ACR Meeting Abstracts

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Abstracts tagged "Aging"

  • Abstract Number: 1220 • 2014 ACR/ARHP Annual Meeting

    Higher Inflammatory Response in Elderly Patients during Gout Attack

    Ji Ae Yang1, Jae Hyun Lee1, Eun Young Lee2, Eun Bong Lee1, Yeong Wook Song3 and Jin Kyun Park1, 1Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, 2Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea

    Higher inflammatory response in elderly patients during gout attack Background/Purpose Clinical experiences suggest that gout attacks in elderly patients are accompanied by stronger systemic inflammatory…
  • Abstract Number: 757 • 2014 ACR/ARHP Annual Meeting

    Distinctive Patterns of Telomere Shortening and Apoptosis in Limited and Diffuse cutaneous  Systemic Sclerosis

    Jasper Broen1, Liane McGlynn2, Dagmara McGuinness2, Rina Wichers3, Jacqueline Thomson2, Rajan Madhok4, Robert Lafyatis5, Carol A. Feghali-Bostwick6, Paul Shiels2 and T.R.D.J. Radstake1, 1Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2University of Glasgow, Glasgow, United Kingdom, 3UMC Utrecht, Utrecht, Netherlands, 4Glasgow Royal Infirmary, Glasgow, United Kingdom, 5Arthritis Center, Boston University, Boston, MA, 6Medicine, Medical University of South Carolina, Charleston, SC

    Background/Purpose: Aberrant telomere shortening and DNA damage-responses have been previously described in SSc, here we aim to validate these observations and incorporate them in a…
  • Abstract Number: 221 • 2014 ACR/ARHP Annual Meeting

    An Analysis of Age-Related Loss of Skeletal Muscle Mass and Its Significance on Osteoarthritis in a Korean Population

    Hyunje Kim1, Minjung Kim1, Choong Ki Lee2 and Young Hoon Hong3, 1Internal medicine, School of medicine, Yeungnam University, Daegu, South Korea, 2Internal medicine, school of medicine, Yeungnam University, Daegu, South Korea, 3Department of Internal medicine, School of Medicine,, Yeungnam University, Daegu, South Korea

    Background/Purpose This study was conducted in order to analyze the effects of sarcopenia and sarcopenic obesity on age-related OA of the knee in a Korean…
  • Abstract Number: 191 • 2014 ACR/ARHP Annual Meeting

    Utilization and Outcomes Following Total Shoulder Arthroplasty in Elderly and Non-Elderly Patients

    Jasvinder A. Singh1 and Rekha Ramachandaran2, 1University of Alabama and VA Medical Center, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: To assess the age-related differences in total shoulder arthroplasty (TSA) outcomes and utilization and associated time-trends.Methods: Nationwide Inpatient Sample (NIS) from 1998-2010 was used…
  • Abstract Number: 44 • 2014 ACR/ARHP Annual Meeting

    Physical Function, Hyperuricemia and Gout in Older Adults

    Mara McAdams-DeMarco1, Bridget Burke2, Andrew Law3, Anna Kottgen4, Alan N. Baer5 and Josef Coresh1, 1Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 2Johns Hopkins University, Baltimore, MD, 3Epidemiology, Johns Hopkins, Baltimore, MD, 4Renal Division, University Hospital Freiburg, Freiburg, Germany, 5Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: The prevalence of gout is higher in older adults than in younger adults and these patients are at risk of physical disability. We sought…
  • Abstract Number: 45 • 2014 ACR/ARHP Annual Meeting

    Body Mass Index Across the Lifespan and Lifetime Incidence of Gout in Men

    Allan C. Gelber1, Lucy Meoni2, Michael Klag2 and Joseph Gallo2, 1Medicine/ Rheumatology, Johns Hopkins University, Baltimore, MD, 2Medicine, Johns Hopkins University, Baltimore, MD

    Background/Purpose: Gout is the leading cause of inflammatory arthritis in men and is linked to higher levels of body weight and obesity in mid-adult life.…
  • Abstract Number: 43 • 2013 ACR/ARHP Annual Meeting

    Overexpression Of Lamin A In Mesenchymal STEM CELLS Compromises Chondrogenesis and Enhances Adipogenesis

    Jesús Mateos1,2, Arancha Landeira1,2, Alexandre De la Fuente1,2, Iván Lesende-Rodríguez1,3, Pablo Fernández-Pernas1,3, Maria Carmen Arufe2,3 and Francisco J. Blanco1,2,4, 1Rhematology Division, ProteoRed/ISCIII. INIBIC-Hospital A Coruña, 15006, A Coruña, Spain, 2CIBER-BBN, Zaragoza, Spain, 3Department of Medicine, Area of Anatomy and Human Embryology, University of A Coruña-INIBIC, A Coruña, Spain, 4Department of Medicine. University of Santiago de Compostela, Santiago de Compostela, Spain

    Background/Purpose: Previous work by our group and others indicated that an accumulation of lamin A (LMNA) is associated with the osteoarthritis (OA) chondrocyte phenotype. Mutations…
  • Abstract Number: 56 • 2013 ACR/ARHP Annual Meeting

    Age-Related Loss Of The Transforming Growth Factor Beta Receptor ALK5 Precedes Osteoarthritis Development In Cartilage

    Arjan van Caam1, Esmeralda N. Blaney Davidson2, Eva Thijssen1, Wim B. van den Berg1 and Peter M. van der Kraan1, 1Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands

