Abstracts tagged "African-Americans"

Abstract Number: 780 • 2016 ACR/ARHP Annual Meeting
Belimumab Use in African-American Patients in an U.S. Academic Medical Center
Paloma Alejandro¹, Anjani Pillarisetty² and Christopher E. Collins³, ¹Rheumatology, MedStar Washington Hospital Center/Georgetown University Medical Center, Washington, DC, ²Internal Medicine, MedStar Washington Hospital Center/Georgetown University Medical Center, Washington, DC, ³MedStar Washington Hospital Center/Georgetown University Medical Center, Washington, DC
Background/Purpose: Belimumab is an anti-BAFF monoclonal antibody approved for the treatment of auto-antibody positive patients with SLE. In two large phase 3 clinical trials, belimumab…
Abstract Number: 1969 • 2016 ACR/ARHP Annual Meeting
Peer Approaches to Lupus Self-Management (PALS): A Novel Lupus Peer Mentorship Intervention
Edith M. Williams¹, Leonard Egede², Jim Oates³, Delia Voronca² and Mulugeta Gebregziabher², ¹Public Health Sciences, Medical University of South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, SC, ³Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that is associated with increased morbidity, mortality, health care costs and decreased quality of life.…
Abstract Number: 2351 • 2016 ACR/ARHP Annual Meeting
Racial Differences in Magnetic Resonance Image-Based Three-Dimensional Bone Shape of the Knee: Data from the Osteoarthritis Initiative (OAI)
Jing-Sheng Li¹, Michael A Bowes², David T. Felson³, Philip G. Conaghan⁴, Carrie Brown⁵ and Tuhina Neogi⁶, ¹Boston University, Boston, MA, ²Imorphics Ltd, Manchester, United Kingdom, ³Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁵Boston University School of Public Health, Boston, MA, ⁶Clinical Epidemiology, Boston University School of Medicine, Boston, MA
Background/Purpose: African Americans have higher prevalence and greater severity of knee osteoarthritis (OA) on radiographs compared with Caucasians. Magnetic resonance imaging (MRI)-based quantification of 3-dimensional…
Abstract Number: 3103 • 2016 ACR/ARHP Annual Meeting
Apolipoprotein L1 Risk Variants Associate with Prevalent Cardiovascular Disease in African American Systemic Lupus Erythematous Patients
Ashira Blazer¹, Robert M Clancy², H. Michael Belmont³, Peter M. Izmirly³, Androo Markham⁴ and Jill P. Buyon⁴, ¹Division of Rheumatology, NYU School of Medicine, New York, NY, ²Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ³New York University School of Medicine, New York, NY, ⁴Medicine, New York University School of Medicine, New York, NY
Background/Purpose: Two Apolipoprotein L1 (APOL1) risk variants (RV), G1 and G2, located on chromosome 22q12.3, have been associated with excess renal risk in African Americans…
Abstract Number: 3241 • 2016 ACR/ARHP Annual Meeting
Genetic Variation and Tobacco Smoke Exposure in Systemic Lupus Erythematosus: A Case Control Study Among African Americans
Bethany Wolf¹, Paula S. Ramos², Paul Nietert³, J. Madison Hyer¹, Viswanathan Ramakrishnan¹, Gary S. Gilkeson⁴, Gerard Hardiman² and Diane L. Kamen⁵, ¹Public Health Sciences, Medical University of South Carolina, Charleston, SC, ²Medicine, Medical University of South Carolina, Charleston, SC, ³Public Health Science, Medical University of South Carolina, Charleston, SC, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁵Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) disproportionately affects African Americans, and the development of SLE is believed to be triggered by exposure to one or more…
Abstract Number: 88 • 2015 ACR/ARHP Annual Meeting
Integrating Evidence for Genetic Association and Natural Selection Helps Detect New Systemic Lupus Erythematosus Risk Loci in African-Americans
