Abstracts tagged "ANCA"

Abstract Number: 1759 • 2017 ACR/ARHP Annual Meeting
Economic Evaluation of Rituximab Versus Azathioprine for Maintenance Treatment of ANCA-Associated Vasculitis. a Prospective, Multicenter Study
Annalisa Montante¹, Alicia Le Bras², Benjamin Terrier³, Pascal Cohen³, Xavier Puéchal⁴, Alexandre Karras⁵, Philippe Ravaud⁶, Loïc Guillevin⁷ and Isabelle Durand-Zaleski⁸, ¹UNITÉ DE RECHERCHE ECONOMIQUE, UNIVERSITE PARIS DESCARTES, PARIS, France, ²UNITE DE RECHERCHE ECONOMIQUE, UNIVERSITE PARIS DESCARTES, PARIS, France, ³Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, ⁴Service de Médecine Interne, Centre de Référence Maladies Auto-Immunes et Auto-Inflammatoires Systémiques Rares, Hôpital Cochin, Paris, France, ⁵Nephrology, HEGP, Paris, France, ⁶Hôpital Hôtel Dieu, Paris, France, ⁷Internal medicine, Cochin University Hospital, paris, France, ⁸UNITE DE RECHERCHE ECONOMIQUE, UNIVERSITE DE PARIS-CRETEIL, PARIS, France
Background/Purpose: Rituximab was proven to be superior to azathioprine as maintenance therapy for ANCA-associated vasculitides (AAVs) at month 28 of MAINRITSAN-1–trial follow-up. Because of rituximab’s…
Abstract Number: 2736 • 2017 ACR/ARHP Annual Meeting
Long-Term Survival in Systemic Necrotizing Vasculitides
Sabine Jardel¹, Xavier Puéchal², Alain Le Quellec³, Matthieu Groh², Mohamed Hamidou⁴, Francois Maurier⁵, Olivier Aumaître⁶, Achille Aouba⁷, Thomas Quémeneur⁸, Jean-François Subra⁹, Vincent Cottin¹⁰, Pascal Godmer¹¹, Patrice Cacoub¹², Philippe Delaval¹³, Anne-Laure Fauchais¹⁴, Eric Hachulla¹⁵, Delphine Maucort-Boulch¹⁶, Loïc Guillevin² and Jean-Christophe Lega¹⁷, ¹Lyon 1 University, Lyon, France, ²National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ³Montpellier, Montpellier, France, ⁴Internal Medicine Department, Internal Medicine Department, Nantes University Hospital, Nantes, France, ⁵Internal Medicine, Sainte-Blandine de Metz Hospital, Metz, France, ⁶CHU Pitié-Salpêtrière - Department of Internal Medicine 2. Referal center for SLE/APS, Paris, France, ⁷Department of Internal Medicine, Caen University Hospital, Caen, France, ⁸Service de néphrologie, médecine interne et vasculaire, Hôpital de Valenciennes, Valenciennes, France, ⁹Angers, Angers, France, ¹⁰Louis Pradel Hospital, Claude Bernard University Lyon 1, Lyon, France, ¹¹Medecine Interne, CH Vannes, Vannes, France, ¹²Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, ¹³Rennes, Rennes, France, ¹⁴Internal Medicine, Internal Medicine, Limoges, France, ¹⁵CHU Lille, Département de Médecine Interne et Immunologie Clinique, F-59000 Lille, France, Lille, France, ¹⁶Biostatistics and bioinformatics, Centre Hospitalier Lyon Sud - Claude Bernard University Lyon 1, Lyon, France, ¹⁷Department of Internal and Vascular Medicine, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France
Background/Purpose: The aim of the study was to describe the evolution of mortality over recent decades in systemic necrotizing vasculitides, including polyarteritis nodosa (PAN), granulomatosis…
Abstract Number: 1762 • 2017 ACR/ARHP Annual Meeting
Association of ETS1 Polymorphism in 3’ Untranslated Region with Susceptibility to Granulomatosis with Polyangiitis and Proteinase 3-ANCA Positive Vasculitis in a Japanese Population
