Abstract Number: 64 • 2013 ACR/ARHP Annual Meeting
Fibulin-3 In Joint Aging and Osteoarthritis Pathogenesis
Background/Purpose: Osteoarthritis (OA) is the most common joint disease. Among the earliest lesions during OA development is disruption of the superficial zone (SZ) of articular…Abstract Number: 68 • 2013 ACR/ARHP Annual Meeting
Autophagy Activation Protects From Mitochondrial Dysfunction In Human Chondrocytes
Background/Purpose: A common feature of aging-related diseases, such as osteoarthritis (OA), is the progressive accumulation of damaged macromolecules leading to cell dysfunction and death. Autophagy,…Abstract Number: 59 • 2013 ACR/ARHP Annual Meeting
Downregulated Forkhead-Box Class O Transcription Factors Attenuate Oxidative Stress Resistance In Human Chondrocytes
Background/Purpose: Aging-associated changes in articular chondrocytes represent a major risk factor for osteoarthritis (OA). The major signaling pathway that regulates cellular aging is the Insulin/IGF-1/Pl3k/Akt/forkhead-box…Abstract Number: 43 • 2013 ACR/ARHP Annual Meeting
Overexpression Of Lamin A In Mesenchymal STEM CELLS Compromises Chondrogenesis and Enhances Adipogenesis
Background/Purpose: Previous work by our group and others indicated that an accumulation of lamin A (LMNA) is associated with the osteoarthritis (OA) chondrocyte phenotype. Mutations…Abstract Number: 56 • 2013 ACR/ARHP Annual Meeting
Age-Related Loss Of The Transforming Growth Factor Beta Receptor ALK5 Precedes Osteoarthritis Development In Cartilage
Background/Purpose: Osteoarthritis (OA) is the most common joint disease and (old) age is its main risk factor. One of OA's main hallmarks is degradation of…Abstract Number: 28 • 2013 ACR/ARHP Annual Meeting
Differentiation, Activation, and Autoreactivity Of CD11c+ B Cells (ABCs)
Background/Purpose: Recently, a population of CD11c+ age-associated B cells (ABCs) was identified in normal aged female mice. These cells could be expanded following activation by…
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