Abstracts tagged "African-Americans"

Abstract Number: 362 • 2019 ACR/ARP Annual Meeting
Methods to Efficiently Recruit Minority Patients with Gout for Clinic-Based Registries
Giovanni Adami¹, Giovanna Rosas ², Joshua Melnick ³, Jeffrey Foster ², Elizabeth Rahn ², Amy Mudano ⁴, Jeffrey Curtis ², Tony Merriman ⁵, S Louis Bridges ⁴ and Kenneth Saag ², ¹University of Verona, Verona, Italy, ²University of Alabama at Birmingham, Birmingham, AL, ³University of Alabama at Birmingham, Birmimgham, AL, ⁴University of Alabama at Birmingham, Birmingham, ⁵University of Otago, Birmingham, AL
Background/Purpose: Gout is frequently misdiagnosed and/or miscoded, making approaches to identifying eligible patients for observational and interventional studies more challenging. Ethnic and racial minorities are…
Abstract Number: 805 • 2019 ACR/ARP Annual Meeting
Risk of Cardiovascular Disease in SLE Is Significant Early and Highlights Racial Disparities
Shivani Garg¹, Christie Bartels ¹, Cristina Drenkard ², Gaobin Bao ² and S Sam Lim ², ¹University of Wisconsin School of Medicine and Public Health, Madison, WI, ²Emory University, Atlanta, GA
Background/Purpose: SLE is an independent risk factor for premature cardiovascular disease (CVD) and afflicts African Americans (AA’s) 3 times more than whites. Two predominantly white…
Abstract Number: 1050 • 2019 ACR/ARP Annual Meeting
Genome-Wide DNA Methylation Signatures in Classical Monocytes from African Ancestry Patients with Systemic Sclerosis
Peter Allen¹, Jena Wirth ², Nathan Wilson ², Jim Oates ³, Melissa Cunningham ², Devin Absher ⁴ and Paula Ramos ², ¹University of Alabama at Birmingham, Birmingham, AL, ²Medical University of South Carolina, Charleston, ³Division of Rheumatology & Immunology/Medical University of South Carolina, Charleston, SC, ⁴HudsonAlpha Institute for Biotechnology, Huntsville, AL
Background/Purpose: Systemic sclerosis (SSc) is a rare, fibrotic autoimmune disorder characterized by cutaneous and visceral fibrosis, immune dysregulation, and vasculopathy. It disproportionately affects individuals of…
Abstract Number: 1828 • 2019 ACR/ARP Annual Meeting
Avascular Necrosis Is Associated with APOL1 Variants in African Americans with Systemic Lupus Erythematosus
Kevin Yip¹, Elizaveta Efuni ², Yingzhi Qian ¹, Robert Clancy ³, Jill Buyon ² and Ashira Blazer ¹, ¹New York University School of Medicine, New York City, ²New York University School of Medicine, New York, NY, ³New York University School of Medicine, New York
Background/Purpose: African Americans (AA) with systemic lupus erythematous (SLE) are at higher risk for both renal disease and avascular necrosis (AVN). The two Apolipoprotein L1…
Abstract Number: 1830 • 2019 ACR/ARP Annual Meeting
Short- and Long-term Morbidity and Mortality Outcomes of African American Patients with Systemic Sclerosis-Related Interstitial Lung Disease
Elizabeth Volkmann¹, Virginia Steen ², Ning Li ³, Michael Roth ⁴, Philip Clements ³, Dinesh Khanna ⁵, Daniel Furst ⁶, Shervin Assassi ⁷, Grace Kim ³, Jonathan Goldin ³, Robert Elashoff ³ and Donald Tashkin ³, ¹University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, ²Georgetown University, Washington, D.C., USA, Georgetown, ³University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, ⁴University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, ⁵Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, ⁶University of California, Los Angeles, CA, ⁷Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, Texas, USA, Houston, TX
