Abstract Number: 2341 • 2017 ACR/ARHP Annual Meeting
The Interaction between Genetic Risk Factors and Age of Disease Onset in Juvenile Dermatomyositis
Background/Purpose: Juvenile dermatomyositis (JDM) is a rare, severe autoimmune disease characterized by muscle weakness and rash. Clinical features of JDM are heterogeneous, and can include…Abstract Number: 2455 • 2017 ACR/ARHP Annual Meeting
Efficacy of Etanercept in Elderly Patients with Rheumatoid Arthritis
Background/Purpose: Ageing is associated with declining immune cell function and age-related comorbidities.1,2 In the US, the prevalence of rheumatoid arthritis (RA) is ~2% in individuals…Abstract Number: 2717 • 2017 ACR/ARHP Annual Meeting
Late Onset of IgA Vasculitis Is Associated with More Severe Renal Involvement
Background/Purpose: Immunoglobulin A vasculitis (IgAV), formerly called Henoch–Schönlein purpura, is a small-vessel vasculitis characterized by immune-complex deposits with predominant IgA. Although the disease is often…Abstract Number: 2945 • 2017 ACR/ARHP Annual Meeting
Incident Hand OA Is Strongly Associated with Reduced Peripheral Blood Leukocyte Telomere Length
Background/Purpose: Hand OA (HOA) is a painful, destructive and deforming polyarticular disorder that impairs an individual’s ability to perform manipulative activities of daily life and…Abstract Number: 2572 • 2016 ACR/ARHP Annual Meeting
Study of Two Biomarkers of Biological Age in the Blood of Patients with Rheumatoid Arthritis
Background/Purpose: Accelerated biological aging of blood cells could contribute to the pathogenesis of RA. However, biological age has multiple facets, some as epigenetic aging not…Abstract Number: 3041 • 2016 ACR/ARHP Annual Meeting
Age-Related Defects in the Immune System of Patients with GCA
Background/Purpose: Advancing age is the strongest risk factor for GCA, a disease that exclusively affects individuals >50 years of age. The immune system undergoes dramatic…Abstract Number: 73 • 2016 ACR/ARHP Annual Meeting
Dysregulation of Hypomethylated Age-Related CpG Sites Characterize T-Cells and Monocytes from Treatment Naive Rheumatoid Arthritis Subjects
Background/Purpose: In the general population, an increase in chronological age is associated with differential DNA methylation of particular CpGs in a highly conserved fashion. Since…Abstract Number: 574 • 2016 ACR/ARHP Annual Meeting
Anti-CCP3.1 and Anti-CCP3-IgA Antibodies Are Associated with Increasing Age in Subjects without Rheumatoid Arthritis
Background/Purpose: Serum anti-CCP antibodies are specific for RA in the setting of inflammatory arthritis (IA) and can be elevated for several years prior to the…Abstract Number: 1538 • 2016 ACR/ARHP Annual Meeting
Lower Ratings of Pain Intensity in Older Adults Lead to Underestimation of Disease Activity By Disease Activity Score 28-C-Reactive Protein (DAS28-CRP) in Patients with Rheumatoid Arthritis
Background/Purpose: To investigate the influence of age on the components of the 28-joint Disease Activity Score (DAS28)-C-reactive protein (CRP) in patients with rheumatoid arthritis…Abstract Number: 1698 • 2016 ACR/ARHP Annual Meeting
Late Onset Psoriatic Arthritis in a Longitudinal Cohort: Disease Presentation, Activity over Time and Prognosis
Background/Purpose: Psoriatic arthritis (PsA) often develops between the 3rd to 5th decades of life. However, little is known about PsA activity and prognosis among patients…Abstract Number: 2132 • 2016 ACR/ARHP Annual Meeting
Deficient Autophagy Induces Premature Senescence in Aging and Osteoarthritis
Background/Purpose: Previous findings indicated that autophagy is defective in Aging and Osteoarthritis (OA). Autophagy is essential to maintain chondrocyte homeostasis by regulating the intracellular macromolecule…Abstract Number: 2142 • 2016 ACR/ARHP Annual Meeting
Identification of Novel Molecules Targeting Cartilage Aging As Osteoarthritis Therapeutics
Background/Purpose: Effective treatments for Osteoarthritis (OA) are not available. In aging-related diseases, including OA, failure of cellular homeostasis mechanisms, such as autophagy can cause extracellular…Abstract Number: 2199 • 2016 ACR/ARHP Annual Meeting
Peri-Aortic Adipose Tissue Volume Is Directly Associated with Fat Accumulation in Adjacent Trunk Muscles Independent of Other Fat Depots: The Framingham Study
Background/Purpose: Multidetector CT abdominal imaging measured PAAT volume (cm3), as well as cross-sectional area (mm2) and attenuation (HU), a marker of fat content, of the…Abstract Number: 326 • 2015 ACR/ARHP Annual Meeting
Older Adults without Extreme Obesity Are at Highest Risk for Accelerated Knee Osteoarthritis
Background/Purpose: Accelerated knee osteoarthritis (AKOA) may be a unique subset of knee osteoarthritis (KOA). AKOA is more common among those who are older, overweight, or…Abstract Number: 1533 • 2015 ACR/ARHP Annual Meeting
Age Related Disability in Daily Life Should be Considered in Older Than Sixty-Five-Year-Old Rheumatoid Arthritis Patient
Background/Purpose: In treating rheumatoid arthritis (RA), patient’s activity in daily life (ADL) is extremely important factor, because RA is chronic inflammatory disease that leads discomfort…
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