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Abstracts tagged "Aging"

  • Abstract Number: 1133 • 2017 ACR/ARHP Annual Meeting

    Are We Ready? Changes in the Profile of Gout Patients over the Last 25 Years

    Sandra Chinchilla1,2, Irati Urionagüena2,3 and Fernando Perez-Ruiz1,2,3, 1University of the Basque Country (UPV/EHU), Bilbao, Spain, 2BioCruces Health Research Institute, Barakaldo, Spain, 3Rheumatology Division, Hospital Universitario Cruces, Baracaldo, Spain

    Background/Purpose:   Gout is a rising cause of hospital admissions and emergency consults. It has even replaced rheumatoid arthritis as the principal rheumatological condition causing hospitalizations.  Some…
  • Abstract Number: 1854 • 2017 ACR/ARHP Annual Meeting

    Identifying Vulnerable Patient Populations Based on Age and Physical Function on Clinical Outcomes Following Total Knee Arthroplasty

    Jesse Christensen1, Andrew Kittelson2, Brian Loyd3, Jackie Del Giorno4, Brian Burnikel5 and Jennifer Stevens-Lapsley6, 1University of Utah, SLC, UT, 2Rehabilitation Science PhD Program, University of Colorado Anschutz Medical Campus, Aurora, CO, 3University of Colorado Anschutz Medical Campus, Aurora, CO, 4ATI Physical Therapy, Greenville, SC, 5Steadman Hawkins Clinic of the Carolinas, Greenville Health Systems, Greenville, SC, 6Universtiy of Colorado, Anschutz Medical Campus, Aurora, CO

    Background/Purpose:  : Total knee arthroplasty (TKA) has historically been viewed as a surgical procedure of last resort for older adults suffering with chronic arthritis. However,…
  • Abstract Number: 1931 • 2017 ACR/ARHP Annual Meeting

    Targeting Cartilage Aging As Osteoarthritis Therapeutics By Drug Repurposing

    Beatriz Carames1, Uxia Nogueira-Recalde2, Maria I. Loza3, Francisco J Blanco2 and Eduardo Dominguez4, 1Cartilage Biology Group. Rheumatology Division, INIBIC–CHUAC, A Coruña, A Coruña, Spain, 2Cartilage Biology Group. Rheumatology Division, INIBIC-CHUAC, A Coruña, A Coruña, Spain, 3BioFarma Research Group. University of Santiago de Compostela, santiago de Compostela, Spain, 4BioFarma Research Group. University of Santiago de Compostela, Santiago de Compostela, Spain

    Background/Purpose: Background: Effective treatments for Osteoarthritis (OA) are not available. In aging-related diseases, including OA, failure of cellular homeostasis mechanisms, such as autophagy can cause…
  • Abstract Number: 2341 • 2017 ACR/ARHP Annual Meeting

    The Interaction between Genetic Risk Factors and Age of Disease Onset in Juvenile Dermatomyositis

    Claire Deakin1, John Bowes2, Lucy Marshall1, Cerise Johnson1, Gulnara Mamyrova3, Rodolfo Curiel4, Kelly A. Rouster-Stevens5, Heinrike Schmeling6, Adam Huber7, Brian M. Feldman8, Ann M Reed9, Lauren M. Pachman10, Soumya Raychaudhuri11, Stephen Eyre12 and Lucy R Wedderburn1, 1Infection, Immunity and Inflammation Programme, UCL Great Ormond Street Institute of Child Health, University College London, United Kingdom, London, United Kingdom, 2Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, 3Rheumatology, George Washington University School of Medicine and Health Sciences, Washington, DC, 4Department of Rheumatology, George Washington University, Washington, DC, 5Pediatric Rheumatology, Emory Children's Center, Atlanta, GA, 6Alberta Children’s Hospital/University of Calgary, Calgary, AB, Canada, 7IWK Health Centre, Halifax, NS, Canada, 8Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 9Rheumatology, Duke University, Durham, NC, 10Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, 11Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 12Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Juvenile dermatomyositis (JDM) is a rare, severe autoimmune disease characterized by muscle weakness and rash. Clinical features of JDM are heterogeneous, and can include…
  • Abstract Number: 73 • 2016 ACR/ARHP Annual Meeting

    Dysregulation of Hypomethylated Age-Related CpG Sites Characterize T-Cells and Monocytes from Treatment Naive Rheumatoid Arthritis Subjects

