Abstracts tagged "Adipocytokines"

Abstract Number: 599 • 2013 ACR/ARHP Annual Meeting
Association Between Serum Leptin and Adiponectin Levels With The Severity Of Proteinuria In Lupus Nephritis
Valeria Diaz-Rizo¹, Nicte Selene Fajardo-Robledo², Alan Joel Ruiz-Padilla², Dalia Sanchez-Mosco³, Tania Marlene Rodriguez-Hernandez⁴, Xochitl Trujillo⁵, Miguel Huerta⁵, Monica Vazquez del Mercado⁶, Laura Gonzalez-Lopez⁴ and Jorge Ivan Gamez-Nava⁷, ¹Doctorado en Ciencias Médicas, Centro Universitario de Investigación Biomédica, Universidad de Colima; UMAE, Hospital de Especialidades, Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jalisco, Mexico, ²Fisiología, Doctorado en Farmacología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, ³Centro Universitario de Investigación Biomédica, Universidad de Colima; Hospital General Regional 110 IMSS, Guadalajara, Jalisco, Mexico, ⁴Departamento de Medicina Interna/Rheumatología, Hospital General Regional 110, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico, ⁵Centro Universitario de Investigación Biomédica, Universidad de Colima, Colima, Mexico, ⁶Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Universidad de Guadalajara, Guadalajara, Mexico, ⁷UMAE, Centro Médico Nacional de Occidente, IMSS; Doctorado en Farmacología, Universidad de Guadalajara, Jalisco, Mexico
Background/Purpose: To identify the association between serum leptin and adiponectin levels and proteinuria secondary to lupus nephritis in women with systemic lupus erythematosus (SLE). Methods:…
Abstract Number: 297 • 2013 ACR/ARHP Annual Meeting
Plasma Nicotinamide Phosphoribosyltransferase Correlates With Markers Of Inflammation and May Predict Early Therapeutic Response To Low-Dose Methotrexate In Juvenile Idiopathic Arthritis
Ryan S. Funk¹, Leon van Haandel¹, Marcia Chan², Lanny J. Rosenwasser², Andrew Lasky³, Maria F. Ibarra⁴, Mark F. Hoeltzel⁵, S.Q. Ye⁶, J.S. Leeder¹ and Mara L Becker⁷, ¹Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, MO, ²Pediatric Immunology Research, Children's Mercy Hospital, Kansas City, MO, ³Pediatrics Rheumatology, Children's Mercy Hospital, Kansas City, MO, ⁴Pediatric Rheumatolgy, Children's Mercy Hospital, Kansas City, MO, ⁵Rheumatology Section, Children's Mercy Hospital, Kansas City, MO, ⁶Medical Genetic Research, Children's Mercy Hospital, Kansas City, MO, ⁷Clinical Pharmacology and Rheumatology, Children's Mercy Hospital, Kansas City, MO
Background/Purpose: Despite a poor understanding of its biochemical role in the inflammatory process, nicotinamide phosphoribosyltransferase (NAMPT) has been implicated in a number of autoimmune…
Abstract Number: 44 • 2013 ACR/ARHP Annual Meeting
Suppressor Of Cytokine Signaling 3 Negatively Modulates Leptin-Mediated Catabolic and Proinflammatory Effects In Cartilage – New Potential Mechanism To Target Obesity-Induced Osteoarthritis
Anna Koskinen¹, Katriina Vuolteenaho¹, Riku Korhonen¹, Teemu Moilanen^1,2 and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland
Background/Purpose: Adipocytokine leptin has been suggested to link obesity and osteoarthritis (OA). Initially leptin was found to regulate energy metabolism through central nervous system. More…
Abstract Number: 2520 • 2012 ACR/ARHP Annual Meeting
Suppressor of Cytokine Signaling 3 Is Reduced in Obese Patients with Osteoarthritis and Regulates Leptin Responses in Chondrocytes
Anna Koskinen¹, Katriina Vuolteenaho¹, Riku Korhonen¹, Teemu Moilanen² and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland
Background/Purpose: Leptin is an adipokine whose concentrations in circulation are proportional to body fat stores and body mass index (BMI). Initially leptin was discovered to…
Abstract Number: 2289 • 2012 ACR/ARHP Annual Meeting
Adiponectin Has Potent Anti-Fibrotic Effects Mediated Via AMP Kinase: Novel Target for Fibrosis Therap
Feng Fang¹, Lei Liu², Yang Yang², Jun Wei¹, Swati Bhattacharyya³, Ross Summer⁴, Boping Ye² and John Varga³, ¹Rheumatology Division, Northwestern University, Chicago, IL, ²School of Life Science and Technology, China Pharmaceutical University, Nanjing, China, ³Division of Rheumatology, Northwestern University, Chicago, IL, ⁴Pulmonary Center, Boston University, Boston, MA
Background/Purpose: Fibrosis in scleroderma is associated with transforming growth factor-β (TGF-β) signaling activation, collagen deposition and myofibroblast accumulation. Peroxisome proliferator activated receptor gamma (PPAR-γ) inhibits…
Abstract Number: 2097 • 2012 ACR/ARHP Annual Meeting
Adiponectin Is Associated with Pro-Inflammatory Cytokines in Autoantibody Positive First-Degree Relatives (FDRs) of Patients with Rheumatoid Arthritis
