Abstracts tagged "Adipokines"

Abstract Number: 3059 • 2015 ACR/ARHP Annual Meeting
Abnormal Body Composition in Takayasu Arteritis Patients: Role of Inflammatory Cytokines and Adipokines
Thiago Ferreira da Silva, Mauricio Levy Neto, Valéria Caparbo, Liliam Takayama and Rosa M R Pereira, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Chronic inflammatory conditions including rheumatic diseases may alter body composition, especially lean and fat mass. In this process, adipokines and inflammatory cytokines appear to…
Abstract Number: 1025 • 2014 ACR/ARHP Annual Meeting
Leptin Production By Osteoarthritis Synovial Fibroblasts: Stimulation By Glucocorticoids and Mineralocorticoids through the Glucocorticoid Receptor and GILZ (Glucocorticoid-Induced Leucine Zipper) Protein
Olivier Malaise¹, Biserka Relic¹, Sophie Neuville², Edith Charlier¹, Dominique de Seny¹ and Michel G. Malaise¹, ¹Department of Rheumatology, GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ²GIGA Research - University of Liège - CHU of Liège, Liège, Belgium
Background/Purpose: Osteoarthritis (OA) is a metabolic disorder for which leptin is playing a catabolic role on cartilage. In mice, obesity due to impaired leptin did…
Abstract Number: 1018 • 2014 ACR/ARHP Annual Meeting
Monolayer Culture Induced the Expression of Zyxin-Related Protein 1 (ZRP-1), α_vβ₃integrin Complex and Leptin in Human Articular Chondrocytes
Edith Charlier¹, Olivier Malaise¹, Mustapha Zeddou², Sophie Neuville³, Gaël Cobraiville³, Philippe Gillet⁴, William Kurth⁴, Dominique de Seny¹, Biserka Relic¹ and Michel G. Malaise¹, ¹Department of Rheumatology, GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ²Department of Biology, Faculty of Sciences, University Mohamed I, Oujda, Morocco, ³GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ⁴Orthopedic Surgery Unit-CHU of Liège, Liège, Belgium
Background/Purpose During Osteoarthritis (OA), chondrocytes loose their initial anabolic properties, undergoing morphological and biochemical modifications similar to those encountered during chondrocyte dedifferentiation. However, the molecular…
Abstract Number: 966 • 2014 ACR/ARHP Annual Meeting
Adiponectin Is an Endogenous Anti-Fibrotic and Target in Systemic Sclerosis: Novel Link Between Fibrosis and Metabolism
Feng Fang¹, Roberta G. Marangoni¹, Xingchun Zhou², Wen Hong³, Boping Ye³, Asano Yoshihide⁴, Shinichi Sato⁵, Yuri Masui⁶, Chengning Zhang⁷, Katja Lakota⁸, Jun Wei⁹, Monique E. Hinchcliff⁷, Philipp Scherer¹⁰, Laszlo Otvos¹¹ and John Varga¹², ¹Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ²College of Life and Science, China Pharmaceutical University, Nanjing, China, ³China Pharmaceutical University, Nanjing, China, ⁴University of Tokyo, Tokyo, Japan, ⁵Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan, ⁶Department of Dermatology, University of Tokyo, Tokyo, Japan, ⁷Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁸Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁹Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ¹⁰University of Texas Southwestern Medical Center, Dallas, TX, ¹¹Temple University, Philadelphia, PA, ¹²Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose :Systemic sclerosis (SSc) skin fibrosis is associated with attenuated cutaneous adipose tissue and adipogenic gene expression. Levels of the adipose-derived cytokine adiponectin (APN) and…
Abstract Number: 773 • 2013 ACR/ARHP Annual Meeting
Adioponectin-Induced p38 MAPK and AMPK Pathways In Rheumatoid Arthritis Synovial Fibroblasts Are Adiponectin Isoform Dependent
Kiran Khawaja¹, Klaus W. Frommer¹, Stefan Rehart², Ulf Müller-Ladner¹ and Elena Neumann³, ¹Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ³Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany
Background/Purpose: Adiponectin, a C1q/tumour necrosis factor (TNF) homologue, was previously known to be secreted by adipocytes. Additionaly, it was found to be synthesized by other…
Abstract Number: 418 • 2013 ACR/ARHP Annual Meeting
Assessment Of Treatment Effect Over Insulin Resistance and Adipokines In Patients With Early Rheumatoid Arthritis: A 6 Months Longitudinal Observational Study
