Abstracts tagged "Aging"

Abstract Number: 45 • 2014 ACR/ARHP Annual Meeting
Body Mass Index Across the Lifespan and Lifetime Incidence of Gout in Men
Allan C. Gelber¹, Lucy Meoni², Michael Klag² and Joseph Gallo², ¹Medicine/ Rheumatology, Johns Hopkins University, Baltimore, MD, ²Medicine, Johns Hopkins University, Baltimore, MD
Background/Purpose: Gout is the leading cause of inflammatory arthritis in men and is linked to higher levels of body weight and obesity in mid-adult life.…
Abstract Number: 43 • 2013 ACR/ARHP Annual Meeting
Overexpression Of Lamin A In Mesenchymal STEM CELLS Compromises Chondrogenesis and Enhances Adipogenesis
Jesús Mateos^1,2, Arancha Landeira^1,2, Alexandre De la Fuente^1,2, Iván Lesende-Rodríguez^1,3, Pablo Fernández-Pernas^1,3, Maria Carmen Arufe^2,3 and Francisco J. Blanco^1,2,4, ¹Rhematology Division, ProteoRed/ISCIII. INIBIC-Hospital A Coruña, 15006, A Coruña, Spain, ²CIBER-BBN, Zaragoza, Spain, ³Department of Medicine, Area of Anatomy and Human Embryology, University of A Coruña-INIBIC, A Coruña, Spain, ⁴Department of Medicine. University of Santiago de Compostela, Santiago de Compostela, Spain
Background/Purpose: Previous work by our group and others indicated that an accumulation of lamin A (LMNA) is associated with the osteoarthritis (OA) chondrocyte phenotype. Mutations…
Abstract Number: 56 • 2013 ACR/ARHP Annual Meeting
Age-Related Loss Of The Transforming Growth Factor Beta Receptor ALK5 Precedes Osteoarthritis Development In Cartilage
Arjan van Caam¹, Esmeralda N. Blaney Davidson², Eva Thijssen¹, Wim B. van den Berg¹ and Peter M. van der Kraan¹, ¹Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Osteoarthritis (OA) is the most common joint disease and (old) age is its main risk factor. One of OA's main hallmarks is degradation of…
Abstract Number: 28 • 2013 ACR/ARHP Annual Meeting
Differentiation, Activation, and Autoreactivity Of CD11c+ B Cells (ABCs)
Alice E. Wiedeman¹, Natalia V. Giltiay², Lena Tanaka³ and Keith B. Elkon³, ¹Immunology, University of Washington, Seattle, WA, ²Department of Immunology, Division of Rheumatology, University of Washington, Seattle, WA, ³Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Recently, a population of CD11c+ age-associated B cells (ABCs) was identified in normal aged female mice. These cells could be expanded following activation by…
Abstract Number: 132 • 2013 ACR/ARHP Annual Meeting
Relation Of Age With Symptom Severity and Quality Of Life In Patients With Fibromyalgia
Juan Jiao^1,2, Ann Vincent³, Connie A. Luedtke⁴, Stephen Cha⁵ and Terry H. Oh⁶, ¹Rheumatology, Guang'anmen Hospital , China Academy of Chinese Medical Sciences, Beijing, China, ²Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, ³General Internal Medicine, Mayo Clinic, Rochester, MN, ⁴Department of Nursing, Mayo Clinic, Rochester, MN, ⁵Health Sciences Research, Mayo Clinic, Rochester, MN, ⁶Physical Medicine & Rehabilitation, Mayo Clinic, Rochester, MN
Background/Purpose: The relationship of age and fibromyalgia symptom severity and quality of life (QOL) is still debated. Reports range from no differences between patients younger…
Abstract Number: 72 • 2013 ACR/ARHP Annual Meeting
Autophagy Changes During Aging: A Study In GFP-LC3 Mice
Beatriz Carames¹, William B. Kiosses², Merissa Olmer³ and Martin Lotz⁴, ¹Cartilage Biology Group. Rheumatology Division, INIBIC–A Coruña, SPAIN, A Coruña, Spain, ²The Scripps Research Institute, La Jolla, CA, ³The Sripps Research Institute, La Jolla, CA, ⁴The Scripps Research Institute, La Jolla, USA, La Jolla, CA
