Abstracts tagged "Aging"

Abstract Number: 2717 • 2017 ACR/ARHP Annual Meeting
Late Onset of IgA Vasculitis Is Associated with More Severe Renal Involvement
Alexandra Audemard-Verger¹, Aurélie Baldolli², Noemie Le Gouellec³, Loic Raffray⁴, Alban Deroux⁵, Julie Goutte⁶, Bertrand Lioger⁷, Zahir Amoura⁸, Patrice Cacoub⁹, Sébastien Sanges¹⁰, Evangeline Pillebout¹¹, Loïc Guillevin for the French Vasculitis Study Group¹² and Benjamin Terrier¹³, ¹Internal Medicine, Caen, France, ²Internal Medicine, CHU, Caen, France, ³Internal Medicine, Lille, France, ⁴Internal Medicine, CHU de Bordeaux, Bordeaux, France, ⁵Internal Medicine, CHU de Grenoble, Grenoble, France, ⁶Internal Medicine, Saint Etienne, France, ⁷GICC UMR 7292, University François Rabelais, Tours, France, ⁸Department of Internal Medicine 2. Referal center for SLE/APS, Hôpital Pitié-Salpêtrière, AP-HP, UPMC Univ Paris 06 & French National Reference Center For Systemic Lupus and Antiphospholipid Syndrome, Paris, France, ⁹Internal Medicine Department, University Hospital “Pitié-Salpêtrière”, “Pierre et Marie Curie Paris VI” University, Paris, France, ¹⁰Université Lille Nord de France, Faculté de Médecine Henri Warembourg, Lille, Lille, France, ¹¹Nephrology, Saint Louis, Paris, France, ¹²Service de Médecine Interne, Centre de Référence Maladies Auto-Immunes et Auto-Inflammatoires Systémiques Rares, Hôpital Cochin, Paris, France, ¹³Internal Medicine, Cochin University Hospital, Paris, France
Background/Purpose: Immunoglobulin A vasculitis (IgAV), formerly called Henoch–Schönlein purpura, is a small-vessel vasculitis characterized by immune-complex deposits with predominant IgA. Although the disease is often…
Abstract Number: 2945 • 2017 ACR/ARHP Annual Meeting
Incident Hand OA Is Strongly Associated with Reduced Peripheral Blood Leukocyte Telomere Length
Timothy E. McAlindon¹, Mary Roberts², Lena Franziska Schaefer³, Jeffrey B. Driban⁴, Jeffrey Duryea³, Francisco J Blanco⁵, Jose-Luis Fernandez-Garcia⁶ and Charles Eaton⁷, ¹Division of Rheumatology, Tufts Medical Center, Boston, MA, ²Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Pawtucket, RI, ³Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ⁴Rheumatology, Tufts Medical Center, Boston, MA, ⁵Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruña, Spain, ⁶Genetic Department, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ⁷Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI
Background/Purpose: Hand OA (HOA) is a painful, destructive and deforming polyarticular disorder that impairs an individual’s ability to perform manipulative activities of daily life and…
Abstract Number: 406 • 2017 ACR/ARHP Annual Meeting
Mapping Changes in Monocyte and Macrophage Populations in the Synovium: An Aging Study in Arthritic KRN Ag7 Mice
Anna B Montgomery¹, Carla Cuda², Philip J. Homan³, Harris Perlman² and Deborah R. WInter², ¹Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease of the joints associated with accelerated aging and increased mortality. Further, RA is linked with a number…
Abstract Number: 904 • 2017 ACR/ARHP Annual Meeting
Deficient Autophagy Induces Lamin a/C Accumulation in Aging and Osteoarthritis
Paloma Lopez de Figueroa¹, Uxia Nogueira-Recalde², Fernando Osorio³, Martin Lotz⁴, Carlos Lopez-Otin³, Francisco J Blanco² and Beatriz Carames¹, ¹Cartilage Biology Group. Rheumatology Division, INIBIC-CHUAC, A Coruña, Spain, A Coruña, Spain, ²Cartilage Biology Group. Rheumatology Division, INIBIC-CHUAC, A Coruña, A Coruña, Spain, ³Degradome Lab, Universidad de Oviedo, Oviedo, Spain, ⁴Department of Molecular & Experience Medicine, Scripps Research Institute, LaJolla, CA
Background/Purpose: Autophagy, an essential chondrocyte homeostasis mechanism, is defective in Aging and Osteoarthritis (OA). However, the targets regulating this mechanism are still unknown. Here, we…
Abstract Number: 73 • 2016 ACR/ARHP Annual Meeting
Dysregulation of Hypomethylated Age-Related CpG Sites Characterize T-Cells and Monocytes from Treatment Naive Rheumatoid Arthritis Subjects