Background/Purpose: Observational studies have demonstrated that African American (AA) patients with systemic sclerosis (SSc) have a more unfavorable prognosis compared with non-AA. However, no studies…
Abstract Number: 2217 • 2019 ACR/ARP Annual Meeting
DEXA Does Not Accurately Reflect FRAX Score in Patients with Autoimmune Disease on Corticosteroids
Sima Terebelo¹, Madina Abduraimova ¹, Latoya Freeman-Beman ¹, Naureen Kabani ², Joshy Pathiparampil ¹, Olga Dvorkina ² and Ellen M Ginzler ³, ¹SUNY Downstate Medical Center, Brooklyn, NY, ²SUNY Downstate Medical Center, Brooklyn, ³State University of New York Downstate Medical Center, Brooklyn, NY
Background/Purpose: Osteoporosis (OP) is a problem in the aging population. Patients with autoimmune disease are at increased risk for OP given their history of steroid…
Abstract Number: 281 • 2018 ACR/ARHP Annual Meeting
Development of an African American Lupus Community-Based Patient and Provider Education Program: Lupus Conversations
Karen Mancera-Cuevas¹, Courtnie Phillip², Cianna Leatherwood³, Chase Correia⁴, James Brucker⁴, Elmer Freeman⁵, Gail Granville⁶, Kay Mimms⁷, Patricia Canessa⁸, Candace H. Feldman³ and Rosalind Ramsey-Goldman⁹, ¹Rheumatology, Northwestern University, Chicago, IL, ²Brigham and Women's Hospital, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Northwestern University, Chicago, IL, ⁵Northeastern University, Boston, MA, ⁶Women of Courage, Inc., Boston, MA, ⁷Lupus Society of Illinois, Chicago, IL, ⁸Illinois Public Health Association, Springfield, IL, ⁹FSM, Northwestern University, Chicago, IL
Background/Purpose: African Americans (AA) with lupus experience severe manifestations and outcomes, and a long journey to diagnosis and care. We developed and tested evidence-based, culturally…
Abstract Number: 1094 • 2018 ACR/ARHP Annual Meeting
Endogenous Ifnβ Production Is Required for Efficient BCR Crosslinking and Survival of SLE B Cells
John D. Mountz¹, Shanrun Liu², PingAr Yang³, Qi Wu⁴, Bao Luo⁵, W. Winn Chatham⁶ and Hui-Chen Hsu⁴, ¹University of Alabama at Birmingham and Birmingham VA Medical center, Birmingham, AL, ²Biochemistry & Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL, ³Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁵Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁶Medcine/Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Increased type I interferon (IFN) has been shown to affect survival and activation of B cells in SLE. This study investigated novel mechanisms of…
Abstract Number: 1120 • 2018 ACR/ARHP Annual Meeting
Strong HLA and Novel Non-HLA Associations Identified By Auto-Antibody Subset Analysis of African Americans with Scleroderma from the Genome Research in African American Scleroderma Patients Cohort
Pravitt Gourh¹, Elaine F. Remmers², Theresa Alexander³, Steven Boyden⁴, Nadia D. Morgan⁵, Ami A. Shah⁶, Maureen D. Mayes⁷, Ayo Doumatey², Amy Bentley², Daniel Shriner⁸, Robyn T. Domsic⁹, Thomas A. Medsger Jr.¹⁰, Virginia D. Steen¹¹, Paula S. Ramos¹², Rick Silver¹³, Benjamin D. Korman¹⁴, John Varga¹⁵, Elena Schiopu¹⁶, Dinesh Khanna¹⁷, Vivien Hsu¹⁸, Jessica K. Gordon¹⁹, Lesley Ann Saketkoo²⁰, Heather Gladue²¹, Brynn Kron²², Lindsey A. Criswell²², Chris T. Derk²³, S. Louis Bridges Jr.