ACR Meeting Abstracts

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Abstracts tagged "ANCA"

  • Abstract Number: 2078 • 2016 ACR/ARHP Annual Meeting

    Global Ethnic and Geographic Differences in the Clinical Features of ANCA-Associated Vasculitis

    Fiona Pearce1, Anthea Craven2, Peter A. Merkel3, Raashid Luqmani4 and Richard A. Watts5, 1Epidemiology and Public Health, University of Nottingham, Nottingham, United Kingdom, 2Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, 3Rheumatology, University of Pennsylvania, Philadelphia, PA, 4NDORMS , Rheumathology, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, 5Rheumatology Department, Ipswich Hospital, Ipswich, Great Britain

    Background/Purpose: There are few data on clinical profiles of ANCA-associated vasculitis (AAV) and or ANCA specificity in different ethnic populations. This study examined differences in…
  • Abstract Number: 1936 • 2016 ACR/ARHP Annual Meeting

    Clinical Characteristics of Inflammatory Eye Disease in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Retrospective Cohort Study

    Patompong Ungprasert1, Cynthia S. Crowson2, Rodrigo Cartin-Ceba3, James A. Garrity4, Wendy M. Smith5, Ulrich Specks6, Eric L. Matteson1 and Ashima Makol7, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Health Sciences Research, Mayo Clinic, Rochester, MN, 3Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, 4Ophthalmology, Mayo Clinic, Rochester, MN, 5Department of Ophthalmology, Mayo Clinic, Rochester, MN, 6Mayo Clinic, Rochester, MN, 7Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN

    Clinical Characteristics of Inflammatory Eye Disease in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Retrospective Cohort Study Background/Purpose: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is…
  • Abstract Number: 2265 • 2016 ACR/ARHP Annual Meeting

    NET-Inducing Capacity Is a Biomarker in ANCA-Associated Vasculitis Independent of ANCA Antibodies

    Tineke Kraaij1, Sylvia Kamerling1, Jaap Bakker2, Francesca Brunini3, Charles Pusey3, Hans Ulrich Scherer4, René E.M. Toes5, Ton Rabelink1, Cees van Kooten1 and Onno Teng1, 1Nephrology, Leiden University Medical Center, Leiden, Netherlands, 2Clinical Chemistry, Leiden University Medical Center, Leiden, Netherlands, 3Imperial College, London, United Kingdom, 4Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 5Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Neutrophil extracellular traps (NETs) play an important role in the pathogenesis of ANCA-associated vasculitis (AAV). Sera of MPO-ANCA or PR3-ANCA positive patients can induce…
  • Abstract Number: 1938 • 2016 ACR/ARHP Annual Meeting

    Bronchiectasis Are Highly Prevalent in Anti-MPO ANCA-Associated Vasculitis and Associate with a Distinct Disease Phenotype

    Antoine Néel1, Alexandra Espitia1, Pierre Paul Arrigoni2, Christelle Volteau3, Agathe Masseau1, Marie Rimbert4, Christian Agard1, Fadi Fakhouri5, Renan Liberge2 and Mohamed Hamidou6, 1Internal Medicine Department, Nantes University Hospital, Nantes, France, 2Radiology Department, Nantes University Hospital, Nantes, France, 3Clinical Research Department, Nantes University Hospital, Nantes, France, 4Immunology Laboratory, Nantes University Hospital, Nantes, France, 5Nephrology Department, Nantes University Hospital, Nantes, France, 6Internal Medicine Department, Internal Medicine Department, Nantes University Hospital, Nantes, France

    Background/Purpose: To assess the prevalence of bronchiectasis in a western cohort of ANCA positive GPA or MPA and its correlations with disease phenotype and outcome.…
  • Abstract Number: 2396 • 2016 ACR/ARHP Annual Meeting

    Initiation of Dialysis in Pediatric ANCA-Associated Vasculitis

    Karen James1, Rui Xiao2,3, Peter A. Merkel4,5 and Pamela F. Weiss6, 1Pediatric Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, 2Department of Pediatrics, Division of Biostatistics, Children's Hospital of Philadelphia, Philadelphia, PA, 3Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, 4Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 5Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 6Division of Rheumatology, Center for Pediatric Clincial Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: ANCA-associated vasculitis (AAV) is a group of rare systemic vasculitidies with significant morbidity and mortality. There have been no comparative effectiveness studies of AAV…
  • Abstract Number: 1939 • 2016 ACR/ARHP Annual Meeting

