ACR Meeting Abstracts

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Abstracts tagged "Angiogenesis"

  • Abstract Number: 0042 • ACR Convergence 2024

    Modulating Inflammation and Angiogenesis in an Advanced 3D Rheumatoid Arthritis Synovial Tissue Model

    Eva Philippon1, Jan Piet van Hamburg1, Lisanne van Rooijen1, Gary Sims2, Conny Van der Laken3 and Sander Tas4, 1Amsterdam UMC, Amsterdam, Netherlands, 2Immunology Biosciences, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 3Amsterdam UMC - location VUMC, Amsterdam, Netherlands, 4Amsterdam UMC, locatie AMC, Amsterdam, Netherlands

    Background/Purpose: Rheumatoid Arthritis (RA) is a progressive and systemic autoimmune disorder characterized by chronic and destructive joint inflammation. Key features of RA include synovial cell…
  • Abstract Number: 0043 • ACR Convergence 2024

    Inflammatory and Angiogenic Serum Profile of Refractory Rheumatoid Arthritis

    Manon Lesturgie-Talarek1, Virginie Gonzalez2, ALICE COMBIER3, Marion THOMAS4, Margaux Boisson5, Sandrine Carves3, Sarah Wanono3, Lucie Poiroux3, Anne Cauvet1, Sophie Hecquet6, Yannick Allanore7 and Jérôme Avouac8, 1Université de Paris, Institut Cochin, INSERM U1016 CNRS UMR8104, Paris, France, 2Université de Paris, Institut Cochin, INSERM U1016 CNRS UMR8104, Paris, Ile-de-France, France, 3Hôpital Cochin - Université Paris Cité, Paris, France, 4APHP, Paris, France, 5Hôpital Cochin - Université Paris Cité, Paris, 6Cochin Hospital, Paris, France, 7Université Paris Cité, Paris, France, 8Rheumatology A Department, Hôpital Cochin, AP-HP Centre - Université Paris Cité, Paris, France

    Background/Purpose: Despite the emergence of new therapies, a considerable proportion of individuals with rheumatoid arthritis (RA) still endure symptoms, giving rise to the concept of…
  • Abstract Number: 0809 • ACR Convergence 2024

    The Utility of the sFlt1:PlGF Ratio to Rule out and Predict Preeclampsia in Women with Lupus

    Megan Clowse1, Kateena Addae-Konadu2, Jerome Federspiel3, Jennifer Gilner2, Andra James2, Eugene Kovalik2, Anika Lucas3, Laura Neil2, Catherine Sims4, Amanda Snyderman2, Samir Soneji2 and Amanda Eudy5, 1Duke University, Chapel Hill, NC, 2Duke University School of Medicine, Durham, 3Duke University School of Medicine, Durham, NC, 4Duke University, Knightdale, NC, 5Duke University, Raleigh, NC

    Background/Purpose: Women with SLE have high rates of preeclampsia caused by poor placental vascularization. The FDA recently approved the ratio of two angiogenic factors, soluble…
  • Abstract Number: 0880 • ACR Convergence 2024

    Investigating the SRPK-1-VEGF-A Alternative Splicing Pathway AsaTherapeutic Target in Arthritis

    Charles Besidonne1, Andrew Benest1, Kim Chisholm1, Jonathan Morris2, Lucy Donaldson3, Jeanette Woolard4 and David Bates1, 1University of Nottingham, Nottingham, United Kingdom, 2University of New South Wales, New South Wales, New South Wales, Australia, 3Versus Arthritis UK, Nottingham, United Kingdom, 4University of Nottingham, Nottingham, England, United Kingdom

    Background/Purpose: Alternative pre-mRNA splicing of Vascular Endothelial Growth Factor-A (VEGF-A) produces pro-angiogenic (VEGF-Axxxa) or anti-angiogenic (VEGF-Axxxb) isoforms that contribute to angiogenesis in inflammatory arthritis. Isoform…
  • Abstract Number: 0949 • ACR Convergence 2024

    CCN1 Is a Novel Therapeutic Target for Reducing Structural Damage in Rheumatoid Arthritis: Demonstration from 2 Preclinical Models