Aya Kawasaki¹, Keita Yamashita², Fumio Hirano³, Ken-ei Sada⁴, Daisuke Tsukui⁵, Yuya Kondo⁶, Yoshitaka Kimura⁵, Kurumi Asako⁵, Shigeto Kobayashi⁷, Hidehiro Yamada⁸, Hiroshi Furukawa¹, Kenji Nagasaka⁹, Takahiko Sugihara¹⁰, Kunihiro Yamagata¹¹, Takayuki Sumida⁶, Shigeto Tohma¹², Hajime Kono⁵, Shoichi Ozaki⁸, Seiichi Matsuo¹³, Hiroshi Hashimoto¹⁴, Hirofumi Makino¹⁵, Yoshihiro Arimura¹⁶, Masayoshi Harigai¹⁷ and Naoyuki Tsuchiya¹, ¹Molecular and Genetic Epidemiology Laboratory, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ²Molecular and Genetic Epidemiology, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ³Departments of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, ⁴Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ⁵Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁶Department of Internal Medicine, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ⁷Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan, ⁸Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, ⁹Department of Rheumatology, Ome Municipal General Hospital, Ome, Japan, ¹⁰Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, ¹¹Department of Nephrology, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, ¹²Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, ¹³Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan, ¹⁴Juntendo University School of Medicine, Tokyo, Japan, ¹⁵Okayama University Hospital, Okayama, Japan, ¹⁶First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan, ¹⁷Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: ETS Proto-oncogene 1, transcription factor (ETS1) is a transcription factor involved in immune responses. Genome-wide association studies on systemic lupus erythematosus (SLE) in Chinese…
Abstract Number: 2754 • 2017 ACR/ARHP Annual Meeting
Comparison of Individually Tailored Vs Systematic Rituximab Regimens to Maintain ANCA-Associated Vasculitis Remissions: Results of a Prospective, Randomized–Controlled, Phase 3 Trial
Pierre Charles¹, Benjamin Terrier², Elodie Perrodeau³, Pascal Cohen², Stanislas Faguer⁴, Antoine Huart⁵, Mohamed Hamidou⁶, Christian Agard⁷, Bernard Bonnotte⁸, Maxime Samson⁸, Alexandre Karras⁹, Noémie Jourde-Chiche¹⁰, François Lifermann¹¹, Pierre Gobert¹², Catherine Hanrotel-Saliou¹³, Pascal Godmer¹⁴, Nicolas Martin Silva¹⁵, Grégory Pugnet¹⁶, Marie Matignon¹⁷, Olivier Aumaître¹⁸, Estibaliz Lazaro¹⁹, Xavier Puéchal²⁰, Philippe Ravaud²¹, Luc Mouthon²² and Loïc Guillevin²⁰, ¹Service de Médecine Interne, Hôpital Cochin, Paris, France, ²Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, ³Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, ⁴2Service de Néphrologie et Immunologie Clinique, Centre Hospitalier Universitaire (CHU) de Toulouse, Toulouse, France, ⁵CHU, Toulouse, France, ⁶Internal Medicine Department, Internal Medicine Department, Nantes University Hospital, Nantes, France, ⁷Internal Medicine Department, Nantes University Hospital, Nantes, France, ⁸Department of Internal Medicine and Clinical Immunology, Hôpital François Mitterrand, CHU de Dijon, Dijon, France, ⁹Nephrology, HEGP, Paris, France, ¹⁰Vascular Research Center of Marseille, Aix-Marseille Univ., Vascular Research Center of Marseille, Marseille, France, ¹¹Dax, Dax, France, ¹²Nephrology, Centre Hospitalier d'Avignon, Avignon, France, ¹³Brest, Brest, France, ¹⁴Medecine Interne, CH Vannes, Vannes, France, ¹⁵Department of Internal Medicine, Caen University Hospital, Caen, France, ¹⁶Department of Internal Medicine, Toulouse University Hospital, University of Toulouse, INSERM UMR 1027, Toulouse, France, ¹⁷Service de Néphrologie, Hôpital Henri-Mondor, Créteil, Créteil, France, ¹⁸CHU Pitié-Salpêtrière - Department of Internal Medicine 2. Referal center for SLE/APS, Paris, France, ¹⁹service de médecine interne et maladies infectieuses, CHU de Bordeaux, Pessac, France, ²⁰National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ²¹Hôpital Hôtel Dieu, Paris, France, ²²Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France ;Université Paris Descartes Sorbonne Paris, Paris, France
