Abstracts tagged "Aging"

Abstract Number: 2002 • ACR Convergence 2025
Methods to Address Survival Bias and Competing Risks in Estimating the Causal Risks of Gout on Dementia Risk
Joshua Baker¹, Harlan Sayles², Chung-Chou Chang³, Brian Coburn⁴, Bryant England² and Ted Mikuls², ¹University of Pennsylvania, Philadelphia, PA, ²University of Nebraska Medical Center, Omaha, NE, ³University of Pittsburgh, Pittsburgh, PA, ⁴Hospital of the University of Pennsylvania, Philadelphia, PA
Background/Purpose: Informative censoring in epidemiologic research studies (the loss of data from the risk set that is related to the exposure and/or outcome) can cause…
Abstract Number: 1065 • ACR Convergence 2025
Age of Disease Onset and Risk of Serious Infection with anti-TNF Use in Older Adults with Rheumatoid Arthritis
Jiha Lee¹, Sofia Pedro² and Kaleb Michaud³, ¹University of Michigan, Ann Arbor, MI, ²Forward, The National Databank for Rheumatic Diseases, Wichita, KS, ³University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Older age is a recognized risk factor for serious infection (SI) associated with anti-TNF therapy in rheumatoid arthritis (RA). Among older adults with RA,…
Abstract Number: 1921 • ACR Convergence 2025
Re-escalation of Treatment in Older Adults with Rheumatoid Arthritis After Anti-TNF Therapy De-escalation
Jiha Lee¹, Jonathan Martindale², Una Makris³ and Julie Bynum², ¹University of Michigan, Ann Arbor, MI, ²University of Michigan, Ann Arbor, ³UT Southwestern Medical Center and Dallas VA, Dallas, TX
Background/Purpose: Older adults with rheumatoid arthritis (RA) treated with biologic disease-modifying antirheumatic drugs (bDMARDs), including anti-TNFs, are at an increased risk of adverse effects. Current…
Abstract Number: 0972 • ACR Convergence 2025
Prominent endothelial senescence in systemic sclerosis skin
Poulami Dey¹, William D Brodie², Megan N Mattichak³, Alexander Cai³, Qi Wu⁴, Johann Gudjonsson⁵, Dinesh Khanna⁵, John Varga⁵ and Pei-Suen Tsou⁵, ¹Michigan Medicine, Ann Arbor, MI, ²Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, Ann Arbor, ³Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA, Ann Arbor, ⁴Michigan Medicine, Ann Arbor, ⁵University of Michigan, Ann Arbor, MI
Background/Purpose: Systemic sclerosis (SSc) is characterized by extensive damage of the microvessels in multiple organs. We and others showed that endothelial cells (ECs) isolated from…
Abstract Number: 1886 • ACR Convergence 2025
Thirty Percent of Older Adults with Rheumatic Disease Receive High-Risk Medication
Christine Anastasiou¹, Eric Roberts², gabriela Schmajuk³ and Jinoos Yazdany⁴, ¹Stanford University, Pleasanton, CA, ²University of California, San Francisco, SF, CA, ³University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, CA, ⁴UCSF, San Francisco, CA
Background/Purpose: High-risk medications (HRMs) may increase the risk of adverse events such as falls and fractures, hospitalizations, hospital length of stay, and death in older…
Abstract Number: 0950 • ACR Convergence 2025
Ep300-Catalyzed Rad50 Lactylation Compromises Genomic Stability and Drives CD4+T cells Cell Senescence in SLE
mingyang zhang¹, huanzi dai², cun lan³ and mingyang sun³, ¹Daping Hospital, Army Medical University, chongqing, Chongqing, China (People's Republic), ²Daping Hospital & Research Institute of Surgery, Army Medical University, Chongqing, PR China., Chongqing, China (People's Republic), ³Daping Hospital, Army Medical University, chongqing, China (People's Republic)
