ACR Meeting Abstracts

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Abstracts tagged "Adipocytokines"

  • Abstract Number: 1848 • 2018 ACR/ARHP Annual Meeting

    Cardiovascular Risk Factors in Adults with Juvenile Idiopathic Arthritis in Sustained Remission

    Ivan Arias de la Rosa1, Inmaculada Concepcion Aranda-Valera2, Rosa Roldan2, Maria Carmen Abalos-Aguilera1, Maria Dolores de la Rosa-Garrido2, Yolanda Jiménez-Gómez3, Carlos Perez-Sanchez3, Alejandro Escudero-Contreras1, Chary Lopez-Pedrera2, Eduardo Collantes-Estévez3 and Nuria Barbarroja3, 1Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain

    Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is one of the more common chronic diseases of childhood that often persists into adulthood and can result in significant…
  • Abstract Number: 56 • 2018 ACR/ARHP Annual Meeting

    Comparison of Metabolic Changes in Osteoarthritis and Rheumatoid Arthritis Mouse Models

    Marie-Lisa Hülser1, Hani Manfred Sauermilch1, Carina Schreiyäck1, Yubin Luo2, Aline Bozec2, Georg Schett3, Ulf Müller-Ladner4 and Elena Neumann1, 1Dept. of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University Gießen, Germany, Bad Nauheim, Germany, 2University of Erlangen-Nürnberg, Department Clinic of Medicine 3 - Immunology and Rheumatology, Erlangen, Germany, Erlangen, Germany, 3Friedrich-Alexander-Universität Erlangen, Nürnberg und Universitätsklinikum Erlangen, Erlangen, Germany, 4Dept. of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University Giessen, Germany, Bad Nauheim, Germany

    Background/Purpose: Adipocytokines are bioactive factors produced mainly by adipose tissue. They not only regulate energy homeostasis, but also influence immune responses. Osteoarthritis (OA) is one…
  • Abstract Number: 85 • 2018 ACR/ARHP Annual Meeting

    Antibodies to Citrullinated Protein Antigens (ACPAs) Induce Adipose Tissue Dysfunction Contributing to the Cardiovascular Disease Risk in Rheumatoid Arthritis. Modulation By Biological Dmards

    Nuria Barbarroja1, Ivan Arias de la Rosa2, Miriam Ruiz-Ponce3, Maria Dolores de la Rosa-Garrido3, Patricia Ruiz-Limon4, Yolanda Jiménez-Gómez1, Carlos Perez-Sanchez1, Maria Carmen Abalos-Aguilera2, Rocio Guzman-Ruiz5, Maria del Mar Malagon6, Francisco Jose Tinahones7, Eduardo Collantes-Estévez1, Chary Lopez-Pedrera3 and Alejandro Escudero-Contreras2, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 4Research Group of Endocrine Diseases, Research Laboratory. Biomedical Research Institute of Malaga (IBIMA).Virgen de la Victoria Universitary Hospital, Malaga, Spain., Málaga, MA, Spain, 5Department of Cell Biology, Physiology, and Immunology,, IMIBIC/University of Córdoba/Reina Sofía University Hospital, Cordoba, Spain, 6Department of Cell Biology, Physiology, and Immunology,I, IMIBIC/University of Córdoba/Reina Sofía University Hospital, Cordoba, Spain, 7Department of Clinical Endocrinology and Nutrition, Institute of Biomedical Research of Málaga (IBIMA), Hospital of Málaga (Virgen de la Victoria), University of Málaga (UMA), Málaga, Spain; CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Ca, Malaga, Spain

    Background/Purpose: 1) To test the relationship among ACPAs and levels of adipocytokines and atherosclerosis in RA patients. 2) To analyze the effects of ACPAs on…
  • Abstract Number: 518 • 2018 ACR/ARHP Annual Meeting

    Cardiometabolic Risk Factors Impact on the Cardioprotective Effect of Apelin on Systolic and Diastolic Function, in Patients with Rheumatoid Arthritis

    Sulé Gunter1, Lebogang Mokotedi2, Monica Gomez2, Linda Tsang2, Aletta Millen3 and Patrick Dessein2, 1Depeartment of Health Sciences, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa, 2Department of Health Sciences, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa, 3Department of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

    Background/Purpose: The rheumatoid arthritis (RA) population demonstrate a significantly increased incidence of cardiac events. Cardiac dysfunction in RA may occur as a result of impaired…
  • Abstract Number: 1662 • 2018 ACR/ARHP Annual Meeting

