Abstracts tagged "Aging"

Abstract Number: 757 • 2014 ACR/ARHP Annual Meeting
Distinctive Patterns of Telomere Shortening and Apoptosis in Limited and Diffuse cutaneous Systemic Sclerosis
Jasper Broen¹, Liane McGlynn², Dagmara McGuinness², Rina Wichers³, Jacqueline Thomson², Rajan Madhok⁴, Robert Lafyatis⁵, Carol A. Feghali-Bostwick⁶, Paul Shiels² and T.R.D.J. Radstake¹, ¹Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²University of Glasgow, Glasgow, United Kingdom, ³UMC Utrecht, Utrecht, Netherlands, ⁴Glasgow Royal Infirmary, Glasgow, United Kingdom, ⁵Arthritis Center, Boston University, Boston, MA, ⁶Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Aberrant telomere shortening and DNA damage-responses have been previously described in SSc, here we aim to validate these observations and incorporate them in a…
Abstract Number: 221 • 2014 ACR/ARHP Annual Meeting
An Analysis of Age-Related Loss of Skeletal Muscle Mass and Its Significance on Osteoarthritis in a Korean Population
Hyunje Kim¹, Minjung Kim¹, Choong Ki Lee² and Young Hoon Hong³, ¹Internal medicine, School of medicine, Yeungnam University, Daegu, South Korea, ²Internal medicine, school of medicine, Yeungnam University, Daegu, South Korea, ³Department of Internal medicine, School of Medicine,, Yeungnam University, Daegu, South Korea
Background/Purpose This study was conducted in order to analyze the effects of sarcopenia and sarcopenic obesity on age-related OA of the knee in a Korean…
Abstract Number: 191 • 2014 ACR/ARHP Annual Meeting
Utilization and Outcomes Following Total Shoulder Arthroplasty in Elderly and Non-Elderly Patients
Jasvinder A. Singh¹ and Rekha Ramachandaran², ¹University of Alabama and VA Medical Center, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: To assess the age-related differences in total shoulder arthroplasty (TSA) outcomes and utilization and associated time-trends.Methods: Nationwide Inpatient Sample (NIS) from 1998-2010 was used…
Abstract Number: 44 • 2014 ACR/ARHP Annual Meeting
Physical Function, Hyperuricemia and Gout in Older Adults
Mara McAdams-DeMarco¹, Bridget Burke², Andrew Law³, Anna Kottgen⁴, Alan N. Baer⁵ and Josef Coresh¹, ¹Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ²Johns Hopkins University, Baltimore, MD, ³Epidemiology, Johns Hopkins, Baltimore, MD, ⁴Renal Division, University Hospital Freiburg, Freiburg, Germany, ⁵Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: The prevalence of gout is higher in older adults than in younger adults and these patients are at risk of physical disability. We sought…
Abstract Number: 45 • 2014 ACR/ARHP Annual Meeting
Body Mass Index Across the Lifespan and Lifetime Incidence of Gout in Men
Allan C. Gelber¹, Lucy Meoni², Michael Klag² and Joseph Gallo², ¹Medicine/ Rheumatology, Johns Hopkins University, Baltimore, MD, ²Medicine, Johns Hopkins University, Baltimore, MD
Background/Purpose: Gout is the leading cause of inflammatory arthritis in men and is linked to higher levels of body weight and obesity in mid-adult life.…
Abstract Number: 2949 • 2014 ACR/ARHP Annual Meeting
Activation of AMP-Activated Protein Kinase (AMPK) By Berberine Limits Both Surgical Knee Instability-Induced and Aging-Related Osteoarthritis in Mice
Ru Bryan¹, Xianling Zhao², Yun Wang³, Han Sol Lee², Hyunje Kim⁴, Alifah Akasdi² and Robert Terkeltaub⁵, ¹Medicine-Rheumatology, VA Medical Center/University of California San Diego, San Diego, CA, ²VAMC, San Diego, CA, ³Medicine-Rheumatology, VA Medical Ctr/UCSD, San Diego, CA, ⁴Internal medicine, School of medicine, Yeungnam University, Daegu, South Korea, ⁵Medicine-Rheumatology, VA Medical Ctr/University of California San Diego, San Diego, CA
