ACR Meeting Abstracts

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Abstracts tagged "ANCA"

  • Abstract Number: 1704 • 2019 ACR/ARP Annual Meeting

    Efficacy of Leflunomide for Treatment of Vasculitis

    NOURA MUSTAPHA 1, Lillian Barra 2, Simon Carette 3, David Cuthbertson 4, Nader A. Khalidi 5, Curry L. Koening 6, Carol Langford 7, Carol McAlear 8, Nataliya Milman 9, Larry Moreland 10, Paul Monach 11, Philip Seo 12, Ulrich Specks 13, Antoine Sreih 14, Steven Ytterberg 13, Peter Merkel 14, Christian Pagnoux15, CanVasc Canadian Vasculitis Research Network 16 and VCRC Vasculitis Clinical Research Consortium 8, 1Hopital Notre Dame, Montreal, QC, Canada, 2St Joseph's health care, London, Canada, 3Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, Canada, 4University of South Florida, Tampa, FL, 5McMaster University, Hamilton, ON, Canada, 6University of Utah Hospital, Salt Lake City, UT, 7Cleveland Clinic, Cleveland, OH, 8University of Pennsylvania, Division of Rheumatology, Philadelphia, 9Arthritis Centre at the Ottawa Hospital, Riverside Campus, Ottawa, Canada, 10University of Pittsburgh, PITTSBURGH, PA, 11Brigham and Women's Hospital, Boston, MA, 12Johns Hopkins Medicine, Baltimore, MD, 13Mayo Clinic College of Medicine, Rochester, MN, 14University of Pennsylvania, Philadelphia, PA, 15Mount Sinai Hospital and University Health Network, Toronto, ON, Canada, 16Mount Sinai Hospital, Vasculitis clinic, toronto, ON, Canada

    Background/Purpose: Only a few small case series, case reports, and one small clinical trial suggested some benefit of leflunomide (LEF) in ANCA-associated vasculitis and other…
  • Abstract Number: 970 • 2019 ACR/ARP Annual Meeting

    New-onset ANCA-associated Vasculitis Is Associated with Significant Phenotypic B Cell Dysfunction

    Emilie Chan1, Susan Hartzell 2, Lisa Anderson 2, Chiara Cantarelli 2, Chiara Guglielmo 2, Ioannis Tassiulas 3, Sofia Andrighetto 2, Andrea Angeletti 4, Joaquin Manrique Escola 5 and Paolo Cravedi 2, 1Mount Sinai Hospital, New York, NY, 2Mount Sinai Hospital, New York, 3Icahn School of Medicine, New York, 4Sant'Orsola-Malpighi Hospital, Bologna, Italy, 5Complejo Hospital de Navarra, Pamplona, Spain

    Background/Purpose: ANCA-associated vasculitis (AAV) is characterized by the production of auto-antibodies and can be treated with rituximab, a B cell-depleting agent. Despite this, limited data…
  • Abstract Number: 1955 • 2019 ACR/ARP Annual Meeting

    Association of TERT and DSP Polymorphisms with Susceptibility to Myeloperoxidase-ANCA-Associated Vasculitis

    Aya Kawasaki1, Natsumi Namba 1, Ken-ei Sada 2, Fumio Hirano 3, Shigeto Kobayashi 4, Hidehiro Yamada 5, Hiroshi Furukawa 6, Kenji Nagasaka 7, Takahiko Sugihara 8, Aika Suzuki 9, Kunihiro Yamagata 10, Takayuki Sumida 11, Shigeto Tohma 12, Sakae Homma 13, Shoichi Ozaki 14, Hiroshi Hashimoto 15, Hirofumi Makino 16, Yoshihiro Arimura 17, Masayoshi Harigai 18 and Naoyuki Tsuchiya 1, 1Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kitaku, Okayama, Japan, 3Department of Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, 4Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan, 5Center for Rheumatic diseases, Seirei Yokohama Hospital, Kawasaki, Japan, 6Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan, 7Department of Rheumatology, Ome Municipal General Hospital, Tokyo, 8Department of Lifetime Clinical Immunology, Tokyo Medical and Dental University, Tokyo, Japan, 9Department of Respiratory Medicine, Toho University Graduate School of Medicine, Tokyo, Japan, 10Department of Nephrology, University of Tsukuba, Tsukuba, Ibaraki, Japan, 11Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 12National Hospital Organization Tokyo National Hospital, Kiyose, Japan, 13Department of Advanced and Integrated Interstitial Lung Diseases Research, School of Medicine, Toho University, Tokyo, Japan, 14St. Marianna University School of Medicine, Kawasaki, Japan, 15Juntendo University School of Medicine, Tokyo, Japan, 16Okayama University, Okayama, Japan, 17Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan, 18Department of Rheumatology, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo, Japan