Background/Purpose: Once ANCA-associated vasculitis (AAV) remission was obtained, rituximab (RTX) superiority to azathioprine (AZA) to maintain remission was shown.1 In that study, at month 28,…
Abstract Number: 797 • 2017 ACR/ARHP Annual Meeting
Temporal Arteritis Revealing Antineutrophil Cytoplasmic Antibody–Associated Vasculitides: A Retrospective Study of 50 Cases
Laure Delaval^1,2, Maxime Samson³, Flora Schein⁴, Christian Agard⁵, Olivier Aumaître⁶, Alban Deroux⁷, Henry Dupuy⁸, Cyril Garrouste⁹, cedric landron¹⁰, Francois Maurier¹¹, Pascal Cathebras¹², Loïc Guillevin^2,13,14 and Benjamin Terrier^15,16,17, ¹National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, paris, France, ²Internal medicine, Cochin University Hospital, paris, France, ³Department of Internal Medicine and Clinical Immunology, Hôpital François Mitterrand, CHU de Dijon, Dijon, France, ⁴Internal medicine, University Hospital St Etienne, Saint Etienne, France, ⁵Internal Medicine Department, Nantes University Hospital, Nantes, France, ⁶CHU Pitié-Salpêtrière - Department of Internal Medicine 2. Referal center for SLE/APS, Paris, France, ⁷Internal Medicine, CHU de Grenoble, Grenoble, France, ⁸Department of Internal Medicine, Haut-Lévêque Hospital, Pessac, France, ⁹Nephrology, CHU, Clermont-Ferrand, France, ¹⁰service de médecine interne, CH Poitiers, CHU Poitiers, poitiers, France, ¹¹Internal Medicine, Sainte-Blandine de Metz Hospital, Metz, France, ¹²Internal Medicine, University Hospital St Etienne, St Etienne, France, ¹³French Vasculitis Study Group (FVSG), Paris, France, ¹⁴National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ¹⁵Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, ¹⁶French Vasculitis Study Group (FVSG), paris, France, ¹⁷Internal Medicine, Cochin University Hospital, Paris, France
Background/Purpose: Giant cell arteritis (GCA) is a non-necrotizing granulomatous arteritis involving large vessels, whereas antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV) are a group of necrotizing…
Abstract Number: 1763 • 2017 ACR/ARHP Annual Meeting
Time to Diagnosis of ANCA-Associated Vasculitides : Data from French Vasculitis Study Group Registry
Caroline Morbieu, Maher Banjari, Benjamin Terrier, Pascal Cohen, Claire Le Jeunne, Luc Mouthon, Xavier Puéchal and Loïc Guillevin for the French Vasculitis Study Group, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France
Background/Purpose: Diagnosing ANCA-associated vasculitides (AAVs) can be challenging. Their clinical presentations are numerous and the time to diagnosis may range from days to years.1,2 The…
Abstract Number: 2935 • 2017 ACR/ARHP Annual Meeting
Nasal Microbiota in Patients with Granulomatosis with Polyangiitis Compared to Healthy Controls
