ACR Meeting Abstracts

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Abstracts tagged "Animal Model"

  • Abstract Number: 1507 • ACR Convergence 2021

    Role of CD4+ T Cells in the Pathogenesis of RA: Immunization with Citrullinated T Cell Epitopes Is Sufficient to Induce Immunological and Clinical Manifestations of Arthritis in DR4-Transgenic Mice

    Elena Tonti1, Bhargavi Duvvuri2, Sudeshna Dhar1, Derek Haaland3, Maggie Larche1 and Mark Larché1, 1McMaster University, Hamilton, ON, Canada, 2University of Washington, Seattle, WA, 3McMaster University, Hamilton, Ontario and The Waterside Clinic, Oro Medonte, ON, Canada

    Background/Purpose: Although the etiology of rheumatoid arthritis (RA) remains unclear, existing research suggests a complex interplay of both genetic and environmental factors. Citrullinated proteins/peptides, and…
  • Abstract Number: 1767 • ACR Convergence 2021

    CXCL5 Dampens Inflammation in Murine Lupus by Orchestral Suppression of Effector Cell Proliferation and Leukocyte Extravasation

    Xiubo Fan1, Chin Teck Ng1, Dianyang Guo1, Frances Lim1, Annie Law2, Julian Thumboo1, William Hwang3 and Andrea Low1, 1Singapore General Hospital, Singapore, Singapore, 2Singhealth, Singapore, Singapore, 3National Cancer Centre Singapore, Singapore, Singapore

    Background/Purpose: Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease characterized by dysregulation of both innate and adaptive immunity. Current therapeutic options are limited,…
  • Abstract Number: 1890 • ACR Convergence 2021

    Cellular Origin and Functions of Osteoclasts in Inflammatory Arthritis

    Hannah Nelson1, Ellen Gravallese2, Julia Charles1 and Christian Jacome-Galarza1, 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: Inflammatory arthritis (IA) is an autoimmune disease targeting multiple joints and characterized by joint destruction caused by osteoclasts (OC), leading to physical disability. However,…
  • Abstract Number: 0028 • ACR Convergence 2021

    Evolution of Anti-modified Protein Antibody Responses Can Be Driven by Consecutive Exposure to Different Post-translational Modifications

    Mikhail Volkov, Arieke Kampstra, Karin van Schie, Tom WJ Huizinga, René Toes and Diane van der Woude, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Besides anti-citrullinated protein antibodies (ACPA), rheumatoid arthritis patients (RA) often display autoantibody reactivities against other post-translationally modified (PTM) proteins, more specifically carbamylated and acetylated…
  • Abstract Number: 1892 • ACR Convergence 2021

    Promotion of Autoimmune Arthritis via Tryptophan Metabolism and Production of the Bacterial-Derived Tryptophan Metabolite Indole

    Brandon Trent1, Meagan Chriswell2, Widian Jubair1 and Kristine Kuhn1, 1University of Colorado Anschutz Medical Campus, Aurora, CO, 2UC Denver SOM, Denver, CO

    Background/Purpose: Significant changes in gut bacterial richness and diversity occur during the development of inflammatory arthritis, in both murine models and human patients; however, the…
  • Abstract Number: 0055 • ACR Convergence 2021

    Time Course of Intestinal Permeability and Intestinal Inflammation in Rat Adjuvant-induced Arthritis

    Sophie Hecquet1, Perle Totoson2, Marie-Paule Algros3, Hélène Martin2, Célian Peyronnel2, Maude Tournier2, Clement Prati1, Daniel Wendling1, Céline Demougeot2 and Frank Verhoeven1, 1Service de rhumatologie, CHU de Besançon, Besançon, France, 2PEPITE EA4267, FHU INCREASE, Bourgogne Franche-Comté University, Besançon, France, 3Service d'anatomopathologie, CHU de Besançon, Besançon, France

    Background/Purpose: Intestinal inflammation (I-Inf) and increased intestinal permeability (IP) and intestinal damage (ID) have been observed in patients with spondyloarthritis (SpA). However, whether these changes…
  • Abstract Number: 1928 • ACR Convergence 2021

    In Vitro and In Vivo Evidence for DOCK8 as a Risk Allele for Cytokine Storm Syndrome, Including COVID-19 and MIS-C

    Randy Cron1, Mingce Zhang1, Niansheng Chu2, Devin Absher3, John Bridges1, Amanda Schnell1, Anshul Vagrecha4, Shannon Lozinsky4, Suchitra Acharya4, Carolyn Levy4, Winn Chatham1 and Edward Behrens2, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Pennsylvania, Philadelphia, PA, 3HudsonAlpha Institute for Biotechnology, Huntsville, AL, 4Hofstra/Northwell School of Medicine, Hempstead, NY

    Background/Purpose: Cytokine storm syndromes (CSS) are frequently fatal complications of a variety of oncologic, rheumatic, and infectious diseases. Many patients with CSS possess heterozygous missense…
  • Abstract Number: 0058 • ACR Convergence 2021

    Effect of Anti-inflammatory Drugs on Intestinal Epithelial Damage and Bacterial Translocation in the Adjuvant-induced Arthritis Model

    Sophie Hecquet1, Perle Totoson2, Maude Tournier2, Clement Prati1, Daniel Wendling1, Céline Demougeot2 and Frank Verhoeven1, 1Service de rhumatologie, CHU de Besançon, Besançon, France, 2PEPITE EA4267, FHU INCREASE, Bourgogne Franche-Comté University, Besançon, France

