ACR Meeting Abstracts

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Abstracts tagged "ANCA"

  • Abstract Number: 1573 • ACR Convergence 2022

    Von – Willebrand Factor, a Possible Marker for Disease Activity in Vasculitis

    Jomana mazareeb1, shiri keret1, Abid Awisat1, Itzhak Rosner2, Michel Rozenbaum3, Lisa Kaly1, Gleb Slobodin1 and Doron Rimar1, 1Bnai Zion Medical Center, Haifa, Israel, 2Bnai Zion Medical Center/Technion, Haifa, Israel, 3Bnei Zion Medical Center, Hertzeliya, Israel

    Background/Purpose: Vasculitis is an inflammation of blood vessels. While in many cases markers of inflammation as c- reactive protein (CRP) or erythrocytes sedimentation rate (ESR)…
  • Abstract Number: 0438 • ACR Convergence 2022

    Characterization of Interstitial Lung Disease in the Presence of Antineutrophil Cytoplasmic Antibodies

    Khai-Tuan Andrew Bui1, Rachel Richard2, Ariane Drouin3, Nader Toban1, Marianne Levesque4, Rosalie-Selene Meunier5, Carolyn Ross6 and Jean-Paul Makhzoum3, 1Department of Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Montréal, QC, Canada, 2Department of Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Laval, QC, Canada, 3Vasculitis Clinic, Canadian Network for Research on Vasculitides (CanVasc), Department of Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Montréal, QC, Canada, 4Division of Respirology, Department of Medicine, Hopital du Sacre-Coeur de Montreal, University of Montreal, Montréal, QC, Canada, 5Hopital Sacre-Coeur, Universite de Montreal, Montréal, QC, Canada, 6University of Montreal, Montréal, QC, Canada

    Background/Purpose: Various pulmonary manifestations may occur in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). ANCA-related interstitial lung disease (ILD) has recently been described in…
  • Abstract Number: 1688 • ACR Convergence 2022

    Biomechanical Phenotype of Circulating Neutrophils Is Altered in ANCA Associated Vasculitis

    Noelle Pisacano1, Stephen P. McAdoo1, Jochen Guck2, Charles D. Pusey1, Edwin R. Chilvers1, Andrew S. Cowburn1, Katharine M. Lodge1 and Maria F. Prendecki1, 1Imperial College London, London, United Kingdom, 2Max Planck Institute, Erlangen, Germany

    Background/Purpose: Real Time-Deformability Cytometry (RT-DC) is a novel technique able to identify morpho-rheological characteristics of individual cells such as size, deformability, and elasticity using only…
  • Abstract Number: 0439 • ACR Convergence 2022

    Clinical Characteristics of Patients with ANCA-Associated Vasculitis with and Without Alpha-1 Antitrypsin Deficiency Alleles

    Lynn Fussner1, David Cuthbertson2, Peter Grayson3, David Jayne4, Carol McAlear5, Michael Walsh6, Katherine Siminovitch7, Ulrich Specks8 and Peter Merkel9, 1The Ohio State University, Columbus, OH, 2University of South Florida, Tampa, FL, 3National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, 4University of Cambridge, Cambridge, United Kingdom, 5Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA, Philadelphia, PA, 6McMaster University, Hamilton, ON, Canada, 7University of Toronto, Toronto, ON, Canada, 8Mayo Clinic, Rochester, MN, 9University of Pennsylvania, Philadelphia, PA

    Background/Purpose: There are multiple reasons to suspect that alpha-1 antitrypsin (A1AT) genotype impacts disease characteristics in ANCA-associated vasculitis (AAV). A1AT serves as the predominant endogenous…
  • Abstract Number: 1928 • ACR Convergence 2022

    Idiopathic Pulmonary Capillaritis Within the Spectrum of Pediatric Diffuse Alveolar Hemorrhage

    Angela Chun1, Tiphanie vogel1, Andrea Ramirez1, Marietta De Guzman2, Eyal Muscal1 and Manuel Silva-Carmona3, 1Baylor College of Medicine, Houston, TX, 2Baylor College of Medicine/ Texas Children's Hospital, Houston, TX, 3Baylor College of Medicine, Texas Children's Hospital, Houston, TX

    Background/Purpose: Diffuse alveolar hemorrhage (DAH) is a life-threatening syndrome with bleeding from the pulmonary microvasculature. It is classified as pulmonary capillaritis if histology shows neutrophilic…
  • Abstract Number: 0442 • ACR Convergence 2022

