ACR Meeting Abstracts

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Abstracts tagged "ANCA"

  • Abstract Number: 1751 • 2017 ACR/ARHP Annual Meeting

    Association of a TNFSF4 Upstream Region Single Nucleotide Polymorphism with Susceptibility to Proteinase 3-ANCA Positive Vasculitis in a Japanese Population

    Yuka Iwahashi1, Aya Kawasaki1, Fumio Hirano2, Ken-ei Sada3, Daisuke Tsukui4, Yuya Kondo5, Shigeto Kobayashi6, Hidehiro Yamada7, Hiroshi Furukawa1, Kenji Nagasaka8, Takahiko Sugihara9, Kunihiro Yamagata10, Takayuki Sumida5, Shigeto Tohma11, Hajime Kono4, Shoichi Ozaki7, Seiichi Matsuo12, Hiroshi Hashimoto13, Hirofumi Makino14, Yoshihiro Arimura15, Masayoshi Harigai16 and Naoyuki Tsuchiya1, 1Molecular and Genetic Epidemiology Laboratory, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, 2Departments of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, 3Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 4Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 5Department of Internal Medicine, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, 6Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan, 7Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 8Department of Rheumatology, Ome Municipal General Hospital, Ome, Japan, 9Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, 10Department of Nephrology, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, 11Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, 12Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 13Juntendo University School of Medicine, Tokyo, Japan, 14Okayama University Hospital, Okayama, Japan, 15First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan, 16Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: In the epidemiology of ANCA-associated vasculitis (AAV), an obvious difference between European and Asian populations has been reported. According to the clinical classification, granulomatosis…
  • Abstract Number: 1778 • 2017 ACR/ARHP Annual Meeting

    Prophylactic Treatment and Incidence of Pneumocystis Jirovecci Pneumonia in Japanese Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

    Izaya Nakaya1, Ken-ei Sada2, Jun Soma1, Yoshihiro Arimura3, Masayoshi Harigai4, Kunihiro Yamagata5, Hirofumi Makino6 and Seiichi Matsuo7, 1Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital, Morioka, Japan, 2Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 3First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan, 4Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 5Department of Nephrology, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, 6Okayama University Hospital, Okayama, Japan, 7Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Background/Purpose: Pneumocystis jiroveciipneumonia (PCP) is a fatal complication in antineutrophil cytoplasmic antibody-associated vasculitis (AAV). However, the current situation of prophylactic treatment of PCP and its…
  • Abstract Number: 1752 • 2017 ACR/ARHP Annual Meeting

    Pharmacokinetics of Rituximab and Clinical Outcomes in Patients with ANCA-Associated Vasculitis

    Divi Cornec1, Brian Kabat1, John Mills1, Melissa Cheu2, Amber Hummel1, Darrell Schroeder1, Matthew Cascino3, Paul Brunetta3, David Murray1, Melissa Snyder1, Fernando Fervenza1, Gary S. Hoffman4, Cees G.M. Kallenberg5, Carol A. Langford6, Peter A. Merkel7, Paul A. Monach8, Philip Seo9, Robert F. Spiera10, E. William St Clair11, John H. Stone12, David Barnidge1 and Ulrich Specks13, 1Mayo Clinic, Rochester, MN, 2Genentech Inc., South San Francisco, CA, 3Genentech, Inc., South San Francisco, CA, 4Rheumatology, Cleveland Clinic, Cleveland, OH, 5Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 6Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 7University of Pennsylvania, Philadelphia, MN, 8Boston University School of Medicine, Boston, MA, 9Medicine, Johns Hopkins University, Baltimore, MD, 10Rheumatology, Hospital for Special Surgery, New York, NY, 11Rheumatology, Duke University Medical Center, Durham, NC, 12Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, 13Mayo Clinic College of Medicine, Rochester, MN

    Background/Purpose: Response to rituximab (RTX) is variable in patients with ANCA-associated vasculitis (AAV), and predictors of treatment efficacy/relapse risk would be useful. Previous studies have…
  • Abstract Number: 1844 • 2017 ACR/ARHP Annual Meeting

    Circulating Cytokine Profiles Reflect ANCA Specificity in Patients with ANCA-Associated Vasculitis

