Abstracts tagged "African-Americans"

Abstract Number: 3241 • 2016 ACR/ARHP Annual Meeting
Genetic Variation and Tobacco Smoke Exposure in Systemic Lupus Erythematosus: A Case Control Study Among African Americans
Bethany Wolf¹, Paula S. Ramos², Paul Nietert³, J. Madison Hyer¹, Viswanathan Ramakrishnan¹, Gary S. Gilkeson⁴, Gerard Hardiman² and Diane L. Kamen⁵, ¹Public Health Sciences, Medical University of South Carolina, Charleston, SC, ²Medicine, Medical University of South Carolina, Charleston, SC, ³Public Health Science, Medical University of South Carolina, Charleston, SC, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁵Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) disproportionately affects African Americans, and the development of SLE is believed to be triggered by exposure to one or more…
Abstract Number: 64 • 2016 ACR/ARHP Annual Meeting
Enrichment of Immune Pathways in Genes Under Geographically Restricted Adaptation in the Gullah African American Population of South Carolina
Paula S. Ramos¹, Satria Sajuthi², Wei-Min Chen³, Jasmin Divers², Jyotika K. Fernandes⁴, Gary S. Gilkeson⁴, Kelly J. Hunt⁵, Diane L. Kamen⁴, Uma Nayak³, W. Timothy Garvey⁶, Michèle M. Sale⁷ and Carl D. Langefeld², ¹Departments of Medicine and Public Health Sciences, Medical University of South Carolina, Charleston, SC, ²Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, NC, ³Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia, Charlottesville, VA, ⁴Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁵Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, ⁶Department of Nutrition Sciences and Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, AL, ⁷Department of Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, VA
Background/Purpose: The reasons for the ethnic disparities in rheumatologic and autoimmune diseases (ADs) are largely unknown. We posit that population-specific selection influencing the allele frequencies…
Abstract Number: 126 • 2016 ACR/ARHP Annual Meeting
Anti-Neutrophil Cytoplasmic Antibodies (ANCA) in African-American Patients: Disease Associations and Clinical Outcomes in an Urban Cohort
Philip McCarthy¹, Jenna Hudy², Marie Melville², Danielle Robson¹, John McKinnon², Sandeep Soman² and Kathleen Maksimowicz-McKinnon³, ¹Michigan State University College of Osteopathic Medicine, East Lansing, MI, ²Henry Ford Hospital, Detroit, MI, ³Rheumatology, Henry Ford Hospital, Detroit, MI
Background/Purpose: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) has been most extensively described and studied in non-African-American populations. The significance of and associations with ANCA in African-Americans,…
Abstract Number: 127 • 2016 ACR/ARHP Annual Meeting
Disease Characteristics and Outcomes in African-American Patients with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: a High Risk Group for Poor Outcomes
Philip McCarthy¹, Danielle Robson¹, Jenna Hudy², Marie Melville², John McKinnon², Sandeep Soman² and Kathleen Maksimowicz-McKinnon³, ¹Michigan State University College of Osteopathic Medicine, East Lansing, MI, ²Henry Ford Hospital, Detroit, MI, ³Rheumatology, Henry Ford Hospital, Detroit, MI
Background/Purpose: Antineutrophil antibody-associated vasculitis (AAV) has been most extensively described and studied in non-African American populations. Little is known about the characteristics and outcomes of…
Abstract Number: 583 • 2016 ACR/ARHP Annual Meeting
Associations of Serum Anti-Citrullinated Proteins and Cytokines with Radiographic Scores in African-American Rheumatoid Arthritis Patients
Dongmei Sun¹, William H Robinson², Xiangqin Cui³, Vincent A. Laufer⁴, Maria I. Danila⁵, Richard J. Reynolds⁶, Chander Raman⁷, Stephanie Ledbetter⁸, Alexander Szalai⁹ and S. Louis Bridges Jr.⁹, ¹Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ³Biostatistics, University of Alabama at Birmingham, Birmingham, AL, ⁴Division of Clinical Rheumatology and Immunology, University of Alabama at Birmingham, Birmingham, AL, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Medicine/Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁸1825 University Blvd., University of Alabama at Birmingham, Birmingham, AL, ⁹Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Serum anti-citrullinated proteins (ACPA, including anti-CCP antibodies) and rheumatoid factor (RF) are critical diagnostic markers for RA, and are associated with more severe radiographic…
