ACR Meeting Abstracts

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Abstracts tagged "ANCA"

  • Abstract Number: 1950 • 2016 ACR/ARHP Annual Meeting

    ANCA-Associated Vasculitides and IgG4-Related Disease: An Overlapping Syndrome? a European Observational Study of 18 Patients

    Francois-Xavier Danlos1, Giovanni Maria Rossi2, Daniel Blockmans3, Giacomo Emmi4, Andreas Kronbichler5, Stéphane Durupt6, Claire Maynard7, Luminita Luca8, Cyril Garrouste9, Bertrand Lioger10, Rachel Mourot11, Robin Dhote12, Jean-Benoit Arlet13, Thomas Hanslik14, Mikael Ebbo15, Agnès Carlotti16, Luc Mouthon17, Loïc Guillevin17, Augusto Vaglio18 and Benjamin Terrier19, 1Internal Medicine, Cochin Hospital, Paris, France, 2Nephrology, Parma, Parma, Italy, 3General Internal Medicine, University Hospitals Gasthuisberg, Leuven, Belgium, 4Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, 5Nephrology, Hospital, Innsbruck, Austria, 6Internal Medicine, CHU, Lyon, France, 7Internal Medicine, CH, Chambéry, France, 8Internal Medicine, CHU, Poitiers, France, 9Nephrology, CHU, Clermont-Ferrand, France, 10GICC UMR 7292, University François Rabelais, Tours, France, 11Internal Medicine, CHU, Strasbourg, France, 12Service de médecine interne. Hôpital Avicenne, Paris, France, 13Service de médecine interne, Hopital Européen Georges Pompidou, Paris, France, 14Internal Medicine, CHU, Boulogne Billancourt, France, 15Internal Medicine, Aix-Marseille Université, AP-HM, Marseille, France, 16Pathology, Cochin Hospital, Paris, France, 17Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, 18Nephrology, University Hospital of Parma, Parma, Italy, 19National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France

    Background/Purpose: Atypical manifestations have been described in patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV), such as periaortic fibrosis, pachymeningitis and orbital mass. Because these…
  • Abstract Number: 1929 • 2016 ACR/ARHP Annual Meeting

    Comparison of Two Different ANCA Iif Methods with EIA and Disease Phenotype

    Pooja Bhadbhade1, Mehrdad Maz2, Lowell Tilzer3, Fred Plapp3 and Jason Springer1, 1Allergy, Clinical Immunology and Rheumatology, The University of Kansas Medical Center, Department of Internal Medicine, Division of Allergy, Clinical Immunology and Rheumatology, Kansas City, KS, 2Allergy, Clinical Immunology, and Rheumatology, The University of Kansas Medical Center, Department of Internal Medicine, Division of Allergy, Clinical Immunology and Rheumatology, Kansas City, KS, 3Pathology and Laboratory Medicine, The University of Kansas Medical Center, Department of Pathology and Laboratory Medicine, Kansas City, KS

    Background/Purpose:  ANCAs are used as diagnostic markers in patients with autoimmune vasculitis such as Granulomatosis with polyangitis (GPA), Microscopic polyangitis (MPA), and Eosinophilic granulomatosis with…
  • Abstract Number: 1951 • 2016 ACR/ARHP Annual Meeting

    Phenotypic and Functional Perturbations of Peripheral B and T Lymphocytes in Granulomatosis with Polyangiitis and Microscopic Polyangiitis

    Jonathan London1,2,3, Nicolas Dumoitier1, Jeremie Dion1,4, Benjamin Chaigne1,5, Sebastien Lofek1, Pascal Cohen2,3, Claire Le Jeunne3, Nadine Varin-Blank6, Loïc Guillevin3,5, Benjamin Terrier1,5,7, Luc Mouthon1,3,5 and the French Vasculitis Study Group, 1INSERM U1016, Institut Cochin, Equipe Neutrophiles et Vascularites, Paris, France, 2Internal Medecine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 3Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, 4Internal medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 5National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 6UFR SMBH, INSERM, UMR978, Bobigny, France, 7Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France

    Background/Purpose: Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are both anti-neutrophil cytoplasm antibodies (ANCA)-associated vasculitides (AAV), but differ in clinical presentation. Anti-myeloperoxydase (MPO)-ANCA were…
  • Abstract Number: 1930 • 2016 ACR/ARHP Annual Meeting

    Factors Associated with Glucocorticoid Exposure in ANCA-Associated Vasculitis

    Matthew D. Cascino1, Ulrich Specks2, Peter A. Merkel3, Philip Seo4, Robert F. Spiera5, Carol A. Langford6, Gary S. Hoffman6, Cees G.M. Kallenberg7, E. William St Clair8, Paul A. Monach9, John H. Stone10 and Paul Brunetta11, 1Division of Rheumatology, University of California, San Francisco, San Francisco, CA, 2Mayo Clinic, Rochester, MN, 3Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 4Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, 5Rheumatology, Hospital for Special Surgery, New York, NY, 6Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 7Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 8Rheumatology, Duke University Medical Center, Durham, NC, 9Rheumatology, Boston University School of Medicine, Boston, MA, 10Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, 11Genentech, Inc., South San Francisco, CA