    Immunologic, Clinical and Demographic Correlates in 51 Cocaine Users with Serum Anti-Neutrophil Cytoplasmic Antibodies

    Grant Hughes1 and Meredith Barnes2, 1University of Washington, Seattle, WA, 2Medicine, University of Washington, Seattle, WA

    Background/Purpose: Exposure to illicit cocaine and its frequent adulterant, levamisole, is associated with the development of serum anti-neutrophil cytoplasmic autoantibodies (ANCA) and a variety of…
  • Abstract Number: 2939 • 2016 ACR/ARHP Annual Meeting

    Risk of Venous Thromboembolism in Patients with Systemic Vasculitides: A Systematic Review and Meta-Analysis

    Patompong Ungprasert1, Matthew J. Koster2 and Kenneth J. Warrington3, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Rheumatology, University of California Los Angeles, CA, USA Mayo Clinic, Rochester, MN, 3Rheumatology, University of California Los Angeles, CA, USA Mayo, Rochester, MN

    Risk of Venous Thromboembolism in Patients with Systemic Vasculitides: A Systematic Review and Meta-analysis Background/Purpose: Venous thromboembolism (VTE) is a common medical problem with a…
  • Abstract Number: 126 • 2016 ACR/ARHP Annual Meeting

    Anti-Neutrophil Cytoplasmic Antibodies (ANCA) in African-American Patients: Disease Associations and Clinical Outcomes in an Urban Cohort

    Philip McCarthy1, Jenna Hudy2, Marie Melville2, Danielle Robson1, John McKinnon2, Sandeep Soman2 and Kathleen Maksimowicz-McKinnon3, 1Michigan State University College of Osteopathic Medicine, East Lansing, MI, 2Henry Ford Hospital, Detroit, MI, 3Rheumatology, Henry Ford Hospital, Detroit, MI

    Background/Purpose: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) has been most extensively described and studied in non-African-American populations. The significance of and associations with ANCA in African-Americans,…
  • Abstract Number: 1940 • 2016 ACR/ARHP Annual Meeting

    High Prevalence of Inflammatory Heart Disease in Eosinophillic Granulomatosis with Polyangiitis (Churg Strauss) Patients

    Eloi Garcia Vives1, Len Harty2 and David Jayne3, 1Vall d'Hebrón Hospital, Barcelona, Spain, 2Vasculitis & Lupus, Addenbrookes Hospital University of Cambridge, Cambridge, United Kingdom, 3Vasculitis and Lupus Clinic, Addenbrookes Hospital University of Cambridge, Cambridge, United Kingdom

    Background/Purpose: To establish EGPA/Churg Strauss inflammatory heart disease prevalence and develop an algorithm for heart disease screening in EGPA patients. Methods: An audit of all…
  • Abstract Number: 3045 • 2016 ACR/ARHP Annual Meeting

    Immunometabolism in ANCA-Associated Glomerulonephritis

    Peter C. Grayson1, Sean Eddy2, Viji Nair2, Hemang Parikh3, Maja Lindenmeyer4, Laura Mariani2, Huateng Huang2, Wenjun Ju3, Casey Greene5, Clemens Cohen4, Jeffrey Krischer3, Matthias Kretzler2, Peter A. Merkel6 and Felix H. Eichinger2, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2Division of Nephrology, University of Michigan, Ann Arbor, MI, 3University of South Florida, Tampa, FL, 4University of Munich, Munich, Germany, 5Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 6Division of Rheumatology, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Mounting an inflammatory response requires immune cells to undergo major changes in metabolism. Mediators such as cytokines can specifically alter the metabolism of different…
  • Abstract Number: 127 • 2016 ACR/ARHP Annual Meeting

    Disease Characteristics and Outcomes in African-American Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis:  a High Risk Group for Poor Outcomes