²⁴, Victoria Shanmugam²⁵, Kathleen D. Kolstad²⁶, Lorinda Chung²⁷, Reem Jan²⁸, Elana J. Bernstein²⁹, Avram Goldberg³⁰, Marcin Trojanowski³¹, Suzanne Kafaja³², Kathleen Maksimowicz-McKinnon³³, Settara C Chandrasekharappa², Adebowale Adeyemo², Charles Rotimi², Fredrick M. Wigley³⁴, Francesco Boin³⁵ and Daniel L. Kastner³⁶, ¹NIAMS-Rheumatology, National Institutes of Health (NIH), National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, ²National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, ³National Institutes of Health, Bethesda, MD, ⁴National Institutes of Health (NIH), National Institute on Deafness and Other Communication Disorders, Bethesda, MD, ⁵Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Division of Rheumatology, Johns Hopkins University, Baltimore, MD, ⁷Rheumatology, University of Texas McGovern Medical School, Houston, TX, ⁸National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, MD, ⁹Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, ¹⁰University of Pittsburgh, Pittsburgh, PA, ¹¹Rheumatology, MedStar Georgetown University Hospital, Washington, DC, ¹²Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, ¹³Rheumatology, Medical University of SC, Charleston, SC, ¹⁴Division of Allergy/Immunology and Rheumatology and Center for Musculoskeletal Research, School of Medicine and Dentistry, University of Rochester Medical School, Rochester, New York, USA, Rochester, NY, ¹⁵Northwestern University, Chicago, IL, ¹⁶University of Michigan, Ann Arbor, MI, ¹⁷Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, ¹⁸Rheumatology, Robert Wood Johnson Medical School, New Brunswick, NJ, ¹⁹Rheumatology, Hospital for Special Surgery, New York, NY, ²⁰Tulane, New Orleans, LA, ²¹Rheumatology, Arthritis and Osteoporosis Consultants of the Carolinas, Charlotte, NC, ²²University of California San Francisco, San Francisco, CA, ²³Rheumatology, University of Pennsylvania, Philadelphia, PA, ²⁴Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, ²⁵Rheumatology, The George Washington University, Washington, DC, ²⁶Rheumatology, Stanford University Medical Center, Stanford, CA, ²⁷Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ²⁸Medicine, Rheumatology, University of Chicago, Chicago, IL, ²⁹Rheumatology, Columbia University, New York, NY, ³⁰NYU Langone Medical Center, New York, NY, ³¹Boston University, Boston, MA, ³²David Geffen School of Medicine, UCLA, Los Angeles, CA, ³³Rheumatology, Henry Ford Hospital, Detroit, MI, ³⁴Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³⁵Rheumatology, University California, San Francisco, San Francisco, CA, ³⁶Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
Background/Purpose: Anti-fibrillarin (nucleolar, AFA) and anti-topoisomerase I (ATA) autoantibodies are specific to systemic sclerosis (SSc) and are common in African Americans (AA). These autoantibodies define…
Abstract Number: 1292 • 2018 ACR/ARHP Annual Meeting
HLA-B*58:01 Genotype and the Risk of Allopurinol-Associated Severe Cutaneous Adverse Reactions in a Predominately Black or African American Population with Advanced Chronic Kidney Disease
Sarah Ford¹, Pamela Kimball¹, Gaurav Gupta¹ and Nehal Shah², ¹Virginia Commonwealth University, Richmond, VA, ²Medicine/Rheumatology, Virginia Commonwealth University, Richmond, VA
Background/Purpose: Allopurinol is the first line urate lowering drug used for treatment of gout. Its most feared side effect includes development of hypersensitivity drug reactions…
Abstract Number: 1842 • 2018 ACR/ARHP Annual Meeting
Implementation of an African American Popular Opinion Leader Model to Address Disparities in Lupus Knowledge and Care
