Abstracts tagged "Aging"

Abstract Number: 2199 • 2016 ACR/ARHP Annual Meeting
Peri-Aortic Adipose Tissue Volume Is Directly Associated with Fat Accumulation in Adjacent Trunk Muscles Independent of Other Fat Depots: The Framingham Study
Robert R. McLean^1,2,3, Elizabeth J. Samelson^1,2,3, Amanda L. Lorbergs^1,2,3, Xiaochun Zhang¹, Dennis E. Anderson^2,3, Udo Hoffmann⁴, Caroline S. Fox⁵, Mary L. Bouxsein^2,3 and Douglas P. Kiel^1,2,3, ¹Hebrew SeniorLife Institute for Aging Research, Boston, MA, ²Harvard Medical School, Boston, MA, ³Beth Israel Deaconess Medical Center, Boston, MA, ⁴Massachusetts General Hospital, Boston, MA, ⁵Merck Research Laboratories, Boston, MA
Background/Purpose: Multidetector CT abdominal imaging measured PAAT volume (cm3), as well as cross-sectional area (mm2) and attenuation (HU), a marker of fat content, of the…
Abstract Number: 2572 • 2016 ACR/ARHP Annual Meeting
Study of Two Biomarkers of Biological Age in the Blood of Patients with Rheumatoid Arthritis
Laura Vidal-Bralo¹, Eva Pérez-Pampin¹, Rosana Varela¹, Juan J Gomez-Reino¹, Steve Horvath² and Antonio Gonzalez¹, ¹Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ²David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA
Background/Purpose: Accelerated biological aging of blood cells could contribute to the pathogenesis of RA. However, biological age has multiple facets, some as epigenetic aging not…
Abstract Number: 3041 • 2016 ACR/ARHP Annual Meeting
Age-Related Defects in the Immune System of Patients with GCA
Zhenke Wen¹, Yasuhiro Shimojima², Gerald Berry³, Ebru Hosgur¹, Joyce Liao⁴, Lindsy Forbess⁵, Michael Weisman⁶, Jorg Goronzy⁷ and Cornelia M. Weyand¹, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan, ³Pathology, Stanford University School of Medicine, Stanford, CA, ⁴Byers Eye Institute at Stanford, Stanford University, Palo Alto, CA, ⁵Rheumatology, Cedars-Sinai, Los Angeles, CA, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Advancing age is the strongest risk factor for GCA, a disease that exclusively affects individuals >50 years of age. The immune system undergoes dramatic…
Abstract Number: 1593 • 2015 ACR/ARHP Annual Meeting
Telomere Length and Cardiovascular Risk in Rheumatoid Arthritis
Michelle J. Ormseth¹, Joseph F. Solus², Annette M. Oeser³, Aihua Bian⁴, Tebeb Gebretsadik⁴, Ayumi Shintani⁵, Paolo Raggi⁶ and C Michael Stein⁵, ¹Department of Medicine, Division of Rheumatology, Vanderbilt University, Nashville, TN, ²Clinical Pharmacology, Vanderbilt University, Nashville, TN, ³Medicine, Vanderbilt University, Nashville, TN, ⁴Biostatistics, Vanderbilt University, Nashville, TN, ⁵Vanderbilt University, Nashville, TN, ⁶Emory University, Atlanta, GA
Background/Purpose: Telomeres protect against DNA damage and shorten with each cell division; their length may be a marker of cardiovascular and overall biological aging. Patients…
Abstract Number: 1663 • 2015 ACR/ARHP Annual Meeting
Influence of Age and Renal Impairment on Pharmacokinetics of Filgotinib (GLPG0634), a Selective JAK1 Inhibitor
Namour Florence¹, Liesbeth Fagard², Annegret Van der Aa², Sandy Goss³, Pille Harrison² and Chantal Tasset², ¹Galapagos SASU, Romainville, France, ²Galapagos NV, Mechelen, Belgium, ³Abbvie, Chicago, IL
Background/Purpose: Filgotinib is an oral, selective Janus kinase 1 (JAK1) inhibitor combining clinical efficacy and a rapid onset of action with a good safety profile…
Abstract Number: 1966 • 2015 ACR/ARHP Annual Meeting
Active PMR and GCA Is Associated with Changes in Monocyte Subset Composition
