Abstracts tagged "Aging"

Abstract Number: 0793 • ACR Convergence 2024
Secular Changes in Widespread Pain Across Two Generations: The Framingham Heart Study
David Felson¹, Juan-Pablo Zertuche¹, Nene Ukonu¹, mike LaValley², Margaret Clancy³ and Tuhina Neogi³, ¹Boston University, Boston, MA, ²Boston University School of Public Health, Arlington, MA, ³Boston University Chobanian & Avedisian School of Medicine, Boston, MA
Background/Purpose: In the general community, widespread musculoskeletal pain is common and often disabling.. Epidemiologic surveys in the US and Europe in the 1990s and early…
Abstract Number: 0903 • ACR Convergence 2024
Distinct Impacts of Mosaic Loss of Chromosome Y and Genetic Risk on the Age of Onset in Patients with Rheumatoid Arthritis
Shunsuke Uchiyama¹, Yuki Ishikawa², Katsunori Ikari³, Suguru Honda⁴, Yoichiro Kamatani⁵, Takahisa Gono⁶, Masataka Kuwana⁷ and Chikashi Terao⁸, ¹Nippon Medical school/ RIKEN, Tokyo, Japan, ²RIKEN, Yokohama, Japan, ³Tokyo Women's Medical University, Shinjuku, Japan, ⁴Tokyo Women's Medical University, Tokyo, Japan, ⁵Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan, ⁶Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ⁷Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan, Tokyo, Japan, ⁸RIKEN, Tokyo, Japan
Background/Purpose: The age of onset of rheumatoid arthritis (RA) is becoming older worldwide. Since patients with late-onset RA (LORA) have unique clinical characteristics, including acute…
Abstract Number: 0924 • ACR Convergence 2024
The Cytosolic DNA Sensor AIM2 Regulates Bone Homeostasis Through Bone Progenitor Cell Differentiation
Jia (Sijia) Chen¹, Yukiko Maeda², Catherine Manning³, Victor Le⁴, Jae-Hyuck Shim⁵, Katherine A. Fitzgerald⁶ and Ellen Gravallese⁷, ¹Brigham and Women's Hospital, Boston, MA, ²Sanofi, worcester, MA, ³Brigham and Women's Hospital, Dedham, MA, ⁴Digital Biology, Boston, MA, ⁵University of Massachusetts, Worcester, MA, ⁶UMass Chan Medical School, Worchester, MA, ⁷Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA
Background/Purpose: Innate sensing pathways and inflammasomes play an important role in autoimmunity and aging. AIM2 is a DNA sensor that triggers inflammasome assembly in myeloid…
Abstract Number: 0982 • ACR Convergence 2024
Urinary Incontinence Among Individuals with Systemic Lupus Erythematosus
Gabriel Salazar¹, Jinoos Yazdany², Courtney Hoge³, S. Sam Lim³, Scott Bauer² and Laura Plantinga⁴, ¹University of California, San Francisco, SF, CA, ²UCSF, San Francisco, CA, ³Emory University, Atlanta, GA, ⁴University of California, San Francisco, San Francisco, CA
Background/Purpose: Although urinary symptoms are often reported by people with SLE and may substantially affect quality of life, little is known about the burden of…
Abstract Number: 0987 • ACR Convergence 2024
Correlates of Depression in Individuals with Chronic Fatigue Syndrome
Joan Morny¹, Raheem Robertson¹, Terrylyna Baffoe-Bonnie², Ufuoma Mamoh³, Soziema Salia⁴ and Ehizogie Edigin⁵, ¹Piedmont Athens Regional Medical Center, athens, GA, ²Medstar Health Union Memorial Hospital, Baltimore, MD, ³Medstar Union Memorial Hospital, Baltimore, MD, ⁴MedStar Union Memorial Hospital, Towson, MD, ⁵The University of Texas Health Science Center, houston, TX
Background/Purpose: Chronic fatigue syndrome (CFS) is a multifaceted illness with a wide range of symptoms. It shares similar symptomatology with depression. In situations where patients have both…
Abstract Number: 1064 • ACR Convergence 2024
Inpatient and Outpatient Palliative Care Referral Practices for Patients with Rheumatic Disease: Retrospective Chart Review at a Single Academic Medical Center