    Philip McCarthy1, Danielle Robson1, Jenna Hudy2, Marie Melville2, John McKinnon2, Sandeep Soman2 and Kathleen Maksimowicz-McKinnon3, 1Michigan State University College of Osteopathic Medicine, East Lansing, MI, 2Henry Ford Hospital, Detroit, MI, 3Rheumatology, Henry Ford Hospital, Detroit, MI

    Background/Purpose: Antineutrophil antibody-associated vasculitis (AAV) has been most extensively described and studied in non-African American populations. Little is known about the characteristics and outcomes of…
  • Abstract Number: 1941 • 2016 ACR/ARHP Annual Meeting

    Retrospective Survey of Concomitant Autoimmune Diseases and Autoantibodies in a Cohort of Patients with ANCA-Associated Vasculitis (AAV)

    Marta Casal Moura1,2, Sergio Prieto-González2, Georgina Espígol-Frigolé2, Giuseppe Murgia2,3, Marco Alba2, Jose Hernández-Rodríguez2 and Maria C. Cid2, 1Department of Internal Medicine, São João Hospital Center, Porto, Portugal, 2Hospital Clínic. University of Barcelona. IDIBAPS, Vasculitis Research Unit. Department of Autoimmune Diseases, Spain, Barcelona, Spain, 3University Clinic for Visceral Surgery and Medicine Bauchzentrum Bern, Bern, Switzerland

    Background/Purpose: Anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis (AAV) - granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA) have heterogenous clinic…
  • Abstract Number: 3046 • 2016 ACR/ARHP Annual Meeting

    Inflammatory Pathways As Shared Molecular Targets Across ANCA-Associated Vasculitis and Nephrotic Syndrome

    Sean Eddy1, Viji Nair1, Hemang Parikh2, Maja Lindenmeyer3, Laura Mariani1, Felix H. Eichinger1, Huateng Huang1, Wenjun Ju2, Casey Greene4, Peter C. Grayson5, Clemens Cohen3, Jeffrey Krischer2, Peter A. Merkel6 and Matthias Kretzler1, 1Division of Nephrology, University of Michigan, Ann Arbor, MI, 2University of South Florida, Tampa, FL, 3University of Munich, Munich, Germany, 4Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 5National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 6Division of Rheumatology, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Clinical trials in rare diseases typically test therapeutic efficacy in one disease defined by a particular clinical phenotype. Improved understanding of the molecular mechanisms…
  • Abstract Number: 978 • 2016 ACR/ARHP Annual Meeting

    A Randomized Clinical Trial of CCX168, an Orally Administered C5aR Inhibitor for Treatment of Patients with ANCA-Associated Vasculitis

    Peter A. Merkel1, John Niles2, Richard Jimenez3, Robert F. Spiera4, Brad H. Rovin5, Andrew Bomback6, Christian Pagnoux7, Antonia Potarca8, Thomas J. Schall9 and Pirow Bekker9, 1Division of Rheumatology, Univ of Pennsylvania; Perelman School of Med, Philadelphia, PA, 2Massachusetts General Hospital, Boston, MA, 3Rheumatology, The Seattle Arthritis Clinic, University of Washington Medicine, Northwest Hospital and Medical Center, Seattle, WA, 4Hospital for Special Surgery, Cornell, New York, NY, 5Ohio State University Medical Center, Columbus, OH, 6Columbia University Medical Center, New York, NY, 7Division of Rheumatology, Mount Sinai Hospital, University Health Network, University of Toronto, Toronto, Canada, Toronto, ON, Canada, 8ChemoCentryx, Inc., Mountain View, CA, 9ChemoCentryx, Mountain View, CA

    Background/Purpose:  Complement 5a (C5a) is involved in the pathogenesis of anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). CCX168 is an orally administered, small molecule selective inhibitor of…
  • Abstract Number: 1942 • 2016 ACR/ARHP Annual Meeting

    Presentation and Clinical Features of ANCA-Associated Vasculitis in US African Americans: Experience from a Single Center  

    Sebastian Sattui1, Andrew Westfall2 and Angelo L. Gaffo3, 1Tinsley Harrison Internal Medicine Residency Program, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 2Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, 3Medicine, Birmingham VA Medical Center, Birmingham, AL

    Title: Presentation and Clinical Features of ANCA-associated Vasculitis in US African Americans: Experience From a Single Center   Background/Purpose: Little is known about the presentation,…
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