    Ines Colmegna1, Marie Forest2, Aurelie Labbe3, Sasha Bernatsky4, Jose Navarro5, Tomi Pastinen6, Celia Greenwood7 and Marie Hudson8, 1Medicine, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 2Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada, 3Epidemiology, Biostatistics & Occupational Health, McGill University, Montreal, QC, Canada, 4Division of Rheumatology, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 5Experimental Medicine, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 6Human Genetics, McGill University, Montreal, QC, Canada, 7Centre for Clinical Epidemiology, Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada, 8Medicine/Rheumatology, Jewish General Hospital, Lady Davis Research Institute, Montreal, QC, Canada

    Background/Purpose: In the general population, an increase in chronological age is associated with differential DNA methylation of particular CpGs in a highly conserved fashion. Since…
  • Abstract Number: 574 • 2016 ACR/ARHP Annual Meeting

    Anti-CCP3.1 and Anti-CCP3-IgA Antibodies Are Associated with Increasing Age in Subjects without Rheumatoid Arthritis

    Heather Berens-Norman1,2, Sonia Khatter3, Wendy M. Kohrt4, Catherine Jankowski5, Michael Weisman6, Michael Mahler7, James R. O'Dell8, Ted R Mikuls8, Richard M. Keating9, Jane H. Buckner10, Peter K. Gregersen11, Jill M. Norris12, V. Michael Holers13, Kevin D. Deane13 and M. Kristen Demoruelle13, 1Division of Rheumatology, University of Colorado Denver, Aurora, CO, 2Division of Rheumatology, University of Colorado School of Medicine, Denver, CO, 3University of Colorado School of Medicine, Aurora, CO, 4Geriatric Medicine Division, University of Colorado Denver, Aurora, CO, 5University of Colorado College of Nursing, Aurora, CO, 6Cedars-Sinai Medical Center, Los Angeles, CA, 7Research and Development, Inova Diagnostics, San Diego, CA, 8Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, 9Division of Rheumatology, Scripps Health, La Jolla, CA, 10Benaroya Research Institute at Virginia Mason, Seattle, WA, 11The Feinstein Institute for Medical Research, Manhasset, NY, 12Epidemiology, Colorado School of Public Health, Aurora, CO, 13Rheumatology Division, University of Colorado Denver, Aurora, CO

    Background/Purpose: Serum anti-CCP antibodies are specific for RA in the setting of inflammatory arthritis (IA) and can be elevated for several years prior to the…
  • Abstract Number: 1538 • 2016 ACR/ARHP Annual Meeting

    Lower Ratings of Pain Intensity in Older Adults Lead to Underestimation of Disease Activity By Disease Activity Score 28-C-Reactive Protein (DAS28-CRP) in Patients with Rheumatoid Arthritis

    Yong Gil Hwang1, Juan (June) Feng2, Heather Eng2, Jason Lyons2, Anthony Fabio2 and Larry W. Moreland1, 1Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, 2Epidemiology, University of Pittsburgh, School of Public Health, Pittsburgh, PA

    Background/Purpose:   To investigate the influence of age on the components of the 28-joint Disease Activity Score (DAS28)-C-reactive protein (CRP) in patients with rheumatoid arthritis…
  • Abstract Number: 1698 • 2016 ACR/ARHP Annual Meeting

    Late Onset Psoriatic Arthritis in a Longitudinal Cohort: Disease Presentation, Activity over Time and Prognosis

    Ari Polachek1, Roa'a Al Johani2, Suzanne Li1, Vinod Chandran1 and Dafna D Gladman3, 1Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Medicine, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3University of Toronto, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis (PsA) often develops between the 3rd to 5th decades of life. However, little is known about PsA activity and prognosis among patients…
  • Abstract Number: 2132 • 2016 ACR/ARHP Annual Meeting

    Deficient Autophagy Induces Premature Senescence in Aging and Osteoarthritis

    Beatriz Carames1, Paloma Lopez de Figueroa1, Madalena Ribeiro1, Valentina Calamia2, Fernando Osorio3, Carlos Lopez-Otin3 and Francisco J. Blanco1,4, 1Cartilage Biology Group. Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 2Osteoarticular and Aging Research Lab. Proteomics Unit - Associated Node to ProteoRed, Rheumatology Division, Proteomics Group-ProteoRed/ISCIII, INIBIC-CHUAC, A Coruña, Spain, 3Degradome Lab, Universidad de Oviedo, Oviedo, Spain, 4Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), La Coruña, Spain

    Background/Purpose: Previous findings indicated that autophagy is defective in Aging and Osteoarthritis (OA). Autophagy is essential to maintain chondrocyte homeostasis by regulating the intracellular macromolecule…
  • Abstract Number: 2142 • 2016 ACR/ARHP Annual Meeting

    Identification of Novel Molecules Targeting Cartilage Aging As Osteoarthritis Therapeutics