Shannon Herndon¹, Jack Kimball¹ and David Leverenz², ¹Duke University Medical Center, Durham, NC, ²Duke University, Durham, NC
Background/Purpose: Palliative medicine prioritizes quality of life and relief of suffering in serious illness. Despite high morbidity and mortality in rheumatic disease, data suggests that…
Abstract Number: 1191 • ACR Convergence 2024
Discordant Associations Among Chronological and Biological Age with Multi-joint Osteoarthritis and Symptom Burden: The Johnston County Health Study
Liubov Arbeeva¹, Yvonne Golightly², Cameron Kurz³, Matlock Jeffries⁴, Virginia Kraus⁵, Richard Loeser⁶, Duncan Lascelles⁷ and Amanda Nelson³, ¹University of North Carolina, Chapel Hill, Carrboro, NC, ²University of Nebraska Medical Center, Omaha, NE, ³University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Duke University, Durham, NC, ⁶University of North Carolina, Chapel Hill, NC, ⁷North Carolina State University, Raleigh, NC
Background/Purpose: Biological age (BA) may be superior to chronological age (CA) in predicting mortality and age-related conditions such as diabetes and cognitive/functional decline (PMID35715611), as…
Abstract Number: 1327 • ACR Convergence 2024
Association of Rheumatoid Arthritis and Frailty Status with Mortality in Patients with Renal Cell Carcinoma
Sherwin Novin¹, Sarah Holt², Maya Swaminathan³, Jonathan Wright², John Gore², Kimme Hyrich⁴, Sizheng Zhao⁵, Jeffrey Sparks⁶, Una Makris⁷, Maria Suarez-Almazor⁸, Petros Grivas², Sarah Psutka² and Namrata Singh⁹, ¹University of Washington, Seattle, WA, ²University of Washington, Seattle, ³MultiCare, Newcastle, WA, ⁴Centre for Musculoskeletal Research, The University of Manchester, Manchester, United Kingdom, ⁵Centre for Musculoskeletal Research, The University of Manchester, Liverpool, United Kingdom, ⁶Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA, ⁷UT Southwestern Medical Center and Dallas VA, Dallas, TX, ⁸MD Anderson Cancer Center, Houston, TX, ⁹University of Washington, Bellevue, WA
Background/Purpose: Few studies have evaluated clinical outcomes and prognosis of patients with cancer with and without rheumatoid arthritis (RA). Renal cell carcinoma (RCC) is particularly…
Abstract Number: 1371 • ACR Convergence 2024
DMARD Utilization Pattern in Older Adults with Rheumatoid Arthritis
Daniela Seelmann¹, Jiha Lee² and Devyani Misra³, ¹Beth Israel Deaconess Medical Canter, Newton, MA, ²University of Michigan, Ann Arbor, MI, ³Beth Israel Deaconess Medical Center, Boston, Boston, MA
Background/Purpose: Disease modifying anti-rheumatic drug (DMARD) use in older adults with rheumatoid arthritis (RA) is challenging due to unique geriatric issues, such as multimorbidity, polypharmacy,…
Abstract Number: 1636 • ACR Convergence 2024
Age-associated B Cells Contribute to Inflammation of Takayasu’s Arteritis in an Antibody-secreting Cell Differentiation Independent Manner
Chenglong Fang¹, Xiaochuan Sun², Shangyi Jin², Lihong du², Jing Li², Xiaofeng Zeng³, Yuexin Chen⁴, Mengtao Li⁵ and Xinping Tian³, ¹Department of Rheumatology, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China (People's Republic), ²Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China, ³Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, ⁴Department of Vascular Surgery, Peking Union Medical College Hospital, Beijing, China, ⁵Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China 2National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China