Sara Manrique-Arija¹, José Rioja², Pedro Valdivielso², María América López-Lasanta³, Pilar Espiño⁴, Inmaculada Ureña⁵, Francisco G. Jiménez-Núñez⁵, Carmen M. Romero-Barco⁵ and Antonio Fernández-Nebro¹, ¹Rheumatology, Hospital Carlos Haya. University of Malaga. IBIMA, Malaga, Spain, ²Department of Medicine. University of Malaga, Malaga, Spain, ³Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, ⁴Hospital Carlos Haya. University of Malaga, Malaga, Spain, ⁵Rheumatology, Hospital Carlos Haya. University of Malaga, Malaga, Spain
Background/Purpose: To analyze treatment effects over insulin resistance (IR), adipokines, inflammatory cytokines and clinical and laboratory characteristics in patients with early rheumatoid arthritis (RA). Methods:…
Abstract Number: 244 • 2013 ACR/ARHP Annual Meeting
Association Between Serum Adipokine Levels and Extent Of Symptomatic Joint Involvement In Hip and Knee Osteoarthritis
Anthony V. Perruccio¹, Vinod Chandran², Nizar N. Mahomed³ and Rajiv Gandhi⁴, ¹Toronto Western Hospital, Toronto Western Research Institute, and University of Toronto, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Orthopaedic Surgery, University Health Network and University of Toronto, Toronto, ON, Canada, ⁴University Health Network, Arthritis Program, Toronto, ON, Canada
Background/Purpose: Osteoarthritis (OA) has not traditionally been considered a systemic joint disease. However, a growing body of evidence suggests that OA cannot solely be accounted…
Abstract Number: 2133 • 2013 ACR/ARHP Annual Meeting
Neuropathic Pain After Primary Total Hip and Knee Arthroplasty
Anne Lubbeke¹, Gabor J. Puskas¹, Domizio Suva¹, Sylvette Bas², Cem Gabay², Axel Finckh³ and Pierre Hoffmeyer¹, ¹Orthopaedic Surgery, Geneva University Hospitals, Geneva, Switzerland, ²Rheumatology, Geneva University Hospitals, Geneva, Switzerland, ³Rheumatology, Geneva University Hospital, Geneva, Switzerland
Background/Purpose: A sizeable number of patients continue to suffer from pain after total joint arthroplasty (TJA). The reason for this is not well established in…
Abstract Number: 2071 • 2013 ACR/ARHP Annual Meeting
Adipokines Contribute To The Inflammatory Response In Adult and Juvenile Myositis
Molly S. Hein¹, Cynthia S. Crowson², Helen Khun², Consuelo Lopez de Padilla³, Erik J. Peterson⁴, Emily Baechler⁵ and Ann M. Reed¹, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ³Rheumatology/Immunology Research, Mayo Clinic, Rochester, MN, ⁴Medicine/Rheumatic and Autoimmune Diseases, University of Minnesota Medical School, Minneapolis, MN, ⁵Medicine, University of Minnesota, Minneapolis, MN
Background/Purpose: Recently adipokines have been implicated for their role in regulating immune and inflammatory responses in autoimmune disease. To test the hypothesis that adipokines are…
Abstract Number: 1683 • 2013 ACR/ARHP Annual Meeting
High Prevalence Of Metabolic Syndrome In Takayasu Arteritis: An Increased Cardiovascular Risk and Lower Adiponectin Serum Levels
Thiago Silva¹, Mauricio Levy-Neto², Rosa M. R. Pereira³ and Eloisa Bonfa⁴, ¹Rheumatology Division, University of São Paulo, São Paulo, Brazil, ²Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ³Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Rheumatology Division, Universidade de Sao Paulo, São Paulo, Brazil
Background/Purpose: The prevalence of Metabolic Syndrome (MetS) tends to be high among rheumatic patients, and cardiovascular disease is the leading cause of death in these…
Abstract Number: 1429 • 2013 ACR/ARHP Annual Meeting
Adiponectin Levels Are Increased After Tocilizumab Therapy Among Adults With Rheumatoid Arthritis: Results From The Measure Study
Hoda Mirjafari¹, Micki Klearman², Jianmei Wang³, Naveed Sattar⁴ and Jon T. Giles⁵, ¹Arthritis Research UK Epidemiology Unit, Institute of Inflammation and Repair, Manchester Academic Health Science Centre; The University of Manchester; and Roche;, Manchester, United Kingdom, ²Roche, South San Francisco, CA, ³Roche Products Ltd., Welwyn Garden City, United Kingdom, ⁴University of Glasgow, Glasgow, United Kingdom, ⁵Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY
Background/Purpose: Cardiovascular disease (CVD) is the leading cause of death in patients (pts) with rheumatoid arthritis (RA). Adiponectin has been shown to have anti-inflammatory and…

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