Abstract Number: 986 • 2019 ACR/ARP Annual Meeting
Tofacitinib Enhanced Cerebral Brain-derived Neurotrophic Factor Levelsin a Rat Model of Rheumatoid Arthritis
Background/Purpose: Cognitive dysfunction including depression-like symptoms is a frequent comorbidity of rheumatoid arthritis (RA). Recently, rats with adjuvant-induced arthritis (AIA) were found to exhibit reduced…Abstract Number: 999 • 2019 ACR/ARP Annual Meeting
Targeted Drug Delivery Using a Novel Joint-homing Peptide for Arthritis Therapy
Background/Purpose: Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disease characterized by inflammation of the synovial tissue of the joints, which if not controlled early…Abstract Number: 86 • 2017 ACR/ARHP Annual Meeting
Regulation of Interleukin-1β Signaling By Inhibition of O-Glc-Nacase in Rheumatoid Arthritis Synovial Fibroblasts
Background/Purpose: O-GlcNAcylation is an important post-translational modification of nuclear and cytosolic proteins involved in the cytokine signaling networks. Studies show both pro- and anti-inflammatory roles…Abstract Number: 389 • 2017 ACR/ARHP Annual Meeting
S-110483 a New Potent EP4 Receptor Antagonist with Immunomodulatory and Analgesic Activities
Background/Purpose: Prostaglandin (PG) E2 is known to enhance the expansion of T helper 17 (Th17) cell population via EP4 receptor (EP4) in the early phase…Abstract Number: 390 • 2017 ACR/ARHP Annual Meeting
S-110483, a Novel and Selective EP4 Receptor Antagonist with Anti-Bone Destruction Activities
Background/Purpose: S-110483 is our novel potent and selective EP4 receptor (EP4) antagonist. In addition to the well-known fact that EP4 antagonists have anti-inflammatory effects, it…Abstract Number: 962 • 2017 ACR/ARHP Annual Meeting
Role of Syndecans in Cytokine Mediated Inflammation in Rheumatoid Arthritis Synovial Fibroblasts
Background/Purpose: Syndecans (SDCs) are type-I transmembrane proteoglycans that prominently interact with heparan sulfate, extracellular matrix (ECM) components and glycoproteins. The present study was carried out…Abstract Number: 480 • 2016 ACR/ARHP Annual Meeting
Local Cryotherapy Down-Regulates Local and Systemic IL-6/IL-17 Pathway with No Effect on TNF-α in Adjuvant-Induced Arthritis
Background/Purpose: Cryotherapy is widely and empirically used in an adjuvant and symptomatic setting in inflammatory rheumatic diseases, with a low level of evidence [1]. The aim…Abstract Number: 483 • 2016 ACR/ARHP Annual Meeting
Non-Steroidal Anti-Inflammatory Drugs Are More Beneficial Than Anti-Tnfα Drugs on the Radiographic Damage in Arthritis: A Study in Adjuvant Induced Arthritis
Background/Purpose: The management of the chronic inflammatory rheumatisms has dramatically evolved in the last decade with a concept of “treat to target”. The theory of…Abstract Number: 582 • 2016 ACR/ARHP Annual Meeting
ACPA Induce Pathogenic Cytokines Expression in PBMC of ACPA+-RA Patients and Inhibition of Its Effect By Cit-ME a Synthetic Citrullinated Peptide
ACPA induce pathogenic cytokines expression in PBMC of ACPA+-RA patients and inhibition of its effect by Cit-ME a synthetic citrullinated peptide.Smadar Gertel1, Gidi Karmon1, Eszter…Abstract Number: 1499 • 2014 ACR/ARHP Annual Meeting
Characterization of ABT-494, a Second Generation Jak1 Selective Inhibitor
Background/Purpose Jak kinase blockade can effectively manage rheumatoid arthritis (RA) and in some cases achieve remission. However, first generation Jak inhibitors have not met expectations…Abstract Number: 330 • 2014 ACR/ARHP Annual Meeting
Prolactin Reduces Bone Erosion in Adjuvant-Induced Arthritis
Background/Purpose Bone erosion is an important feature of rheumatoid arthritis (RA) that frequently results in lifelong crippling. The receptor activator of NFkB ligand (RANKL)/osteoprotegerin (OPG)/RANK…Abstract Number: 2360 • 2014 ACR/ARHP Annual Meeting
Glucocorticoids and Vascular Function in Arthritis: Benefic or Deleterious Effects? Study in Rat
Background/Purpose: Rheumatoid Arthritis (RA) is associated to an increase of cardiovascular (CV) risk explained in part by an accelerated atherosclerosis as a consequence of endothelial…Abstract Number: 2819 • 2013 ACR/ARHP Annual Meeting
Administration Of a Multi-Epitope Citrullinated Peptide Attuneuates adjuvant Induced Arthritis In Rats Via Induction Of Immune Tolerance
Background/Purpose: Antigen-induced peripheral tolerance is a potentially efficient and specific therapeutic approach to attenuate autoimmunity. Citrullinated peptides are major targets of disease-specific autoantibodies in Rheumatoid…Abstract Number: 2222 • 2013 ACR/ARHP Annual Meeting
Positive Allosteric Modulation Of The Adenosine A2a Receptor Alters Inflammatory Cytokine Production and Alleviates Chronic Arthritis In Rats
Background/Purpose: Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by inflammation and joint destruction; a consequence of which is the high local concentration of…Abstract Number: 1302 • 2013 ACR/ARHP Annual Meeting
Application of Cytostatic Agent Kinesin Eg5 Inhibitor Litronesib (KF89617) On Rat Adjuvant-Induced Arthritis and Mouse Type II Collagen-Induced Arthritis
Background/Purpose: Kinesins are family of motor proteins that are involved in mitosis and intracellular transport of vesicles and organelles. The mitotic kinesin, Eg5, acts…
ACR Meeting Abstracts