    Manon Lesturgie-Talarek1, Jérôme Avouac2, Virginie Gonzalez3, Anne Cauvet1, Francoise Tilotta4 and Yannick Allanore5, 1Université de Paris, Institut Cochin, INSERM U1016 CNRS UMR8104, Paris, France, 2Rheumatology A Department, Hôpital Cochin, AP-HP Centre - Université Paris Cité, Paris, France, 3Université de Paris, Institut Cochin, INSERM U1016 CNRS UMR8104, Paris, Ile-de-France, France, 4UFR Odontologie, and Plateforme Imagerie du Vivant, Université Paris Cité, Montrouge, France, 5Université Paris Cité, Paris, France

    Background/Purpose: We have previously shown that the matricellular protein CCN1, characterized by angiogenic and immunomodulatory properties, is overexpressed in endothelial cells and synovial tissue of…
  • Abstract Number: 1272 • ACR Convergence 2024

    Angiopoietin-2 and Soluble Tumor Necrosis Factor Receptor Type II Are Elevated in Treatment Naïve JDM Plasma and Associate with Increased Muscle Disease Activity and Decreased Nailfold Capillary Density

    Sophia Matossian1, Julie Sturza2, Megan Mattichak1, William Brodie1, Christine Goudsmit1, Nicholas McClellan1, J. Michelle Kahlenberg1, Pei-Suen Tsou1 and Jessica Turnier3, 1University of Michigan, Ann Arbor, MI, 2Michigan Medicine Biostatistics and Data Management, Ann Arbor, MI, 3University of Michigan, Saline, MI

    Background/Purpose: Juvenile Dermatomyositis (JDM) is an autoimmune disease characterized by vasculopathy in skin and muscle, where endothelial cell (EC) dysfunction is thought to contribute to…
  • Abstract Number: 2446 • ACR Convergence 2024

    Nailfold Videocapillaroscopy Findings in Patients with Limited Cutaneous versus Diffuse Cutaneous Systemic Sclerosis: The First Detailed Retrospective Study

    Ana Margarida Correia1, Rosanna Campitiello2, Emanuele Gotelli3, Carmen Pizzorni4, Alberto Sulli5, vanessa smith6 and Maurizio Cutolo3, 1Hospital de Braga, Unidade Local de Saúde de Braga, Braga, Portugal, 2Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genova, Liguria, Italy, 3Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genova, Italy, 4Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy, 5Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Genova, Italy, 6Ghent University Hospital, Gent, Belgium

    Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease characterized by microvascular damage, immune system activation and fibrosis. Clinical phenotypes are defined according to skin…
  • Abstract Number: 1745 • ACR Convergence 2023

    Chronic Inflammation and Collagen IV Fragment Canstatin Influence Rheumatoid Arthritis Synovial Fibroblast and Endothelial Cell Interactions in Vitro and in Vivo

    Corinna Heck1, Sophie Haun1, Daria Kürsammer1, Klaus Frommer1, Mona Arnold1, Markus Rickert2, Katrin Susanne Lips3, Stefan Rehart4, Ulf Müller-Ladner1 and Elena Neumann1, 1Justus Liebig University Gießen, Campus Kerckhoff, Bad Nauheim, Germany, 2Dept. of Orthopaedics and Orthopaedic Surgery, University Hospital Giessen and Marburg, Giessen, Germany, 3Justus Liebig University Gießen, Department of Experimental Trauma Surgery, Giessen, Germany, 4Dept. of Orthopaedics and Trauma Surgery, Agaplesion Markus Hospital Frankfurt, Frankfurt, Germany

    Background/Purpose: In the inflamed synovium of RA patients, increased and altered angiogenesis is a pathological feature. Key players are chronically activated RA synovial fibroblasts (RASF),…
  • Abstract Number: 2153 • ACR Convergence 2023

    Effects of One-year Tofacitinib Therapy on Angiogenic Biomarkers in Rheumatoid Arthritis

    György Kerekes1, Monika Czókolyová1, Attila Hamar1, Anita Pusztai1, Gábor Tajti1, Mónika Katkó1, Edit Végh1, Zsófia Pethő1, Nóra Bodnár1, Ágnes Horváth1, Boglárka Soós1, Szilvia Szamosi1, Zsolt Hascsi1, Mariann Harangi1, Katalin Hodosi1, György Panyi1, Tamas Seres2, Gabriella Szücs1 and Zoltán Szekanecz1, 1University of Debrecen, Faculty of Medicine, Debrecen, Hungary, 2University of Colorado Anschutz Medical Campus, Aurora, CO

    Background/Purpose: Cardiovascular (CV) morbidity, mortality and perpetuated synovial angiogenesis have been associated with rheumatoid arthritis (RA). In our study we evaluated angiogenic factors in relation…
  • Abstract Number: 0042 • ACR Convergence 2022