    Background/Purpose: Osteoarthritis (OA) is the most common joint disease and (old) age is its main risk factor.  One of OA's main hallmarks is degradation of…
  • Abstract Number: 28 • 2013 ACR/ARHP Annual Meeting

    Differentiation, Activation, and Autoreactivity Of CD11c+ B Cells (ABCs)

    Alice E. Wiedeman1, Natalia V. Giltiay2, Lena Tanaka3 and Keith B. Elkon3, 1Immunology, University of Washington, Seattle, WA, 2Department of Immunology, Division of Rheumatology, University of Washington, Seattle, WA, 3Rheumatology, University of Washington, Seattle, WA

    Background/Purpose: Recently, a population of CD11c+ age-associated B cells (ABCs) was identified in normal aged female mice. These cells could be expanded following activation by…
  • Abstract Number: 132 • 2013 ACR/ARHP Annual Meeting

    Relation Of Age With Symptom Severity and Quality Of Life In Patients With Fibromyalgia

    Juan Jiao1,2, Ann Vincent3, Connie A. Luedtke4, Stephen Cha5 and Terry H. Oh6, 1Rheumatology, Guang'anmen Hospital , China Academy of Chinese Medical Sciences, Beijing, China, 2Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, 3General Internal Medicine, Mayo Clinic, Rochester, MN, 4Department of Nursing, Mayo Clinic, Rochester, MN, 5Health Sciences Research, Mayo Clinic, Rochester, MN, 6Physical Medicine & Rehabilitation, Mayo Clinic, Rochester, MN

    Background/Purpose: The relationship of age and fibromyalgia symptom severity and quality of life (QOL) is still debated. Reports range from no differences between patients younger…
  • Abstract Number: 72 • 2013 ACR/ARHP Annual Meeting

    Autophagy Changes During Aging: A Study In GFP-LC3 Mice

    Beatriz Carames1, William B. Kiosses2, Merissa Olmer3 and Martin Lotz4, 1Cartilage Biology Group. Rheumatology Division, INIBIC–A Coruña, SPAIN, A Coruña, Spain, 2The Scripps Research Institute, La Jolla, CA, 3The Sripps Research Institute, La Jolla, CA, 4The Scripps Research Institute, La Jolla, USA, La Jolla, CA

    Background/Purpose: Aging is a main risk factor for osteoarthritis (OA), the most prevalent musculoskeletal disorder. Aging-associated changes in autophagy, an essential cellular homeostasis mechanism, have…
  • Abstract Number: 2909 • 2013 ACR/ARHP Annual Meeting

    2010 Medical Care Expenditures Among US Adults With Arthritis

    Miriam Cisternas1, Louise Murphy2, David Pasta3, Edward H. Yelin4 and Charles G. Helmick5, 1MGC Data Services, Carlsbad, CA, 2Division of Population Health, CDC, Atlanta, GA, 3DMA Corporation, Palo Alto, CA, 4Medicine, UC San Francisco, San Francisco, CA, 5National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA

    Background/Purpose: Using data from the 2010 Medical Expenditure Panel Survey (MEPS), we estimated total and arthritis-attributable medical care expenditures among US adults age 18 years…
  • Abstract Number: 2854 • 2013 ACR/ARHP Annual Meeting

    Restricting Back Pain and Subsequent Mobility Disability In Community-Living Older Persons

    Una E. Makris1, Liana Fraenkel2, Ling Han3, Linda Leo-Summers3 and Thomas M. Gill4, 1Rheumatology, UT Southwestern Medical Center, VA Medical Center, Dallas, TX, 2Medicine, Section of Rheumatology, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, New Haven, CT, 3Internal Medicine, Department of Medicine, New Haven, CT, 4Internal Medicine, Section of Geriatrics, Yale University, New Haven, CT

    Background/Purpose: Although back pain is common and costly, few longitudinal studies have evaluated the association between back pain, severe enough to restrict activity (hereafter referred…
  • Abstract Number: 2710 • 2013 ACR/ARHP Annual Meeting

    Deficiency Of The Protein Kinase Ataxia Telangiectasia Mutated Accelerates T Cell Aging In Rheumatoid Arthritis

    Zhen Yang1, Hiroshi Fujii2, Eric L. Matteson3, Jorg J. Goronzy1 and Cornelia M. Weyand4, 1Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 2Department of Hematology and Rheumatology, Tohoku University, Sendai, Japan, 3Rheumatology, Mayo Clinic, Rochester, MN, 4Medicine, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: T lymphocytes hold a pinnacle position in the pathogenesis of rheumatoid arthritis (RA) and through their longevity contribute to disease chronicity. The protein kinase…
  • Abstract Number: 2331 • 2013 ACR/ARHP Annual Meeting

    Efficacy and Safety Of Tofacitinib In Older and Younger Patients With Rheumatoid Arthritis

    J. R. Curtis1, H. Schulze-Koops2, L Takiya3, C. A. Mebus4, K. Terry4, R. Chew4 and T. V. Jones3, 1Rheumatology & Immunology, University of Alabama at Birmingham, Birmingham, AL, 2University of Munich, Munich, Germany, 3Pfizer Inc, Collegeville, PA, 4Pfizer Inc, Groton, CT

    Background/Purpose: Tofacitinib is a novel, oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). The clinical development program for tofacitinib in RA enrolled ˃500…
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