Paula S. Ramos¹, Satria Sajuthi², Jasmin Divers³, Kenneth M. Kaufman⁴, Uma Nayak⁵, Wei-Min Chen⁵, Kelly J. Hunt⁶, Diane L. Kamen⁷, Gary S. Gilkeson⁸, Jyotika K. Fernandes⁷, Ida J. Spruill⁹, Robert P. Kimberly¹⁰, John B. Harley¹¹, W. Timothy Garvey¹², Michèle M. Sale¹³ and Carl D. Langefeld², ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ³Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁴Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Public Health Sciences, University of Virginia, Charlottesville, VA, ⁶Public Health Sciences, Medical University of South Carolina, Charleston, SC, ⁷Medicine, Medical University of South Carolina, Charleston, SC, ⁸Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁹Nursing, Medical University of South Carolina, Charleston, SC, ¹⁰Medicine, Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹¹Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹²Department of Nutrition Sciences and Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, AL, ¹³Department of Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, VA
Background/Purpose: In many rheumatologic and autoimmune diseases African Americans (AA) have a higher prevalence and greater disease severity than other ethnicities. We posit that population-specific…
Abstract Number: 390 • 2015 ACR/ARHP Annual Meeting
Treatment and Outcomes in Pediatric SLE Patients in South Africa
Laura Lewandowski¹, Christiaan Scott², Laura Schanberg³ and Nathan Thielman⁴, ¹Pediatric Rheumatology, Duke University Medical Center, Durham, NC, ²Rheumatology, Red Cross War Memorial Children's Hospital, Cape Town, South Africa, ³Duke University, Durham, NC, ⁴Duke Hubert Yeargan Center for Global Health, Durham, NC
Background/Purpose: Although African children with SLE may be at high risk for poor outcomes based on race, socioeconomic status, and age, little research has…
Abstract Number: 715 • 2015 ACR/ARHP Annual Meeting
Investigating the Role of Vitamin D in Patients with SLE
Briana K. Ply¹ and Diane L. Kamen², ¹Medical University of South Carolina, Charleston, SC, ²Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Vitamin D is a steroid hormone that not only functions in maintaining calcium and bone metabolism, but also displays immunoregulatory and anti-inflammatory properties. Recent…
Abstract Number: 790 • 2015 ACR/ARHP Annual Meeting
An Intervention to Improve Quality of Life for African-American Lupus Patients
Edith M. Williams¹, Johnese Bostic², Alyssa Adkins³, Larisa Bruner², Jiajia Zhang², Diane L. Kamen⁴ and Jim Oates⁴, ¹Institute for Partnerships to Eliminate Health Disparities, University of South Carolina, Columbia, SC, ²University of South Carolina, Columbia, SC, ³University of South Carolina, Greenville, SC, ⁴Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: The Intervention to Improve Quality of life for African-AmericaN lupus patients (IQAN) Project is designed to examine whether a uniquely tailored intervention program can…
Abstract Number: 808 • 2015 ACR/ARHP Annual Meeting
Heritable Endotheliopathy and ApolipoproteinL1 Risk Traits in SLE
Ashira Blazer¹, Andrew Markham², Sara Rasmussen³, Jill P. Buyon⁴, H. Michael Belmont⁵, Shilpi Mehta-Lee⁶, Janet Nwaukoni⁴, Peter M. Izmirly⁷ and Robert Clancy⁴, ¹Division of Rheumatology, NYU School of Medicine, New York, NY, ²Medicine, New York University School of Medicine, New York, NY, ³Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁵Hosp for Joint Disease, New York, NY, ⁶Obstetrics and Gynecology, New York University School of Medicine, New York, NY, ⁷Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: With higher prevalence of renal and cardiovascular diseases (CVD), as well as HTN, African American (AA) SLE patients experience accelerated damage accrual and excess…
Abstract Number: 1004 • 2015 ACR/ARHP Annual Meeting
Prevalence and Cross-Sectional Risk Factors of Ankle Osteoarthritis in a Community-Based Cohort
Shahmeer Lateef¹, Yvonne M. Golightly², Jordan B. Renner³, Joanne M. Jordan¹ and Amanda E. Nelson¹, ¹Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ²Epidemiology, University of North Carolina, Chapel Hill, NC, ³Radiology, University of North Carolina, Chapel Hill, NC
