Abstracts tagged "Adipocytokines"

Abstract Number: 56 • 2018 ACR/ARHP Annual Meeting
Comparison of Metabolic Changes in Osteoarthritis and Rheumatoid Arthritis Mouse Models
Marie-Lisa Hülser¹, Hani Manfred Sauermilch¹, Carina Schreiyäck¹, Yubin Luo², Aline Bozec², Georg Schett³, Ulf Müller-Ladner⁴ and Elena Neumann¹, ¹Dept. of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University Gießen, Germany, Bad Nauheim, Germany, ²University of Erlangen-Nürnberg, Department Clinic of Medicine 3 - Immunology and Rheumatology, Erlangen, Germany, Erlangen, Germany, ³Friedrich-Alexander-Universität Erlangen, Nürnberg und Universitätsklinikum Erlangen, Erlangen, Germany, ⁴Dept. of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University Giessen, Germany, Bad Nauheim, Germany
Background/Purpose: Adipocytokines are bioactive factors produced mainly by adipose tissue. They not only regulate energy homeostasis, but also influence immune responses. Osteoarthritis (OA) is one…
Abstract Number: 85 • 2018 ACR/ARHP Annual Meeting
Antibodies to Citrullinated Protein Antigens (ACPAs) Induce Adipose Tissue Dysfunction Contributing to the Cardiovascular Disease Risk in Rheumatoid Arthritis. Modulation By Biological Dmards
Nuria Barbarroja¹, Ivan Arias de la Rosa², Miriam Ruiz-Ponce³, Maria Dolores de la Rosa-Garrido³, Patricia Ruiz-Limon⁴, Yolanda Jiménez-Gómez¹, Carlos Perez-Sanchez¹, Maria Carmen Abalos-Aguilera², Rocio Guzman-Ruiz⁵, Maria del Mar Malagon⁶, Francisco Jose Tinahones⁷, Eduardo Collantes-Estévez¹, Chary Lopez-Pedrera³ and Alejandro Escudero-Contreras², ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁴Research Group of Endocrine Diseases, Research Laboratory. Biomedical Research Institute of Malaga (IBIMA).Virgen de la Victoria Universitary Hospital, Malaga, Spain., Málaga, MA, Spain, ⁵Department of Cell Biology, Physiology, and Immunology,, IMIBIC/University of Córdoba/Reina Sofía University Hospital, Cordoba, Spain, ⁶Department of Cell Biology, Physiology, and Immunology,I, IMIBIC/University of Córdoba/Reina Sofía University Hospital, Cordoba, Spain, ⁷Department of Clinical Endocrinology and Nutrition, Institute of Biomedical Research of Málaga (IBIMA), Hospital of Málaga (Virgen de la Victoria), University of Málaga (UMA), Málaga, Spain; CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Ca, Malaga, Spain
Background/Purpose: 1) To test the relationship among ACPAs and levels of adipocytokines and atherosclerosis in RA patients. 2) To analyze the effects of ACPAs on…
Abstract Number: 518 • 2018 ACR/ARHP Annual Meeting
Cardiometabolic Risk Factors Impact on the Cardioprotective Effect of Apelin on Systolic and Diastolic Function, in Patients with Rheumatoid Arthritis
Sulé Gunter¹, Lebogang Mokotedi², Monica Gomez², Linda Tsang², Aletta Millen³ and Patrick Dessein², ¹Depeartment of Health Sciences, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa, ²Department of Health Sciences, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa, ³Department of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Background/Purpose: The rheumatoid arthritis (RA) population demonstrate a significantly increased incidence of cardiac events. Cardiac dysfunction in RA may occur as a result of impaired…
Abstract Number: 1662 • 2018 ACR/ARHP Annual Meeting
Interplay Among Inflammation, Adipokines and Endothelial Dysfunction in Patients with Psoriatic Arthritis. Relationship with Cardiovascular and Metabolic Comorbidities. Modulation By Apremilast
Nuria Barbarroja¹, Ivan Arias de la Rosa², Maria Dolores de la Rosa-Garrido³, Carlos Perez-Sanchez¹, Maria Carmen Abalos-Aguilera², Miriam Ruiz-Ponce³, Yolanda Jiménez-Gómez¹, Alejandro Escudero-Contreras², Eduardo Collantes-Estévez¹, Chary Lopez-Pedrera¹ and Maria Dolores Lopez Montilla³, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain
Background/Purpose: 1) To evaluate the association of inflammation, adipokines and endothelial dysfunction with the cardiovascular risk profile and the metabolic comorbidities associated with psoriatic arthritis…
Abstract Number: 1848 • 2018 ACR/ARHP Annual Meeting