Background/Purpose: Senescent CD4+ T cells are increasingly implicated in systemic lupus erythematosus (SLE) pathogenesis. While metabolic reprogramming in lupus T cells enhances glycolysis and lactate…
Abstract Number: 1805 • ACR Convergence 2025
Human meniscus histopathological and transcriptomic changes at early and advanced stages of knee osteoarthritis
Takuya Sakamoto¹, Merissa Olmer¹, chelsea Kenvisay¹, Rachel Miller², Anne-Marie Malfait³, Darryl D'Lima⁴, William Bugbee⁵, Hannah Swahn⁶ and Martin Lotz⁷, ¹Scripps Research Institute, La Jolla, CA, ²Rush University Medical Center, Chicago, IL, ³Rush University, Oak Park, IL, ⁴Scripps Clinic, San Diego, CA, ⁵Scripps Clinic, La Jolla, CA, ⁶Scripps Research Institute, Carlsbad, CA, ⁷Scripps Research, La Jolla, CA
Background/Purpose: The knee menisci are essential in joint biomechanics while meniscus damage is a driver of knee osteoarthritis (OA) and an important source of knee…
Abstract Number: 0893 • ACR Convergence 2025
Transcriptomic insights into GCA compared to clinically diverse controls: Inflammation, Aging, Therapeutic Targets and the role of SPP1 in the temporal artery
Ingrid Lindquist¹, Alisha Eskew², Dongsoek Choi³, David Wilson⁴, Diva Salomao⁵, Hillary Stiefel⁴, Daniel Albert⁴, Kiana Vakil-Gilani⁶, Daniela Ghetie⁷, James Rosenbaum⁸ and Marcia Friedman⁹, ¹Portland VA Medical Center, Portland, OR, ²OHSU, Portland, OR, ³OHSU, Portland, ⁴Casey Eye Institute OHSU, Portland, OR, ⁵Mayo Clinic, Rochester, MN, ⁶PeaceHealth, Portland, OR, ⁷OHSU, Lake Oswego, OR, ⁸Legacy Devers Eye Institute, Portland, OR, ⁹Immpact Bio, Beaverton, OR
Background/Purpose: Giant cell arteritis (GCA) is the most common vasculitis in people over 50 years old and is a clinical diagnosis bolstered by non-specific inflammatory…
Abstract Number: 1796 • ACR Convergence 2025
Multi-Tissue Molecular and Histopathological Profiling of Facet Joints and Intervertebral Discs
Nashrah Ahmad¹, Lisa Janssen¹, Hannah Swahn², Rachel Miller³, Anne-Marie Malfait⁴, Merissa Olmer⁵ and Martin Lotz⁶, ¹Scripps Research, San Diego, CA, ²Scripps Research Institute, Carlsbad, CA, ³Rush University Medical Center, Chicago, IL, ⁴Rush University, Oak Park, IL, ⁵Scripps Research Institute, La Jolla, CA, ⁶Scripps Research, La Jolla, CA
Background/Purpose: Intervertebral disc (IVD) degeneration and facet joint (FJ) osteoarthritis (OA) often co-exist, and both are major contributors to lower back pain (LBP). Despite their…
Abstract Number: 0892 • ACR Convergence 2025
Relapse and Immune Dysregulation in Giant Cell Arteritis Are Linked to Mosaic Loss of the Y Chromosome
Simon M. Petzinna, Sophie-Marie Kirch, Maike S. Adamson, De Xi, Claus-Jürgen Bauer, Lena Kreis, Pantelis Karakostas, Rayk Behrendt, Sebastian Zimmer, Raul N. Jamin and Valentin S. Schäfer, University Hospital Bonn, Bonn, Nordrhein-Westfalen, Germany
Background/Purpose: Mosaic loss of the Y chromosome (mLOY) is the most common acquired somatic mutation. Epidemiological studies have linked mLOY to malignancies, as well as…
Abstract Number: 1793 • ACR Convergence 2025
Sex-associated changes to synovial macrophages in the aging joint
Matthew Dapas¹, Erica De Jong², Yidan Wang³, Cally Mills³, Samuel Dowling⁴, Tyler Therron⁵, Carla Marie Cuda³, Dawn Bowdish⁶ and Deborah Rachelle Winter⁷, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²McMaster Immunology Research Centre, Hamilton, ON, Canada, ³Northwestern University, Chicago, IL, ⁴Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, ⁵Northwestern Feinberg School of Medicine, Chicago, IL, ⁶McMaster University, Hamilton, ON, Canada, ⁷Northwestern University, Skokie, IL
