ACR Meeting Abstracts

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Abstracts tagged "Animal Model"

  • Abstract Number: 0031 • ACR Convergence 2024

    Beyond Pain and Inflammation: Intra-articular Liraglutide’s Comprehensive Benefits on Synovial Health and Cartilage in Osteoarthritis Compared to Dexamethasone

    Coralie Meurot1, Celine Martin1, Margot Vieubled1, Jerome Breton1, Indira Toillon2, Revital Rattenbach3 and Francis Berenbaum2, 14Moving Biotech, lille, France, 2Sorbonne University, Paris, France, 34Moving Biotech, Paris, France

    Background/Purpose: Osteoarthritis (OA) is an age-related joint disease that causes chronic pain and limited mobility. Patients mainly have access to therapies aimed at reducing inflammation…
  • Abstract Number: 0923 • ACR Convergence 2024

    Immunization of Arthritis Prone Mice with Malondialdehyde-Acetaldehyde Modified Vimentin Induces Post-Translational Protein Modifications and Extracellular Matrix Deposition in Heart Tissues

    Kimberley Sinanan1, Wenxian Zhou2, Michael Duryee1, Nozima Aripova1, Jill Poole1, Carlos Hunter1, Amy Nelson1, Tate Johnson1, Daniel Anderson3, Ted Mikuls1 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Nebraska Medical Center, Bellevue, NE, 3University of Nebraska Medical Center, Durham, NC

    Background/Purpose: Recent studies have highlighted the importance of malondialdehyde-acetaldehyde (MAA)-modified proteins and resulting immune responses in the pathogenesis of rheumatoid arthritis (RA). MAA adducts have…
  • Abstract Number: 2078 • ACR Convergence 2024

    Increased RAGE Expression in Myositis

    Madison King1, Rita Spathis2, Elizabeth Bagley1 and Melissa Morales3, 1Binghamton University, Johnson City, NY, 2Binghamton University School of Pharmacy and Pharmaceutical Sciences, Johnson City, NY, 3SUNY Binghamton, Johnson City, NY

    Background/Purpose: Myositis is a broad term for a group of rare autoimmune diseases that cause persistent muscle inflammation, weakness, and fatigue. Currently, first-line treatment for…
  • Abstract Number: 0032 • ACR Convergence 2024

    Increased Expression of Malondialdehyde-Acetaldehyde and Citrullinated Proteins in Myocardial Tissues During the Early Evolution of Collagen-Induced Arthritis

    Wenxian Zhou1, Michael Duryee2, Nozima Aripova2, Jill Poole2, Carlos Hunter2, Amy Nelson2, Tate Johnson2, Daniel Anderson3, Geoffrey Thiele2 and Ted Mikuls2, 1University of Nebraska Medical Center, Bellevue, NE, 2University of Nebraska Medical Center, Omaha, NE, 3University of Nebraska Medical Center, Durham, NC

    Background/Purpose: The risk of heart failure (HF) is increased in patients with rheumatoid arthritis (RA), although mechanisms of myocardial dysfunction underlying HF development in RA…
  • Abstract Number: 0924 • ACR Convergence 2024

    The Cytosolic DNA Sensor AIM2 Regulates Bone Homeostasis Through Bone Progenitor Cell Differentiation

    Jia (Sijia) Chen1, Yukiko Maeda2, Catherine Manning3, Victor Le4, Jae-Hyuck Shim5, Katherine A. Fitzgerald6 and Ellen Gravallese7, 1Brigham and Women's Hospital, Boston, MA, 2Sanofi, worcester, MA, 3Brigham and Women's Hospital, Dedham, MA, 4Digital Biology, Boston, MA, 5University of Massachusetts, Worcester, MA, 6UMass Chan Medical School, Worchester, MA, 7Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: Innate sensing pathways and inflammasomes play an important role in autoimmunity and aging. AIM2 is a DNA sensor that triggers inflammasome assembly in myeloid…
  • Abstract Number: 2539 • ACR Convergence 2024