Background/Purpose: Aging is a main risk factor for osteoarthritis (OA), the most prevalent musculoskeletal disorder. Aging-associated changes in autophagy, an essential cellular homeostasis mechanism, have…
Abstract Number: 2909 • 2013 ACR/ARHP Annual Meeting
2010 Medical Care Expenditures Among US Adults With Arthritis
Miriam Cisternas¹, Louise Murphy², David Pasta³, Edward H. Yelin⁴ and Charles G. Helmick⁵, ¹MGC Data Services, Carlsbad, CA, ²Division of Population Health, CDC, Atlanta, GA, ³DMA Corporation, Palo Alto, CA, ⁴Medicine, UC San Francisco, San Francisco, CA, ⁵National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Using data from the 2010 Medical Expenditure Panel Survey (MEPS), we estimated total and arthritis-attributable medical care expenditures among US adults age 18 years…
Abstract Number: 2854 • 2013 ACR/ARHP Annual Meeting
Restricting Back Pain and Subsequent Mobility Disability In Community-Living Older Persons
Una E. Makris¹, Liana Fraenkel², Ling Han³, Linda Leo-Summers³ and Thomas M. Gill⁴, ¹Rheumatology, UT Southwestern Medical Center, VA Medical Center, Dallas, TX, ²Medicine, Section of Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT, ³Internal Medicine, Department of Medicine, New Haven, CT, ⁴Internal Medicine, Section of Geriatrics, Yale University, New Haven, CT
Background/Purpose: Although back pain is common and costly, few longitudinal studies have evaluated the association between back pain, severe enough to restrict activity (hereafter referred…
Abstract Number: 2710 • 2013 ACR/ARHP Annual Meeting
Deficiency Of The Protein Kinase Ataxia Telangiectasia Mutated Accelerates T Cell Aging In Rheumatoid Arthritis
Zhen Yang¹, Hiroshi Fujii², Eric L. Matteson³, Jorg J. Goronzy¹ and Cornelia M. Weyand⁴, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Department of Hematology and Rheumatology, Tohoku University, Sendai, Japan, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: T lymphocytes hold a pinnacle position in the pathogenesis of rheumatoid arthritis (RA) and through their longevity contribute to disease chronicity. The protein kinase…
Abstract Number: 2331 • 2013 ACR/ARHP Annual Meeting
Efficacy and Safety Of Tofacitinib In Older and Younger Patients With Rheumatoid Arthritis
J. R. Curtis¹, H. Schulze-Koops², L Takiya³, C. A. Mebus⁴, K. Terry⁴, R. Chew⁴ and T. V. Jones³, ¹Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, ²University of Munich, Munich, Germany, ³Pfizer Inc, Collegeville, PA, ⁴Pfizer Inc, Groton, CT
Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). The clinical development program for tofacitinib in RA enrolled ˃500…
Abstract Number: 2162 • 2013 ACR/ARHP Annual Meeting
Physical, Psychological, and Social Impacts Of Restricting Back Pain: The Older Person’s Perspective
Una E. Makris¹, Trisha V. Melhado², Simon C. Lee³, Heidi A. Hamann², Lisa M. Walke⁴, Thomas M. Gill⁴ and Liana Fraenkel⁵, ¹Rheumatology, UT Southwestern Medical Center, VA Medical Center, Dallas, TX, ²Clinical Sciences, UT Southwestern Medical Center, Dallas, TX, ³UT Southwestern Medical Center, Dallas, TX, ⁴Internal Medicine, Section of Geriatrics, Yale University, New Haven, CT, ⁵Medicine, Section of Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT
Background/Purpose: Although back pain is the most common type of pain reported by older adults, we have a limited understanding of its impact on the…
Abstract Number: 1787 • 2013 ACR/ARHP Annual Meeting