Ines Colmegna¹, Marie Forest², Aurelie Labbe³, Sasha Bernatsky⁴, Jose Navarro⁵, Tomi Pastinen⁶, Celia Greenwood⁷ and Marie Hudson⁸, ¹Medicine, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ²Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada, ³Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, QC, Canada, ⁴Division of Rheumatology, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁵Experimental Medicine, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ⁶Human Genetics, McGill University, Montreal, QC, Canada, ⁷Centre for Clinical Epidemiology, Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada, ⁸Medicine/Rheumatology, Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada
Background/Purpose: In the general population, an increase in chronological age is associated with differential DNA methylation of particular CpGs in a highly conserved fashion. Since…
Abstract Number: 574 • 2016 ACR/ARHP Annual Meeting
Anti-CCP3.1 and Anti-CCP3-IgA Antibodies Are Associated with Increasing Age in Subjects without Rheumatoid Arthritis
Heather Berens-Norman^1,2, Sonia Khatter³, Wendy M. Kohrt⁴, Catherine Jankowski⁵, Michael Weisman⁶, Michael Mahler⁷, James R. O'Dell⁸, Ted R Mikuls⁸, Richard M. Keating⁹, Jane H. Buckner¹⁰, Peter K. Gregersen¹¹, Jill M. Norris¹², V. Michael Holers¹³, Kevin D. Deane¹³ and M. Kristen Demoruelle¹³, ¹Division of Rheumatology, University of Colorado Denver, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Denver, CO, ³University of Colorado School of Medicine, Aurora, CO, ⁴Geriatric Medicine Division, University of Colorado Denver, Aurora, CO, ⁵University of Colorado College of Nursing, Aurora, CO, ⁶Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Research and Development, Inova Diagnostics, San Diego, CA, ⁸Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁹Division of Rheumatology, Scripps Health, La Jolla, CA, ¹⁰Benaroya Research Institute at Virginia Mason, Seattle, WA, ¹¹The Feinstein Institute for Medical Research, Manhasset, NY, ¹²Epidemiology, Colorado School of Public Health, Aurora, CO, ¹³Rheumatology Division, University of Colorado Denver, Aurora, CO
Background/Purpose: Serum anti-CCP antibodies are specific for RA in the setting of inflammatory arthritis (IA) and can be elevated for several years prior to the…
Abstract Number: 1538 • 2016 ACR/ARHP Annual Meeting
Lower Ratings of Pain Intensity in Older Adults Lead to Underestimation of Disease Activity By Disease Activity Score 28-C-Reactive Protein (DAS28-CRP) in Patients with Rheumatoid Arthritis
Yong Gil Hwang¹, Juan (June) Feng², Heather Eng², Jason Lyons², Anthony Fabio² and Larry W. Moreland¹, ¹Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²Epidemiology, University of Pittsburgh, School of Public Health, Pittsburgh, PA
Background/Purpose: To investigate the influence of age on the components of the 28-joint Disease Activity Score (DAS28)-C-reactive protein (CRP) in patients with rheumatoid arthritis…
Abstract Number: 1698 • 2016 ACR/ARHP Annual Meeting
Late Onset Psoriatic Arthritis in a Longitudinal Cohort: Disease Presentation, Activity over Time and Prognosis
Ari Polachek¹, Roa'a Al Johani², Suzanne Li¹, Vinod Chandran¹ and Dafna D Gladman³, ¹Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³University of Toronto, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) often develops between the 3rd to 5th decades of life. However, little is known about PsA activity and prognosis among patients…
Abstract Number: 2132 • 2016 ACR/ARHP Annual Meeting
Deficient Autophagy Induces Premature Senescence in Aging and Osteoarthritis
Beatriz Carames¹, Paloma Lopez de Figueroa¹, Madalena Ribeiro¹, Valentina Calamia², Fernando Osorio³, Carlos Lopez-Otin³ and Francisco J. Blanco^1,4, ¹Cartilage Biology Group. Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Osteoarticular and Aging Research Lab. Proteomics Unit - Associated Node to ProteoRed, Rheumatology Division, Proteomics Group-ProteoRed/ISCIII, INIBIC-CHUAC, A Coruña, Spain, ³Degradome Lab, Universidad de Oviedo, Oviedo, Spain, ⁴Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), La Coruña, Spain
Background/Purpose: Previous findings indicated that autophagy is defective in Aging and Osteoarthritis (OA). Autophagy is essential to maintain chondrocyte homeostasis by regulating the intracellular macromolecule…
Abstract Number: 2142 • 2016 ACR/ARHP Annual Meeting
