Abstracts tagged "Animal Model"

Abstract Number: 0846 • ACR Convergence 2020
MHC Class I Epitopes Derived from Autoantibody Variable Regions, Conjugated to Synthetic Oligodeoxynuleotides, Induce Cytotoxic T Cells That Deplete Autoreactive B Cells and Ameliorate Murine Lupus
Ram Singh¹, ¹UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: B cell depletion or modulation is emerging as a major treatment modality for autoimmune diseases. However, the current treatments to accomplish this non-specifically target…
Abstract Number: 0968 • ACR Convergence 2020
Combined Inhibition of Autophagy and Glutamine Metabolism Suppresses Cell Growth of RA Synoviocytes and Ameliorates Arthritis in SKG Mice
Ikuko Naka¹, Jun Saegusa², Kenichi Uto², Yuzuru Yamamoto³, Yoshihide Ichise⁴, Hirotaka Yamada⁴, Yo Ueda⁵, Takaichi Okano⁴, Soshi Takahashi⁶, Sho Sendo⁷ and Akio Morinobu⁸, ¹Kobe University, Kobe, ²Department of Clinical Laboratory, Kobe University Hospital, Kobe, Japan, ³Kobe University, Kobe-city, Japan, ⁴Kobe University, Kobe, Japan, ⁵Kobe UniversityRheumatology and Clinical Immunology, Kobe University Hospital, Kobe, Japan, ⁶Kobe univerity, Kobe, Japan, ⁷Kobe university, Kobe city, Japan, ⁸Rheumatology and Clinical Immunology, Kobe University Hospital, Kobe, Japan
Background/Purpose: Immunometabolism is now recognaized to be crucial in the pathogenesis of rheumatoid arthritis (RA). We have recently shown that the expression of glutaminase 1…
Abstract Number: 0969 • ACR Convergence 2020
Investigating Murine Joint-Draining Lymphatics: Lineage Tracing and Single Cell RNA Sequencing Reveal Evidence That Popliteal Lymphatic Muscle Cells and Their Progenitors Represent Distinct Cell Types Divergent from Striated and Vascular Muscle Cells
H. Mark Kenney¹, Richard Bell², Elysia Masters¹, Lianping Xing¹, Christopher Ritchlin³ and Edward Schwarz¹, ¹University of Rochester Medical Center, Rochester, ²Hospital for Special Surgery, New York, ³Department of Medicine, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Previous studies demonstrated that tumor necrosis factor transgenic (TNF-Tg) mice with inflammatory arthritis have damaged lymphatic muscle cells (LMCs) and eventual loss of popliteal…
Abstract Number: 0976 • ACR Convergence 2020
Kidney-infiltrating T Cells in Murine Lupus Nephritis Exhibit Transcriptional Heterogeneity and Oligoclonal Expansion
Shuchi Smita¹, Minjung Kim¹, Maria Chikina¹, Mark Shlomchik¹ and Jeremy Tilstra¹, ¹University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Lupus nephritis (LN) is a hallmark of SLE, affecting 50-60% of patients within 10 years of diagnosis. Current treatments for LN have suboptimal response…
Abstract Number: 1221 • ACR Convergence 2020
Evaluation of Methotrexate Efficacy and Exploration of Metabolites Associated with Disease Activity in Collagen-induced Arthritis Mouse Model
Yu Kyoung Cho¹ and Ryan Funk¹, ¹UNIVERSITY OF KANSAS, Kansas City, KS
Background/Purpose: Methotrexate (MTX) is cornerstone of therapy for rheumatoid arthritis. However, response to MTX is variable and unpredictable among patients. Therefore, there is a critical…
Abstract Number: 1410 • ACR Convergence 2020
Resident Memory T Cells Persist in Joints of Anakinra-Treated Mice in Spontaneous Arthritis Model
Anais Levescot¹, Margaret Chang², Alexandra Wactor¹, Rachel Blaustein¹, Nathan Nelson-Maney¹, Robert Fuhlbrigge³ and Peter Nigrovic⁴, ¹Brigham and Women's Hospital, Boston, MA, ²Boston Children's Hospital, Boston, MA, ³University of Colorado, Denver, CO, ⁴Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston
