Abstracts tagged "Aging"

Abstract Number: 2132 • 2016 ACR/ARHP Annual Meeting
Deficient Autophagy Induces Premature Senescence in Aging and Osteoarthritis
Beatriz Carames¹, Paloma Lopez de Figueroa¹, Madalena Ribeiro¹, Valentina Calamia², Fernando Osorio³, Carlos Lopez-Otin³ and Francisco J. Blanco^1,4, ¹Cartilage Biology Group. Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Osteoarticular and Aging Research Lab. Proteomics Unit - Associated Node to ProteoRed, Rheumatology Division, Proteomics Group-ProteoRed/ISCIII, INIBIC-CHUAC, A Coruña, Spain, ³Degradome Lab, Universidad de Oviedo, Oviedo, Spain, ⁴Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), La Coruña, Spain
Background/Purpose: Previous findings indicated that autophagy is defective in Aging and Osteoarthritis (OA). Autophagy is essential to maintain chondrocyte homeostasis by regulating the intracellular macromolecule…
Abstract Number: 2142 • 2016 ACR/ARHP Annual Meeting
Identification of Novel Molecules Targeting Cartilage Aging As Osteoarthritis Therapeutics
Beatriz Carames¹, Uxia Nogueira-Recalde¹, Eduardo Dominguez², Maria I. Loza³ and Francisco J. Blanco^1,4, ¹Cartilage Biology Group. Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²BioFarma Research Group. University of Santiago de Compostela, Santiago de Compostela, Spain, ³BioFarma Research Group. University of Santiago de Compostela, santiago de Compostela, Spain, ⁴Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), La Coruña, Spain
Background/Purpose: Effective treatments for Osteoarthritis (OA) are not available. In aging-related diseases, including OA, failure of cellular homeostasis mechanisms, such as autophagy can cause extracellular…
Abstract Number: 2199 • 2016 ACR/ARHP Annual Meeting
Peri-Aortic Adipose Tissue Volume Is Directly Associated with Fat Accumulation in Adjacent Trunk Muscles Independent of Other Fat Depots: The Framingham Study
Robert R. McLean^1,2,3, Elizabeth J. Samelson^1,2,3, Amanda L. Lorbergs^1,2,3, Xiaochun Zhang¹, Dennis E. Anderson^2,3, Udo Hoffmann⁴, Caroline S. Fox⁵, Mary L. Bouxsein^2,3 and Douglas P. Kiel^1,2,3, ¹Hebrew SeniorLife Institute for Aging Research, Boston, MA, ²Harvard Medical School, Boston, MA, ³Beth Israel Deaconess Medical Center, Boston, MA, ⁴Massachusetts General Hospital, Boston, MA, ⁵Merck Research Laboratories, Boston, MA
Background/Purpose: Multidetector CT abdominal imaging measured PAAT volume (cm3), as well as cross-sectional area (mm2) and attenuation (HU), a marker of fat content, of the…
Abstract Number: 326 • 2015 ACR/ARHP Annual Meeting
Older Adults without Extreme Obesity Are at Highest Risk for Accelerated Knee Osteoarthritis
Jeffrey Driban¹, Grace H. Lo², Charles B. Eaton³, Lori Lyn Price⁴, Bing Lu⁵, Mary Barbe⁶ and Timothy E. McAlindon⁷, ¹Tufts Medical Center, Boston, MA, ²VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Medical Care Line and Research Care Line; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, ³Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁴Clinical Care Research, Tufts Medical Center, Boston, MA, ⁵Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁶Temple University School of Medicine, Philadelphia, PA, ⁷Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Accelerated knee osteoarthritis (AKOA) may be a unique subset of knee osteoarthritis (KOA). AKOA is more common among those who are older, overweight, or…
Abstract Number: 1533 • 2015 ACR/ARHP Annual Meeting
Age Related Disability in Daily Life Should be Considered in Older Than Sixty-Five-Year-Old Rheumatoid Arthritis Patient