Rennie L. Rhee¹, Antoine G. Sreih¹, Catherine E. Najem¹, Peter C. Grayson², Chunyu Zhao³, Kyle Bittinger³, Ronald G. Collman⁴ and Peter A. Merkel⁵, ¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ²National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD, ³Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Medicine & Microbiology, University of Pennsylvania, Philadelphia, PA, ⁵Division of Rheumatology, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Prior studies have suggested a potential link between nasal microbes, in particular Staphylococcus aureus, and granulomatosis with polyangiitis (GPA; Wegener’s) but these studies relied…
Abstract Number: 814 • 2017 ACR/ARHP Annual Meeting
Clinical Presentation and Outcome of Orbital Mass in Antineutrophil Cytoplasmic Antibody-Associated Vasculitides
Cécile-Audrey Durel¹, Arnaud Hot², Ludovic Trefond³, Olivier Aumaître⁴, Grégory Pugnet⁵, Maxime Samson⁶, Sébastien Abad⁷, Alexandre Belot⁸, Claire Blanchard-Delaunay⁹, Pascal Cathebras¹⁰, Pascal Cohen¹¹, Fleur Cohen¹², Vincent Cottin¹³, Bruno Crestani¹⁴, Stéphanie Dumonteil¹⁵, Claire de Moreuil¹⁶, Stéphane Durupt¹⁷, Jean-Gabriel Fuzibet¹⁸, Margaux Garzaro-regard¹⁹, Nicolas Girszyn²⁰, Bertrand Godeau²¹, Eric Hachulla²², Yvan Jamilloux²³, Patrick Jego²⁴, Estibaliz Lazaro²⁵, Thomas Le Gallou²⁶, Eric Liozon²⁷, Thierry Martin²⁸, Thomas Papo²⁹, Antoinette Perlat²⁶, Pascal Pillet³⁰, Karim Sacre³¹, Pascal Sève³², Loïc Guillevin for the French Vasculitis Study Group³³ and Benjamin Terrier¹¹, ¹Internal Medicine, Hôpital Edouard Herriot, lyon, France, ²Internal Medicine, Hopital Edouard Herriot, Lyon, France, ³Internal medicine, CHU Gabriel-Montpied, clermont-ferrand, France, ⁴CHU Pitié-Salpêtrière - Department of Internal Medicine 2. Referal center for SLE/APS, Paris, France, ⁵Service de Médecine Interne, CHU de Toulouse, Toulouse, Toulouse, France, ⁶Dijon University Hospital, Dijon, France, ⁷Internal medicine, Hôpital Avicennes, avicennes, France, ⁸Pediatric Rheumatology, CHU lyon, Hospices Civils de Lyon, HFME, lyon, France, ⁹Internal Medicine, Centre Hospitalier, Niort, France, ¹⁰Internal Medicine, University Hospital St Etienne, St Etienne, France, ¹¹Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, ¹²Department of Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France, ¹³Louis Pradel Hospital, Claude Bernard University Lyon 1, Lyon, France, ¹⁴Pneumologie A, Hôpital Bichat - Claude Bernard, Paris, France, ¹⁵Internal medicine, CHU de Limoges, Limoges, France, ¹⁶CHU de Brest, Brest, France, ¹⁷Department of Internal and Vascular Medicine, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France, ¹⁸Internal medicine, Hôpital l'Archet, Nice, France, ¹⁹Internal medicine, CHU de Nice, Nice, France, ²⁰CHU de Rouen, Rouen, France, ²¹Internal medicine, Hôpital Henri-Mondor, Créteil, France, ²²CHU Lille, Département de Médecine Interne et Immunologie Clinique, F-59000 Lille, France, Lille, France, ²³Internal medicine department, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France, ²⁴Medecine Interne, CHU Rennes, Rennes, France, ²⁵service de médecine interne et maladies infectieuses, CHU de Bordeaux, Pessac, France, ²⁶Internal medicine, CHU de Rennes, Rennes, France, ²⁷Departement of Internal Medicine, Limoges University Hospital, Limoges, France, ²⁸Cnrs UPR9021, Department of Clinical Immunology and Internal Medicine, Strasbourg University Hospital, IBMC CNRS UPR9021, Strasbourg, France, ²⁹Paris Bichat, Paris, France, ³⁰Paediatrics, Hôpital Pellegrin, University Hospital of Bordeaux, Bordeaux, France, ³¹Department of Internal Medicine, Bichat Hospital, Paris, France, ³²Internal medicine, Internal medicine department, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France, ³³Service de Médecine Interne, Centre de Référence Maladies Auto-Immunes et Auto-Inflammatoires Systémiques Rares, Hôpital Cochin, Paris, France
