Abstracts tagged "Adhesion molecules"

Abstract Number: 1 • 2015 ACR/ARHP Annual Meeting
The Integrin Very Late Antigen-4 Plays a Key Role in the Recruitment of B Cells at the Inflammatory Foci
Estefanía Armas-González¹, Ana Díaz-Martín², María Jesús Domínguez-Luis³, María Teresa Arce-Franco² and Federico Díaz-González⁴, ¹Universidad de La Laguna, Pharmacology Department, Tenerife, Spain, ²Hospital Universitario de Canarias, Rheumatology Service, Tenerife, Spain, ³CIBICAN, Center of Biomedical Research of the Canary Islands, University of La Laguna, Tenerife, Spain, ⁴Investigation Unit, Sociedad Española de Reumatológía, Madrid, Spain
Background/Purpose: Experimental data suggest that B cells must migrate and accumulate into the synovial membrane to exert their pathogenic role in rheumatoid arthritis (RA). Leukocyte…
Abstract Number: 4 • 2015 ACR/ARHP Annual Meeting
The Influence of Adipokines on the Interaction of Rheumatoid Arthritis Synovial Fibroblasts with Endothelial Cells
Rebecca Hasseli¹, Klaus W. Frommer², Thomas Dr. Umscheid³, Markus Prof. Dr. Schönburg⁴, Stefan Rehart⁵, Ulf Müller-Ladner² and Elena Neumann², ¹Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ³William Harvey Klinik; Bad Nauheim, Germany, Bad Nauheim, Germany, ⁴Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, ⁵Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany
Background/Purpose: Rheumatoid Arthritis (RA) is a systemic chronic inflammatory disease. Adipose tissue, being an endocrine organ, plays an important role in inflammatory processes. Adipokines are…
Abstract Number: 209 • 2015 ACR/ARHP Annual Meeting
Different Autoimmune Rheumatic Diease IgG Have Differential Effects upon Neutrophil Binding, Activation and Neutrophil Extracellular Trap Formation
Akif A. Khawaja^1,2, Charis Pericleous³, Vera M. Ripoll², Joanna C. Porter⁴ and Ian Giles⁵, ¹Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, ²Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ³Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, ⁴Centre for Inflammation and Tissue Repair, Division of Medicine, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, ⁵Rayne Intitiute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom
Background/Purpose: Dysregulation of neutrophil activation and function is important in the pathogenesis of various inflammatory and autoimmune rheumatic diseases (ARDs). Neutrophil dysfunction is well recognised…
Abstract Number: 2357 • 2014 ACR/ARHP Annual Meeting
Vascular Adhesion Molecule-1 Overexpression in Collagen-Induced Arthritis: Modeling Vascular Dysfunction in Rheumatoid Arthritis
Luca Semerano^1,2, Gaelle Clavel³, Delphine Lemeiter⁴, Marie-Christophe Boissier^4,5 and Anne Denys¹, ¹INSERM UMR U1125, University Paris 13, Sorbonne Paris Cité, Bobigny, France, ²Rheumatology, Avicenne Teaching Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP),, Bobigny, France, ³Fondation Ophtalmologique A. De Rothschild, Paris cedex 19, France, ⁴INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France, ⁵Rheumatology, AvicenneTeaching Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Bobigny, France
Vascular adhesion molecule-1 Overexpression in collagen-induced arthritis: modeling vascular dysfunctionS in rheumatoid arthritis Background/Purpose: Rheumatoid Arthritis (RA) patients are at risk of developing primary coronary…
Abstract Number: 2349 • 2014 ACR/ARHP Annual Meeting
Early Sympathectomy Inhibits Egress of Lymphocytes in Control and Arthritic Animals and Ameliorates Arthritic Disease
Susanne Klatt¹ and Rainer Straub², ¹Internal Medicine I, University Hospital Regensburg, Regensburg, Germany, ²Internal Medicine, University Hospital Regensburg, Regensburg, Germany