    Background/Purpose: Factors associated with cumulative glucocorticoid exposure in granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) have not previously been described. We examined the association…
  • Abstract Number: 1952 • 2016 ACR/ARHP Annual Meeting

    Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis

    Judith Land1, Lucas L. Lintermans1, Coen A. Stegeman2, Ernesto J. Muñoz-Elías3, Peter Heeringa4, Abraham Rutgers1 and Wayel H. Abdulahad1, 1Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 2Nephrology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3Kineta Inc, Seattle, WA, 4Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Granulomatosis with polyangiitis (GPA) patients are often treated with immunesuppressives or B cell depleting therapy. While B cells are involved in GPA pathogenesis as…
  • Abstract Number: 1931 • 2016 ACR/ARHP Annual Meeting

    MRI Findings in Granulomatosis with Polyangiitis: Pachymeningitis and Implications in Quality of Life

    Violeta Higuera-Ortiz1, Natllely Ruiz1, Daniel Carrillo2, Abraham Reynoso2, Rosa Delia Delgado-Hernández2 and Luis F. Flores-Suarez1, 1Primary Systemic Vasculitides Clinic, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico, 2Radiology and Molecular Imaging, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico

    Background/Purpose: The frequency of CNS involvement in granulomatosis with polyangiitis (GPA) is uncommon (4-18%). Among them, pachymeningitis (PM) has been reported in 0.6-8%. Improvement of…
  • Abstract Number: 1955 • 2016 ACR/ARHP Annual Meeting

    Rituximab Versus Azathioprine to Maintain Remission of ANCA-Associated Vasculitides (MAINRITSAN): Follow-up at 60 Months

    Benjamin Terrier1, Christian Pagnoux2, Elodie Perrodeau3, Alexandre Karras4, Chahéra Khouatra5, Olivier Aumaître6, Pascal Cohen7, Francois Maurier8, Olivier Decaux9, Hélène Desmurs-Clavel10, Pierre Gobert11, Thomas Quémeneur12, Claire Blanchard-Delaunay13, Pascal Godmer14, Xavier Puéchal15, Luc Mouthon15, Philippe Ravaud16 and Loïc Guillevin15, 1National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 2Mount Sinai Hospital, Toronto, ON, Canada, 3Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, 4Nephrology, HEGP, Paris, France, 5CHU Lyon, Lyon, France, 6CHU Pitié-Salpêtrière - Department of Internal Medicine 2. Referal center for SLE/APS, Paris, France, 7Internal Medicine, Cochin Hospital, Paris, France, 8Department of Internal Medicine, HP Metz Belle Isle Hospital, Metz, France, 9Department of Internal Medicine, Rennes University Hospital, Rennes, France, 10Department of Internal Medicine 2. Referal center for SLE/APS, CHU Pitié-Salpêtrière, Paris, France, 11Nephrology, Centre Hospitalier d'Avignon, Avignon, France, 12Service de néphrologie, médecine interne et vasculaire, Hôpital de Valenciennes, Valenciennes, France, 13Internal Medicine, Centre Hospitalier, Niort, France, 14CH Vannes, Vannes, France, 15Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, Paris, France, 16Hôpital Hôtel Dieu, Paris, France

    Background/Purpose: The previously reported prospective, randomizedÐcontrolled MAINRITSAN trial compared rituximab (RTX) to azathioprine (AZA) for maintenance of ANCA-associated vasculitis (AAV) remissions obtained with a combined…
  • Abstract Number: 1933 • 2016 ACR/ARHP Annual Meeting

    M2 Macrophage Is the Predominant Phenotype in Airways Inflammatory Lesions in Patients with Granulomatosis with Polyangiitis

    Alexandre W.S. Souza1, Mirjan van Timmeren2, Jan-Stephan Sanders3, Coen A. Stegeman4, Peter Heeringa5, Cees G.M. Kallenberg6 and Johanna Westra6, 1Universidade Federal de São Paulo, São Paulo, Brazil, 2University of Groningen, Groningen, Netherlands, 3University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 4Nephrology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 5Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 6Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose:  Macrophages may present two main phenotypes indicated as M1 and M2 under different stimuli. M1- and M2-macrophages have divergent functions that range from enhancement…
  • Abstract Number: 2078 • 2016 ACR/ARHP Annual Meeting

    Global Ethnic and Geographic Differences in the Clinical Features of ANCA-Associated Vasculitis

    Fiona Pearce1, Anthea Craven2, Peter A. Merkel3, Raashid Luqmani4 and Richard A. Watts5, 1Epidemiology and Public Health, University of Nottingham, Nottingham, United Kingdom, 2Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, 3Rheumatology, University of Pennsylvania, Philadelphia, PA, 4NDORMS , Rheumathology, Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, United Kingdom, 5Rheumatology Department, Ipswich Hospital, Ipswich, Great Britain

