ACR Meeting Abstracts

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Abstracts tagged "ANCA"

  • Abstract Number: 1085 • ACR Convergence 2022

    Safety of Plasmapheresis as an Adjuvant Therapy in Severe Pediatric Anti-neutrophil Cytoplasmic Antibody Associated Vasculitis: A Single Center Cohort

    Sharanya Joginpalli1, Alvaro Orjuela2, Marietta De Guzman3 and Emily Frierson2, 1Baylor College of Medicine- Texas Children's Hospital, Houston, TX, 2Baylor College of Medicine, Texas Children's Hospital, Houston, TX, 3Baylor College of Medicine/ Texas Children's Hospital, Houston, TX

    Background/Purpose: Therapeutic plasma exchange (TPE) is used in anti-neutrophil cytoplasmic antibody associated vasculitis (AAV) as adjunct treatment for severe disease. There is paucity of data…
  • Abstract Number: 1086 • ACR Convergence 2022

    Characteristics and Outcomes of Patients with ANCA Associated Vasculitis Treated with Plasma Exchange: An Analysis of the National Inpatient Sample Database

    Vinit Gilvaz1, Akil Sherif2, Sonu Abraham3, Anu Saji2 and Anthony Reginato4, 1Brown University, East Providence, RI, 2Saint Vincent Hospital, Worcester, MA, 3Lahey Medical Center, Burlington, MA, 4Brown University, Providence, RI

    Background/Purpose: Plasma exchange (PLEX) has been used in the management of patients with severe anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) for decades. The most recent…
  • Abstract Number: 1089 • ACR Convergence 2022

    Prognostic Value of Proteinuria Monitoring in Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis

    Yeo jin lee1, Soo Min Ahn2, Ji Seon Oh3, Yong Gil Kim2, Chang Keun Lee2, Bin Yoo2 and Seokchan Hong2, 1Asan medical center, Seoul, Republic of Korea, 2Department of Rheumatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea, Seoul, Republic of Korea, 3Department of Information Medicine, Big Data Research Center, Asan Medical Center, Seoul, Republic of Korea

    Background/Purpose: Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is an autoimmune disease that can involve various organs systematically. Kidney involvement, one of the major manifestations of AAV,…
  • Abstract Number: 0436 • ACR Convergence 2022

    Clinical Characteristics and Outcome of ANCA-Associated Vasculitides Induced by Anti-Thyroid Drugs: A Multicenter Retrospective Cohort Study

    Julien Culerrier1, Yann Nguyen2, Omer Karadag3, Sule Yasar Bilge4, Tuba DEMIRCI YILDIRIM5, Tahir Saygin Öğüt6, Veli Yazisiz6, Cemal Bes7, Ayse Cefle8, Oznur Sadioglu Cagdas9, Ayten Yazici8, Andreas Kronbichler10, David Jayne10, Alexis Regent11, Vitor Teixeira12, Sylvain Marchand-Adam13, PIerre Duffau14, Saskia Oro15, Baptiste Andre16, Luminita Luca17, Sarah Lechtman18, Achille Aouba19, Celine Lebas20, Amélie Servettaz21, Amandine Dernoncourt22, Marc Ruivard23, Anne-Marie Milesi24, Vincent Poindron25, Patrick Jego26, Roberto Padoan27, Paolo Delvino28, Frédéric Vandergheynst29, Christian Pagnoux30, Elaine Yacyshyn31, Peter Lamprecht32, Oliver Flossmann33, Xavier Puéchal11 and Benjamin Terrier11, 1Université Paris Cité, Paris, France, Paris, France, 2AP-HP.Centre Universit Paris Cit Hôpital Cochin, Montmorency, France, 3Hacettepe University, Ankara, Turkey, 4Eskişehir Osmangazi Üniversity, Eskisehir, Turkey, 5Dokuz Eylul University, İzmir, Turkey, 6Akdeniz University, Antalya, Turkey, 7Bahçeşehi University, Istanbul, Turkey, 8Kocaeli University School of Medicine Division of Rheumatology, Kocaeli, Turkey, 9Kocaeli University, Kocaeli, Turkey, 10University of Cambridge, Cambridge, United Kingdom, 11National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, 12Hospital de Faro, CHUA, Lisbon, Portugal, 13Tours University Hospital, Tours, France, 14CHU Bordeaux, Bordeaux, France, 15Assistance Publique - Hôpitaux de Paris., Paris, France, 16Hôpital de la Timone, Marseille, Marseille, France, 17CHU de Poitiers, Poitiers, France, 18CHU Nice, Nice, France, 19Department of Internal Medicine, UR4650 PSIR, Normandie Univ, UNICAEN, CHU de Caen Normandie, Caen, France, 20CHRU Lille, Lille, France, 21CHU Reims, Reims, France, 22CHU Amiens - Picardie, Amiens, France, 23Clermont Ferrand University Hospital, Clermont-Ferrand, France, 24Centre hospitalier de Vichy, Vichy, France, 25Immunologie clinique et médecine interne, Hôpitaux universitaires de Strasbourg, Strasbourg, France, 26CHU Rennes, Paris, France, 27University of Padova, Padova, Italy, 28Università di Pavia, Vercelli, Italy, 29Professeur de Médecine Interne et Sémiologie médicale, Directeur de la Clinique de Médecine Interne Générale, Université Libre de Bruxelles, Bruxelles, France, 30Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, 31University of Alberta, Edmonton, AB, Canada, 32Department of Rheumatology University of Lübeck Ratzeburger Allee, Lübeck, Germany, 33Royal Berkshire Hospital, Reading, United Kingdom