Ichiro Yoshii¹ and Tatsumi Chijiwa², ¹Department of Orthopaedic Surgery, Yoshii Hospital, Shimanto, Japan, ²Rheumatology, Kochi Memorial Hospital, Kochi, Japan
Background/Purpose: In treating rheumatoid arthritis (RA), patient’s activity in daily life (ADL) is extremely important factor, because RA is chronic inflammatory disease that leads discomfort…
Abstract Number: 1593 • 2015 ACR/ARHP Annual Meeting
Telomere Length and Cardiovascular Risk in Rheumatoid Arthritis
Michelle J. Ormseth¹, Joseph F. Solus², Annette M. Oeser³, Aihua Bian⁴, Tebeb Gebretsadik⁴, Ayumi Shintani⁵, Paolo Raggi⁶ and C Michael Stein⁵, ¹Department of Medicine, Division of Rheumatology, Vanderbilt University, Nashville, TN, ²Clinical Pharmacology, Vanderbilt University, Nashville, TN, ³Medicine, Vanderbilt University, Nashville, TN, ⁴Biostatistics, Vanderbilt University, Nashville, TN, ⁵Vanderbilt University, Nashville, TN, ⁶Emory University, Atlanta, GA
Background/Purpose: Telomeres protect against DNA damage and shorten with each cell division; their length may be a marker of cardiovascular and overall biological aging. Patients…
Abstract Number: 1663 • 2015 ACR/ARHP Annual Meeting
Influence of Age and Renal Impairment on Pharmacokinetics of Filgotinib (GLPG0634), a Selective JAK1 Inhibitor
Namour Florence¹, Liesbeth Fagard², Annegret Van der Aa², Sandy Goss³, Pille Harrison² and Chantal Tasset², ¹Galapagos SASU, Romainville, France, ²Galapagos NV, Mechelen, Belgium, ³Abbvie, Chicago, IL
Background/Purpose: Filgotinib is an oral, selective Janus kinase 1 (JAK1) inhibitor combining clinical efficacy and a rapid onset of action with a good safety profile…
Abstract Number: 1966 • 2015 ACR/ARHP Annual Meeting
Active PMR and GCA Is Associated with Changes in Monocyte Subset Composition
Qi Wang¹, Kornelis S.M. van der Geest², Wayel H. Abdulahad¹, Johanna Westra³, Annemieke M.H. Boots¹ and Elisabeth Brouwer¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ²Hanzeplein 1, Hpc: Aa21, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ³Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two closely related syndromes affecting older people. Proinflammatory cytokine IL-6 is found increased in both…
Abstract Number: 2477 • 2015 ACR/ARHP Annual Meeting
What Older Adults with Restricting Back Pain Worry about: Deteriorating Function, Reliance on Others, Distrust of Medications
Una E. Makris^1,2, Liana Fraenkel³, David W Serrano⁴, Jae H Yun⁴, Thomas M. Gill⁵ and MC Reid⁶, ¹Rheumatology, Dallas VA Medical Ctr, Dallas, TX, ²Rheumatology, UT Southwestern Medical Center, Dallas, TX, ³Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT, ⁴Internal Medicine, UT Southwestern Medical Center, Dallas, TX, ⁵Geriatrics, Yale School of Medicine, New Haven, CT, ⁶Geriatrics, Weill Cornell Medical College, New York City, NY
Background/Purpose: Although back pain is the most common type of pain disorder reported by older adults, its impact on the daily life of older adults…
Abstract Number: 2643 • 2015 ACR/ARHP Annual Meeting
Decreased Pain Level with Aging Leads to Underestimation of Disease Activity in Rheumatoid Arthritis
Yong Gil Hwang¹, Juan (June) Feng², Heather Eng³, Jason Lyons⁴, Anthony Fabio⁵ and Larry W. Moreland⁶, ¹Department of Medicine, University of Pittsburgh, Pittsburgh, PA, ²Epidemiology Data Center, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, ³Epidemiology, Univ of Pittsburgh, Pittsburgh, PA, ⁴School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, ⁵Department Of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, ⁶Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Rheumatoid arthritis (RA) is most prevalent in those who are 60 years of age or older. It has not been clearly established whether…