    Telocytes Integrated into Mast Cells and Joint-Draining Lymphatic Vessels Potentially Regulate Lymphatic Clearance

    Yue Peng1, H. Mark Kenney2, Karen Bentley1, Lianping Xing3, Benjamin Korman4, Christopher Ritchlin5 and Edward Schwarz1, 1University of Rochester School of Medicine and Dentistry, Rochester, NY, 2University of Rochester School of Medicine and Dentistry, Henrietta, NY, 3University of Rochester School of Medicine and Dentistry, Webster, NY, 4University of Rochester, Rochester, NY, 5Department of Medicine, Allergy, Immunology, and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY

    Background/Purpose: Rheumatoid arthritis (RA) patients and TNF-transgenic mice have lymphatic dysfunction (1). Recently, we showed mast cells involvement, as genetic ablation and drug inhibition decreased…
  • Abstract Number: 0068 • ACR Convergence 2024

    Enhanced Expression of GPR65 in Inflammatory Sites and Bone Formation Regions in Ankylosing Spondylitis: Evidence from ScRNA-seq Analysis

    Yong-Wook Park1, Ki-Jeong Park2, Sungsin Jo3, Tae-Hwan Kim4 and Tae-Jong Kim1, 1Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea, 2Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea, 3Hanyang University Institute for Rheumatology Research, Seoul, Republic of Korea, 4Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea

    Background/Purpose: Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton. T helper 17 (Th17) cells play a pivotal role in the…
  • Abstract Number: 0925 • ACR Convergence 2024

    Macrophages Produce Bone Anabolic Factors in Settings of Inflammation-Induced Bone Formation

    Jia (Sijia) Chen1, Megan Hanlon2, Catherine Manning3, Susan MacLauchlan1, Paul Hoover4, Christian Jacome-Galarza5 and Ellen Gravallese6, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women’s Hospital, Boston, MA, 3Brigham and Women's Hospital, Dedham, MA, 4Brigham and Women's Hospital, SWAMPSCOTT, MA, 5Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 6Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: Understanding the pathogenesis of inflammation-induced pathologic bone formation remains a significant challenge in spondyloarthritis patients. We thought to uncover the pivotal events driving the…
  • Abstract Number: 2542 • ACR Convergence 2024

    Group 2 Innate Lymphoid Cells Aggravates Development of Inflammatory Arthritis

    Anders Nguyen1, Miriam Bollmann1, Agnieszka Lastowska2, Anna-Karin Hultgård Ekwall1, Dietmar Zaiss3, Gary Firestein4 and Mattias Svensson5, 1University of Gothenburg, Göteborg, Sweden, 2University of Gothenburg, Goteborg, Sweden, 3University Hospital Regensburg, Regensburg, Germany, 4University of California, San Diego, San Diego, CA, 5University of Gothenburg, Gothenburg, Sweden

    Background/Purpose: Activation of fibroblast-like synoviocytes (FLS) by immune cells drives inflammation and joint damage in rheumatoid arthritis (RA). Hence, understanding factors that induce destructive behaviors…
  • Abstract Number: 0073 • ACR Convergence 2024

    Self or Bacteria-reactive Th17 Expand from Conventional and Regulatory T Cells in Parabacteroides Goldsteinii Gnotobiotic Arthritic SKG Mice, in Context of Interferon-driven Synovial Inflammatory Macrophages and Reduced Bacterial Immune Regulation

    Benjamin Cai1, Zewen Kelvin Tuong2, Mark Morrison1, Anne-Sophie Bergot1 and Ranjeny Thomas3, 1Frazer Institute, University of Queensland, Brisbane, Australia, 2Child Health Research Centre, University of Queensland, South Brisbane, Queensland, Australia, 3University of Queensland, Brisbane, Australia

    Background/Purpose: In ankylosing spondylitis, spondyloarthritis (SpA) is often associated with gut inflammation. The strong genetic association with HLA-B27 and expanded CD8 TCR public clonotypes implicate…
  • Abstract Number: 0927 • ACR Convergence 2024