Background/Purpose: Orbital mass is a rare ophthalmologic manifestation of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) that remains a therapeutic challenge. This study aimed to describe…
Abstract Number: 1764 • 2017 ACR/ARHP Annual Meeting
Small RNA Sequencing Shows Differential Plasma Microrna Expression in Patients with ANCA-Associated Vasculitis: A Pilot Study
Kevin Byram¹, Joseph F. Solus¹, Quanhu Sheng¹, Yan Guo¹, C Michael Stein¹ and Michelle J. Ormseth², ¹Vanderbilt University Medical Center, Nashville, TN, ²Rheumatology, Vanderbilt Medical Center, Nashville, TN
Background/Purpose: MicroRNAs (miRNAs) are small RNA molecules (~22 nucleotides) that participate in post-transcriptional gene regulation. miRNAs have potential both as biomarkers for diagnosis and prognosis…
Abstract Number: 2936 • 2017 ACR/ARHP Annual Meeting
B-Cell Depletion By Rituximab Affects the Distribution of Effector Th-Cell Subsets in Patients with ANCA Associated Vasculitis
Wayel H. Abdulahad¹, Ulrich Specks², Theo Bijma³, Deborah J. Phippard⁴, Fredrick Karnell⁵, Noha Lim⁵, John H. Stone⁶ and Cees G.M. Kallenberg¹, ¹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Mayo Clinic College of Medicine, Rochester, MN, ³UMCG, Groningen, Netherlands, ⁴3 Bethesda Metro Center,, Suite 400, Bethesda, MD, ⁵Immune Tolerance Network, Bethesda, MD, ⁶Rheumatology Unit, Massachusetts General Hospital, Boston, MA
Background/Purpose: The current study is aimed to assess the effect of B-cell depletion on the distribution of effector T-cell subsets in AAV-patients. Alterations in CD4+…
Abstract Number: 893 • 2017 ACR/ARHP Annual Meeting
Efficacy and Safety of Belimumab in Combination with Azathioprine for Remission Maintenance in Granulomatosis with Polyangiitis and Microscopic Polyangiitis: A Multicenter Randomized, Placebo-Controlled Study
David Jayne¹, Daniel Blockmans², Raashid Luqmani³, Beulah Ji⁴, Yulia Green⁵, Leanne Hall⁶, David Roth⁷ and Peter A. Merkel⁸, ¹Vasculitis and Lupus Clinic, Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ²General Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium, ³Botnar Research Centre, University of Oxford, Oxford, United Kingdom, ⁴GSK Stockley Park, Uxbridge, United Kingdom, ⁵GSK Stockley Park, Stockley Park, United Kingdom, ⁶GSK Stevenage, Stevenage, United Kingdom, ⁷GSK Collegeville, Collegeville, PA, ⁸Division of Rheumatology, University of Pennsylvania, Philadelphia, MN
Background/Purpose: GPA (Wegener’s) and MPA are organ- and life-threatening systemic vasculitides characterized by the presence of ANCA-associated vasculitis (AAV), implicating B cells in disease pathogenesis.…
Abstract Number: 1767 • 2017 ACR/ARHP Annual Meeting
The Effect on Health-Related Quality of Life of Treatment for Remission Maintenance in ANCA-Associated Vasculitis Beyond 18 Months