    Alvise Berti1, Roscoe Warner2, Kent Johnson3, Divi Cornec4, Darrell Schroder5, Brian Kabat5, Peter A. Merkel6, Carol A. Langford7, Gary S. Hoffman8, Cees G.M. Kallenberg9, Philip Seo10, Robert F. Spiera11, Eugene St. Clair12, John H. Stone13, Ulrich Specks14 and Paul A. Monach15, 1Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, 2University of Michigan Medical School, Ann Arbor,, MI, 3University of Michigan Medical School, Ann Arbor, MI, 4Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN, 5Mayo Clinic, Rochester, MN, 6Division of Rheumatology, University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA, 7Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 8Rheumatology, Cleveland Clinic, Cleveland, OH, 9Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 10Medicine, Johns Hopkins University, Baltimore, MD, 11Rheumatology, Hospital for Special Surgery, New York, NY, 12Department of Medicine, Duke University Medical Center, Durham, NC, 13Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, 14Mayo Clinic College of Medicine, Rochester, MN, 15Boston University School of Medicine, Boston, MA

    Background/Purpose: To evaluate serum cytokine and chemokine profiles in patients with ANCA-associated vasculitis (AAV) classified by ANCA specificity (proteinase 3 (PR3)-ANCA versus myeloperoxidase (MPO)-ANCA) or…
  • Abstract Number: 1755 • 2017 ACR/ARHP Annual Meeting

    Safety of Methotrexate and Low-Dose Trimethoprim-Sulfamethoxazole in Patients with ANCA-Associated Vasculitis

    Hiromichi Tamaki1, Robert Butler2 and Carol A. Langford3, 1Rheumatology, Cleveland Clinic, Cleveland, OH, 2Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, 3Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH

    Background/Purpose: Low-dose trimethoprim-sulfamethoxazole (LDTS, 160mg-800mg 3x/week or 80mg-400mg/day) is effective for prevention of Pneumocystis jiroveci pneumonia (PCP), a serious opportunistic infection seen in patients with…
  • Abstract Number: 1846 • 2017 ACR/ARHP Annual Meeting

    Increased CD38hiCD27+ Plasmablast Frequency in Remission Predicts Relapsing Disease in Granulomatosis with Polyangiitis Patients

    Anouk von Borstel1, Wayel H. Abdulahad2, Abraham Rutgers2, Judith Land2, Coen A. Stegeman1, Peter Heeringa3 and Jan-Stephan F. Sanders1, 1Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 2Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Patients with granulomatosis with polyangiitis (GPA) are prone to disease relapse. Changes in anti-neutrophil cytoplasmic autoantibodies (ANCA) levels can predict relapses in individual patients…
  • Abstract Number: 1758 • 2017 ACR/ARHP Annual Meeting

    Risk of Serious Infection in Granulomatosis with Polyangiitis or Microscopic Polyangiitis: Long-Term Outcomes of 126 Wegent Trial Patients

    Xavier Puéchal1, Christian Pagnoux2, Elodie Perrodeau3, Mohamed Hamidou4, Jean-Jacques Boffa5, Xavier Kyndt6, François Lifermann7, Thomas Papo8, Dominique Merrien9, Amar Smail10, Philippe Delaval11, Catherine Hanrotel-Saliou12, Bernard Imbert13, Chahéra Khouatra14, Marc Lambert15, Charles Leské16, Kim H. Ly17, Edouard Pertuiset18, Pascal Roblot19, Marc Ruivard20, Jean-François Subra21, Jean-Francois Viallard22, Benjamin Terrier23, Pascal Cohen23, Luc Mouthon24, Philippe Ravaud3 and Loïc Guillevin for the French Vasculitis Study Group25, 1National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 2Mount Sinai Hospital, Toronto, ON, Canada, 3Paris Hotel Dieu, Paris, France, 4Medecine Interne, CHU Hôtel Dieu, Nantes, France, 5Paris Tenon, Paris, France, 6Valenciennes, Valenciennes, France, 7Dax, Dax, France, 8Paris Bichat, Paris, France, 9Compiègne, Compiègne, France, 10Amiens, Amiens, France, 11Rennes, Rennes, France, 12Brest, Brest, France, 13Grenoble, Grenoble, France, 14Lyon, Lyon, France, 15Lille, Lille, France, 16Cholet, Cholet, France, 17Limoges, Limoges, France, 18Pontoise, Pontoise, France, 19Poitiers, Poitiers, France, 20CHU Estaing, Department of Internal Medicine, Clermont-Ferrand, France, Clermont Ferrand, France, 21Angers, Angers, France, 22Bordeaux, Bordeaux, France, 23Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, 24Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France ;Université Paris Descartes Sorbonne Paris, Paris, France, 25Service de Médecine Interne, Centre de Référence Maladies Auto-Immunes et Auto-Inflammatoires Systémiques Rares, Hôpital Cochin, Paris, France

    Background/Purpose: Adverse events, rather than active vasculitis, are the greatest threat to patients with ANCA-associated vasculitides (AAVs) during the first year of therapy but long-term…
  • Abstract Number: 1849 • 2017 ACR/ARHP Annual Meeting