Qi Wang¹, Kornelis S.M. van der Geest², Wayel H. Abdulahad¹, Johanna Westra³, Annemieke M.H. Boots¹ and Elisabeth Brouwer¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Hanzeplein 1, Hpc: Aa21, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ³Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two closely related syndromes affecting older people. Proinflammatory cytokine IL-6 is found increased in both…
Abstract Number: 2477 • 2015 ACR/ARHP Annual Meeting
What Older Adults with Restricting Back Pain Worry about: Deteriorating Function, Reliance on Others, Distrust of Medications
Una E. Makris^1,2, Liana Fraenkel³, David W Serrano⁴, Jae H Yun⁴, Thomas M. Gill⁵ and MC Reid⁶, ¹Rheumatology, Dallas VA Medical Ctr, Dallas, TX, ²Rheumatology, UT Southwestern Medical Center, Dallas, TX, ³Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT, ⁴Internal Medicine, UT Southwestern Medical Center, Dallas, TX, ⁵Geriatrics, Yale School of Medicine, New Haven, CT, ⁶Geriatrics, Weill Cornell Medical College, New York City, NY
Background/Purpose: Although back pain is the most common type of pain disorder reported by older adults, its impact on the daily life of older adults…
Abstract Number: 2643 • 2015 ACR/ARHP Annual Meeting
Decreased Pain Level with Aging Leads to Underestimation of Disease Activity in Rheumatoid Arthritis
Yong Gil Hwang¹, Juan (June) Feng², Heather Eng³, Jason Lyons⁴, Anthony Fabio⁵ and Larry W. Moreland⁶, ¹Department of Medicine, University of Pittsburgh, Pittsburgh, PA, ²Epidemiology Data Center, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, ³Epidemiology, Univ of Pittsburgh, Pittsburgh, PA, ⁴School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, ⁵Department Of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, ⁶Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Rheumatoid arthritis (RA) is most prevalent in those who are 60 years of age or older. It has not been clearly established whether…
Abstract Number: 326 • 2015 ACR/ARHP Annual Meeting
Older Adults without Extreme Obesity Are at Highest Risk for Accelerated Knee Osteoarthritis
Jeffrey Driban¹, Grace H. Lo², Charles B. Eaton³, Lori Lyn Price⁴, Bing Lu⁵, Mary Barbe⁶ and Timothy E. McAlindon⁷, ¹Tufts Medical Center, Boston, MA, ²VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Medical Care Line and Research Care Line; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ³Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁴Clinical Care Research, Tufts Medical Center, Boston, MA, ⁵Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁶Temple University School of Medicine, Philadelphia, PA, ⁷Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Accelerated knee osteoarthritis (AKOA) may be a unique subset of knee osteoarthritis (KOA). AKOA is more common among those who are older, overweight, or…
Abstract Number: 1533 • 2015 ACR/ARHP Annual Meeting
Age Related Disability in Daily Life Should be Considered in Older Than Sixty-Five-Year-Old Rheumatoid Arthritis Patient
Ichiro Yoshii¹ and Tatsumi Chijiwa², ¹Department of Orthopaedic Surgery, Yoshii Hospital, Shimanto, Japan, ²Rheumatology, Kochi Memorial Hospital, Kochi, Japan
Background/Purpose: In treating rheumatoid arthritis (RA), patient’s activity in daily life (ADL) is extremely important factor, because RA is chronic inflammatory disease that leads discomfort…
Abstract Number: 2949 • 2014 ACR/ARHP Annual Meeting
Activation of AMP-Activated Protein Kinase (AMPK) By Berberine Limits Both Surgical Knee Instability-Induced and Aging-Related Osteoarthritis in Mice