    Induction Therapy Patterns for Severe ANCA-associated Vasculitis Differ Based on Physician Specialty, Expertise, and Practice Setting: An International Survey

    Lilian Xu1, Faten Aqeel1, Ojaswi Tomar2, Tingting Li2 and Duvuru Geetha1, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Washington University in St. Louis School of Medicine, St. Louis, MO

    Background/Purpose: Therapies for ANCA-associated vasculitis (AAV) have evolved over the last 3 decades. In light of new data on plasma exchange (PLEX) and glucocorticoid (GC)…
  • Abstract Number: 1948 • ACR Convergence 2022

    Clinical Characteristics and Outcomes of Pediatric ANCA-Associated Vasculitis Patients: Single-Center Inception Cohort

    Hyun Ho Lee1, Lauren Blazek2 and Eveline Wu3, 1The University of North Carolina Chapel Hill, Chapel Hill, NC, 2UNC Kidney Center, The University of North Carolina Chapel Hill, Chapel Hill, NC, 3University of North Carolina, Chapel Hill, NC

    Background/Purpose: ANCA associated vasculitis (AAV) is a chronic autoimmune disorder characterized by ANCA production and small vessel inflammation and necrosis. ANCA autoantigen targets include myeloperoxidase…
  • Abstract Number: 0443 • ACR Convergence 2022

    Prognosis of Non-PR3 ANCA-Associated Vasculitis with Glomerulonephritis

    Aurélien Chepy1, Hélène Béhal2, Alexandre Karras3, Xavier Puéchal4, Benjamin Terrier4, David Jayne5, Thomas Quéméneur6 and Mary-Jane Guerry7, 1CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Auto-immunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), Lille, France, 2University of Lille, CHU Lille, ULR 2694 - METRICS: Évaluation des Technologies de Santé et des Pratiques Médicales, Lille, France, 3HEGP, Paris, France, 4National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, 5University of Cambridge, Cambridge, United Kingdom, 6Valenciennes Hospital, Valenciennes, France, 7Department of Nephrology, Centre Hospitalier de Valenciennes, Valenciennes., Valenciennes, France

    Background/Purpose: Immunosuppressive treatments have improved the prognosis of anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV), transforming these formerly fatal diseases into chronic conditions, with periods of…
  • Abstract Number: 0450 • ACR Convergence 2022

    Incidence of Solid and Hematologic Tumors in Patients with ANCA: A 10-year Retrospective Cohort Study

    Enrico Brunetta1, Giacomo Ramponi2, marco folci2, Maria De Santis3, Giacomo Maria Guidelli1, Angela Ceribelli4, Nicoletta Luciano1, Marta Caprioli5, Arianna Sonaglia1 and Carlo Selmi6, 1IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Rozzano, Italy, 2IRCCS Humanitas Research Hospital, Internal Medicine, Rozzano, Italy, 3Humanitas University, IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Pieve Emanuele, Italy, 4Humanitas Research Hospital, Humanitas University, Rozzano (MI) Italy, Borgo San Giacomo, Italy, 5IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Pavia, Italy, 6IRCCS Humanitas Research Hospital, Humanitas University, Rozzano (MI), Italy, Rozzano, Italy

    Background/Purpose: Serum antineutrophil cytoplasmic antibodies (ANCA) are significantly associated with the development of ANCA-associated vasculitides (AAV) but may also be detected in patients with other…
  • Abstract Number: 0457 • ACR Convergence 2022

    A Systematic Literature Review Informing the 2022 Update of the EULAR Recommendations for the Management of ANCA-associated Vasculitis

    Jan Schirmer1, Beatriz Sanchez-Alamo2, Sara Monti3, Bernhard Hellmich4, David Jayne5 and Gunnar Tomasson6, 1University Medical Center Schleswig-Holstein, Kiel, Germany, 2Lund University, Skåne University Hospital, Lund, Sweden, 3Rheumatology, Fondazione IRCCS Policlinico S. Matteo, University of Pavia, Pavia, Italy, 4Medius Kliniken, University of Tübingen, Kirchheim Teck, Germany, 5University of Cambridge, Cambridge, United Kingdom, 6Centre for Rheumatology Research, University Hospital Reykjavik, Reykjavik, Iceland

    Background/Purpose: Since the publication of the 2016 European Alliance of Associations for Rheumatology (EULAR) recommendations for the management of ANCA-associated vasculitis (AAV), the publication of…
  • Abstract Number: 0513 • ACR Convergence 2022