    Background/Purpose: The intestine is no longer considered as an organ targeted by spondyloarthritis (SpA) but also an actor of the disease alongside environmental and immunological…
  • Abstract Number: 0459 • ACR Convergence 2021

    CCN1: An Angiogenic Actor Implicated in the Structural Damages of Rheumatoid Arthritis

    Jerome Avouac1, Alexia Steelandt2, Olivia Amiar2, Agathe Leblond2, Cindy Orvain2, Anne Cauvet2, Virginie Gonzalez2 and Yannick Allanore1, 1Université de Paris, Service de Rhumatologie, Hôpital Cochin, AP-HP.CUP, Paris, France, 2INSERM U1016, Institut Cochin, Paris, France

    Background/Purpose: We have previously shown that decreased expression of the deacetylase sirtuin-1 (SIRT1) contributes to the proliferative, activated and proangiogenic profile of endothelial cells (EC)…
  • Abstract Number: 0976 • ACR Convergence 2020

    Kidney-infiltrating T Cells in Murine Lupus Nephritis Exhibit Transcriptional Heterogeneity and Oligoclonal Expansion

    Shuchi Smita1, Minjung Kim1, Maria Chikina1, Mark Shlomchik1 and Jeremy Tilstra1, 1University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Lupus nephritis (LN) is a hallmark of SLE, affecting 50-60% of patients within 10 years of diagnosis. Current treatments for LN have suboptimal response…
  • Abstract Number: 1221 • ACR Convergence 2020

    Evaluation of Methotrexate Efficacy and Exploration of Metabolites Associated with Disease Activity in Collagen-induced Arthritis Mouse Model

    Yu Kyoung Cho1 and Ryan Funk1, 1UNIVERSITY OF KANSAS, Kansas City, KS

    Background/Purpose: Methotrexate (MTX) is cornerstone of therapy for rheumatoid arthritis. However, response to MTX is variable and unpredictable among patients. Therefore, there is a critical…
  • Abstract Number: 1410 • ACR Convergence 2020

    Resident Memory T Cells Persist in Joints of Anakinra-Treated Mice in Spontaneous Arthritis Model

    Anais Levescot1, Margaret Chang2, Alexandra Wactor1, Rachel Blaustein1, Nathan Nelson-Maney1, Robert Fuhlbrigge3 and Peter Nigrovic4, 1Brigham and Women's Hospital, Boston, MA, 2Boston Children's Hospital, Boston, MA, 3University of Colorado, Denver, CO, 4Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston

    Background/Purpose: Inflammatory arthritis is characterized by chronic inflammation of joints which can be suppressed with immunomodulatory therapy. However, two-thirds of patients will have an arthritis…
  • Abstract Number: 1447 • ACR Convergence 2020

    Vitamin D Deficiency Enhances Antiphospholipid Antibody-Mediated Thrombosis in a Passive Immunization Mouse Model

    Rohan Willis1, Karen Roye-Green2, Zurina Romay-Penabad1, Elizabeth Papalardo1, Alvaro Schleh3, Vijaya Murthy4, Monica Smikle2 and Emilio Gonzalez1, 1University of Texas Medical Branch, Galveston, TX, 2University of the West Indies, Kingston, Jamaica, 3Antiphospholipid Standardization Laboratory, GALVESTON, TX, 4University of Texas Medical Branch, League City, TX

    Background/Purpose: Abnormal vitamin D levels occur frequently in antiphospholipid (APS) patients and are correlated with thrombosis. It remains unclear however if vitamin D deficiency observed…
  • Abstract Number: 0173 • ACR Convergence 2020

    mTORC1 Signaling Promotes Monocytosis and Arthritis Development in IL-1 Receptor Antagonist-deficient Mice

    Zhengping Huang1, Ying Li2, Alexandra Wactor3, Peter Nigrovic4 and Pui Lee5, 11.Guangdong Second Provincial General Hospital;2.Brigham and Women's Hospital;3.Harvard Medical School, BOSTON, MA, 21.Brandeis University;2.Brigham and Women's Hospital, Waltham, MA, 3Brigham and Women's Hospital, Boston, MA, 4Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston, 51.Boston Children's Hospital;2.Brigham and Women's Hospital;3.Harvard Medical School, Newton, MA

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is potentially life-threatening disease characterized by prolonged fever, systemic inflammation and skin rash in addition to joint inflammation. Aberrant…
  • Abstract Number: 1453 • ACR Convergence 2020

    A First in Class Therapeutic Nanoparticle for Specific Targeting of Anti-citrullinated Protein Antibody Ameliorates Serum Transfer and Collagen Induced Arthritis

    Sangita Khatri1, Jonas Hansen1, Mads Clausen1, Tue Wenzel Kragstrup2, Shu-Chen Hung3, Elizabeth Mellins4 and Kira Astakhova1, 1Technical University of Denmark, Copenhagen, Denmark, 2Aarhus University, Aarhus, Denmark, 3Amgen, Thousand Oaks, 4Stanford University, Stanford, CA

    Background/Purpose: Rheumatoid arthritis (RA) is an immune mediated inflammatory disease with autoimmune features, including antibodies to citrullinated proteins and peptides (ACPAs). Several in vitro studies…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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