    Beatriz Carames1, Uxia Nogueira-Recalde1, Eduardo Dominguez2, Maria I. Loza3 and Francisco J. Blanco1,4, 1Cartilage Biology Group. Rheumatology Division, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 2BioFarma Research Group. University of Santiago de Compostela, Santiago de Compostela, Spain, 3BioFarma Research Group. University of Santiago de Compostela, santiago de Compostela, Spain, 4Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), La Coruña, Spain

    Background/Purpose: Effective treatments for Osteoarthritis (OA) are not available. In aging-related diseases, including OA, failure of cellular homeostasis mechanisms, such as autophagy can cause extracellular…
  • Abstract Number: 2199 • 2016 ACR/ARHP Annual Meeting

    Peri-Aortic Adipose Tissue Volume Is Directly Associated with Fat Accumulation in Adjacent Trunk Muscles Independent of Other Fat Depots: The Framingham Study

    Robert R. McLean1,2,3, Elizabeth J. Samelson1,2,3, Amanda L. Lorbergs1,2,3, Xiaochun Zhang1, Dennis E. Anderson2,3, Udo Hoffmann4, Caroline S. Fox5, Mary L. Bouxsein2,3 and Douglas P. Kiel1,2,3, 1Hebrew SeniorLife Institute for Aging Research, Boston, MA, 2Harvard Medical School, Boston, MA, 3Beth Israel Deaconess Medical Center, Boston, MA, 4Massachusetts General Hospital, Boston, MA, 5Merck Research Laboratories, Boston, MA

    Background/Purpose:  Multidetector CT abdominal imaging measured PAAT volume (cm3), as well as cross-sectional area (mm2) and attenuation (HU), a marker of fat content, of the…
  • Abstract Number: 2572 • 2016 ACR/ARHP Annual Meeting

    Study of Two Biomarkers of Biological Age in the Blood of Patients with Rheumatoid Arthritis

    Laura Vidal-Bralo1, Eva Pérez-Pampin1, Rosana Varela1, Juan J Gomez-Reino1, Steve Horvath2 and Antonio Gonzalez1, 1Instituto Investigacion Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, 2David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Accelerated biological aging of blood cells could contribute to the pathogenesis of RA. However, biological age has multiple facets, some as epigenetic aging not…
  • Abstract Number: 3041 • 2016 ACR/ARHP Annual Meeting

    Age-Related Defects in the Immune System of Patients with GCA

    Zhenke Wen1, Yasuhiro Shimojima2, Gerald Berry3, Ebru Hosgur1, Joyce Liao4, Lindsy Forbess5, Michael Weisman6, Jorg Goronzy7 and Cornelia M. Weyand1, 1Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 2Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan, 3Pathology, Stanford University School of Medicine, Stanford, CA, 4Byers Eye Institute at Stanford, Stanford University, Palo Alto, CA, 5Rheumatology, Cedars-Sinai, Los Angeles, CA, 6Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 7Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA

    Background/Purpose:  Advancing age is the strongest risk factor for GCA, a disease that exclusively affects individuals >50 years of age. The immune system undergoes dramatic…
  • Abstract Number: 2643 • 2015 ACR/ARHP Annual Meeting

    Decreased Pain Level with Aging Leads to Underestimation of Disease Activity in Rheumatoid Arthritis

    Yong Gil Hwang1, Juan (June) Feng2, Heather Eng3, Jason Lyons4, Anthony Fabio5 and Larry W. Moreland6, 1Department of Medicine, University of Pittsburgh, Pittsburgh, PA, 2Epidemiology Data Center, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, 3Epidemiology, Univ of Pittsburgh, Pittsburgh, PA, 4School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, 5Department Of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 6Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose:   Rheumatoid arthritis (RA) is most prevalent in those who are 60 years of age or older. It has not been clearly established whether…
  • Abstract Number: 326 • 2015 ACR/ARHP Annual Meeting

    Older Adults without Extreme Obesity Are at Highest Risk for Accelerated Knee Osteoarthritis

    Jeffrey Driban1, Grace H. Lo2, Charles B. Eaton3, Lori Lyn Price4, Bing Lu5, Mary Barbe6 and Timothy E. McAlindon7, 1Tufts Medical Center, Boston, MA, 2VA HSR&D Center for Innovations in Quality, Effectiveness and Safety; Medical Care Line and Research Care Line; Department of Medicine, Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, 3Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, 4Clinical Care Research, Tufts Medical Center, Boston, MA, 5Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 6Temple University School of Medicine, Philadelphia, PA, 7Division of Rheumatology, Tufts Medical Center, Boston, MA

    Background/Purpose: Accelerated knee osteoarthritis (AKOA) may be a unique subset of knee osteoarthritis (KOA). AKOA is more common among those who are older, overweight, or…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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