    Background/Purpose: Epidemiology of ANCA-associated vasculitis (AAV) is substantially different between East Asian and European populations. Microscopic polyangiitis (MPA) and MPO-ANCA positive AAV (MPO-AAV) are prevalent…
  • Abstract Number: 1661 • 2019 ACR/ARP Annual Meeting

    Circulating Cell Free DNA Released from Eosinophils Is a Practical Biomarker in Patients with Eosinophilic Granulomatosis with Polyangiitis

    Teppei Hashimoto1, Yuichi Yokoyama 2, Tetsuya Furukawa 3, Takahiro Yoshikawa 3, Naoto Azuma 2, Kohsuke Yoshida 4, Akira Hashiramoto 4 and Kiyoshi Matsui 3, 1Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Kobe, Hyogo, Japan, 2Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan, 3Division of Rheumatology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan, 4Kobe University Graduate School of Health Sciences, Kobe, Hyogo, Japan

    Background/Purpose: Fragmented cell-free DNA (cfDNA) is released into blood circulation as results of damage or death of peripheral blood cells as well as organ tissues,…
  • Abstract Number: 2621 • 2019 ACR/ARP Annual Meeting

    Association Between Outcome Renal, Clinical Variables and Findings of Renal Biopsy in Patients with ANCA Vasculitis

    Linda Vergel Orduz1, Alejandro Brigante 2, Diego Marino 3, Natalia Perrotta 3, Romina Hassan 4, Gisele Verna 5, Adriana Hamaui 6, Eduardo Kerzberg 7 and Diana Dubinsky 6, 1Sanatorio Guemes, Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina, 2Sanatorio Güemes, Servicio de Medicina Interna – Reumatología, Francisco Acuña de Figueroa 1240, C1180AAD, Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, 3Hospital de Clínicas José de San Martín, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, 4Hospital Ramos Mejía, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, 5Sanatorio Guemes, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, 6Sanatorio Güemes, Buenos Aires, Argentina, 7Hospital Ramos Mejia, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: In associated ANCA vasculitis (AAV), rapidly progressive glomerulonephritis (GN) is one of the most serious complications. In 40% of cases they progress to chronic…
  • Abstract Number: 1662 • 2019 ACR/ARP Annual Meeting

    Does PR3-ANCA+ Eosinophilic Granulomatosis with Polyangiitis (Churg–Strauss)Really Exist?