Background/Purpose: Macrophages are found in nearly every tissue of the body where they maintain homeostasis and drive healthy immune response. However, macrophages are dysregulated with…
Abstract Number: 0836 • ACR Convergence 2025
Growth Differentiation Factor-15 Predicts Frailty and Death in Rheumatoid Arthritis
Katherine Wysham¹, Hannah Brubeck², Aaron Baraff², Christian Lood³, Punyasha Roul⁴, Bryant England⁵, Beth Wallace⁶, Grant Cannon⁷, Gary Kunkel⁸, Ted Mikuls⁵, Patti Katz⁹, Dolores Shoback¹⁰, Jose Garcia¹¹, Ariela Orkaby¹², Joshua Baker¹³ and Tate Johnson⁵, ¹VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, ²VA Puget Sound Health Care System, Seattle, WA, ³University of Washington, Seattle, WA, ⁴UNMC, Omaha, NE, ⁵University of Nebraska Medical Center, Omaha, NE, ⁶Michigan Medicine, VA Ann Arbor Healthcare System, Ann Arbor, MI, ⁷University of Utah and Salt Lake City VA, Salt Lake City, UT, ⁸University of Utah and George E Wahlen VAMC, Salt Lake City, UT, ⁹UCSF, San Rafael, CA, ¹⁰San Francisco VA Medical Center & University of California San Francisco, San Francisco, CA, ¹¹VA Puget Sound Health Care System, VA GRECC, and University of Washington, Seattle, WA, ¹²VA Boston Healthcare System & Division of Aging, Brigham and Women’s Hospital, Harvard Medical School & VA Geriatrics Research Education and Clinical Center, Boston, MA, ¹³University of Pennsylvania, Philadelphia, PA
Background/Purpose: RA is associated with premature aging and frailty. Growth differentiation factor-15 (GDF-15) is a biomarker that increases in response to cellular stress and inflammation…
Abstract Number: 1784 • ACR Convergence 2025
Multimodal Preclinical Screening Of Glucocorticoid-Induced Disruption Of Bone Remodeling In Rat
Anik Tuladhar, Caitlyn Carter, Erin Vaughan, martin j.voorbach, Sabyasachi Biswas, Timothy Brayman, Pankaj Kumar, anastasia marinopoulos, Xin Huang, Sjoerd J. Finnema, Romy Christmann, Terry vanVleet, Brian Enright, Magali Guffroy and Stacey Fossey, AbbVie, North Chicago, IL
Background/Purpose: Bone toxicity during drug development can arise from intended pharmacologic mechanisms or off-target effects. Standard histopathological evaluation often fails to detect early skeletal alterations,…
Abstract Number: 0817 • ACR Convergence 2025
More than 40% of Older Adults with Rheumatic Diseases Are Prescribed Opioid Medications
Christine Anastasiou¹, Eric Roberts², gabriela Schmajuk³ and Jinoos Yazdany⁴, ¹Stanford University, Pleasanton, CA, ²University of California, San Francisco, SF, CA, ³University of California, San Francisco, and San Francisco Veterans Affairs Medical Center, San Francisco, CA, ⁴UCSF, San Francisco, CA
Background/Purpose: Patients with rheumatic diseases commonly experience acute or chronic pain that may lead to both short- and long-term opioid use. Many patients do not…
Abstract Number: 1656 • ACR Convergence 2025
Risk of Serious Infection associated with non-TNF biologic initiation after Anti-TNF Use in Older Adults with Rheumatoid Arthritis
Jiha Lee¹, Sofia Pedro² and Kaleb Michaud³, ¹University of Michigan, Ann Arbor, ²Forward, The National Databank for Rheumatic Diseases, Wichita, KS, ³University of Nebraska Medical Center, Omaha, NE
Background/Purpose: In older adults with rheumatoid arthritis (RA), anti-TNF therapies are typically used as first-line biologic treatment. However, many patients require a switch to non-TNF…

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