Abstracts tagged "Aging"

Abstract Number: 0734 • ACR Convergence 2022
Comfort Levels and Practice Patterns for Osteoporosis-Related Care Among Persons Living with HIV in Peru: A National Physician Survey
Rebecca Slotkin¹, Camila Lucero Granda Calderón², Diego Cabrera³, Carlos Manuel Benites Villafane⁴, Patricia Jannet Garcia⁵ and Evelyn Hsieh³, ¹Yale University School of Public Health, New Haven, CT, ²Facultad de Medicina Alberto Hurtado de la Universidad Peruana Cayetano Heredia, Lima, Peru, ³Section of Rheumatology, Allergy and Immunology, Yale School of Medicine, New Haven, CT, ⁴Ministerio de Salud, Lima, Peru, ⁵Epidemiology, STD, and HIV Unit, School of Public Health, Universidad Peruana Cayetano Heredia, Lima, Peru
Background/Purpose: As they age, persons living with HIV (PLWH) are at increased risk for osteoporosis due to chronic infection and antiretroviral therapies (ART). In Peru,…
Abstract Number: 0837 • ACR Convergence 2022
Providers’ Adoption of 2017 Guidelines on DMARD Use Perioperatively for Elective Total Hip and Knee Arthroplasty at a Single Academic Center
Chris Ching¹, Erica Mulcaire-Jones², Andrew Shaffer¹, Jeremy Gililland¹, Michael Battistone³ and Dorota Lebiedz-Odrobina¹, ¹University of Utah, Salt Lake City, UT, ²Intermountain Healthcare, Salt Lake City, UT, ³Salt Lake City VA, Salt Lake City, UT
Background/Purpose: Rate of prosthetic joint infection (PJI) after total joint arthroplasty (TJA) is higher in patients with rheumatic conditions than in patients with OA. Our…
Abstract Number: 1196 • ACR Convergence 2022
Interaction of Cumulative Inflammation with Smoking and Lipids in Risk Modification of Dementia Among Patients with Rheumatoid Arthritis: A Population-based Cohort Study
Chanakya Kodishala¹, Stephanie Duong², Cassondra Hulshizer², Ryan Lennon², Rabia Javed², Maria Vassilaki², Michelle Mielke³, John Davis², Cynthia Crowson⁴ and Elena Myasoedova², ¹Mayo Clinic Rochester Minnesota, Rochester, MN, ²Mayo Clinic, Rochester, MN, ³Wake Forest University School of Medicine, Winston-Salem, NC, ⁴Mayo Clinic, Eyota, MN
Background/Purpose: Patients with rheumatoid arthritis (RA) have increased risk of developing dementia. Systemic inflammation is implicated in the pathogenesis of cognitive decline. However, the association…
Abstract Number: 1327 • ACR Convergence 2022
Immune Cell Subsets and Risk of Incident Hip Fracture in Older Adults: The Cardiovascular Health Study
Rachel Elam¹, Petra Buzkova², Joseph Delaney³, Howard Fink⁴, Joshua Barzilay⁵, Laura Carbone¹, Rick Saha¹, John Robbins⁶, Kenneth Mukamal⁷, Rodrigo Valderrabano⁸, Bruce Psaty², Russell Tracy⁹, Nels Olson⁹, Sally Huber¹⁰, Margaret Doyle⁹, Alan Landay¹¹ and Jane Cauley¹², ¹Augusta University, Augusta, GA, ²University of Washington, Seattle, WA, ³University of Manitoba, Winnipeg, MB, Canada, ⁴University of Minnesota, Minneapolis, MN, ⁵Kaiser Permanente, Atlanta, GA, ⁶UC Davis, Davis, CA, ⁷Beth Israel Deaconess Medical Center, Boston, MA, ⁸Brigham and Women's Hospital, Boston, MA, ⁹University of Vermont, Burlington, VT, ¹⁰University of Vermont, Burlingon, VT, ¹¹Rush University Medical Center, Chicago, IL, ¹²University of Pittsburgh, PIttsburgh, PA
Background/Purpose: Cell-mediated immunity may play a role in osteoporosis development. Fracture is the major consequence of osteoporosis. Thus, cell-mediated immunity may impact fracture risk. We…
Abstract Number: 1514 • ACR Convergence 2021
Age-related Metabolic Reprogramming of Memory CD4+ T Cells Is Associated with Reactive Oxygen Species-induced Immune Cell Dysfunction
