Abstracts tagged "Angiogenesis and rheumatoid arthritis (RA)"

Abstract Number: 1062 • 2018 ACR/ARHP Annual Meeting
Linking Systemic Angiogenic Markers to Synovial Vascularization in Rheumatoid Arthritis
Agathe Leblond¹, Sonia Pezet¹, Anne priscille Trouvin², Muriel Elhai², Virginie Gonzalez¹, Yannick Allanore³ and Jérôme Avouac², ¹Université Paris Descartes, Sorbonne Paris Cité, INSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France, Paris, France, ²Université Paris Descartes, Sorbonne Paris Cité, Service de Rhumatologie A, Hôpital Cochin, Paris, France, Paris, France, ³Service de Rhumatologie A, Hôpital Cochin, Paris, France
Background/Purpose: Neoangiogenesis is a crucial event to promote the development of the hyperplasic proliferative pathologic synovium in Rheumatoid arthritis (RA). Ultrasound (US) is sensitive for…
Abstract Number: 1066 • 2018 ACR/ARHP Annual Meeting
Tocilizumab Effect on Serum Angiogenic Factors in Rheumatoid Arthritis Patients
Muna Elias¹, Michal Amit Rahat², Joy Feld¹, Itzhak Rosner³, Lisa Kaly⁴, Idit Lavi⁵, Tal Gazitt⁶ and Devy Zisman⁷, ¹Rheumatology Unit Carmel Medical Center, Haifa, Israel, ²Immunotherapy laboratory, Carmel medical center, Haifa, Israel, ³Rheumaoloy Unit, Bnai Zion Medical Center, Haifa, Israel, ⁴Rheumatology unit, Bnai-Zion Medical Center, Haifa, Israel, ⁵Epidemiology Unit Carmel Medical Center, Haifa, Israel, ⁶Rheumatology unit, Carmel medical center, Haifa, Israel, ⁷Rheumatology Unit, Carmel Medical Center, Haifa, Israel
Background/Purpose: Several inducers of angiogenesis have been shown to play a central role in rheumatoid arthritis (RA) pathogenesis: VEGF (Vascular Endothelial Growth Factor), EMMPRIN (Extracellular…
Abstract Number: 2576 • 2016 ACR/ARHP Annual Meeting
uPAR Promotes Tumor-like Biologic Role of Fibroblast-like Synoviocytes through PI3K/Akt Signaling Pathway in Patients with Rheumatoid Arthritis
Yan Liu¹, Yunfeng Pan² and Song Guo Zheng³, ¹Center for Clinic Immunology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Guangzhou, China, ²Rheumatology, third affiliated hospital of Sun Yat-sen Universtiy, Guangzhou, China, ³Medicine/Rheumatology, Penn State Hershey Medical Center, Hershey, PA
Background/Purpose: Urokinase-type plasminogen activator receptor (uPAR), is a multi-functional receptor on cell surface, widely present in endothelial cells, fibroblasts, and a variety of malignant cells.…
Abstract Number: 10 • 2015 ACR/ARHP Annual Meeting
CD13/Aminopeptidase N Contributes to Angiogenesis and Monocyte Chemotaxis in Rheumatoid Arthritis
Rachel Morgan¹, M. Asif Amin¹, Jeffrey Ruth¹, Gautam Edhayan², Stephanie Rasmussen³ and David A. Fox¹, ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Aminopeptidase N (CD13, EC 3.4.11.2) is a metalloproteinase expressed on the surface of fibroblast like synoviocytes (FLS), and as a soluble protein in serum…
Abstract Number: 17 • 2015 ACR/ARHP Annual Meeting
Disentangling the Role of Hypoxia-Inducible Factor 1 and 2 in the Adaption Process of Human Microvascular Endothelial Cells to Pathophysiological Hypoxia
Martin Hahne¹, Peggy Kunath², Mathias Mursell³, Cindy Strehl², Gerd Burmester⁴, Frank Buttgereit² and Timo Gaber², ¹Miltenyi Biotec GmbH, Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ³German Rheumatism Research Center (DRFZ), Berlin, Germany, ⁴Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Angiogenesis is a prominent feature of the pathogenesis of RA. Although new blood vessels deliver oxygen to the augmented inflammatory cell mass, the neovascular…

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