Abstract Number: 88 • 2015 ACR/ARHP Annual Meeting
Integrating Evidence for Genetic Association and Natural Selection Helps Detect New Systemic Lupus Erythematosus Risk Loci in African-Americans
Paula S. Ramos¹, Satria Sajuthi², Jasmin Divers³, Kenneth M. Kaufman⁴, Uma Nayak⁵, Wei-Min Chen⁵, Kelly J. Hunt⁶, Diane L. Kamen⁷, Gary S. Gilkeson⁸, Jyotika K. Fernandes⁷, Ida J. Spruill⁹, Robert P. Kimberly¹⁰, John B. Harley¹¹, W. Timothy Garvey¹², Michèle M. Sale¹³ and Carl D. Langefeld², ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ³Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁴Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Public Health Sciences, University of Virginia, Charlottesville, VA, ⁶Public Health Sciences, Medical University of South Carolina, Charleston, SC, ⁷Medicine, Medical University of South Carolina, Charleston, SC, ⁸Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁹Nursing, Medical University of South Carolina, Charleston, SC, ¹⁰Medicine, Clinical Immun & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ¹¹Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹²Department of Nutrition Sciences and Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, AL, ¹³Department of Medicine and Center for Public Health Genomics, University of Virginia, Charlottesville, VA
Background/Purpose: In many rheumatologic and autoimmune diseases African Americans (AA) have a higher prevalence and greater disease severity than other ethnicities. We posit that population-specific…
Abstract Number: 390 • 2015 ACR/ARHP Annual Meeting
Treatment and Outcomes in Pediatric SLE Patients in South Africa
Laura Lewandowski¹, Christiaan Scott², Laura Schanberg³ and Nathan Thielman⁴, ¹Pediatric Rheumatology, Duke University Medical Center, Durham, NC, ²Rheumatology, Red Cross War Memorial Children's Hospital, Cape Town, South Africa, ³Duke University, Durham, NC, ⁴Duke Hubert Yeargan Center for Global Health, Durham, NC
Background/Purpose: Although African children with SLE may be at high risk for poor outcomes based on race, socioeconomic status, and age, little research has…
Abstract Number: 715 • 2015 ACR/ARHP Annual Meeting
Investigating the Role of Vitamin D in Patients with SLE
Briana K. Ply¹ and Diane L. Kamen², ¹Medical University of South Carolina, Charleston, SC, ²Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Vitamin D is a steroid hormone that not only functions in maintaining calcium and bone metabolism, but also displays immunoregulatory and anti-inflammatory properties. Recent…
Abstract Number: 790 • 2015 ACR/ARHP Annual Meeting
An Intervention to Improve Quality of Life for African-American Lupus Patients
Edith M. Williams¹, Johnese Bostic², Alyssa Adkins³, Larisa Bruner², Jiajia Zhang², Diane L. Kamen⁴ and Jim Oates⁴, ¹Institute for Partnerships to Eliminate Health Disparities, University of South Carolina, Columbia, SC, ²University of South Carolina, Columbia, SC, ³University of South Carolina, Greenville, SC, ⁴Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: The Intervention to Improve Quality of life for African-AmericaN lupus patients (IQAN) Project is designed to examine whether a uniquely tailored intervention program can…
Abstract Number: 808 • 2015 ACR/ARHP Annual Meeting
Heritable Endotheliopathy and ApolipoproteinL1 Risk Traits in SLE