Yuling Chen¹, Pierre-Louis Krau², Pelle Löwe³, Moritz Pfeiffenberger⁴, Lisa Ehlers³, Alexandra Damerau⁴, Paula Hoff³, Frank Buttgereit⁵ and Timo Gaber⁴, ¹Charité University Medicine Berlin, Berlin, Germany, ²Charit Universittsmedizin Berlin, corporate member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, ³Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany, ⁴Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, ⁵Charité – Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Inflamm-aging is a sterile, low-grade, chronic systemic inflammatory state characterized by an increase in proinflammatory cytokines involved in the development of most age-related diseases…
Abstract Number: 0158 • ACR Convergence 2021
The Influence of Age on the Prevalence of Inflammatory and Post-inflammatory MRI Lesions in the Sacroiliac Joints of Patients with and Without Axial Spondyloarthritis
Xenofon Baraliakos, Styliani Tsiami, Anna Kühn, Martin Fruth and Jürgen Braun, Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany
Background/Purpose: Axial spondyloarthritis (axSpA) is clinically characterized by chronic inflammatory back pain and by inflammatory and structural changes in the sacroiliac joint (SIJ) as assessed…
Abstract Number: 1678 • ACR Convergence 2021
Favorable Balance of Benefit and Harm of Long-Term, Low Dose Prednisolone Added to Standard Treatment in Rheumatoid Arthritis Patients Aged 65+: The Pragmatic, Multicenter, Placebo-Controlled GLORIA Trial
Maarten Boers¹, Linda Hartman¹, Daniela Opris-Belinski², Reinhard Bos³, Marc Kok⁴, Jose Pereira da Silva⁵, Ed Griep⁶, Ruth Klaasen⁷, Cornelia F. Allaart⁸, Paul Baudoin⁹, Hennie Raterman¹⁰, Zoltan Szekanecz¹¹, Frank Buttgereit¹², Pavol Masaryk¹³, L. Thomas Klausch¹, Sabrina Paolino¹⁴, Annemarie Schilder³, Willem Lems¹⁵ and Maurizio Cutolo¹⁴, ¹Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands, ²Carol Davila University, Bucharest, Romania, ³Medical Center Leeuwarden, Leeuwarden, Netherlands, ⁴Maasstad Hospital, Rotterdam, Netherlands, ⁵University of Coimbra | UC · Clínica Universitária de Reumatologia. Faculty of Medicine, Columbia, Portugal, ⁶Antonius Hospital, Sneek, Netherlands, ⁷Meander Medical Center, Amersfoort, Netherlands, ⁸Leiden University Medical Center, Leiden, Netherlands, ⁹Reumazorg Flevoland, Emmeloord, Netherlands, ¹⁰Northwest Clinics, Alkmaar, Netherlands, ¹¹Division of Rheumatology, University of Debrecen, Faculty of Medicine, Debrecen, Hungary, ¹²Charité – Universitätsmedizin Berlin, Berlin, Germany, ¹³National Institute for the Rheumatic Diseases, Bratislava, Slovakia, ¹⁴Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Polyclinic San Martino Hospital, Genoa, Italy, ¹⁵VUmc, Amsterdam, Netherlands
Background/Purpose: Low-dose glucocorticoid (GC) therapy is widely used in rheumatoid arthritis (RA) but the balance of benefit and harm is still unclear. We studied the…
Abstract Number: 0352 • ACR Convergence 2021
Native American and African American Rheumatic Disease Patients Exhibit Accelerated Biological Aging Compared to European Americans
Joseph Kheir, Carla Guthridge, Nicolas Dominguez, Wade DeJager, Sarah Cooper, Joel Guthridge and Judith James, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: The universal process of aging is associated with increased risk of disease and death as a result of changing physiologic and molecular processes. In…
Abstract Number: 1862 • ACR Convergence 2021
Clonal Hematopoiesis Across the Age Spectrum in Patients with Systemic Vasculitis