    Urinary Epidermal Growth Factor and Monocyte Chemoattractant Protein-1 As Biomarkers of Renal Involvement in ANCA-Associated Vasculitis

    Catherine E. Najem1, Wenjun Ju2, Viji Nair2, David Cuthbertson3, Rennie L. Rhee1, Laura Mariani4, Simon Carette5, Nader A. Khalidi6, Curry L. Koening7, Carol A. Langford8, Carol A. McAlear9, Paul A. Monach10, Larry W. Moreland11, Christian Pagnoux5, Philip Seo12, Ulrich Specks13, Antoine G. Sreih1, Steven R. Ytterberg14, Jeffrey Krischer15, Matthias Kretzler4 and Peter A. Merkel16, 1Rheumatology, University of Pennsylvania, Philadelphia, PA, 2University of Michigan, Ann Arbor, MI, 3Biostatistics and Informatics, Department of Pediatrics, University of South Florida, Tampa, FL, 4Division of Nephrology, University of Michigan, Ann Arbor, MI, 5Division of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 6Rheumatology, McMaster University, Hamilton, ON, Canada, 7Rheumatology, University of Utah, Salt Lake City, UT, 8Rheumatic and Immunologic Diseases, Cleveland Clinic, Cleveland, OH, 9University of Pennsylvania, Philadelphia, PA, 10Boston University School of Medicine, Boston, MA, 11Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 12Medicine, Johns Hopkins University, Baltimore, MD, 13Mayo Clinic College of Medicine, Rochester, MN, 14Rheumatology, Mayo Clinic, Rochester, MN, 15University of South Florida, Tampa, FL, 16Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA

    Background/Purpose :Epidermal growth factor (EGF) mediates distal tubular epithelial cell function and regeneration. Monocyte chemoattractant protein-1 (MCP-1) participates in recruitment of leukocytes to areas of…
  • Abstract Number: 1759 • 2017 ACR/ARHP Annual Meeting

    Economic Evaluation of Rituximab Versus Azathioprine for Maintenance Treatment of ANCA-Associated Vasculitis. a Prospective, Multicenter Study

    Annalisa Montante1, Alicia Le Bras2, Benjamin Terrier3, Pascal Cohen3, Xavier Puéchal4, Alexandre Karras5, Philippe Ravaud6, Loïc Guillevin7 and Isabelle Durand-Zaleski8, 1UNITÉ DE RECHERCHE ECONOMIQUE, UNIVERSITE PARIS DESCARTES, PARIS, France, 2UNITE DE RECHERCHE ECONOMIQUE, UNIVERSITE PARIS DESCARTES, PARIS, France, 3Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, 4Service de Médecine Interne, Centre de Référence Maladies Auto-Immunes et Auto-Inflammatoires Systémiques Rares, Hôpital Cochin, Paris, France, 5Nephrology, HEGP, Paris, France, 6Hôpital Hôtel Dieu, Paris, France, 7Internal medicine, Cochin University Hospital, paris, France, 8UNITE DE RECHERCHE ECONOMIQUE, UNIVERSITE DE PARIS-CRETEIL, PARIS, France

    Background/Purpose: Rituximab was proven to be superior to azathioprine as maintenance therapy for ANCA-associated vasculitides (AAVs) at month 28 of MAINRITSAN-1–trial follow-up. Because of rituximab’s…
  • Abstract Number: 2736 • 2017 ACR/ARHP Annual Meeting

    Long-Term Survival in Systemic Necrotizing Vasculitides

    Sabine Jardel1, Xavier Puéchal2, Alain Le Quellec3, Matthieu Groh2, Mohamed Hamidou4, Francois Maurier5, Olivier Aumaître6, Achille Aouba7, Thomas Quémeneur8, Jean-François Subra9, Vincent Cottin10, Pascal Godmer11, Patrice Cacoub12, Philippe Delaval13, Anne-Laure Fauchais14, Eric Hachulla15, Delphine Maucort-Boulch16, Loïc Guillevin2 and Jean-Christophe Lega17, 1Lyon 1 University, Lyon, France, 2National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 3Montpellier, Montpellier, France, 4Internal Medicine Department, Internal Medicine Department, Nantes University Hospital, Nantes, France, 5Internal Medicine, Sainte-Blandine de Metz Hospital, Metz, France, 6CHU Pitié-Salpêtrière - Department of Internal Medicine 2. Referal center for SLE/APS, Paris, France, 7Department of Internal Medicine, Caen University Hospital, Caen, France, 8Service de néphrologie, médecine interne et vasculaire, Hôpital de Valenciennes, Valenciennes, France, 9Angers, Angers, France, 10Louis Pradel Hospital, Claude Bernard University Lyon 1, Lyon, France, 11Medecine Interne, CH Vannes, Vannes, France, 12Department of Internal Medicine and Clinical Immunology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France, 13Rennes, Rennes, France, 14Internal Medicine, Internal Medicine, Limoges, France, 15CHU Lille, Département de Médecine Interne et Immunologie Clinique, F-59000 Lille, France, Lille, France, 16Biostatistics and bioinformatics, Centre Hospitalier Lyon Sud - Claude Bernard University Lyon 1, Lyon, France, 17Department of Internal and Vascular Medicine, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France