Ashira Blazer¹, Andrew Markham², Sara Rasmussen³, Jill P. Buyon⁴, H. Michael Belmont⁵, Shilpi Mehta-Lee⁶, Janet Nwaukoni⁴, Peter M. Izmirly⁷ and Robert Clancy⁴, ¹Division of Rheumatology, NYU School of Medicine, New York, NY, ²Medicine, New York University School of Medicine, New York, NY, ³Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁵Hosp for Joint Disease, New York, NY, ⁶Obstetrics and Gynecology, New York University School of Medicine, New York, NY, ⁷Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: With higher prevalence of renal and cardiovascular diseases (CVD), as well as HTN, African American (AA) SLE patients experience accelerated damage accrual and excess…
Abstract Number: 1004 • 2015 ACR/ARHP Annual Meeting
Prevalence and Cross-Sectional Risk Factors of Ankle Osteoarthritis in a Community-Based Cohort
Shahmeer Lateef¹, Yvonne M. Golightly², Jordan B. Renner³, Joanne M. Jordan¹ and Amanda E. Nelson¹, ¹Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ²Epidemiology, University of North Carolina, Chapel Hill, NC, ³Radiology, University of North Carolina, Chapel Hill, NC
Background/Purpose: Historically, ankle osteoarthritis (OA) has been considered uncommon, and its development has been thought of as a consequence of primarily ankle injury. Other etiologies…
Abstract Number: 2066 • 2015 ACR/ARHP Annual Meeting
Elevated Innate, Adaptive, and TNF-Superfamily Soluble Inflammatory Mediators Mark Impending Disease Flare, While Regulatory Mediators Distinguish Lack of Impending Disease Flare in African-American SLE Patients with Active Disease
Melissa E. Munroe¹, Evan G. Vista², Joan T. Merrill³, Joel M. Guthridge¹, Virginia C. Roberts¹ and Judith A. James⁴, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Rheumatology and Clinical Immunology, University of Santo Tomas, Taguig City, Philippines, ³Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology, University of Oklahoma Health Sciences Center and Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: SLE is a multifaceted disease characterized by immune dysregulation and varied disease activity. Identifying mechanistic mediators of altered disease activity would help prevent damage…
Abstract Number: 1672 • 2014 ACR/ARHP Annual Meeting
Facilitating the Medication Decision-Making process—What Do Patients with Lupus Nephritis Say?
Ricahrd Shewchuk¹, Haiyan Qu², W. Winn Chatham², Jinoos Yazdany³, Maria Dall'era⁴ and Jasvinder A. Singh⁵, ¹University fo Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³Medicine, University of California, San Francisco, San Francisco, CA, ⁴Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁵University of Alabama and VA Medical Center, Birmingham, AL
Background/Purpose: Low medication adherence in lupus nephritis puts patients at risk for poor outcomes, but to our knowledge, relatively little is known about what patients…
Abstract Number: 1668 • 2014 ACR/ARHP Annual Meeting
Identifying Patient Perceptions of Medication Decision Making Barriers in Minorities with Lupus Nephritis
Jasvinder A. Singh¹, Haiyan Qu², Jinoos Yazdany³, W. Winn Chatham², Maria Dall'era⁴ and Ricahrd Shewchuk⁵, ¹University of Alabama and VA Medical Center, Birmingham, AL, ²University of Alabama at Birmingham, Birmingham, AL, ³Medicine, University of California, San Francisco, San Francisco, CA, ⁴Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, ⁵University fo Alabama at Birmingham, Birmingham, AL
Background/Purpose: Studies suggest that adherence to medications for lupus nephritis is low. However, there are limited data available on the barriers that patients with lupus…
Abstract Number: 1635 • 2014 ACR/ARHP Annual Meeting
Association Between Carrying at Least One Apolipoprotein1 Variant Allele and Hypertension in Lupus Patients with Normal Renal Function
Ashira Blazer¹, H. Michael Belmont², Robert Clancy³, Peter M. Izmirly⁴ and Jill P. Buyon⁵, ¹Division of Rheumatology, NYU School of Medicine, New York, NY, ²NYU School of Medicine, New York, NY, ³Rheumatology, NYU Medical Center, New York, NY, ⁴Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁵Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose The apolipoprotein1 (APOL1) gene encodes a 3 domain protein found both in serum and intracellularly in endothelial cells among other cell types. Variant APOL1…

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