Kristina Wells¹, Fernanda Gutierrez-Rodrigues², Bhavisha Patel², Kaitlin Quinn³, Keith Sikora¹, Neal Young⁴ and Peter Grayson⁵, ¹National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, ²National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Washington, DC, ⁴National Heart, Lung, and Blood Institute (NHLBI), National Institues of Health, Bethesda, MD, ⁵National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD
Background/Purpose: Clonal hematopoiesis (CH) is a pre-malignant state characterized by somatic mutations in hematologic precursor cells in genes associated with myeloid malignancies. Incidence of CH…
Abstract Number: 0375 • ACR Convergence 2021
Optimizing a Referral Strategy for Patients with a High Probability of Axial Spondyloarthritis:the Role of Age and Symptom Duration
Fabian Proft¹, Laura Spiller¹, Burkhard Muche², Mikhail Protopopov¹, Judith Rademacher¹, Valeria Rios Rodriguez¹, Murat Torgutalp¹, Denis Poddubnyy³ and Imke Redeker⁴, ¹Charité University Medicine Berlin, Berlin, Germany, ²Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Berlin, Germany, ³Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany, ⁴German Rheumatism Research Centre (DRFZ), Berlin, Germany
Background/Purpose: One of the most important prerequisites for a timely diagnosis of axial spondyloarthritis (axSpA) is the early referral of a patient with back pain…
Abstract Number: 0584 • ACR Convergence 2021
High Number of Comorbidities and Concomitant Medications at Baseline in the Glucocorticoid Low-dose Outcome in Rheumatoid Arthritis (GLORIA) Study: An Older Population with Rheumatoid Arthritis
Maarten Boers¹, Linda Hartman¹, Daniela Opris-Belinski², Reinhard Bos³, Marc Kok⁴, Jose Pereira da Silva⁵, Eduard N Griep⁶, Ruth Klaasen⁷, Cornelia F. Allaart⁸, Paul Baudoin⁹, Hennie Raterman¹⁰, Zoltan Szekanecz¹¹, Frank Buttgereit¹², Pavol Masaryk¹³, L. Thomas Klausch¹, Sabrina Paolino¹⁴, Annemarie Schilder¹⁵, Willem Lems¹⁶ and Maurizio Cutolo¹⁴, ¹Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands, ²Carol Davila University, Bucharest, Romania, ³Department of Rheumatology, Medical Centre Leeuwarden, Leeuwarden, Netherlands, ⁴Maasstad Hospital, Rotterdam, Netherlands, ⁵University of Coimbra | UC · Clínica Universitária de Reumatologia. Faculty of Medicine, Columbia, Portugal, ⁶Antonius Hospital, Leeuwarden, Netherlands, ⁷Meander Medical Center, Amersfoort, Netherlands, ⁸Leiden University Medical Center, Leiden, Netherlands, ⁹Reumazorg ZWN, Almere, Netherlands, ¹⁰Northwest Clinics, Alkmaar, Netherlands, ¹¹Division of Rheumatology, University of Debrecen, Faculty of Medicine, Debrecen, Hungary, ¹²Charité – Universitätsmedizin Berlin, Berlin, Germany, ¹³National Institute for the Rheumatic Diseases, Bratislava, Slovakia, ¹⁴Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Polyclinic San Martino Hospital, Genoa, Italy, ¹⁵Medical Centre Leeuwarden, Leeuwarden, Netherlands, ¹⁶VUmc, Amsterdam, Netherlands
Background/Purpose: Older people are often underrepresented in trials because the generally high number of comorbid conditions (1). The objective of this abstract is to document…
Abstract Number: 0603 • ACR Convergence 2021
Barriers and Potential Solutions in the Recruitment and Retention of Older Patients in Clinical Trials – Lessons Learned from Six Large Multi-center Randomized Controlled Trials