Abstract Number: 44 • 2014 ACR/ARHP Annual Meeting
Physical Function, Hyperuricemia and Gout in Older Adults
Mara McAdams-DeMarco¹, Bridget Burke², Andrew Law³, Anna Kottgen⁴, Alan N. Baer⁵ and Josef Coresh¹, ¹Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ²Johns Hopkins University, Baltimore, MD, ³Epidemiology, Johns Hopkins, Baltimore, MD, ⁴Renal Division, University Hospital Freiburg, Freiburg, Germany, ⁵Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: The prevalence of gout is higher in older adults than in younger adults and these patients are at risk of physical disability. We sought…
Abstract Number: 45 • 2014 ACR/ARHP Annual Meeting
Body Mass Index Across the Lifespan and Lifetime Incidence of Gout in Men
Allan C. Gelber¹, Lucy Meoni², Michael Klag² and Joseph Gallo², ¹Medicine/ Rheumatology, Johns Hopkins University, Baltimore, MD, ²Medicine, Johns Hopkins University, Baltimore, MD
Background/Purpose: Gout is the leading cause of inflammatory arthritis in men and is linked to higher levels of body weight and obesity in mid-adult life.…
Abstract Number: 2949 • 2014 ACR/ARHP Annual Meeting
Activation of AMP-Activated Protein Kinase (AMPK) By Berberine Limits Both Surgical Knee Instability-Induced and Aging-Related Osteoarthritis in Mice
Ru Bryan¹, Xianling Zhao², Yun Wang³, Han Sol Lee², Hyunje Kim⁴, Alifah Akasdi² and Robert Terkeltaub⁵, ¹Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, ²VAMC, San Diego, CA, ³Medicine-Rheumatology, VA Medical Ctr/UCSD, San Diego, CA, ⁴Internal medicine, School of medicine, Yeungnam University, Daegu, South Korea, ⁵Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA
Background/Purpose Human knee OA articular cartilage chondrocytes and aged mouse knee cartilage chondrocytes demonstrate decreased activation of master cellular energy bio-sensor AMPK. Moreover, inflammatory stimuli…
Abstract Number: 2857 • 2014 ACR/ARHP Annual Meeting
Restricting Back Pain Is Strongly Associated with Disability in Community-Living Older Persons over the Course of 13 Years
Una Makris^1,2, Liana Fraenkel³, Ling Han⁴, Linda Leo-Summers⁴ and Thomas M. Gill⁵, ¹Rheumatology, UT Southwestern Medical Center, Dallas, UT, ²Rheumatology, Dallas VA Medical Ctr, Dallas, TX, ³Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare Systems, New Haven, CT, ⁴Internal Medicine, Department of Medicine, New Haven, CT, ⁵Internal Medicine, Section of Geriatrics, Yale University, New Haven, CT
Background/Purpose: Although back pain is common and costly, few longitudinal studies have evaluated the association between back pain severe enough to restrict activity [hereafter referred…
Abstract Number: 1872 • 2014 ACR/ARHP Annual Meeting
Gout in Older Adult
Mara McAdams-DeMarco¹, Anna Kottgen², Bridget Burke³, Andrew Law⁴, Josef Coresh¹ and Alan N. Baer⁵, ¹Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ²Renal Division, University Hospital Freiburg, Freiburg, Germany, ³Johns Hopkins University, Baltimore, MD, ⁴Epidemiology, Johns Hopkins, Baltimore, MD, ⁵Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: To evaluate whether traditional and genetic risk factors in middle-aged members of a longitudinal population-based cohort predict the onset of gout in older age.…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].