Cardiovascular Risk Factors in Adults with Juvenile Idiopathic Arthritis in Sustained Remission
Ivan Arias de la Rosa¹, Inmaculada Concepcion Aranda-Valera², Rosa Roldan², Maria Carmen Abalos-Aguilera¹, Maria Dolores de la Rosa-Garrido², Yolanda Jiménez-Gómez³, Carlos Perez-Sanchez³, Alejandro Escudero-Contreras¹, Chary Lopez-Pedrera², Eduardo Collantes-Estévez³ and Nuria Barbarroja³, ¹Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is one of the more common chronic diseases of childhood that often persists into adulthood and can result in significant…
Abstract Number: 1943 • 2017 ACR/ARHP Annual Meeting
Adipocytokines in an Osteoarthritis Mouse Model
Marie-Lisa Hülser¹, Carina Schreiyäck¹, Yubin Luo², Aline Bozec², Georg Schett³, Elena Neumann⁴ and Ulf Müller-Ladner⁵, ¹Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ²Department Clinic of Medicine 3 - Immunology und Rheumatology, University of Erlangen-Nürnberg, Department Clinic of Medicine 3 - Immunology and Rheumatology, Erlangen, Germany, Erlangen, Germany, ³Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, ⁴Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ⁵Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: In the Western society adiposity and metabolic syndrome are an increasing field of medical research. Both entities influence the expression of adipokines such as…
Abstract Number: 9 • 2015 ACR/ARHP Annual Meeting
Serum Visfatin Levels in Patients with Axial Spondyloarthitis and Early Rheumatoid Arthritis: Relation to Inflammation and Bone Changes
Hana Hulejova¹, Klára Prajzlerová², Olga Krystufkova², Krystýna Grobelná², Maria Filkova², Herman F Mann³, Karel Pavelka⁴, Jiri Vencovsky³ and Ladislav Senolt⁵, ¹Institute of Rheumatology and Department of Rheumatology, Prague, Czech Republic, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ³Institute of Rheumatology, Prague, Czech Republic, ⁴Charles University, Prague, Czech Republic, ⁵Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Visfatin may represent a novel biomarker of disease severity. Serum visfatin levels are elevated in patients with early rheumatoid arthritis (ERA) and axial spondyloarthritis…
Abstract Number: 332 • 2015 ACR/ARHP Annual Meeting
Adipokine SERUM Levels in Patients with EARLY Knee Osteoarthritis with and without Metabolic Syndrome
Istar Guzman¹, Rolando Espinosa-Morales², Ignacio-Alfredo Valerio-Morales³, Austreberto Sanchez¹, Paulina P⁴ and Carlos Lozada¹, ¹Rheumatology, National Institute of Rehabilitation, Mexico, Mexico, ²Mexican Board of Rheumatology, Mexico City, Mexico, ³Rheumatology, National Institute of Rehablitation, Mexico, Mexico, ⁴Rheumatology, National institute of Rehabilitation, Mexico, Mexico
Background/Purpose: Osteoarthritis is a chronic, inflammatory, multifactorial disease. The metabolic syndrome (MS) has been linked to this disease; adipokines levels have been associated in the…
Abstract Number: 1803 • 2015 ACR/ARHP Annual Meeting
Serum Adipocyte Fatty Acid-Binding Protein Level Is Elevated in Patients with Systemic Lupus Erythematosus (SLE) but Not Associated with Biophysical Markers of Cardiovascular Disease
Anselm Mak^1,2, Herbert Schwarz³, Nien Yee Kow², Sen Hee Tay⁴ and Lieng Hsi Ling^2,5, ¹National University Health System, Singapore, Singapore, ²Medicine, National University of Singapore, Singapore, Singapore, ³Physiology, National Unversity of Singapore, Singapore, Singapore, ⁴National University of Singapore, Singapore, Singapore, ⁵National Unversity Heart Centre Singapore, National Unversity Health System, Singapore, Singapore
Background/Purpose: Adipocyte fatty acid-binding protein (aFABP) is an intracellular lipid-binding protein expressed in adipocytes and macrophages, particularly in inflammatory conditions. Recently, high circulating serum aFABP…
Abstract Number: 435 • 2014 ACR/ARHP Annual Meeting
Smoking Functions As a Negative Regulator of IGF-1 Levels and Adipokine Network in Patients with Rheumatoid Arthritis