Background/Purpose Human knee OA articular cartilage chondrocytes and aged mouse knee cartilage chondrocytes demonstrate decreased activation of master cellular energy bio-sensor AMPK. Moreover, inflammatory stimuli…
Abstract Number: 132 • 2013 ACR/ARHP Annual Meeting
Relation Of Age With Symptom Severity and Quality Of Life In Patients With Fibromyalgia
Juan Jiao^1,2, Ann Vincent³, Connie A. Luedtke⁴, Stephen Cha⁵ and Terry H. Oh⁶, ¹Rheumatology, Guang'anmen Hospital , China Academy of Chinese Medical Sciences, Beijing, China, ²Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, ³General Internal Medicine, Mayo Clinic, Rochester, MN, ⁴Department of Nursing, Mayo Clinic, Rochester, MN, ⁵Health Sciences Research, Mayo Clinic, Rochester, MN, ⁶Physical Medicine & Rehabilitation, Mayo Clinic, Rochester, MN
Background/Purpose: The relationship of age and fibromyalgia symptom severity and quality of life (QOL) is still debated. Reports range from no differences between patients younger…
Abstract Number: 72 • 2013 ACR/ARHP Annual Meeting
Autophagy Changes During Aging: A Study In GFP-LC3 Mice
Beatriz Carames¹, William B. Kiosses², Merissa Olmer³ and Martin Lotz⁴, ¹Cartilage Biology Group. Rheumatology Division, INIBIC–A Coruña, SPAIN, A Coruña, Spain, ²The Scripps Research Institute, La Jolla, CA, ³The Sripps Research Institute, La Jolla, CA, ⁴The Scripps Research Institute, La Jolla, USA, La Jolla, CA
Background/Purpose: Aging is a main risk factor for osteoarthritis (OA), the most prevalent musculoskeletal disorder. Aging-associated changes in autophagy, an essential cellular homeostasis mechanism, have…
Abstract Number: 2909 • 2013 ACR/ARHP Annual Meeting
2010 Medical Care Expenditures Among US Adults With Arthritis
Miriam Cisternas¹, Louise Murphy², David Pasta³, Edward H. Yelin⁴ and Charles G. Helmick⁵, ¹MGC Data Services, Carlsbad, CA, ²Division of Population Health, CDC, Atlanta, GA, ³DMA Corporation, Palo Alto, CA, ⁴Medicine, UC San Francisco, San Francisco, CA, ⁵National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA
Background/Purpose: Using data from the 2010 Medical Expenditure Panel Survey (MEPS), we estimated total and arthritis-attributable medical care expenditures among US adults age 18 years…
Abstract Number: 2854 • 2013 ACR/ARHP Annual Meeting
Restricting Back Pain and Subsequent Mobility Disability In Community-Living Older Persons
Una E. Makris¹, Liana Fraenkel², Ling Han³, Linda Leo-Summers³ and Thomas M. Gill⁴, ¹Rheumatology, UT Southwestern Medical Center, VA Medical Center, Dallas, TX, ²Medicine, Section of Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT, ³Internal Medicine, Department of Medicine, New Haven, CT, ⁴Internal Medicine, Section of Geriatrics, Yale University, New Haven, CT
Background/Purpose: Although back pain is common and costly, few longitudinal studies have evaluated the association between back pain, severe enough to restrict activity (hereafter referred…
Abstract Number: 2710 • 2013 ACR/ARHP Annual Meeting
Deficiency Of The Protein Kinase Ataxia Telangiectasia Mutated Accelerates T Cell Aging In Rheumatoid Arthritis
Zhen Yang¹, Hiroshi Fujii², Eric L. Matteson³, Jorg J. Goronzy¹ and Cornelia M. Weyand⁴, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Department of Hematology and Rheumatology, Tohoku University, Sendai, Japan, ³Rheumatology, Mayo Clinic, Rochester, MN, ⁴Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: T lymphocytes hold a pinnacle position in the pathogenesis of rheumatoid arthritis (RA) and through their longevity contribute to disease chronicity. The protein kinase…