Background/Purpose: The sympathetic nervous system (SNS) plays an important role in course and development of autoimmune diseases like arthritis. In type II collagen- induced arthritis…
Abstract Number: 1975 • 2014 ACR/ARHP Annual Meeting
Profiling 14-3-3η in Human Primary Cell Based BioMAP^® Disease Models Reveals a Unique Pro-Inflammatory Phenotypic Signature Consistent with RA-Inflammation Biology
Alison O'Mahony¹, Ellen L. Berg¹, Walter P. Maksymowych², Yuan Gui³ and Anthony Marotta⁴, ¹BioSeek, South San Francisco, CA, ²Department of Medicine, University of Alberta, Edmonton, AB, Canada, ³Augurex Life Sciences Corp., North Vancouver, BC, Canada, ⁴1423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada
Background/Purpose 14-3-3 proteins represent a highly conserved seven-member family of ubiquitously expressed intracellular chaperonins that perform a broad range of signaling functions. The 14-3-3 eta…
Abstract Number: 1966 • 2014 ACR/ARHP Annual Meeting
CTLA4-Ig (abatacept) Modulate in Vitro the ICAM1 and VEGFR-2 Expression in Human Endothelial Cells
Maurizio Cutolo¹, Paola Montagna², Stefano Soldano², Paola Contini³, Barbara Villaggio⁴, Alberto Sulli¹, Sabrina Paolino¹, Carmen Pizzorni¹, Bruno Seriolo¹, Giuseppe Zampogna², Marco A. Cimmino¹ and Renata Brizzolara², ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ³Division of Clinical Immunology, Department of Internal Medicine, University of Genova, Genova, Italy, ⁴Research Laboratory of Nephrology, Department of Internal Medicine, University of Genova, Genova, Italy
Background/Purpose CTLA4-Ig (abatacept) is employed as biological agent in rheumatoid arthtritis (RA) treatment and interacts with the costimulatory molecule CD86 expressed by different cells involved…
Abstract Number: 1028 • 2014 ACR/ARHP Annual Meeting
ADAM-10 Plays Monocyte Migration and Adhesion in Rheumatoid Arthritis Synovial Fibroblasts
Takeo Isozaki^1,2, Sho Ishii², Shinichiro Nishimi², Airi Maeoka², Mayu Saito², Nao Oguro², Shinya Seki², Yoko Miura², Yusuke Miwa², Koei Oh³, Yoichi Toyoshima³, Masanori Nakamura³, Katsunori Inagaki³ and Tsuyoshi Kasama², ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan, ³Department of Orthopedics, Showa University School of Med, Tokyo, Japan
Background/Purpose :A disintegrin and metalloprotease family proteins (ADAMs) have been reported to be involved in a number of inflammatory conditions. We previously reported that ADAM-10…
Abstract Number: 612 • 2014 ACR/ARHP Annual Meeting
Association of Platelet Endothelial Cell Adhesion Molecule-1 and beta1 Integrin Gene Polymorphisms with Uveitis Development in Ankylosing Spondylitis
Seong-Wook Kang¹, Seung-Taek Song¹, Su-Jin Yoo², Mi-Kyoung Lim³, Dong-Hyuk Sheen⁴, In-Seol Yoo², Jinhyun Kim¹ and Seung-Cheol Shim¹, ¹Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ²Departmen of Internal medicine, Chungnam National University School of Medicine, Daejeon, South Korea, ³Rheumatology, Eulji University Hospital, Daejeon, South Korea, ⁴Department of Internal Medicine, Eulji University Hospital, Daejeon, South Korea
Background/Purpose Genetic factors provide over 90% of the overall susceptibility to ankylosing spondylitis (AS) and recent studies have focused on non-major histocompatibility complex genes. The…
Abstract Number: 930 • 2013 ACR/ARHP Annual Meeting
The Endocannabinoid Anandamide Modulates Adhesion, Proliferation and The Production Of Inflammatory Mediators In Rheumatoid Arthritis Synovial Fibroblasts By Activating CB₁, TRPV1, TRPA1 and Non-Cannabinoid Receptor Targets
Torsten Lowin, Angelika Graeber and Rainer H. Straub, Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany
Background/Purpose: In rheumatoid arthritis (RA), synovial fibroblasts (SF) secrete large amounts of IL-6, IL-8 and matrix metalloproteinases (MMPs) which are crucial for cartilage destruction. RASFs…
Abstract Number: 772 • 2013 ACR/ARHP Annual Meeting
Neovascularization and CD15s Influence Long Distance Migration Of Synovial Fibroblasts From Patients With Rheumatoid Arthritis
Birgit Zimmermann¹, Sina Köppert¹, Stephanie Lefèvre¹, Stefan Rehart², Ulf Müller-Ladner¹ and Elena Neumann³, ¹Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ³Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany
Background/Purpose: Rheumatoid arthritis (RA) synovial fibroblasts (SF) are central cells of cartilage destruction and neoangiogenesis. RASF show an increased migratory potential in the synovium towards…
Abstract Number: 775 • 2013 ACR/ARHP Annual Meeting
Cytokine-Mediated Repression Of The Lncrna Hotair Enhances Intracellular Signaling and The Expression Of Adhesion Molecules In Synovial Fibroblasts
Michelle Trenkmann¹, Mojca Frank Bertoncelj¹, Matthias Brock², Christoph Kolling³, Renate E. Gay⁴, Beat A. Michel⁵, Diego Kyburz¹, Lars C. Huber² and Steffen Gay¹, ¹Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, ²Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland, ³Schultess Clinic, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁵Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Rheumatoid arthritis (RA) synovial fibroblasts (SF) are characterized by a stably activated phenotype which is, at least in part, because of the epigenetic inheritance…

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