    Background/Purpose: ANCA-associated vasculitides (AAV) induced by anti-thyroid drugs (ATD) is a well-known entity. However, characteristics, requirement for immunosuppressive agents and the risk of relapse remain…
  • Abstract Number: 1573 • ACR Convergence 2022

    Von – Willebrand Factor, a Possible Marker for Disease Activity in Vasculitis

    Jomana mazareeb1, shiri keret1, Abid Awisat1, Itzhak Rosner2, Michel Rozenbaum3, Lisa Kaly1, Gleb Slobodin1 and Doron Rimar1, 1Bnai Zion Medical Center, Haifa, Israel, 2Bnai Zion Medical Center/Technion, Haifa, Israel, 3Bnei Zion Medical Center, Hertzeliya, Israel

    Background/Purpose: Vasculitis is an inflammation of blood vessels. While in many cases markers of inflammation as c- reactive protein (CRP) or erythrocytes sedimentation rate (ESR)…
  • Abstract Number: 0438 • ACR Convergence 2022

    Characterization of Interstitial Lung Disease in the Presence of Antineutrophil Cytoplasmic Antibodies

    Khai-Tuan Andrew Bui1, Rachel Richard2, Ariane Drouin3, Nader Toban1, Marianne Levesque4, Rosalie-Selene Meunier5, Carolyn Ross6 and Jean-Paul Makhzoum3, 1Department of Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Montréal, QC, Canada, 2Department of Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Laval, QC, Canada, 3Vasculitis Clinic, Canadian Network for Research on Vasculitides (CanVasc), Department of Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Montréal, QC, Canada, 4Division of Respirology, Department of Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Montréal, QC, Canada, 5Hopital Sacre-Coeur, Universite de Montreal, Montréal, QC, Canada, 6University of Montreal, Montréal, QC, Canada

    Background/Purpose: Various pulmonary manifestations may occur in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). ANCA-related interstitial lung disease (ILD) has recently been described in…
  • Abstract Number: 1688 • ACR Convergence 2022

    Biomechanical Phenotype of Circulating Neutrophils Is Altered in ANCA Associated Vasculitis

    Noelle Pisacano1, Stephen P. McAdoo1, Jochen Guck2, Charles D. Pusey1, Edwin R. Chilvers1, Andrew S. Cowburn1, Katharine M. Lodge1 and Maria F. Prendecki1, 1Imperial College London, London, United Kingdom, 2Max Planck Institute, Erlangen, Germany

    Background/Purpose: Real Time-Deformability Cytometry (RT-DC) is a novel technique able to identify morpho-rheological characteristics of individual cells such as size, deformability, and elasticity using only…
  • Abstract Number: 0439 • ACR Convergence 2022

    Clinical Characteristics of Patients with ANCA-Associated Vasculitis with and Without Alpha-1 Antitrypsin Deficiency Alleles

    Lynn Fussner1, David Cuthbertson2, Peter Grayson3, David Jayne4, Carol McAlear5, Michael Walsh6, Katherine Siminovitch7, Ulrich Specks8 and Peter Merkel9, 1The Ohio State University, Columbus, OH, 2University of South Florida, Tampa, FL, 3National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 4University of Cambridge, Cambridge, United Kingdom, 5Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, PA, 6McMaster University, Hamilton, ON, Canada, 7University of Toronto, Toronto, ON, Canada, 8Mayo Clinic, Rochester, MN, 9University of Pennsylvania, Philadelphia, PA

    Background/Purpose: There are multiple reasons to suspect that alpha-1 antitrypsin (A1AT) genotype impacts disease characteristics in ANCA-associated vasculitis (AAV). A1AT serves as the predominant endogenous…
  • Abstract Number: 1928 • ACR Convergence 2022

    Idiopathic Pulmonary Capillaritis Within the Spectrum of Pediatric Diffuse Alveolar Hemorrhage

    Angela Chun1, Tiphanie vogel1, Andrea Ramirez1, Marietta De Guzman2, Eyal Muscal1 and Manuel Silva-Carmona3, 1Baylor College of Medicine, Houston, TX, 2Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, 3Baylor College of Medicine, Texas Children's Hospital, Houston, TX

    Background/Purpose: Diffuse alveolar hemorrhage (DAH) is a life-threatening syndrome with bleeding from the pulmonary microvasculature. It is classified as pulmonary capillaritis if histology shows neutrophilic…
  • Abstract Number: 0442 • ACR Convergence 2022