    Matthias Papo1, Renato A. Sinico 2, Vítor Teixeira 3, Maria-Letizia Urban 4, Juliane Mahrhold 5, Francesco Locatelli 6, Giulia Cassone 7, Franco Schiavon 8, Benjamin Seeliger 9, Thomas Neumann 10, Claus Kroegel 11, Matthieu Groh 12, Chiara Marvisi 13, Maxime Samson 14, Thomas Barba 15, David Jayne 16, Bernhard Hellmich 5, Sara Monti 17, Carlomaurizio Montecucco 6, Carlo Salvarani 18, Jean-Emmanuel Kahn 12, Cécile-Audrey Durel 15, Loic Guillevin 19, Giacomo Emmi 4, Augusto Vaglio 20 and Benjamin Terrier 19, 1Department of Internal Medicine, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, INSERM Unité 1016, Centre de Référence pour les Maladies Auto-immunes Rares, Paris, France, Paris, France, 2Department of Medicine and Surgery, Università degli Studi di Milano - Bicocca , Italy, Milan, Italy, 3Rheumatology and Bone Diseases Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte; Lisbon, Portugal., Lisbon, Portugal, 4Department of Experimental and Clinical Medicine, University of Firenze, Florence, Italy, Florence, Italy, 5Department of Internal Medicine, Rheumatology and Immunology, Vasculitis-Center Tübingen-Kirchheim, Medius Klinik Kirchheim, University of Tübingen, Kirchheim-Teck, Germany, Kirchheim, Germany, 6Department of Rheumatology, IRCCS Policlinico S. Matteo Foundation, University of Pavia, Pavia, Italy, Pavia, Italy, 7Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy. Rheumatology Unit, IRCCS Arcispedale Santa Maria Nuova, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy, Modena and Reggio Emilia, Italy, 8Operative Unit of Rheumatology, Department of Medicine DIMED, University of Padova, Padova, Italy, Padova, Italy, 9Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany, Hannover, Germany, 10Division of Rheumatology and Immunolog, Kantonsspital St. Gallen, St. Gallen, Sankt Gallen, Switzerland, 11Department of Pneumology and Allergology, Clinic of Internal Medicine I, Jena University Hospital, Jena, Germany, Jena, Germany, 12Service de Médecine Interne, Centre de Référence des Syndromes Hyperéosinophiliques-CEREO, Hôpital Foch, Université Versailles–Saint-Quentin-en-Yvelines, Suresnes, France, Suresnes, France, 13Nephrology Unit, Parma University Hospital, Parma, Italy, Parma, Italy, 14CHU Dijon, Dijon, France, 15Department of Internal Medicine, Hôpital Edouard Herriot, Lyon, France, Lyon, France, 16Vasculitis and Lupus Clinic, Addenbrooke’s Hospital, University of Cambridge, UK, Cambridge, United Kingdom, 17University of Pavia, Pavia, Italy, 18Division of Rheumatology, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy, 19National Referral Center for Rare Systemic Autoimmune Diseases Paris Cochin, Paris, France, 20Nephrology Unit, Parma University Hospital, Parma, Italy, Nephrology Unit, Parma University Hospital, Parma, Italy, Italy

    Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) (Churg–Strauss) is a small-vessel necrotizing vasculitis characterized by blood and tissue eosinophilia and asthma. Only a third of EGPA…
  • Abstract Number: 2625 • 2019 ACR/ARP Annual Meeting

    Predictors of Advanced Chronic Kidney Disease in Patients with ANCA Vasculitis and Renal Involvement

    Gelsomina Alle1, John Jaramillo Gallego 2, Marina Scolnik 3, Valeria Scaglioni 2, Martin Brom 4, Carlos Varela 5, Gustavo Greloni 5 and Enrique Soriano 6, 1Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina, Ciudad Autónoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, 2Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina, Ciudad Autónoma de Buenos Aires, Argentina, 3Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, 4Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina, Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, 5Nephrology Service, Hospital Italiano de Buenos Aires, Argentina, Ciudad Autónoma de Buenos Aires, Argentina, 6Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina., Buenos Aires, Buenos Aires, Argentina

    Background/Purpose: The aim of this study was to evaluate the predictors of advanced chronic kidney disease (ACKD) in patients with Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis…
  • Abstract Number: 1664 • 2019 ACR/ARP Annual Meeting

    Reducing the Number of Rituximab Infusions at Onset of Maintenance Therapy for ANCA-associated Vasculitides: Results of a Post Hoc Analysis from a Randomized–controlled Trial