    Interplay Among Inflammation, Adipokines and Endothelial Dysfunction in Patients with Psoriatic Arthritis. Relationship with Cardiovascular and Metabolic Comorbidities. Modulation By Apremilast

    Nuria Barbarroja1, Ivan Arias de la Rosa2, Maria Dolores de la Rosa-Garrido3, Carlos Perez-Sanchez1, Maria Carmen Abalos-Aguilera2, Miriam Ruiz-Ponce3, Yolanda Jiménez-Gómez1, Alejandro Escudero-Contreras2, Eduardo Collantes-Estévez1, Chary Lopez-Pedrera1 and Maria Dolores Lopez Montilla3, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 3IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain

    Background/Purpose: 1) To evaluate the association of inflammation, adipokines and endothelial dysfunction with the cardiovascular risk profile and the metabolic comorbidities associated with psoriatic arthritis…
  • Abstract Number: 1943 • 2017 ACR/ARHP Annual Meeting

    Adipocytokines in an Osteoarthritis Mouse Model

    Marie-Lisa Hülser1, Carina Schreiyäck1, Yubin Luo2, Aline Bozec2, Georg Schett3, Elena Neumann4 and Ulf Müller-Ladner5, 1Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, 2Department Clinic of Medicine 3 - Immunology und Rheumatology, University of Erlangen-Nürnberg, Department Clinic of Medicine 3 - Immunology and Rheumatology, Erlangen, Germany, Erlangen, Germany, 3Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, 4Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, 5Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany

    Background/Purpose: In the Western society adiposity and metabolic syndrome are an increasing field of medical research. Both entities influence the expression of adipokines such as…
  • Abstract Number: 9 • 2015 ACR/ARHP Annual Meeting

    Serum Visfatin Levels in Patients with Axial Spondyloarthitis and Early Rheumatoid Arthritis: Relation to Inflammation and Bone Changes

    Hana Hulejova1, Klára Prajzlerová2, Olga Krystufkova2, Krystýna Grobelná2, Maria Filkova2, Herman F Mann3, Karel Pavelka4, Jiri Vencovsky3 and Ladislav Senolt5, 1Institute of Rheumatology and Department of Rheumatology, Prague, Czech Republic, 2Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 3Institute of Rheumatology, Prague, Czech Republic, 4Charles University, Prague, Czech Republic, 5Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Visfatin may represent a novel biomarker of disease severity. Serum visfatin levels are elevated in patients with early rheumatoid arthritis (ERA) and axial spondyloarthritis…
  • Abstract Number: 332 • 2015 ACR/ARHP Annual Meeting

    Adipokine SERUM Levels in Patients with EARLY Knee Osteoarthritis with and without Metabolic Syndrome

    Istar Guzman1, Rolando Espinosa-Morales2, Ignacio-Alfredo Valerio-Morales3, Austreberto Sanchez1, Paulina P4 and Carlos Lozada1, 1Rheumatology, National Institute of Rehabilitation, Mexico, Mexico, 2Mexican Board of Rheumatology, Mexico City, Mexico, 3Rheumatology, National Institute of Rehablitation, Mexico, Mexico, 4Rheumatology, National institute of Rehabilitation, Mexico, Mexico

    Background/Purpose: Osteoarthritis is a chronic, inflammatory, multifactorial disease. The metabolic syndrome (MS) has been linked to this disease; adipokines levels have been associated in the…
  • Abstract Number: 1803 • 2015 ACR/ARHP Annual Meeting

    Serum Adipocyte Fatty Acid-Binding Protein Level Is Elevated in Patients with Systemic Lupus Erythematosus (SLE) but Not Associated with Biophysical Markers of Cardiovascular Disease

    Anselm Mak1,2, Herbert Schwarz3, Nien Yee Kow2, Sen Hee Tay4 and Lieng Hsi Ling2,5, 1National University Health System, Singapore, Singapore, 2Medicine, National University of Singapore, Singapore, Singapore, 3Physiology, National Unversity of Singapore, Singapore, Singapore, 4National University of Singapore, Singapore, Singapore, 5National Unversity Heart Centre Singapore, National Unversity Health System, Singapore, Singapore

    Background/Purpose: Adipocyte fatty acid-binding protein (aFABP) is an intracellular lipid-binding protein expressed in adipocytes and macrophages, particularly in inflammatory conditions. Recently, high circulating serum aFABP…
  • Abstract Number: 2933 • 2014 ACR/ARHP Annual Meeting