    Background/Purpose: There are few data on clinical profiles of ANCA-associated vasculitis (AAV) and or ANCA specificity in different ethnic populations. This study examined differences in…
  • Abstract Number: 1936 • 2016 ACR/ARHP Annual Meeting

    Clinical Characteristics of Inflammatory Eye Disease in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Retrospective Cohort Study

    Patompong Ungprasert1, Cynthia S. Crowson2, Rodrigo Cartin-Ceba3, James A. Garrity4, Wendy M. Smith5, Ulrich Specks6, Eric L. Matteson1 and Ashima Makol7, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Health Sciences Research, Mayo Clinic, Rochester, MN, 3Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, 4Ophthalmology, Mayo Clinic, Rochester, MN, 5Department of Ophthalmology, Mayo Clinic, Rochester, MN, 6Mayo Clinic, Rochester, MN, 7Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN

    Clinical Characteristics of Inflammatory Eye Disease in Patients with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis: A Retrospective Cohort Study Background/Purpose: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is…
  • Abstract Number: 2265 • 2016 ACR/ARHP Annual Meeting

    NET-Inducing Capacity Is a Biomarker in ANCA-Associated Vasculitis Independent of ANCA Antibodies

    Tineke Kraaij1, Sylvia Kamerling1, Jaap Bakker2, Francesca Brunini3, Charles Pusey3, Hans Ulrich Scherer4, René E.M. Toes5, Ton Rabelink1, Cees van Kooten1 and Onno Teng1, 1Nephrology, Leiden University Medical Center, Leiden, Netherlands, 2Clinical Chemistry, Leiden University Medical Center, Leiden, Netherlands, 3Imperial College, London, United Kingdom, 4Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 5Rheumatology, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Neutrophil extracellular traps (NETs) play an important role in the pathogenesis of ANCA-associated vasculitis (AAV). Sera of MPO-ANCA or PR3-ANCA positive patients can induce…
  • Abstract Number: 1938 • 2016 ACR/ARHP Annual Meeting

    Bronchiectasis Are Highly Prevalent in Anti-MPO ANCA-Associated Vasculitis and Associate with a Distinct Disease Phenotype

    Antoine Néel1, Alexandra Espitia1, Pierre Paul Arrigoni2, Christelle Volteau3, Agathe Masseau1, Marie Rimbert4, Christian Agard1, Fadi Fakhouri5, Renan Liberge2 and Mohamed Hamidou6, 1Internal Medicine Department, Nantes University Hospital, Nantes, France, 2Radiology Department, Nantes University Hospital, Nantes, France, 3Clinical Research Department, Nantes University Hospital, Nantes, France, 4Immunology Laboratory, Nantes University Hospital, Nantes, France, 5Nephrology Department, Nantes University Hospital, Nantes, France, 6Internal Medicine Department, Internal Medicine Department, Nantes University Hospital, Nantes, France

    Background/Purpose: To assess the prevalence of bronchiectasis in a western cohort of ANCA positive GPA or MPA and its correlations with disease phenotype and outcome.…
  • Abstract Number: 2396 • 2016 ACR/ARHP Annual Meeting

    Initiation of Dialysis in Pediatric ANCA-Associated Vasculitis

    Karen James1, Rui Xiao2,3, Peter A. Merkel4,5 and Pamela F. Weiss6, 1Pediatric Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, 2Department of Pediatrics, Division of Biostatistics, Children's Hospital of Philadelphia, Philadelphia, PA, 3Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, 4Penn Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 5Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 6Division of Rheumatology, Center for Pediatric Clincial Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: ANCA-associated vasculitis (AAV) is a group of rare systemic vasculitidies with significant morbidity and mortality. There have been no comparative effectiveness studies of AAV…
  • Abstract Number: 1939 • 2016 ACR/ARHP Annual Meeting

    Immunologic, Clinical and Demographic Correlates in 51 Cocaine Users with Serum Anti-Neutrophil Cytoplasmic Antibodies

    Grant Hughes1 and Meredith Barnes2, 1University of Washington, Seattle, WA, 2Medicine, University of Washington, Seattle, WA

    Background/Purpose: Exposure to illicit cocaine and its frequent adulterant, levamisole, is associated with the development of serum anti-neutrophil cytoplasmic autoantibodies (ANCA) and a variety of…
  • Abstract Number: 2939 • 2016 ACR/ARHP Annual Meeting

    Risk of Venous Thromboembolism in Patients with Systemic Vasculitides: A Systematic Review and Meta-Analysis

    Patompong Ungprasert1, Matthew J. Koster2 and Kenneth J. Warrington3, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Rheumatology, University of California Los Angeles, CA, USA Mayo Clinic, Rochester, MN, 3Rheumatology, University of California Los Angeles, CA, USA Mayo, Rochester, MN

    Risk of Venous Thromboembolism in Patients with Systemic Vasculitides: A Systematic Review and Meta-analysis Background/Purpose: Venous thromboembolism (VTE) is a common medical problem with a…
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