    Synovial Macrophage Heterogeneity and Dynamics in Steady Stateand Rheumatoid Arthritis Mouse Model Time Course

    Jessica Maciuch1, Yidan Wang2, Tyler Therron3, Harris Perlman1 and Deborah Winter4, 1Northwestern University, Chicago, IL, 2Northwestern University, Hanover Park, IL, 3Northwestern University, Chicago, 4Northwestern University, Skokie, IL

    Background/Purpose: Macrophages are vital contributors to both pro-inflammatory signaling and tissue repair processes involved in the pathogenesis and remission of Rheumatoid Arthritis (RA). Recent research…
  • Abstract Number: 2543 • ACR Convergence 2024

    Novel IgG Degrader BHV-1300 Demonstrates the Ability to Remove Anti-bDMARD ADA and Allows for Co-administration with Fc-containing Biologics

    Elizabeth Dierks1, Anna Bunin1, Peter Ackerman1, Dennis Heller2, Frank Engler2, Gene Dubowchik1, David Spiegel3, Irfan Qureshi1, David Pirman1, Vlad Coric1 and Bruce Car1, 1Biohaven Pharmaceuticals, New Haven, CT, 2Certara, Radnor, PA, 3Yale University School of Medicine, New Haven, CT

    Background/Purpose: BHV-1300 is a molecular degrader of extracellular protein (MoDETM) in development for the treatment of IgG-driven autoimmune diseases, including rheumatoid arthritis. MoDEs are bifunctional…
  • Abstract Number: 0074 • ACR Convergence 2024

    Tofacitinib Therapy Ameliorates Inflammation in a Mouse Model of Psoriasis and Arthritis by Inducing Type 2 Immunity

    Maria de la Luz Garcia-Hernandez1, Javier Rangel-Moreno1, Ananta Paine2, Angel Rangel-Garcia1, Marissa Krantz3, Delaney Martino1, Marc Nuzzo1 and Christopher Ritchlin4, 1University of Rochester, Rochester, NY, 2ORNA Tx, Southborough, MA, 3University of Rochester, Rochester, NY, 4Department of Medicine, Allergy, Immunology, and Rheumatology Division, University of Rochester Medical School, Canandaigua, NY

    Background/Purpose: Psoriatic arthritis (PsA), a chronic progressive inflammatory arthritis, affects peripheral joints and causes patient disability. PsA patients also have skin plaques initiated by activation…
  • Abstract Number: 0935 • ACR Convergence 2024

    Molecular Degraders of Extracellular Protein (MoDEsTM) Rapidly and Effectively Remove Interstitial IgG and Disease-Relevant Immune Complexes Through Endo-lysosomal Degradation in the Liver

    Charlotte Spliid1, Seong Lee1, Kathleen McGrath1, Ana Estrella1, Hanna Yousuf1, Kathren Croce1, Brett Rasile1, Silvina Del Carmen1, Ann Marie Rossi1, Gene Dubowchik1, David Spiegel2, David Pirman1, Anna Bunin1, Vlad Coric1 and Bruce Car1, 1Biohaven Pharmaceuticals, New Haven, CT, 2Yale University School of Medicine, New Haven, CT

    Background/Purpose: Novel extracellular IgG degraders (BHV-1300/-1310) from the innovative molecular degraders of extracellular protein (MoDE) drug platform are being developed for the treatment of IgG-mediated…
  • Abstract Number: 2544 • ACR Convergence 2024

    Spatial Transcriptomics Suggests Synovial Macrophage Niches Are Sexually Dimorphic in a Mouse Inflammatory Arthritis Model

    Richard Bell1, Ruoxi Yuan2, Mary Huang2, Ewurama Cann2, Chao Yang2, Franck Barrat1 and Lionel Ivashkiv1, 1Hospital for Special Surgery, New York, NY, 2HSS, New York, NY

    Background/Purpose: Monocytes and Macrophages (MФ) play a key pathogenic role in Rheumatoid Arthritis (RA), a disease that exhibits female sex bias. Recent work using scRNAseq…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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