    The Association Between Age of Diagnosis and Disease Characteristics and Damage in Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

    Jessica Bloom1, Kaci Pickett2, Lori Silveira2, David Cuthbertson3, Nader Khalidi4, Curry Koening5, Carol Langford6, Carol McAlear7, Paul Monach8, Larry Moreland1, Christian Pagnoux9, Rennie Rhee10, Philip Seo11, Ulrich Specks12, Kenneth J. Warrington12, Robert Fuhlbrigge1 and Peter Merkel10, 1University of Colorado, Denver, CO, 2University of Colorado Anschutz Medical Campus, Aurora, CO, 3University of South Florida, Tampa, FL, 4McMaster University, Hamilton, ON, Canada, 5University of Texas Dell Medical School, Austin, TX, 6Cleveland Clinic, Cleveland, OH, 7University of Pennsylvania, Philadelphia, 8VA Boston Healthcare System, Boston, MA, 9Mount Sinai Hospital, Toronto, ON, Canada, 10University of Pennsylvania, Philadelphia, PA, 11Johns Hopkins University, Baltimore, MD, 12Mayo Clinic, Rochester, MN

    Background/Purpose: Clinical characteristics and outcomes often differ between children and adults diagnosed with the same rheumatic condition; however, such comparative data is limited in ANCA-associated…
  • Abstract Number: 0526 • ACR Convergence 2022

    Characteristics and Outcomes of Participants with and Without Diffuse Alveolar Hemorrhage in the Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis (PEXIVAS) Trial

    Lynn Fussner1, Luis Felipe Flores-Suarez2, Rodrigo Cartin-Ceba3, Ulrich Specks3, P. Gerard Cox4, David Jayne5, Peter Merkel6 and Michael Walsh4, 1The Ohio State University, Columbus, OH, 2Instituto Nacional de Enfermedades Respiratorias, Ciudad de México, Mexico, 3Mayo Clinic, Rochester, MN, 4McMaster University, Hamilton, ON, Canada, 5University of Cambridge, Cambridge, United Kingdom, 6University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Diffuse alveolar hemorrhage (DAH) is a potentially life-threatening manifestation of ANCA-associated vasculitis (AAV). Studies describing patients with DAH in AAV have typically been small…
  • Abstract Number: 1072 • ACR Convergence 2022

    Efficacy and Safety Assessment of a Rituximab Biosimilar in Patients with Granulomatosis with Polyangiitis (GPA)

    Adil Vural1, Komal Mushtaq1, Chao Zhang1, Mahmoud Alwakeel1, Vickie Sayles1, Kristine Duly2, Carol Langford1 and Rula Hajj-Ali3, 1Cleveland Clinic, Cleveland, OH, 2Cleveland Clinic, Fairview Park, OH, 3Cleveland Clinic, Hunting Valley, OH

    Background/Purpose: A biosimilar is a medication that is highly similar to a biologic agent that is already approved by a regulatory organization. Considering the share…
  • Abstract Number: 1073 • ACR Convergence 2022

    Analysis of Clinical Outcomes in ANCA-associated Vasculitis Treated with Rituximab: Eighty Years a Single Center Experience in Japan

    Soko Kawashima1, Mitsumasa Kishimoto2, Yoshinori Komagata3 and Shinya kaname4, 1Kyorin University, Mitaka Tokyo, Japan, 2Kyorin University School of Medicine, Yokohama, Japan, 3Kyorin University School of Medicine, Tokyo, Japan, 4Kyorin University, Tokyo, Japan

    Background/Purpose: Contrary to many Western countries, MPO-ANCA-associated vasculitis (MPO-AAV) is dominant in Japan. The therapeutic response to rituximab (RTX) may differ. Therefore, we conducted a…
  • Abstract Number: 0418 • ACR Convergence 2021

    Longitudinal Patterns of Renal Function in ANCA-Associated Vasculitis

    Jennifer Hanberg1, Xiaoqing Fu1, Claire Cook2, John Stone3, Hyon K. Choi4 and Zachary Wallace5, 1Massachusetts General Hospital, Boston, MA, 2Division of Rheumatology, Allergy, and Immunology, Mass General Hospital, Boston, MA, 3Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, 4Massachusetts General Hospital, Lexington, MA, 5Massachusetts General Hospital, Newton, MA

    Background/Purpose: Renal involvement is common in ANCA-associated vasculitis (AAV). Prior analyses show that end stage renal disease (ESRD) in AAV may be multifactorial. Little is…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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