Identification of Novel Molecules Targeting Cartilage Aging As Osteoarthritis Therapeutics
Beatriz Carames¹, Uxia Nogueira-Recalde¹, Eduardo Dominguez², Maria I. Loza³ and Francisco J. Blanco^1,4, ¹Cartilage Biology Group. Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²BioFarma Research Group. University of Santiago de Compostela, Santiago de Compostela, Spain, ³BioFarma Research Group. University of Santiago de Compostela, santiago de Compostela, Spain, ⁴Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), La Coruña, Spain
Background/Purpose: Effective treatments for Osteoarthritis (OA) are not available. In aging-related diseases, including OA, failure of cellular homeostasis mechanisms, such as autophagy can cause extracellular…
Abstract Number: 2199 • 2016 ACR/ARHP Annual Meeting
Peri-Aortic Adipose Tissue Volume Is Directly Associated with Fat Accumulation in Adjacent Trunk Muscles Independent of Other Fat Depots: The Framingham Study
Robert R. McLean^1,2,3, Elizabeth J. Samelson^1,2,3, Amanda L. Lorbergs^1,2,3, Xiaochun Zhang¹, Dennis E. Anderson^2,3, Udo Hoffmann⁴, Caroline S. Fox⁵, Mary L. Bouxsein^2,3 and Douglas P. Kiel^1,2,3, ¹Hebrew SeniorLife Institute for Aging Research, Boston, MA, ²Harvard Medical School, Boston, MA, ³Beth Israel Deaconess Medical Center, Boston, MA, ⁴Massachusetts General Hospital, Boston, MA, ⁵Merck Research Laboratories, Boston, MA
Background/Purpose: Multidetector CT abdominal imaging measured PAAT volume (cm3), as well as cross-sectional area (mm2) and attenuation (HU), a marker of fat content, of the…
Abstract Number: 2572 • 2016 ACR/ARHP Annual Meeting
Study of Two Biomarkers of Biological Age in the Blood of Patients with Rheumatoid Arthritis
Laura Vidal-Bralo¹, Eva Pérez-Pampin¹, Rosana Varela¹, Juan J Gomez-Reino¹, Steve Horvath² and Antonio Gonzalez¹, ¹Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, ²David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA
Background/Purpose: Accelerated biological aging of blood cells could contribute to the pathogenesis of RA. However, biological age has multiple facets, some as epigenetic aging not…
Abstract Number: 3041 • 2016 ACR/ARHP Annual Meeting
Age-Related Defects in the Immune System of Patients with GCA
Zhenke Wen¹, Yasuhiro Shimojima², Gerald Berry³, Ebru Hosgur¹, Joyce Liao⁴, Lindsy Forbess⁵, Michael Weisman⁶, Jorg Goronzy⁷ and Cornelia M. Weyand¹, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan, ³Pathology, Stanford University School of Medicine, Stanford, CA, ⁴Byers Eye Institute at Stanford, Stanford University, Palo Alto, CA, ⁵Rheumatology, Cedars-Sinai, Los Angeles, CA, ⁶Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁷Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Advancing age is the strongest risk factor for GCA, a disease that exclusively affects individuals >50 years of age. The immune system undergoes dramatic…
Abstract Number: 1593 • 2015 ACR/ARHP Annual Meeting
Telomere Length and Cardiovascular Risk in Rheumatoid Arthritis
Michelle J. Ormseth¹, Joseph F. Solus², Annette M. Oeser³, Aihua Bian⁴, Tebeb Gebretsadik⁴, Ayumi Shintani⁵, Paolo Raggi⁶ and C Michael Stein⁵, ¹Department of Medicine, Division of Rheumatology, Vanderbilt University, Nashville, TN, ²Clinical Pharmacology, Vanderbilt University, Nashville, TN, ³Medicine, Vanderbilt University, Nashville, TN, ⁴Biostatistics, Vanderbilt University, Nashville, TN, ⁵Vanderbilt University, Nashville, TN, ⁶Emory University, Atlanta, GA
Background/Purpose: Telomeres protect against DNA damage and shorten with each cell division; their length may be a marker of cardiovascular and overall biological aging. Patients…
Abstract Number: 1663 • 2015 ACR/ARHP Annual Meeting
Influence of Age and Renal Impairment on Pharmacokinetics of Filgotinib (GLPG0634), a Selective JAK1 Inhibitor
Namour Florence¹, Liesbeth Fagard², Annegret Van der Aa², Sandy Goss³, Pille Harrison² and Chantal Tasset², ¹Galapagos SASU, Romainville, France, ²Galapagos NV, Mechelen, Belgium, ³Abbvie, Chicago, IL
Background/Purpose: Filgotinib is an oral, selective Janus kinase 1 (JAK1) inhibitor combining clinical efficacy and a rapid onset of action with a good safety profile…

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