    Pierre Charles1, Agnes Dechartres 2, Benjamin Terrier 3, Pascal Cohen 3, Stanislas Faguer 4, Antoine Huart 4, Mohamed Hamidou 5, Christian Agard 5, Bernard Bonnotte 6, Maxime Samson 7, Alexandre Karras 8, Noémie Jourde-Chiche 9, François Lifermann 10, Pierre Gobert 11, Catherine Hanrotel-Saliou 12, Pascal Godmer 13, Nicolas Martin-Silva 14, Grégory Pugnet 15, Marie Matignon 16, Olivier Aumaitre 17, Jean-François Viallard 18, François Maurier 19, Nadine Meaux Ruault 20, Sophie Rivière 21, Jean Sibilia 22, Xavier Puéchal for the French Vasculitis Study Group 3, Luc Mouthon 3 and Loic Guillevin 3, 1Institut Mutualiste Montsouris, Paris, France, 2APHP, Paris, France, 3National Referral Center for Rare Systemic Autoimmune Diseases Paris Cochin, Paris, France, 4CHU Toulouse, Toulouse, France, 5CHU Nantes, Nantes, France, 6Service de Médecine Interne et Immunologie Clinique, CHU Dijon Bourgogne, Hôpital François Mitterrand, Dijon ; Université Bourgogne-Franche Comté, INSERM, EFS BFC, UMR1098, F-21000 Dijon, Dijon, France, 7CHU Dijon, Dijon, France, 8Paris HEGP, Paris, France, 9APHM, Marseille, Marseille, France, 10CH Dax, Dax, France, 11CH Avignon, Avignon, France, 12CHU Brest, Brest, France, 13CH Bretagne-Atlantique, Vannes, France, 14CHU Caen, Caen, France, 15CHU de Toulouse, Hôpital Purpan, Service de Médecine Interne, Toulouse, France, 16APHP, Créteil, France, 17CHU Clermont Ferrand, Clermont Ferrand, France, 18CHU Bordeaux, Bordeaux, France, 19Service de Médecine Interne, Hôpital Belle Isle, Metz, Metz, France, 20CHU Besançon, Besançon, France, 21CHU Montpellier, Montpellier, France, 22CHU Strasbourg, Strasbourg, France

    Background/Purpose: Rituximab (RTX) superiority over azathioprine to maintain ANCA-associated vasculitis (AAV) remission was demonstrated.The MAINRITSAN2 trial was designed to compare an individually tailored RTX-infusion schedule…
  • Abstract Number: 2627 • 2019 ACR/ARP Annual Meeting

    Association of Work Productivity Assessed by Absenteeism and Presenteeism with Disease Activity, Damage and Health-related Quality of Life in Patients with ANCA-associated Vasculitis

    Shinya Hirahara1, Yasuhiro Katsumata 1, Ken-ei Sada 2, Hiroko Nagafuchi 3, Eiichi Tanaka 1 and Masayoshi Harigai 1, 1Department of Rheumatology, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo, Japan, 2Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kitaku, Okayama, Japan, 3Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki City, Kanagawa, Japan

    Background/Purpose: Chronic inflammatory diseases such as antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) substantially affects patients’ daily lives, including their ability to work. Although the management…
  • Abstract Number: 1665 • 2019 ACR/ARP Annual Meeting

    Glucocorticoids in Incident ANCA-Associated Vasculitis (AAV) Patients – A Study of Routine Clinical Practice in the EU Demonstrates Prolonged Use and Temporal Relationship to Adverse Events and Infections

    Dieter Goette1 and Peter Rutherford 1, 1Vifor Pharma, Zurich, Zurich, Switzerland

    Background/Purpose: AAV is a severe systemic vasculitis and rapid induction of remission is essential and  high dose glucocorticoids (GC) are part of standard of care.…
  • Abstract Number: 2628 • 2019 ACR/ARP Annual Meeting

    Mortality Predictors in ANCA-associated Vasculitis: Experience of a Brazilian Monocentric Cohort of a Rheumatology Center

    Marilia Dagostin1, Sergio Nunes 2, Samuel Shinjo 3 and Rosa Pereira 4, 1University of Sao Paulo, São Paulo, Brazil, 2Univeristy Of Sao Paulo, São Paulo, 3Univeristy Of Sao Paulo, São Paulo, Brazil, 4Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, Sao Paulo, Brazil