    The Pathogenic Role of Lymphatic Vessels in Autoimmune Valvular Carditis

    Amritha Yellamilli1, Victoria Osinski2, Maria Firulyova3, Jennifer Auger4, Lee Meier2, Jessica Faragher5, Aubyn Marath6, Konstantin Zaitsev3 and Bryce Binstadt5, 1Stanford University School of Medicine, Palo Alto, 2University of Minnesota School of Medicine, Minneapolis, MN, 3ITMO University, Saint Petersburg, Russia, 4University of Minnesota Medical School, Minneapolis, MN, 5University of Minnesota, Minneapolis, MN, 6CardioStart, Portland

    Background/Purpose: Valvular carditis is a serious complication of systemic autoimmune diseases. Although endothelial cells are thought to play an important role in autoimmune valvular carditis,…
  • Abstract Number: 0620 • ACR Convergence 2022

    Neovascularization Is Altered by Rheumatoid Arthritis Synovial Fibroblasts and Canstatin in Vitro and in Vivo

    Corinna Heck1, Daria Kürsammer1, Klaus Frommer2, Mona Arnold3, Stefan Rehart4, Ulf Müller-Ladner5 and Elena Neumann3, 1Justus Liebig University Gießen, Department of Rheumatology and Clinical Immunology, Bad Nauheim, Germany, 2Justus Liebig University Gießen, Department of Rheumatology and Clinical Immunology, Campus Kerckhoff, Bad Nauheim, Germany, 3JLU Gießen, Campus Kerckhoff, Bad Nauheim, Germany, 4Agaplesion Markus Hospital, Dpt of Orthopaedics and Trauma Surgery, Frankfurt, Germany, 5JLU Campus KK, Bad Nauheim, Germany

    Background/Purpose: In the pathogenesis of rheumatoid arthritis (RA), neovascularization is increased in the activated and inflamed synovium. RA synovial fibroblasts (RASF) are key players in…
  • Abstract Number: 1230 • ACR Convergence 2022

    Diabetes Mellitus Nailfold Capillaroscopy Pattern: DM Pattern

    Genessis Maldonado1, Amala Chacko1, Diana Franco1, Lydia Robles1, Deyger Navarrete1, Madalina Ionescu1 and Zineb Aouhab2, 1Loyola MacNeal Hospital, Berwyn, IL, 2Loyola University Medical Center, Maywood, IL

    Background/Purpose: Recent data has shown the presence of nailfold architecture abnormalities in type 2 diabetes mellitus (T2DM), the changes has been associated with uncontrolled disease.…
  • Abstract Number: 0459 • ACR Convergence 2021

    CCN1: An Angiogenic Actor Implicated in the Structural Damages of Rheumatoid Arthritis

    Jerome Avouac1, Alexia Steelandt2, Olivia Amiar2, Agathe Leblond2, Cindy Orvain2, Anne Cauvet2, Virginie Gonzalez2 and Yannick Allanore1, 1Université de Paris, Service de Rhumatologie, Hôpital Cochin, AP-HP.CUP, Paris, France, 2INSERM U1016, Institut Cochin, Paris, France

    Background/Purpose: We have previously shown that decreased expression of the deacetylase sirtuin-1 (SIRT1) contributes to the proliferative, activated and proangiogenic profile of endothelial cells (EC)…
  • Abstract Number: 0512 • ACR Convergence 2021

    Peficitinib and Filgotinib Inhibit Angiogenesis via Suppression of VEGF Production in Rheumatoid Arthritis Fibroblast-like Synoviocytes

    Yuzo Ikari, Takeo Isozaki, Kuninobu Wakabayashi and Tsuyoshi Kasama, Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan

    Background/Purpose: Peficitinib and filgotinib are novel Janus kinase (JAK) inhibitors developed for the treatment of rheumatoid arthritis (RA). Peficitinib inhibits all JAKs, especially JAK3. Filgotinib,…
  • Abstract Number: 0545 • ACR Convergence 2021

    SIRT1 Modulates the Senescent Phenotype in Scleroderma Endothelial Cells

    Ellen Model, Morgan Omara, Pamela Palisoc, Dinesh Khanna and Eliza Pei-Suen Tsou, University of Michigan, Ann Arbor, MI

    Background/Purpose: Vascular abnormalities in systemic sclerosis (SSc) are characterized by injury to vascular wall and extensive damage of the microvessels. It has been shown that…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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