    Induction Therapy Patterns for Severe ANCA-associated Vasculitis Differ Based on Physician Specialty, Expertise, and Practice Setting: An International Survey

    Lilian Xu1, Faten Aqeel1, Ojaswi Tomar2, Tingting Li2 and Duvuru Geetha1, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Washington University in St. Louis School of Medicine, St. Louis, MO

    Background/Purpose: Therapies for ANCA-associated vasculitis (AAV) have evolved over the last 3 decades. In light of new data on plasma exchange (PLEX) and glucocorticoid (GC)…
  • Abstract Number: 1948 • ACR Convergence 2022

    Clinical Characteristics and Outcomes of Pediatric ANCA-Associated Vasculitis Patients: Single-Center Inception Cohort

    Hyun Ho Lee1, Lauren Blazek2 and Eveline Wu3, 1The University of North Carolina Chapel Hill, Chapel Hill, NC, 2UNC Kidney Center, The University of North Carolina Chapel Hill, Chapel Hill, NC, 3University of North Carolina, Chapel Hill, NC

    Background/Purpose: ANCA associated vasculitis (AAV) is a chronic autoimmune disorder characterized by ANCA production and small vessel inflammation and necrosis. ANCA autoantigen targets include myeloperoxidase…
  • Abstract Number: 0443 • ACR Convergence 2022

    Prognosis of Non-PR3 ANCA-Associated Vasculitis with Glomerulonephritis

    Aurélien Chepy1, Hélène Béhal2, Alexandre Karras3, Xavier Puéchal4, Benjamin Terrier4, David Jayne5, Thomas Quéméneur6 and Mary-Jane Guerry7, 1CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Auto-immunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), Lille, France, 2University of Lille, CHU Lille, ULR 2694 - METRICS: Évaluation des Technologies de Santé et des Pratiques Médicales, Lille, France, 3HEGP, Paris, France, 4National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, 5University of Cambridge, Cambridge, United Kingdom, 6Valenciennes Hospital, Valenciennes, France, 7Department of Nephrology, Centre Hospitalier de Valenciennes, Valenciennes., Valenciennes, France

    Background/Purpose: Immunosuppressive treatments have improved the prognosis of anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV), transforming these formerly fatal diseases into chronic conditions, with periods of…
  • Abstract Number: 0450 • ACR Convergence 2022

    Incidence of Solid and Hematologic Tumors in Patients with ANCA: A 10-year Retrospective Cohort Study

    Enrico Brunetta1, Giacomo Ramponi2, marco folci2, Maria De Santis3, Giacomo Maria Guidelli1, Angela Ceribelli4, Nicoletta Luciano1, Marta Caprioli5, Arianna Sonaglia1 and Carlo Selmi6, 1IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Rozzano, Italy, 2IRCCS Humanitas Research Hospital, Internal Medicine, Rozzano, Italy, 3Humanitas University, IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Pieve Emanuele, Italy, 4Humanitas Research Hospital, Humanitas University, Rozzano (MI) Italy, Borgo San Giacomo, Italy, 5IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Pavia, Italy, 6IRCCS Humanitas Research Hospital, Humanitas University, Rozzano (MI), Italy, Rozzano, Italy

    Background/Purpose: Serum antineutrophil cytoplasmic antibodies (ANCA) are significantly associated with the development of ANCA-associated vasculitides (AAV) but may also be detected in patients with other…
  • Abstract Number: 0457 • ACR Convergence 2022

    A Systematic Literature Review Informing the 2022 Update of the EULAR Recommendations for the Management of ANCA-associated Vasculitis

    Jan Schirmer1, Beatriz Sanchez-Alamo2, Sara Monti3, Bernhard Hellmich4, David Jayne5 and Gunnar Tomasson6, 1University Medical Center Schleswig-Holstein, Kiel, Germany, 2Lund University, Skåne University Hospital, Lund, Sweden, 3Rheumatology, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy, 4Medius Kliniken, University of Tübingen, Kirchheim Teck, Germany, 5University of Cambridge, Cambridge, United Kingdom, 6Centre for Rheumatology Research, University Hospital Reykjavik, Reykjavik, Iceland

    Background/Purpose: Since the publication of the 2016 European Alliance of Associations for Rheumatology (EULAR) recommendations for the management of ANCA-associated vasculitis (AAV), the publication of…
  • Abstract Number: 0418 • ACR Convergence 2021

    Longitudinal Patterns of Renal Function in ANCA-Associated Vasculitis

    Jennifer Hanberg1, Xiaoqing Fu1, Claire Cook2, John Stone3, Hyon K. Choi4 and Zachary Wallace5, 1Massachusetts General Hospital, Boston, MA, 2Division of Rheumatology, Allergy, and Immunology, Mass General Hospital, Boston, MA, 3Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, 4Massachusetts General Hospital, Lexington, MA, 5Massachusetts General Hospital, Newton, MA

    Background/Purpose: Renal involvement is common in ANCA-associated vasculitis (AAV). Prior analyses show that end stage renal disease (ESRD) in AAV may be multifactorial. Little is…
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