Background/Purpose: Historically, ankle osteoarthritis (OA) has been considered uncommon, and its development has been thought of as a consequence of primarily ankle injury. Other etiologies…
Abstract Number: 2066 • 2015 ACR/ARHP Annual Meeting
Elevated Innate, Adaptive, and TNF-Superfamily Soluble Inflammatory Mediators Mark Impending Disease Flare, While Regulatory Mediators Distinguish Lack of Impending Disease Flare in African-American SLE Patients with Active Disease
Melissa E. Munroe¹, Evan G. Vista², Joan T. Merrill³, Joel M. Guthridge¹, Virginia C. Roberts¹ and Judith A. James⁴, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Rheumatology and Clinical Immunology, University of Santo Tomas, Taguig City, Philippines, ³Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: SLE is a multifaceted disease characterized by immune dysregulation and varied disease activity. Identifying mechanistic mediators of altered disease activity would help prevent damage…
Abstract Number: 2688 • 2014 ACR/ARHP Annual Meeting
Comparison of Systemic Lupus Erythematosus and Healthy Anti-Nuclear Antibody Positive African-Americans Reveals Distinct Differences in T Cell and Progenitor Populations
Rufei Lu^1,2, Samantha Slight-Webb¹, Holden T. Maecker³, Paul J. Utz⁴, Joel M. Guthridge¹ and Judith A. James^5,6, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Medicine and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁴Medicine, Stanford University School of Medicine, Stanford, CA, ⁵Clinical Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder which arises from both genetic and environmental factors that likely affect phenotypic and functional characteristics…
Abstract Number: 2453 • 2014 ACR/ARHP Annual Meeting
High-Density Genotyping of Risk Loci in African Americans with RA
Maria I. Danila¹, Richard Reynolds², Qi Yan³, Nianjun Liu³, Peter K. Gregersen⁴, CLEAR Investigators², Donna K. Arnett² and S. Louis Bridges Jr.^2,5, ¹Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ⁴Genomics and Human Genetics, Feinstein Institute for Medical Research, Manhasset, NY, ⁵Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Genetic studies have identified 101 risk loci for RA in individuals of Caucasian and Asian descent. However, to date the genetic determinants of RA…
Abstract Number: 2454 • 2014 ACR/ARHP Annual Meeting
Genetic Influences on Rheumatoid Arthritis in African-Americans
Vincent A. Laufer^1,2, Richard J. Reynolds³, Maria I. Danila⁴, Gordon Wu⁵, Amit Patki⁵, Devin Absher⁶, Carl D. Langefeld⁷, R. Curtis Hendrickson⁸, Elliot J. Lefkowitz⁹, Ted R. Mikuls¹⁰, Peter K. Gregersen¹¹, Elizabeth E. Brown⁸, Robert P. Kimberly⁸, John B. Harley¹², Donna K. Arnett⁸, Hemant K. Tiwari⁵ and S. Louis Bridges Jr.^8,13, ¹Division of Clinical Rheumatology and Immunology, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham Medical Scientist Training Program, Birmingham, AL, ³Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁴Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ⁶Hudson Alpha Institute for Biotechnology, Huntsville, AL, ⁷Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁸University of Alabama at Birmingham, Birmingham, AL, ⁹Microbiology, University of Alabama at Birmingham, Birmingham, AL, ¹⁰Veteran Affairs Nebraska Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ¹¹Genomics and Human Genetics, Feinstein Institute Medical Research and North Shore-Long Island Jewish Health System, Manhasset, NY, ¹²Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹³Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Rheumatoid arthritis (RA) affects 0.5-1% of the population worldwide. The genetics of RA has been analyzed in large European and Asian studies, but much…

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