Background/Purpose: Although Takayasu’s arteritis (TAK) is not a prototypical autoantibody-mediated autoimmune disease, several lines of evidence suggested the pathogenic potential of B cells. However, limited…
Abstract Number: 0028 • ACR Convergence 2024
Human Meniscus Histopathological and Transcriptomic Changes at Early and Advanced Stages of Knee Osteoarthritis
Takuya Sakamoto¹, Hannah Swahn¹, Merissa Olmer¹, Rachel Miller², Anne-Marie Malfait³ and Martin Lotz¹, ¹Scripps Research Institute, La Jolla, CA, ²Rush University Medical Center, Chicago, IL, ³Rush University Medical Center, Division of Rheumatology, Chicago, IL
Background/Purpose: The knee menisci are essential elements in joint biomechanics and meniscus damage is a driver of cartilage destruction and knee osteoarthritis. Meniscus damage and…
Abstract Number: 1887 • ACR Convergence 2024
High Rates of Cost-Related Medication Non-Adherence Among Younger Patients Receiving Immunosuppression Are Exacerbated by Other Chronic Conditions
Samuel Good¹, Bryant England² and Elizabeth Volkmann³, ¹University of California, Los Angeles, Los Angeles, CA, ²University of Nebraska Medical Center, Omaha, NE, ³University of California, Department of Medicine, Los Angeles, CA, USA, Los Angeles
Background/Purpose: Medication non-adherence is associated with worse autoimmune disease outcomes; however, it is unknown whether adherence rates related to cost barriers differ across diseases and…
Abstract Number: 0145 • ACR Convergence 2024
Community Mobility in a Diverse Cohort of Individuals with Systemic Lupus Erythematosus
Leila Milanfar¹, Jinoos Yazdany², Amanda Eudy³, Courtney Hoge⁴, Charmayne M. Dunlop-Thomas⁵, Patti Katz⁶ and Laura Plantinga⁷, ¹University of California San Francisco, San Francisco, CA, ²UCSF, San Francisco, CA, ³Duke University, Raleigh, NC, ⁴Emory University, Atlanta, GA, ⁵Emory University School of Medicine, Department of Medicine, Division of Rheumatology, Atlanta, GA, ⁶UCSF, San Rafael, CA, ⁷University of California, San Francisco, San Francisco, CA
Background/Purpose: Measurement of the extent to which individuals move throughout their community and participate in social activities (“community mobility”) can provide a snapshot of how…
Abstract Number: 2090 • ACR Convergence 2024
Prevalence of Steatotic Liver Disease and Liver Fibrosis Among Patients with Osteoarthritis (OA)
Athanasios Vassilopoulos¹, Stephanos Vassilopoulos², Markos Kalligeros², Eleftherios Mylonakis³ and Anthony M. Reginato⁴, ¹Warren Alpert Medical School of Brown University, Providence, RI, ²Division of Internal Medicine, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, Rhode Island, Providence, RI, ³Department of Medicine, Houston Methodist Hospital, Houston, ⁴Brown University, Providence, RI
Background/Purpose: Steatotic liver disease (SLD) and osteoarthritis (OA) affect a large proportion of the general population and prevalence of both is expected to increase given…
Abstract Number: 0166 • ACR Convergence 2024
Limitations in Activities of Daily Living Among Individuals with SLE
Laura Plantinga¹, Jinoos Yazdany², Courtney Hoge³, Charmayne M. Dunlop-Thomas⁴ and Patti Katz⁵, ¹University of California, San Francisco, San Francisco, CA, ²UCSF, San Francisco, CA, ³Emory University, Atlanta, GA, ⁴Emory University School of Medicine, Department of Medicine, Division of Rheumatology, Atlanta, GA, ⁵UCSF, San Rafael, CA
Background/Purpose: A better understanding of the capacity of individuals with SLE to perform routine daily life tasks is needed to effectively support the independence and…

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