Does Age At Disease Onset Influence Disease Activity and Function In Rheumatoid Arthritis Patients? Results From The Ontario Best Practices Research Initiative (OBRI) Registry
Thanu Nadarajah¹, Binu Jacob², Pooneh Akhavan³, Bindee Kuriya⁴, Edward C. Keystone⁵ and Claire Bombardier⁶, ¹Department of Medicine, University of Toronto, Toronto, ON, Canada, ²University Health Network, Toronto General Research Institute, Toronto, ON, Canada, ³Medicine, Mount Sinai Hospital/University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁵Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁶Rheumatology, University of Toronto, Toronto, ON, Canada
Background/Purpose: The population of elderly individuals with rheumatoid arthritis (RA) is increasing. The aim of this study was to assess whether age at disease onset…
Abstract Number: 1343 • 2013 ACR/ARHP Annual Meeting
Are There Differences Between Young and Older Onset Early Rheumatoid Arthritis and Does This Impact Outcomes? An Analysis From The Canadian Early Arthritis Cohort
Michael Arnold¹, Vivian P. Bykerk², Gilles Boire³, Boulos Haraoui⁴, Carol A. Hitchon⁵, J. Carter Thorne⁶, Edward Keystone⁷ and Janet E. Pope⁸, ¹Medicine/Rheumatology, University College Dublin, Ireland, Dublin, Ireland, ²Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ³Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁴Rheumatology, Institut de Rhumatologie de Montréal, Montreal, QC, Canada, ⁵Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ⁶Southlake Regional Health Centre, Newmarket, ON, Canada, ⁷Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, University of Toronto, Toronto, ON, Canada, ⁸Medicine, Divsion of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
Background/Purpose: To determine the impact of age on disease and remission in early rheumatoid arthritis (ERA). Methods: Data from the Canadian Early Arthritis Cohort (CATCH)…
Abstract Number: 64 • 2013 ACR/ARHP Annual Meeting
Fibulin-3 In Joint Aging and Osteoarthritis Pathogenesis
Akihiko Hasegawa^1,2, Tomo Yonezawa¹, Noboru Taniguchi¹, Koji Otabe¹, Yukio Akasaki¹, Tetsuya Matsukawa¹, Masahiko Saito³, Masashi Neo⁴, Lihua Y. Marmorstein⁵ and Martin K. Lotz¹, ¹Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, ²Orthopaedic Surgery, Osaka Medical College, Takatsuki, Osaka, Japan, ³Orthopaedic Surgery, Toho University Sakura Medical Center, Sakura, Japan, ⁴Department of Orthopedic Surgery, Osaka Medical College, Osaka, Japan, ⁵Department of Ophthalmology and Vision Science, University of Arizona, Tucson, AZ
Background/Purpose: Osteoarthritis (OA) is the most common joint disease. Among the earliest lesions during OA development is disruption of the superficial zone (SZ) of articular…
Abstract Number: 68 • 2013 ACR/ARHP Annual Meeting
Autophagy Activation Protects From Mitochondrial Dysfunction In Human Chondrocytes
Beatriz Caramés¹, Paloma López de Figueroa², Martin Lotz³ and Francisco J. Blanco⁴, ¹Osteoarticular and Aging Research Lab, INIBIC–Complejo Hospitalario Universitario A Coruña, SPAIN, A Coruña, Spain, ²Cartilage Biology group. Rheumatology Division, INIBIC-A Coruña, Spain, A Coruña, Spain, ³The Scripps Research Institute, La Jolla, USA, La Jolla, CA, ⁴Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain
Background/Purpose: A common feature of aging-related diseases, such as osteoarthritis (OA), is the progressive accumulation of damaged macromolecules leading to cell dysfunction and death. Autophagy,…

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