    Background/Purpose: Mortality of patients with ANCA-associated vasculitis (AAV) is higher than the general population. There are few papers in the literature regarding the factors associated…
  • Abstract Number: 1666 • 2019 ACR/ARP Annual Meeting

    Maintenance Treatment in ANCA Associated Vasculitis in Real World Clinical Practice – Burden of Disease, Use of Glucocorticoids and Impact on Patient Functional Status Remain Major Problems

    Dieter Goette1 and Peter Rutherford 1, 1Vifor Pharma, Zurich, Zurich, Switzerland

    Background/Purpose: After successful remission induction AAV is a relapsing remitting long term condition and patients are at risk of organ damage from both active AAV…
  • Abstract Number: 2629 • 2019 ACR/ARP Annual Meeting

    Urinary Inflammatory Cell Analysis Reflects the Renal Histopathology in Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis

    Yoko Wada1, Masanori Sudo 2, Takeshi Kuroda 3, Masaaki Nakano 4 and Ichiei Narita 2, 1Niigata Rinko Hospital, Niigata, Niigata, Japan, 2Division of Clinical Nephrology and Rheumatology, Niigata University, Niigata, Niigata, Japan, 3Health administration office, Niigata University, Niigata, Niigata, Japan, 4School of Health Sciences, Faculty of Medicine, Niigata University, Niigata, Niigata, Japan

    Background/Purpose: The anti-neutrophil cytoplasmic autoantibody (ANCA)- associated vasculitides (AAVs) include microscopic polyangiitis (MPA), granulomatosis with polyangitis (GPA), and eosinophilic granulomatosis with polyangitis (EGPA). These small-vessel…
  • Abstract Number: 1669 • 2019 ACR/ARP Annual Meeting

    Comparison of Mizoribine with Azathioprine in Efficacy and Safety for ANCA-Associated Vasculitis

    Sho Fukui 1, Satoshi Kawaai1, Genki Kidoguchi 1, Takehiro Nakai 2, Hiroki Ozawa 1, Ayako Koido 1, Yukihiko Ikeda 1, Masei Suda 1, Haruyuki Yanaoka 1, Hisanori Shimizu 1, Hiromichi Tamaki 1, Tokutaro Tsuda 1, Mitsumasa Kishimoto 3, Kenichi Yamaguchi 1 and Masato Okada 1, 1St.Luke International Hospital Immuno-Rheumatology Center, Tokyo, Japan, 2St.Luke International Hospital Immuno-Rheumatology Center, Tokyo, Tokyo, Japan, 3Immuno-Rheumatology Center, St. Luke’s International Hospital, Tokyo, Japan

    Background/Purpose: Mizoribine (MZR) is an immunosuppressant working as an inhibitor of purine synthesis, which mechanism of action is similar to mycophenolate mofetil. MZR is approved…
  • Abstract Number: 2630 • 2019 ACR/ARP Annual Meeting

    A Dutch Consensus Statement on the Diagnosis and Treatment of ANCA Associated Vasculitis

    Ebru Dirikgil1, Peter Verhoeven 2, Sander Tas 3, Abraham Rutgers 4, Hein Bernelot Moens 5, Jacob van Laar 6, Willem Jan Bos 7 and Onno Teng 1, 1LUMC, Leiden, Netherlands, 2The Dutch Vasculitis Foundation, Silvolde, Netherlands, 3Amsterdam Rheumatology & immunology Center, Amsterdam UMC/University of Amsterdam, Amsterdam, Netherlands, 4University Medical Center Groningen, Groningen, Netherlands, 5Ziekenhuisgroep Twente, Almelo, Netherlands, 6UMC Utrecht, Department of Rheumatology & Clinical Immunology, Utrecht, The Netherlands, Utrecht, Netherlands, 7St. Antoniusziekenhuis, Nieuwegein, Netherlands

    Background/Purpose: Several guidelines have been published on the diagnosis and treatment of anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis (AAV). These guidelines provide an evidence-based approach…
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