Jan M. Hughes-Austin¹, Kevin D. Deane², Lezlie A. Derber³, Gary O. Zerbe⁴, Dana M. Dabelea¹, Jeremy Sokolove⁵, William H. Robinson⁶, V. Michael Holers⁷ and Jill M. Norris⁸, ¹Epidemiology, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³University of Colorado School of Medicine, Division of Rheumatology, Aurora, CO, ⁴Biostatistics and Informatics, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, ⁵Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁶Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁷Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁸Epidemiology, Colorado School of Public Health, Aurora, CO
Background/Purpose: While adiponectin is generally considered an anti-inflammatory adipokine, it has also been shown to participate in active RA in inflammatory, matrix-destructive and fibrotic processes…
Abstract Number: 890 • 2012 ACR/ARHP Annual Meeting
The Role of Adipocytokines in Osteophyte Formation in Osteoarthritis
Susann Junker¹, Grit Krumbholz¹, Klaus Frommer¹, Angela Lehr², Stefan Rehart³, Jürgen Steinmeyer⁴, Markus Rickert⁵, Georg A. Schett⁶, Ulf Müller-Ladner⁷ and Elena Neumann⁸, ¹Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Dept Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ³Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ⁴Dept of Orthopedics and Orthopedic Surgery, University Hospital Gießen and Marburg, Gießen, Germany, ⁵Dept of Orthopedics and Orthopedic Surgery, University Hospital Giessen and Marburg, Giessen, Germany, ⁶Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁷Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁸Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany
Background/Purpose: Obesity is an established risk factor in osteoarthritis (OA), but there is not much known about the interaction between bone formation and the so-called…
Abstract Number: 480 • 2012 ACR/ARHP Annual Meeting
Etanercept Induces A Significant Decrease of Oxidative Stress and Osteoprotegerin Compared with Sdmard in Patients with Rheumatoid Arthritis
Claire I. Daien¹, Anne-Marie Dupuy Gorce², Edith Pinot², Thibault Mura³, Jean-Paul Cristol², Bernard Combe⁴ and Jacques Morel⁵, ¹Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, ²Biochemistry, Hopital Lapeyronie, Montpellier, France, ³CIC, Hopital Gui De Chauliac, Montpellier, France, ⁴Rheumatology, Hopital Lapeyronie, Montpellier, France, ⁵Dpartment of Rheumatology, Lapeyronie Hospital, Montpellier, France
Background/Purpose: TNF-inhibitors are known to decrease cardiovascular events in rheumatoid arthritis (RA) as compared with synthetic disease modifying anti-rheumatic drugs (sDMARD). However, mechanisms involved remain…
Abstract Number: 43 • 2012 ACR/ARHP Annual Meeting
Serum Amyloid A Level in Knee Osteoarthritis: Systemic and/or Local Production and Pro-Inflammatory Properties On Human Chondrocytes and Fibroblast-Like Synoviocytes
Dominique de Seny¹, Gaël Cobraiville², Sophie Neuville², Edith Charlier³, Biserka Relic¹, Florence Quesada Calvo³, Olivier Malaise³, Denis Malaise⁴, Laurence Lutteri⁵, Jean-Paul Chapelle⁵ and Michel G. Malaise¹, ¹Department of Rheumatology, GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ²GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ³Department of Rheumatology, GIGA Research - University of Liège - CHU Liège, Liège, Belgium, ⁴University of Liège, Liège, Belgium, ⁵Medical Chemistry - CHU Liège, Liège, Belgium
Background/Purpose: Knee osteoarthritis (OA) is a disease frequently seen in obese patients, but the relationship might be more linked to fat than to weight. A-SAA…
Abstract Number: 13 • 2012 ACR/ARHP Annual Meeting
Visfatin/Nampt in Osteoarthritis: Sites of Production in Human Joints and Role of Its Enzymatic Activity
Marie-Charlotte Laiguillon¹, Carole Bougault¹, Xavier Houard², Marjolaine Gosset³, Geoffroy Nourissat⁴, Sabrina Priam¹, Zvezdana Mladenovic¹, Claire Jacques¹, Francis Berenbaum⁵ and Jeremie Sellam⁶, ¹Ur-4, Pierre et Marie Curie University Paris VI, Paris, France, ²Sorbonne Universités, UPMC Univ Paris 06, UMRS 938 and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris, France, ³EA 2496, Paris Descartes University, Montrouge, France, ⁴Orthopaedic Surgery and Traumatology, Pierre et Marie Curie University Paris VI, Paris, France, ⁵Rheumatology, AP-HP, St Antoine Hospital, Paris, France, ⁶Rheumatology, Hopital Saint-Antoine, Pierre et Marie Curie University Paris 6, AP-HP, 75012, France
Background/Purpose: The role of cytokines produced by obese-derived adipose tissue, namely adipokines, in the pathophysiology of osteoarthritis (OA) is now well established. We recently suggested…

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