoplasmic reticulum membrane. It is crucial for the…
  • Abstract Number: 1664 • ACR Convergence 2023

    Fibroblast Specific Interferon Regulatory Factor 7 (IRF7) Expression Is a Key Link Between Type I Interferon Activation and the Exaggerated Dermal and Pulmonary Fibrosis in Systemic Sclerosis

    Minghua Wu1, Jerry Alonso2, Julio charles2, Brian Skaug2, Tingting Mills3, Maureen Mayes2 and Shervin Assassi4, 1Department of Internal Medicine, Division of Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX, 2Division of Rheumatology, University of Texas McGovern Medical School, Houston, TX, 3Biochemistry Department, University of Texas McGovern Medical School, Houston, TX, 4University of Texas McGovern Medical School at Houston, Houston, TX

    Background/Purpose: A prominent interferon (IFN) activation signature has been observed at the peripheral blood and end-organ levels in systemic sclerosis (SSc). However, the mechanisms by…
  • Abstract Number: 0059 • ACR Convergence 2023

    GM-CSF by Natural Killer Cells Drives Inflammatory Arthritis in HIV-Infected Humanized Mice

    Can Sungur1, Li-ping Yang2, Liang Shan1 and wayne Yokoyama3, 1Washington University, St. Louis, MO, 2Washington University in St. Louis, St. Louis, MO, 3Washington University School of Medicine, St. Louis, MO

    Background/Purpose: Human immunodeficiency virus (HIV) remains a significant life-threatening agent and burden on public health. Lesser studied and understood aspects of HIV include HIV-associated inflammatory…
  • Abstract Number: 0889 • ACR Convergence 2023

    Axl Receptor Tyrosine Kinase Ameliorates Pristane Induced Diffuse Alveolar Hemorrhage in Mice by Regulating Macrophage Polarization

    Wenwen Pei1, Ranran Yao1, Ziye Wang2, Ruyu Liang3, Renge Liang2, Xiaolin Sun4 and Yin Su2, 1Peking University, Beijing, China, 2Peking University People's Hospital, Beijing, China, 3Peking University, XiCheng, China, 4Peking University People’s Hospital, Beijing, China

    Background/Purpose: Diffusealveolar hemorrhage (DAH) is an infrequent but life-threatening complication in patients with systemic lupus erythematosus (SLE). Cells of the monocyte/macrophage lineage are essential to…
  • Abstract Number: 1716 • ACR Convergence 2023

    High-Throughput Semi-Automated Micro-CT Analysis Identifies the Cuboid Bone as a Sex-Dependent Biomarker of Inflammatory-Erosive Arthritis in TNF-Tg Mice

    H. Mark Kenney1, Kiana Chen2, Lindsay Schnur3, Jeffrey Fox3, Ronald Wood3, Lianping Xing4, Christopher T Ritchlin5, Homaira Rahimi6, Edward Schwarz6 and Hani Awad3, 1University of Rochester School of Medicine and Dentistry, Henrietta, NY, 2University of Rochester School of Medicine and Dentistry, Rochester, NY, 3University of Rochester Medical Center, Rochester, NY, 4University of Rochester Medical Center, Webster, NY, 5University of Rochester Medical School, Allergy, Immunology & Rheumatology Division, Canandaigua, NY, 6University of Rochester, Rochester, NY

    Background/Purpose: Development of reliable disease activity biomarkers is critical for diagnostics, prognostics, and novel drug development. In the case of preclinical models of inflammatory-erosive arthritis,…
  • Abstract Number: 0070 • ACR Convergence 2023

    Activation of Joint CD8+ TRM Localize Autoantibody Mediated Arthritis

    Sahar Lotfi-Emran, Nicole Koziol and David Masopust, University of Minnesota, Minneapolis, MN

    Background/Purpose: In humans, upper respiratory infections have been associated with onset of Rheumatoid Arthritis. In mice, following viral infection, CD8+ T cells take up residence…
  • Abstract Number: 0890 • ACR Convergence 2023

    Specificity of Brain-Intrinsic and Hematopoietic-Derived Mechanisms in Mediating Neuropsychiatric Symptoms of Systemic Lupus Erythematosus

    Hadijat Makinde, Yidan Wang, Stumpf Cecilia and Carla Cuda, Northwestern University, Chicago, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects multiple end organs including the brain. Despite a prevalence of over 50% in…
  • Abstract Number: 1717 • ACR Convergence 2023

    Endothelial Cell Sphingosine 1-Phophate Receptor 1 Restrains VE-cadherin Cleavage and Attenuates Experimental Inflammatory Arthritis

    Nathalie Burg1, Miles Tran2, Kevin Wei3, Carl Blobel1 and Jane Salmon1, 1Hospital for Special Surgery, New York, NY, 2Brigham and Women's Hospital, Boston, MA, 3Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: In rheumatoid arthritis, inflammatory mediators extravasate from blood into joints via gaps between endothelial cells (EC), but the contribution of ECs to inflammatory arthritis…
  • Abstract Number: 0095 • ACR Convergence 2023

    Kynurenine Is a Proinflammatory Metabolite That Activates a Positive Feedback Loop of Rab4A-dependent CD98 Expression and mTORC1 and mTORC2 Activation in SLE