Abstract Number: 2331 • 2013 ACR/ARHP Annual Meeting
Efficacy and Safety Of Tofacitinib In Older and Younger Patients With Rheumatoid Arthritis
J. R. Curtis¹, H. Schulze-Koops², L Takiya³, C. A. Mebus⁴, K. Terry⁴, R. Chew⁴ and T. V. Jones³, ¹Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, ²University of Munich, Munich, Germany, ³Pfizer Inc, Collegeville, PA, ⁴Pfizer Inc, Groton, CT
Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). The clinical development program for tofacitinib in RA enrolled ˃500…
Abstract Number: 2162 • 2013 ACR/ARHP Annual Meeting
Physical, Psychological, and Social Impacts Of Restricting Back Pain: The Older Person’s Perspective
Una E. Makris¹, Trisha V. Melhado², Simon C. Lee³, Heidi A. Hamann², Lisa M. Walke⁴, Thomas M. Gill⁴ and Liana Fraenkel⁵, ¹Rheumatology, UT Southwestern Medical Center, VA Medical Center, Dallas, TX, ²Clinical Sciences, UT Southwestern Medical Center, Dallas, TX, ³UT Southwestern Medical Center, Dallas, TX, ⁴Internal Medicine, Section of Geriatrics, Yale University, New Haven, CT, ⁵Medicine, Section of Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT
Background/Purpose: Although back pain is the most common type of pain reported by older adults, we have a limited understanding of its impact on the…
Abstract Number: 1787 • 2013 ACR/ARHP Annual Meeting
Does Age At Disease Onset Influence Disease Activity and Function In Rheumatoid Arthritis Patients? Results From The Ontario Best Practices Research Initiative (OBRI) Registry
Thanu Nadarajah¹, Binu Jacob², Pooneh Akhavan³, Bindee Kuriya⁴, Edward C. Keystone⁵ and Claire Bombardier⁶, ¹Department of Medicine, University of Toronto, Toronto, ON, Canada, ²University Health Network, Toronto General Research Institute, Toronto, ON, Canada, ³Medicine, Mount Sinai Hospital/University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁵Department of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁶Rheumatology, University of Toronto, Toronto, ON, Canada
Background/Purpose: The population of elderly individuals with rheumatoid arthritis (RA) is increasing. The aim of this study was to assess whether age at disease onset…
Abstract Number: 1343 • 2013 ACR/ARHP Annual Meeting
Are There Differences Between Young and Older Onset Early Rheumatoid Arthritis and Does This Impact Outcomes? An Analysis From The Canadian Early Arthritis Cohort
Michael Arnold¹, Vivian P. Bykerk², Gilles Boire³, Boulos Haraoui⁴, Carol A. Hitchon⁵, J. Carter Thorne⁶, Edward Keystone⁷ and Janet E. Pope⁸, ¹Medicine/Rheumatology, University College Dublin, Ireland, Dublin, Ireland, ²Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ³Rheumatology Division, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC, Canada, ⁴Rheumatology, Institut de Rhumatologie de Montréal, Montreal, QC, Canada, ⁵Rheumatology, University of Manitoba, Winnipeg, MB, Canada, ⁶Southlake Regional Health Centre, Newmarket, ON, Canada, ⁷Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, University of Toronto, Toronto, ON, Canada, ⁸Medicine, Divsion of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
Background/Purpose: To determine the impact of age on disease and remission in early rheumatoid arthritis (ERA). Methods: Data from the Canadian Early Arthritis Cohort (CATCH)…

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