Gunnar Tomasson¹, Antoine G. Sreih², David Cuthbertson³, Simon Carette⁴, Nader A. Khalidi⁵, Curry L. Koening⁶, Carol A. Langford⁷, Carol A. McAlear⁸, Paul A. Monach⁹, Larry W. Moreland¹⁰, Philip Seo¹¹, Ulrich Specks¹², Steven R. Ytterberg¹³ and Peter A. Merkel¹⁴, ¹University of Iceland, Faculty of Medicine, Reykjavik, IS, ²Rheumatology, University of Pennsylvania, Philadelphia, PA, ³Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, ⁴Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁵Rheumatology, McMaster University, Hamilton, ON, Canada, ⁶Rheumatology, University of Utah, Salt Lake City, UT, ⁷Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, ⁸University of Pennsylvania, Philadelphia, PA, ⁹Boston University School of Medicine, Boston, MA, ¹⁰Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ¹¹Medicine, Johns Hopkins University, Baltimore, MD, ¹²Mayo Clinic College of Medicine, Rochester, MN, ¹³Rheumatology, Mayo Clinic, Rochester, MN, ¹⁴Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA
Background/Purpose: Standard management of ANCA-associated vasculitis (AAV) involves treatment with immunosuppressive agents for at least 18 months. Treatment beyond 18 months reduces the rates of…
Abstract Number: 895 • 2017 ACR/ARHP Annual Meeting
Temporal Trends in Incidence and Outcomes of End-Stage Renal Disease Due to Granulomatosis with Polyangiitis in the US from 1995-2014
Zachary S. Wallace¹, Yuqing Zhang², Leo Lu³, John H. Stone⁴ and Hyon K. Choi⁵, ¹Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Department of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Allergy, Immunology, and Rheumatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ⁵Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Temporal Trends in Incidence and Outcomes of End-Stage Renal Disease due to Granulomatosis with Polyangiitis in the US from 1995-2014 Background/Purpose: Granulomatosis with polyangiitis (GPA)…
Abstract Number: 1768 • 2017 ACR/ARHP Annual Meeting
Cocaine and ANCA Associated Vasculitis-like Syndromes – a Case Series
Sujith Subesinghe¹, Sander van Leuven², Leena Yalakki³, Shirish Sangle (Joint First Author)³ and David P. D'Cruz³, ¹Rheumatology and Lupus, Guy's and St Thomas' Hospitals NHS Foundation Trust, London, United Kingdom, ²Rheumatology, Radboud University, Nijmegen, Netherlands, ³Louise Coote Lupus Unit, Rheumatology and Lupus, Guy's and St Thomas' Hospitals NHS Foundation Trust, London, United Kingdom
Background/Purpose: Cocaine is a potent illicit stimulant and may trigger a ÔpseudovasculitisÕ mimicking idiopathic ANCA vasculitis. We describe the clinical and serological manifestations of patients…
Abstract Number: 896 • 2017 ACR/ARHP Annual Meeting
The Steroid Tapering in ANCA Vasculitis Evaluation Study (STAVE) 2: A Systematic Review and Meta-Analysis
Jennifer Rodrigues¹, David Collister¹, Amy Archer², Kim Cheema³, Paul Alexander⁴, Christian Pagnoux⁵, Lehana Thabane⁴, Peter A. Merkel⁶, David Jayne⁷ and Michael Walsh¹, ¹Nephrology, McMaster University, Hamilton, ON, Canada, ²Rheumatology, Northwestern University, Chicago, IL, ³Nephrology, University of Calgary, Calgary, AB, Canada, ⁴Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada, ⁵Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁶Division of Rheumatology, University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA, ⁷Vasculitis and Lupus Clinic, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
Background/Purpose: Relapses of ANCA-associated vasculitis (AAV) are associated with death, decreased renal function, and end-stage renal disease. Whether longer-term treatment with glucocorticoids (GC) reduces the…

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