Background/Purpose: Inflammatory arthritis is characterized by chronic inflammation of joints which can be suppressed with immunomodulatory therapy. However, two-thirds of patients will have an arthritis…
Abstract Number: 1447 • ACR Convergence 2020
Vitamin D Deficiency Enhances Antiphospholipid Antibody-Mediated Thrombosis in a Passive Immunization Mouse Model
Rohan Willis¹, Karen Roye-Green², Zurina Romay-Penabad¹, Elizabeth Papalardo¹, Alvaro Schleh³, Vijaya Murthy⁴, Monica Smikle² and Emilio Gonzalez¹, ¹University of Texas Medical Branch, Galveston, TX, ²University of the West Indies, Kingston, Jamaica, ³Antiphospholipid Standardization Laboratory, GALVESTON, TX, ⁴University of Texas Medical Branch, League City, TX
Background/Purpose: Abnormal vitamin D levels occur frequently in antiphospholipid (APS) patients and are correlated with thrombosis. It remains unclear however if vitamin D deficiency observed…
Abstract Number: 0173 • ACR Convergence 2020
mTORC1 Signaling Promotes Monocytosis and Arthritis Development in IL-1 Receptor Antagonist-deficient Mice
Zhengping Huang¹, Ying Li², Alexandra Wactor³, Peter Nigrovic⁴ and Pui Lee⁵, ¹1.Guangdong Second Provincial General Hospital;2.Brigham and Women's Hospital;3.Harvard Medical School, BOSTON, MA, ²1.Brandeis University;2.Brigham and Women's Hospital, Waltham, MA, ³Brigham and Women's Hospital, Boston, MA, ⁴Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston, ⁵1.Boston Children's Hospital;2.Brigham and Women's Hospital;3.Harvard Medical School, Newton, MA
Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is potentially life-threatening disease characterized by prolonged fever, systemic inflammation and skin rash in addition to joint inflammation. Aberrant…
Abstract Number: 1453 • ACR Convergence 2020
A First in Class Therapeutic Nanoparticle for Specific Targeting of Anti-citrullinated Protein Antibody Ameliorates Serum Transfer and Collagen Induced Arthritis
Sangita Khatri¹, Jonas Hansen¹, Mads Clausen¹, Tue Wenzel Kragstrup², Shu-Chen Hung³, Elizabeth Mellins⁴ and Kira Astakhova¹, ¹Technical University of Denmark, Copenhagen, Denmark, ²Aarhus University, Aarhus, Denmark, ³Amgen, Thousand Oaks, ⁴Stanford University, Stanford, CA
Background/Purpose: Rheumatoid arthritis (RA) is an immune mediated inflammatory disease with autoimmune features, including antibodies to citrullinated proteins and peptides (ACPAs). Several in vitro studies…
Abstract Number: 0492 • ACR Convergence 2020
Microbiota-induced Intestinal Barrier Dysfunction Initiates the Shuttling of Immune Cells from the Gut to the Joints
Narges Tajik¹, Michael Frech², Carolin Brandl¹, Juan Cañete³, Francesco Ciccia⁴, Georg Schett⁵ and Mario Zaiss⁶, ¹Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany; 2 Deutsches Zentrum für Immuntherapie (DZI), Erlangen, Germany, ²Department of Internal Medicine 3, Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany; 2 Deutsches Zentrum für Immuntherapie (DZI), Erlangen, ³Departamento de Reumatología, Hospital Clínic de Barcelona e IDIBAPS, Barcelona, Spain, Barcelona, Spain, ⁴Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo, Palermo, Italy, Palermo, Italy, ⁵Friedrich-Alexander-Universität Erlangen- Nuremberg, Erlangen, Germany, ⁶Department of Internal Medicine 3, Friedrich-Alexander University (FAU) Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany
Background/Purpose: While it is known that microbial dysbiosis is associated with the onset of rheumatoid arthritis, mechanistic insights how it facilitates the development of arthritis…
Abstract Number: 1491 • ACR Convergence 2020