Ru Bryan¹, Xianling Zhao², Yun Wang³, Han Sol Lee², Hyunje Kim⁴, Alifah Akasdi² and Robert Terkeltaub⁵, ¹Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, ²VAMC, San Diego, CA, ³Medicine-Rheumatology, VA Medical Ctr/UCSD, San Diego, CA, ⁴Internal medicine, School of medicine, Yeungnam University, Daegu, South Korea, ⁵Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA
Background/Purpose Human knee OA articular cartilage chondrocytes and aged mouse knee cartilage chondrocytes demonstrate decreased activation of master cellular energy bio-sensor AMPK. Moreover, inflammatory stimuli…
Abstract Number: 2857 • 2014 ACR/ARHP Annual Meeting
Restricting Back Pain Is Strongly Associated with Disability in Community-Living Older Persons over the Course of 13 Years
Una Makris^1,2, Liana Fraenkel³, Ling Han⁴, Linda Leo-Summers⁴ and Thomas M. Gill⁵, ¹Rheumatology, UT Southwestern Medical Center, Dallas, UT, ²Rheumatology, Dallas VA Medical Ctr, Dallas, TX, ³Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare Systems, New Haven, CT, ⁴Internal Medicine, Department of Medicine, New Haven, CT, ⁵Internal Medicine, Section of Geriatrics, Yale University, New Haven, CT
Background/Purpose: Although back pain is common and costly, few longitudinal studies have evaluated the association between back pain severe enough to restrict activity [hereafter referred…
Abstract Number: 1872 • 2014 ACR/ARHP Annual Meeting
Gout in Older Adult
Mara McAdams-DeMarco¹, Anna Kottgen², Bridget Burke³, Andrew Law⁴, Josef Coresh¹ and Alan N. Baer⁵, ¹Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ²Renal Division, University Hospital Freiburg, Freiburg, Germany, ³Johns Hopkins University, Baltimore, MD, ⁴Epidemiology, Johns Hopkins, Baltimore, MD, ⁵Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: To evaluate whether traditional and genetic risk factors in middle-aged members of a longitudinal population-based cohort predict the onset of gout in older age.…
Abstract Number: 1737 • 2014 ACR/ARHP Annual Meeting
Altered Phenotype and Function of Senescent Regulatory T Cells in Rheumatoid Arthritis
Johannes Fessler¹, Chrsitine Schwarz¹, Anja C. Ficjan¹, Rusmir Husic², Evelyne Höller³, Angelika Lackner¹, Winfried B. Graninger⁴ and Christian Dejaco^1,5, ¹Rheumatology and Immunology, Medical University Graz, Graz, Austria, ²Rheumatology, Medical University Graz, Graz, Austria, ³Endocrinology, Medical University Graz, Graz, Austria, ⁴Internal medicine/Rheumatology and Immunology, Medical University Graz, Graz, Austria, ⁵Department of Rheumatology and Immunology, Medical University Graz, Graz A-8036, Austria
Background/Purpose Immunosenescence accompanied by accumulation of senescent T cells is a hallmark feature in the pathogenesis of rheumatoid arthritis (RA). Here we characterize a novel senescent…
Abstract Number: 1379 • 2014 ACR/ARHP Annual Meeting
Studies on Ageing and the Severity of Radiographic Joint Damage in Rheumatoid Arthritis
L. Mangnus¹, H.W. van Steenbergen¹, E. Brouwer², E. Lindqvist³, M. Reijnierse⁴, P.K. Gregersen⁵, S. M. Rantapää-Dahlqvist⁶, D. M. van der Heijde¹ and A. H. M. van der Helm- van Mil¹, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Dept. of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Rheumatology, Lund University, Lund, Sweden, ⁴Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁵The Feinstein Institute for Medical Research, Manhasset, NY, ⁶Department for Public Health and Clinical Medicine/ Rheumatology, Umeå University, Umeå, Sweden
Background/Purpose: The Western population is getting older; consequently the proportion of elderly persons presenting with Rheumatoid Arthritis (RA) is increasing. We studied whether age is…

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