    Background/Purpose: The aim of the study was to describe the evolution of mortality over recent decades in systemic necrotizing vasculitides, including polyarteritis nodosa (PAN), granulomatosis…
  • Abstract Number: 1762 • 2017 ACR/ARHP Annual Meeting

    Association of ETS1 Polymorphism in 3’ Untranslated Region with Susceptibility to Granulomatosis with Polyangiitis and Proteinase 3-ANCA Positive Vasculitis in a Japanese Population

    Aya Kawasaki1, Keita Yamashita2, Fumio Hirano3, Ken-ei Sada4, Daisuke Tsukui5, Yuya Kondo6, Yoshitaka Kimura5, Kurumi Asako5, Shigeto Kobayashi7, Hidehiro Yamada8, Hiroshi Furukawa1, Kenji Nagasaka9, Takahiko Sugihara10, Kunihiro Yamagata11, Takayuki Sumida6, Shigeto Tohma12, Hajime Kono5, Shoichi Ozaki8, Seiichi Matsuo13, Hiroshi Hashimoto14, Hirofumi Makino15, Yoshihiro Arimura16, Masayoshi Harigai17 and Naoyuki Tsuchiya1, 1Molecular and Genetic Epidemiology Laboratory, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, 2Molecular and Genetic Epidemiology, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, 3Departments of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, 4Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, 5Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, 6Department of Internal Medicine, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, 7Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan, 8Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan, 9Department of Rheumatology, Ome Municipal General Hospital, Ome, Japan, 10Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, 11Department of Nephrology, University of Tsukuba, Faculty of Medicine, Tsukuba, Japan, 12Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan, 13Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan, 14Juntendo University School of Medicine, Tokyo, Japan, 15Okayama University Hospital, Okayama, Japan, 16First Department of Internal Medicine, Kyorin University School of Medicine, Tokyo, Japan, 17Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: ETS Proto-oncogene 1, transcription factor (ETS1) is a transcription factor involved in immune responses. Genome-wide association studies on systemic lupus erythematosus (SLE) in Chinese…
  • Abstract Number: 2754 • 2017 ACR/ARHP Annual Meeting

    Comparison of Individually Tailored Vs Systematic Rituximab Regimens to Maintain ANCA-Associated Vasculitis Remissions: Results of a Prospective, Randomized–Controlled, Phase 3 Trial

    Pierre Charles1, Benjamin Terrier2, Elodie Perrodeau3, Pascal Cohen2, Stanislas Faguer4, Antoine Huart5, Mohamed Hamidou6, Christian Agard7, Bernard Bonnotte8, Maxime Samson8, Alexandre Karras9, Noémie Jourde-Chiche10, François Lifermann11, Pierre Gobert12, Catherine Hanrotel-Saliou13, Pascal Godmer14, Nicolas Martin Silva15, Grégory Pugnet16, Marie Matignon17, Olivier Aumaître18, Estibaliz Lazaro19, Xavier Puéchal20, Philippe Ravaud21, Luc Mouthon22 and Loïc Guillevin20, 1Service de Médecine Interne, Hôpital Cochin, Paris, France, 2Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, 3Epidemiology, Hopital Hotel Dieu, Paris Descartes University, Paris, France, 42Service de Néphrologie et Immunologie Clinique, Centre Hospitalier Universitaire (CHU) de Toulouse, Toulouse, France, 5CHU, Toulouse, France, 6Internal Medicine Department, Internal Medicine Department, Nantes University Hospital, Nantes, France, 7Internal Medicine Department, Nantes University Hospital, Nantes, France, 8Department of Internal Medicine and Clinical Immunology, Hôpital François Mitterrand, CHU de Dijon, Dijon, France, 9Nephrology, HEGP, Paris, France, 10Vascular Research Center of Marseille, Aix-Marseille Univ., Vascular Research Center of Marseille, Marseille, France, 11Dax, Dax, France, 12Nephrology, Centre Hospitalier d'Avignon, Avignon, France, 13Brest, Brest, France, 14Medecine Interne, CH Vannes, Vannes, France, 15Department of Internal Medicine, Caen University Hospital, Caen, France, 16Department of Internal Medicine, Toulouse University Hospital, University of Toulouse, INSERM UMR 1027, Toulouse, France, 17Service de Néphrologie, Hôpital Henri-Mondor, Créteil, Créteil, France, 18CHU Pitié-Salpêtrière - Department of Internal Medicine 2. Referal center for SLE/APS, Paris, France, 19service de médecine interne et maladies infectieuses, CHU de Bordeaux, Pessac, France, 20National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 21Hôpital Hôtel Dieu, Paris, France, 22Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France ;Université Paris Descartes Sorbonne Paris, Paris, France