Association of a Leaky Gut but Not Microbial Dysbiosis with Obesity-related OA: A Translational Study
Richard Loeser¹, Liubov Arbeeva¹, Kathryn Kelley², Anthony Fodor³, Shan Sun³, Veronica Ulici⁴, Lara Longobardi², Yang Cui², Susan Sumner², Andrea Azcarate-Peril², Balfour Sartor², Ian Carrol² and Amanda Nelson¹, ¹University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ²University of North Carolina, Chapel Hill, NC, ³University of North Carolina-Charlotte, Charlotte, NC, ⁴Brown University, Providence, RI
Background/Purpose: To test the hypothesis that an altered gut microbiota (dysbiosis) plays a causal role in the obese OA phenotype (obesity with both hand and…
Abstract Number: 0709 • ACR Convergence 2020
Anatomical Distribution of Mrgprd-expressing Nonpeptidergic C-fibers in the Mouse Knee
Alia Obeidat¹, Rachel Miller¹ and Anne-Marie Malfait¹, ¹Rush University, CHICAGO, IL
Background/Purpose: The voltage-gated sodium channel, NaV1.8, marks the majority of C-fiber nociceptors. We have used NaV1.8 tdTomato reporter mice to describe the nociceptive innervation of…
Abstract Number: 1519 • ACR Convergence 2020
Interleukin-17D, a Cytokine Derived from Stromal Cells, Attenuates Joint Inflammation
Sijia Chen¹, Catherine Manning², Melissa van Tok³, Yukiko Maeda⁴, Daniel Montoro⁵, Jung-Min Kim⁶, Jeroen den Dunnen³, Nataliya Yeremenko³, Jae-Hyuck Shim⁴, Dominique Baeten⁷ and Ellen Gravallese⁸, ¹Brigham and Women's Hospital, Boston, ²Brigham and Women’s Hospital, Boston, ³Amsterdam University Medical Centers, Amsterdam, Netherlands, ⁴University of Massachusetts Medical School, worcester, MA, ⁵Broad Institute of Massachusetts Institute of Technology and Harvard, Boston, ⁶University of Massachusetts Medical School, Worcester, ⁷UCB Pharma / Amsterdam University Medical Centers, Amsterdam, Netherlands, ⁸Brigham and Women's Hospital, Boston, MA
Background/Purpose: Interleukin(IL)-17D is a little recognized member of the IL-17 family of cytokines. While the activities of IL-17A and IL-17F in the pathogenesis of spondyloarthritis…
Abstract Number: 0739 • ACR Convergence 2020
Toll-like Receptor Inhibitor Peptide Improves the Clinical, Immunologic, and Pathologic Manifestations of Systemic Lupus Erythematosus
Chang-Hee Suh¹, Wook-Young Baek¹, Ji-Won Kim¹, Yang-Seon Choi², Sung-Min Lee¹, In-Ok Son¹, Ki-Woong Jeon¹ and Sangdun Choi², ¹Ajou University School of Medicine, Suwon, Republic of Korea, ²Ajou University, Suwon, Republic of Korea
Background/Purpose: Toll-like receptors (TLRs) are a type of protein that plays a major role in the innate immune system. In recent years, several studies have…
Abstract Number: 1524 • ACR Convergence 2020
Interstitial Lung Disease, Kidney Inflammation and Myositis Are Induced by Transfer of PBMC Derived from Systemic Sclerosis Patients into Rag2-/-/ IL2rg-/- mice
Xiaoyang Yue¹, Frank Petersen¹, Xinhua Yu¹, Gabriela Riemekasten², Peter Lamprecht³, Antje Müller³ and Junping Yin⁴, ¹Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL), Borstel, Germany, ²University of Lübeck, Department of Rheumatology and Clinical Immunology,, Lübeck, Germany, ³University of Lübeck, Department of Rheumatology and Clinical Immunology, Lübeck, Germany, ⁴1 Priority Area Asthma & Allergy, Research Center Borstel, Airway Research Center North (ARCN), Members of the German Center for Lung Research (DZL),, Borstel, Germany
Background/Purpose: To explore the pathogenic potential of lymphocytes in systemic sclerosis (SSc) and granulomatosis with polyangiitis (GPA), a humanized mouse model was generated by transferring…

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