Abstract Number: 780 • 2016 ACR/ARHP Annual Meeting
Belimumab Use in African-American Patients in an U.S. Academic Medical Center
Background/Purpose: Belimumab is an anti-BAFF monoclonal antibody approved for the treatment of auto-antibody positive patients with SLE. In two large phase 3 clinical trials, belimumab…Abstract Number: 1969 • 2016 ACR/ARHP Annual Meeting
Peer Approaches to Lupus Self-Management (PALS): A Novel Lupus Peer Mentorship Intervention
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that is associated with increased morbidity, mortality, health care costs and decreased quality of life.…Abstract Number: 2351 • 2016 ACR/ARHP Annual Meeting
Racial Differences in Magnetic Resonance Image-Based Three-Dimensional Bone Shape of the Knee: Data from the Osteoarthritis Initiative (OAI)
Background/Purpose: African Americans have higher prevalence and greater severity of knee osteoarthritis (OA) on radiographs compared with Caucasians. Magnetic resonance imaging (MRI)-based quantification of 3-dimensional…Abstract Number: 3103 • 2016 ACR/ARHP Annual Meeting
Apolipoprotein L1 Risk Variants Associate with Prevalent Cardiovascular Disease in African American Systemic Lupus Erythematous Patients
Background/Purpose: Two Apolipoprotein L1 (APOL1) risk variants (RV), G1 and G2, located on chromosome 22q12.3, have been associated with excess renal risk in African Americans…Abstract Number: 3241 • 2016 ACR/ARHP Annual Meeting
Genetic Variation and Tobacco Smoke Exposure in Systemic Lupus Erythematosus: A Case Control Study Among African Americans
Background/Purpose: Systemic lupus erythematosus (SLE) disproportionately affects African Americans, and the development of SLE is believed to be triggered by exposure to one or more…Abstract Number: 790 • 2015 ACR/ARHP Annual Meeting
An Intervention to Improve Quality of Life for African-American Lupus Patients
Background/Purpose: The Intervention to Improve Quality of life for African-AmericaN lupus patients (IQAN) Project is designed to examine whether a uniquely tailored intervention program can…Abstract Number: 808 • 2015 ACR/ARHP Annual Meeting
Heritable Endotheliopathy and ApolipoproteinL1 Risk Traits in SLE
Background/Purpose: With higher prevalence of renal and cardiovascular diseases (CVD), as well as HTN, African American (AA) SLE patients experience accelerated damage accrual and excess…Abstract Number: 1004 • 2015 ACR/ARHP Annual Meeting
Prevalence and Cross-Sectional Risk Factors of Ankle Osteoarthritis in a Community-Based Cohort
Background/Purpose: Historically, ankle osteoarthritis (OA) has been considered uncommon, and its development has been thought of as a consequence of primarily ankle injury. Other etiologies…Abstract Number: 2066 • 2015 ACR/ARHP Annual Meeting
Elevated Innate, Adaptive, and TNF-Superfamily Soluble Inflammatory Mediators Mark Impending Disease Flare, While Regulatory Mediators Distinguish Lack of Impending Disease Flare in African-American SLE Patients with Active Disease
Background/Purpose: SLE is a multifaceted disease characterized by immune dysregulation and varied disease activity. Identifying mechanistic mediators of altered disease activity would help prevent damage…Abstract Number: 88 • 2015 ACR/ARHP Annual Meeting
Integrating Evidence for Genetic Association and Natural Selection Helps Detect New Systemic Lupus Erythematosus Risk Loci in African-Americans
Background/Purpose: In many rheumatologic and autoimmune diseases African Americans (AA) have a higher prevalence and greater disease severity than other ethnicities. We posit that population-specific…Abstract Number: 390 • 2015 ACR/ARHP Annual Meeting
Treatment and Outcomes in Pediatric SLE Patients in South Africa
Background/Purpose: Although African children with SLE may be at high risk for poor outcomes based on race, socioeconomic status, and age, little research has…Abstract Number: 715 • 2015 ACR/ARHP Annual Meeting
Investigating the Role of Vitamin D in Patients with SLE
Background/Purpose: Vitamin D is a steroid hormone that not only functions in maintaining calcium and bone metabolism, but also displays immunoregulatory and anti-inflammatory properties. Recent…Abstract Number: 2956 • 2014 ACR/ARHP Annual Meeting
Identification of Autoimmune Functional Variants Under Positive Selection in the Gullah African American Population of South Carolina
Background/Purpose The reasons for the ethnic disparities in rheumatologic and autoimmune diseases (ADs) are largely unknown. We posit that population-specific selection influencing the allele frequencies…Abstract Number: 2688 • 2014 ACR/ARHP Annual Meeting
Comparison of Systemic Lupus Erythematosus and Healthy Anti-Nuclear Antibody Positive African-Americans Reveals Distinct Differences in T Cell and Progenitor Populations
Background/Purpose Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder which arises from both genetic and environmental factors that likely affect phenotypic and functional characteristics…Abstract Number: 2453 • 2014 ACR/ARHP Annual Meeting
High-Density Genotyping of Risk Loci in African Americans with RA
Background/Purpose: Genetic studies have identified 101 risk loci for RA in individuals of Caucasian and Asian descent. However, to date the genetic determinants of RA…