Thomas Buttgereit¹, Andriko Palmowski¹, Noah Forsat¹, Maarten Boers², Miles Witham³, Nicolas Rodondi⁴, Elisavet Moutzouri⁴, Antonio Jesus Quesada Navidad⁵, Arnoud van’t Hof⁶, Bart van der Worp⁷, Laura Coll-Planas⁸, Marieke Voshaar⁹, Maarten de Wit¹⁰, Jose Pereira da Silva¹¹, Sven Stegemann¹², Johannes Bijlsma¹³, Marcus Koeller¹⁴, Simon Mooijaart¹⁵, Patricia Kearney¹⁶ and Frank Buttgereit¹, ¹Charité – Universitätsmedizin Berlin, Berlin, Germany, ²Amsterdam UMC, Vrije Universiteit, Amsterdam, Netherlands, ³AGE Research Group, NIHR Newcastle Biomedical Research Centre, Translational and Clinical Research Institute, Newcastle University and Newcastle upon Tyne Hospitals Trust, Newcastle, United Kingdom, ⁴Department of General Internal Medicine, Inselspital, Bern University Hospital, Bern, Switzerland, ⁵CNIC – Spanish National Center for Cardiovascular Research, Madrid, ⁶Cardiology Department, Maastricht UMC, Maastricht, Netherlands, ⁷Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, Netherlands, ⁸Fundació Salut i Envelliment, Universitat Autònoma de Barcelona, Barcelona, Spain, ⁹Department Psychology, Health and Technology, University of Twente, Twente, Netherlands, ¹⁰EULAR Patient Research Partner, Zaltbommel, Netherlands, ¹¹University of Coimbra | UC · Clínica Universitária de Reumatologia. Faculty of Medicine, Columbia, Portugal, ¹²TU Graz, Institute for Process and Particle Engineering, Graz, Australia, ¹³Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, ¹⁴Faculty of Geriatric Medicine, Medical University of Vienna, Vienna, Austria, ¹⁵Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands; Institute for Evidence-based Medicine in Old Age | IEMO, Leiden, Netherlands, ¹⁶School of Epidemiology and Public Health, University College Cork, Cork, Ireland
Background/Purpose: Older people remain underrepresented in clinical trials, and evidence generated in younger populations cannot always be generalized to older patients.We aimed to identify key…
Abstract Number: 0857 • ACR Convergence 2021
Association of Telomere Length with Phenotypic Frailty in Systemic Lupus Erythematosus
Sarah Lieber¹, Robyn Lipschultz¹, Syed Zahid², Mangala Rajan², Myriam Lin¹, Laura Donlin¹, Neal Lue² and Lisa Mandl¹, ¹Hospital for Special Surgery, New York, NY, ²Weill Cornell Medicine, New York, NY
Background/Purpose: Frailty is a novel risk factor for adverse health outcomes in systemic lupus erythematosus (SLE). Although frailly is conceptualized as “accelerated aging,” whether the…
Abstract Number: 0897 • ACR Convergence 2021
Age-Stratified Trend of Spinal Radiographic Damage Progression in Patients with Ankylosing Spondylitis
Tae-Han Lee¹, Bon San Koo², Bora Nam³, Seunghun Lee⁴, Kyung Bin Joo⁴ and Tae-Hwan Kim³, ¹Keimyung University Dongsan Hospital, Daegu, Republic of Korea, ²Inje University Seoul Paik Hospital, Seoul, Republic of Korea, ³Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ⁴Hanyang University Hospital, Seoul, Republic of Korea
Background/Purpose: Previous studies investigating the course of spinal structural progression in patients with ankylosing spondylitis (AS) using the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS)…
Abstract Number: 0942 • ACR Convergence 2021
Transcriptional Regulation of Synovial Macrophages in the Aging Joint
Shang-Yang Chen¹, Anna Montgomery¹, Anna Woo¹, Gaurav Gadhvi¹, Harris Perlman¹, Carla Cuda¹, Dawn Bowdish² and Deborah Winter³, ¹Northwestern University, Chicago, IL, ²McMaster University, Hamilton, ON, Canada, ³Northwestern University Division of Rheumatology, Chicago, IL
Background/Purpose: Macrophages are critical in maintaining tissue homeostasis, as well as in inflammation and immune response, but their function deteriorates with age increasing susceptibility to…

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