    Thomas Winans1, Nick Huang1, Joshua Lewis1, Xiaojing Wang1, Tamas Faludi1, Daniel Krakko2, Laurence Morel3 and Andras Perl4, 1SUNY Upstate Medical University, Syracuse, NY, 2North Carolina State University, Raleigh, NC, 3University of Texas health San Antonio, San Antonio, TX, 4SUNY, Syracuse, NY

    Background/Purpose: The kynurenine (KYN) pathway has been linked to disease pathogenesis in patients with systemic lupus erythematosus (SLE) (https://pubmed.ncbi.nlm.nih.gov/26366134/). Genetically enforced overexpression of Rab4A activates…
  • Abstract Number: 0897 • ACR Convergence 2023

    Steroid-sparing Effects of Afimetoran (BMS-986256), an Equipotent Toll-like Receptor (TLR)7 and TLR8 Antagonist, in a Lupus Mouse Model

    Shailesh Dudhgaonkar1, Puneet Chopra2, Anjuman Rudra2, Siva Subramani2, Sourabha Palachandra2, Nikita Bhatt2, Veeresh Pabbala2, Sourabh Ranade2, Durga Siva Prasad Ega2, Alaric Dyckman3 and Qihong Zhao3, 1Bristol Myers Squibb, Bangalore, India, 2Biocon Bristol Myers Squibb Research Center, Bangalore, India, 3Bristol Myers Squibb, Lawrenceville, NJ

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with extensive phenotypic heterogeneity due to the underlying molecular diversity of dysregulated pathways. Patients with…
  • Abstract Number: 1721 • ACR Convergence 2023

    The Therapeutic Effects of Gingival Mesenchymal Stem Cells and Their Exosomes in a Chimeric Model of Rheumatoid Arthritis

    shane Bruckner1, Braden Zeno2, Vittoria Capria1, William Willis3, Latha Prabha Ganesan1 and wael Jarjour1, 1Ohio State University, Columbus, OH, 2Ohio State University, Upper Arlington, OH, 3Ohio State University, Reynoldsburg, OH

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that leads to progressive joint destruction involving multiple joints. There is a large body of…
  • Abstract Number: 0270 • ACR Convergence 2023

    Exploring the Potential of Oral Administration of 5-aminolevulinic Acid/sodium Ferrous Citrate in Adult-onset Still’s Disease: Preclinical Study in Mice and Pilot Investigation in Humans to Assess Efficacy and Safety

    Tomohiro Koga1, Remi Sumiyoshi1, Yoshika Tsuji1, Ken Kodama2, Kaori Furukawa1, Yushiro Endo1 and Atsushi Kawakami3, 1Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University, Nagasaki, Japan, 2Neophama Japan, Tokyo, Japan, 3Nagasaki University, Nagasaki, Japan

    Background/Purpose: The primary objective of this study is to elucidate the therapeutic potential of 5-aminolevulinic acid/sodium ferrous citrate (5-ALA/SFC) in ameliorating the pathological manifestations associated…
  • Abstract Number: 0920 • ACR Convergence 2023

    Proinflammatory Neutrophils and NETs Mediate Skin and Kidney Inflammation During Lupus Flare in Asymptomatic Lupus-prone Mice Triggered by UVB

    Xing Lyu1, minghui li1, ping zhang2, Wei Wei3, victoria werth4 and Ming-Lin Liu5, 1Tianjin Medical University, Tianjin, China, 2Beaumont Hospital Royal Oak, Royal Oak, MI, 3Tianjin Medical University General Hospital, Tianjin, China, 4University of Pennsylvania, Wynnewood, PA, 5University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Ultraviolet B (UVB) exposure triggers lupus flare by worsening both skin lesions and systemic symptoms, i.e. lupus nephritis. We recently reported that UVB exposure…
  • Abstract Number: 1724 • ACR Convergence 2023

    Human Embryonic Stem Cell-derived Mesenchymal Stem Cells Attenuates Experimental Pulmonary Fibrosis Through Mitochondria Transfer Mediated Anti-apoptotic and Immunomodulatory Effects

    Hanna Lee1, Suhee Kim2, Mingyo Kim2, Ok-Yi Jeong3 and Sang-Il Lee2, 1Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, South Korea, 2Department of Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine and Hospital, JinJu, South Korea, 3Division of Rheumatology, Department of Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine and Gyeongsang National University Hospital, Jinju, South Korea

    Background/Purpose: Interstitial lung disease (ILD) is a serious condition characterized by inflammation and fibrosis in the lung interstitium. The important subtypes of ILD include idiopathic…
  • Abstract Number: 0727 • ACR Convergence 2023

    A Novel Active Pemphigus Vulgaris Mouse Model Induced by Immunization with TLR Ligand Adjuvanted Recombinant Desmoglein 3 Protein Vaccine

    Changxing Gao, Zijun Wang and Qianjin Lu, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China. 3. Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, China

    Background/Purpose: Pemphigus vulgaris (PV) is an autoimmune bullous skin disease mediated by desmoglein-3 (Dsg3) specific auto-antibody present in skin and mucosae. The binding of pathogenic…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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