Maria Bokarewa¹, Malin Erlandsson², Sofia Töyrä Silfverswärd³, Andreea Ioan-Fascinay⁴ and Roberto Doria Medina⁵, ¹Guldhedsgatan 10, University of Goteborg, Goteborg, Sweden, ²Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, ³Rheumatology and Inflammation Research, University of Göteborg, Göteborg, Sweden, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵University of Göteborg, Göteborg, Sweden
Background/Purpose Smoking is an important player in the pathogenesis of rheumatoid arthritis (RA) being tightly connected to the genetic (carriage of HLA-DRB1 shared epitope) and…
Abstract Number: 2933 • 2014 ACR/ARHP Annual Meeting
Metabolic Syndrome, Adipocytokines and Inflammation in Sjögren’s Syndrome
Kristopherson Lustosa Augusto¹, Eloisa Bonfá², Rosa M. R. Pereira¹, Cleonice Bueno³, Vilma S. T. Viana⁴ and Sandra G. Pasoto⁵, ¹Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ²Rheumatology Division, University of Sao Paulo, Sao Paulo, Brazil, ³Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ⁴Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁵Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
Background/Purpose Systemic inflammation has been linked to increased frequency of metabolic syndrome (MetS) in autoimmune diseases. However, there are no studies concerning the frequency of…
Abstract Number: 532 • 2014 ACR/ARHP Annual Meeting
Adipose Tissue Is Prominent in Salivary Glands of Sjögren’s Syndrome Patients and Appears to Influence the Autoimmune Microenvironment in These Organs
Kathrine Skarstein^1,2, Lara Adnan Aqrawi³, Roland Jonsson^4,5 and Janicke Cecilie Liaaen Jensen⁶, ¹Gade Laboratorium for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, ²Department of Pathology, Haukeland University Hospital, Bergen, Norway, ³Department of Clinical Science, University of Bergen, Bergen, Norway, ⁴Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ⁵Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ⁶Department of Oral Surgery and Oral Medicine, University of Oslo, Oslo, Norway
Background/Purpose A positive salivary gland (SG) biopsy with a focus score of ≥1 is the only widely accepted pathological finding confirming the salivary gland component…
Abstract Number: 2474 • 2013 ACR/ARHP Annual Meeting
Fat Mass and Resistin: Predictive Factors For Anti-TNF Therapy Response In Ankylosing Spondylitis Patients
Carla G.S. Saad¹, Andressa Silva Abreu¹, Ana Cristina Medeiros Ribeiro¹, Julio C. B. Moraes², Luiz A. Perandini¹, Thalita Dassouki³, Rosa M. R. Pereira⁴, Eloisa Bonfa⁵ and Ana Lucia S. Pinto¹, ¹Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁴Reumatologia, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil, ⁵Rheumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: The adipose tissue immune properties and pharmacokinetic consequences can contribute to the pathogenesis of inflammatory conditions. The hole of fat tissue in active Ankylosing…
Abstract Number: 1397 • 2013 ACR/ARHP Annual Meeting
Changes In MMP In Fibroblast-Like Synoviocytes Following Adipogenesis
Satoshi Yamasaki, Kazuhiko Kumagai, Kouji Endo, Takaki Nojima and Eiji Sugiyama, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan
Background/Purpose: Fibroblast-like synovial cells (FLS) play important roles in the disease progression of RA. FLS produce cytokines and chemokines that contribute to chronic inflammation…
Abstract Number: 727 • 2013 ACR/ARHP Annual Meeting
Adiponectin Promotes The Differentiation Of naïve T Cell To Th17 Cell and Aggravates Collagen-Induced Arthritis
Miaojia Zhang¹, Xiaoxuan Sun², Wenfeng Tan³, Xiaoke Feng⁴ and Ke Gan⁵, ¹Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA., Nanjing, China, ²Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA, Nanjing, China, ³Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ⁴Rheumatology, the First Affiliated Hospital of Nanjing Medical University, China, Nanjing, China, ⁵Rheumatology Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Background/Purpose: To investigate a role of Adiponectin (AD) on the differentiation of naïve T cell to Th17 cell and bone erosion in collagen-induced arthritis (CIA)…

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