    Background/Purpose: Once ANCA-associated vasculitis (AAV) remission was obtained, rituximab (RTX) superiority to azathioprine (AZA) to maintain remission was shown.1 In that study, at month 28,…
  • Abstract Number: 797 • 2017 ACR/ARHP Annual Meeting

    Temporal Arteritis Revealing Antineutrophil Cytoplasmic Antibody–Associated Vasculitides: A Retrospective Study of 50 Cases

    Laure Delaval1,2, Maxime Samson3, Flora Schein4, Christian Agard5, Olivier Aumaître6, Alban Deroux7, Henry Dupuy8, Cyril Garrouste9, cedric landron10, Francois Maurier11, Pascal Cathebras12, Loïc Guillevin2,13,14 and Benjamin Terrier15,16,17, 1National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, paris, France, 2Internal medicine, Cochin University Hospital, paris, France, 3Department of Internal Medicine and Clinical Immunology, Hôpital François Mitterrand, CHU de Dijon, Dijon, France, 4Internal medicine, University Hospital St Etienne, Saint Etienne, France, 5Internal Medicine Department, Nantes University Hospital, Nantes, France, 6CHU Pitié-Salpêtrière - Department of Internal Medicine 2. Referal center for SLE/APS, Paris, France, 7Internal Medicine, CHU de Grenoble, Grenoble, France, 8Department of Internal Medicine, Haut-Lévêque Hospital, Pessac, France, 9Nephrology, CHU, Clermont-Ferrand, France, 10service de médecine interne, CH Poitiers, CHU Poitiers, poitiers, France, 11Internal Medicine, Sainte-Blandine de Metz Hospital, Metz, France, 12Internal Medicine, University Hospital St Etienne, St Etienne, France, 13French Vasculitis Study Group (FVSG), Paris, France, 14National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, 15Service de Médecine Interne, Hôpital Cochin, Centre de référence national pour les maladies systémiques autoimmunes rares d’Ile de France, DHU Authors, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France, Paris, France, 16French Vasculitis Study Group (FVSG), paris, France, 17Internal Medicine, Cochin University Hospital, Paris, France

    Background/Purpose: Giant cell arteritis (GCA) is a non-necrotizing granulomatous arteritis involving large vessels, whereas antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides (AAV) are a group of necrotizing…
  • Abstract Number: 1763 • 2017 ACR/ARHP Annual Meeting

    Time to Diagnosis of ANCA-Associated Vasculitides : Data from French Vasculitis Study Group Registry

    Caroline Morbieu, Maher Banjari, Benjamin Terrier, Pascal Cohen, Claire Le Jeunne, Luc Mouthon, Xavier Puéchal and Loïc Guillevin for the French Vasculitis Study Group, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France

    Background/Purpose: Diagnosing ANCA-associated vasculitides (AAVs) can be challenging. Their clinical presentations are numerous and the time to diagnosis may range from days to years.1,2 The…
  • Abstract Number: 2935 • 2017 ACR/ARHP Annual Meeting

    Nasal Microbiota in Patients with Granulomatosis with Polyangiitis Compared to Healthy Controls

    Rennie L. Rhee1, Antoine G. Sreih1, Catherine E. Najem1, Peter C. Grayson2, Chunyu Zhao3, Kyle Bittinger3, Ronald G. Collman4 and Peter A. Merkel5, 1Rheumatology, University of Pennsylvania, Philadelphia, PA, 2National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD, 3Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, 4Medicine & Microbiology, University of Pennsylvania, Philadelphia, PA, 5Division of Rheumatology, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Prior studies have suggested a potential link between nasal microbes, in particular Staphylococcus aureus, and granulomatosis with polyangiitis (GPA; Wegener’s) but these studies relied…
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