Courtnie Phillip¹, Cianna Leatherwood², Elmer Freeman³, Gail Granville⁴, Gayna Sealy⁵, Toni Wiley⁵, Chase Correia⁶, Karen Mancera-Cuevas⁷, Patricia Canessa⁸, Rosalind Ramsey-Goldman⁹ and Candace H. Feldman², ¹Brigham and Women's Hospital, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ³Northeastern University, Boston, MA, ⁴Women of Courage, Inc., Boston, MA, ⁵Sportsmen's Tennis and Enrichment Center, Dorchester, MA, ⁶Northwestern University, Chicago, IL, ⁷Rheumatology, Northwestern University, Chicago, IL, ⁸Illinois Public Health Association, Springfield, IL, ⁹FSM, Northwestern University, Chicago, IL
Background/Purpose: Lupus is a chronic, autoimmune disease that disproportionately affects African American individuals. Community-based educational interventions that capitalize on rich social networks can be used…
Abstract Number: 1943 • 2018 ACR/ARHP Annual Meeting
Apolipoprotein L1 Risk Variants Associate with Poor Renal Outcomes, Damage Accrual, and Death: A Prospective Ghanaian SLE Cohort
Ashira Blazer¹, Ida Dzifa Dey², Margaret Reynolds³, Festus Ankrah³, Nancyanne Schmidt⁴, Robert M. Clancy⁵ and Jill P. Buyon⁶, ¹Internal Medicine Division of Rheumatology, NYU School of Medicine, New York, NY, ²Department of Medicine, Rheumatology Unit, School of Medicine and Dentistry,University of Ghana, Accra, Ghana, ³Internal Medicine, The University of Ghana, Accra, Ghana, ⁴Internal Medicine, New York University School of Medicine, New York, NY, ⁵NYU School of Medicine, New York, NY, ⁶Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Two Apolipoprotein L1 (APOL1) risk variants (RV), G1 and G2, are enriched in ancestrally African populations due to a conferred superior resistance to Trypanosoma…
Abstract Number: 2733 • 2018 ACR/ARHP Annual Meeting
From a Myth to a Menace: Increased Disease Severity and Poor Outcomes in an Urban Cohort of African-American Patients with ANCA-Associated Vasculitis
Kathleen Maksimowicz-McKinnon¹, Philip McCarthy², Sandeep Soman³ and John McKinnon³, ¹Rheumatology, Henry Ford Hospital, Detroit, MI, ²Michigan State University College of Osteopathic Medicine, East Lansing, MI, ³Henry Ford Hospital, Detroit, MI
Background/Purpose: Anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is a systemic inflammatory disorder frequently associated with significant disability and morbidity, which may lead to end-stage renal disease…
Abstract Number: 2769 • 2018 ACR/ARHP Annual Meeting
A Single Center Experience of Temporal Artery Biopsies Performed in 30 African American Patients
Ammar Haikal¹, Garth Fraga², Jason Springer¹ and Mehrdad Maz³, ¹Department of Internal Medicine, The University of Kansas Medical Center, Division of Allergy, Clinical Immunology & Rheumatology, Kansas City, KS, ²The University of Kansas Medical Center, Department of Pathology and Laboratory Medicine, Kansas City, KS, ³Allergy, Clinical Immunology, and Rheumatology, Division of Allergy, Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS
Background/Purpose: Giant cell arteritis (GCA) is a systemic vasculitis of large and medium-sized arteries mostly reported in Caucasians (CCs) over 50 y.o. There is limited…
Abstract Number: 2982 • 2017 ACR/ARHP Annual Meeting
Morbidity and Mortality of Scleroderma in African Americans
Duncan F. Moore¹, Elisabeth Kramer¹, Rami Eltaraboulsi² and Virginia D. Steen¹, ¹Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, ²MedStar Georgetown University Hospital, Washington, DC
Background/Purpose: Retrospective cohorts have demonstrated that African Americans (AAs) with scleroderma are more likely to have severe disease and higher mortality than non-AAs. A prior…

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