    Metabolic Syndrome, Adipocytokines and Inflammation in Sjögren’s Syndrome

    Kristopherson Lustosa Augusto1, Eloisa Bonfá2, Rosa M. R. Pereira1, Cleonice Bueno3, Vilma S. T. Viana4 and Sandra G. Pasoto5, 1Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, 2Rheumatology Division, University of Sao Paulo, Sao Paulo, Brazil, 3Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, 4Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 5Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil

    Background/Purpose Systemic inflammation has been linked to increased frequency of metabolic syndrome (MetS) in autoimmune diseases. However, there are no studies concerning the frequency of…
  • Abstract Number: 532 • 2014 ACR/ARHP Annual Meeting

    Adipose Tissue Is Prominent in Salivary Glands of Sjögren’s Syndrome Patients and Appears to Influence the Autoimmune Microenvironment in These Organs

    Kathrine Skarstein1,2, Lara Adnan Aqrawi3, Roland Jonsson4,5 and Janicke Cecilie Liaaen Jensen6, 1Gade Laboratorium for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, 2Department of Pathology, Haukeland University Hospital, Bergen, Norway, 3Department of Clinical Science, University of Bergen, Bergen, Norway, 4Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, 5Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, 6Department of Oral Surgery and Oral Medicine, University of Oslo, Oslo, Norway

    Background/Purpose A positive salivary gland (SG) biopsy with a focus score of ≥1 is the only widely accepted pathological finding confirming the salivary gland component…
  • Abstract Number: 435 • 2014 ACR/ARHP Annual Meeting

    Smoking Functions As a Negative Regulator of IGF-1 Levels and Adipokine Network in Patients with Rheumatoid Arthritis

    Maria Bokarewa1, Malin Erlandsson2, Sofia Töyrä Silfverswärd3, Andreea Ioan-Fascinay4 and Roberto Doria Medina5, 1Guldhedsgatan 10, University of Goteborg, Goteborg, Sweden, 2Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, 3Rheumatology and Inflammation Research, University of Göteborg, Göteborg, Sweden, 4Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 5University of Göteborg, Göteborg, Sweden

    Background/Purpose Smoking is an important player in the pathogenesis of rheumatoid arthritis (RA) being tightly connected to the genetic (carriage of HLA-DRB1 shared epitope) and…
  • Abstract Number: 2474 • 2013 ACR/ARHP Annual Meeting

    Fat Mass and Resistin: Predictive Factors For Anti-TNF Therapy Response In Ankylosing Spondylitis Patients

    Carla G.S. Saad1, Andressa Silva Abreu1, Ana Cristina Medeiros Ribeiro1, Julio C. B. Moraes2, Luiz A. Perandini1, Thalita Dassouki3, Rosa M. R. Pereira4, Eloisa Bonfa5 and Ana Lucia S. Pinto1, 1Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, 2Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 3Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, 4Reumatologia, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil, 5Rheumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: The adipose tissue immune properties and pharmacokinetic consequences can contribute to the pathogenesis of inflammatory conditions. The hole of fat tissue in active Ankylosing…
  • Abstract Number: 1397 • 2013 ACR/ARHP Annual Meeting

    Changes In MMP In Fibroblast-Like Synoviocytes Following Adipogenesis

    Satoshi Yamasaki, Kazuhiko Kumagai, Kouji Endo, Takaki Nojima and Eiji Sugiyama, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan

    Background/Purpose:   Fibroblast-like synovial cells (FLS) play important roles in the disease progression of RA. FLS produce cytokines and chemokines that contribute to chronic inflammation…
  • Abstract Number: 727 • 2013 ACR/ARHP Annual Meeting

    Adiponectin Promotes The Differentiation Of naïve T Cell To Th17 Cell and Aggravates Collagen-Induced Arthritis

    Miaojia Zhang1, Xiaoxuan Sun2, Wenfeng Tan3, Xiaoke Feng4 and Ke Gan5, 1Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA., Nanjing, China, 2Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA, Nanjing, China, 3Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 4Rheumatology, the First Affiliated Hospital of Nanjing Medical University, China, Nanjing, China, 5Rheumatology Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    Background/Purpose: To investigate a role of Adiponectin (AD) on the differentiation of naïve T cell to Th17 cell and bone erosion in collagen-induced arthritis (CIA)…
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