ACR Meeting Abstracts

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Abstracts tagged "Adhesion molecules"

  • Abstract Number: 129 • 2019 ACR/ARP Annual Meeting

    Surface Proteins on Exosomes Derived from Plasma of APS Patients Indicate an Altered Immune, Cell Adhesion and Coagulation Profile

    Ula Štok 1, Elizabeta blokar 1, Aleš Ambrožič 1, Matija Tomsic 1, Snezna Sodin-Semrl 2, Saša Čučnik 1 and Polona Žigon3, 1Department of Rheumatology, University Medical Center Ljubljana, Slovenia, Ljubljana, Slovenia, 2Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, Ljubljana, Slovenia, 3Department of Rheumatology, University Medical Center Ljubljana, Slovenia, Ljubljana

    Background/Purpose: Antiphospholipid syndrome (APS) is characterized by thromboses and/or obstetric complications in presence of antiphospholipid antibodies (aPL). Extracellular vesicles have been suggested to play a…
  • Abstract Number: 986 • 2018 ACR/ARHP Annual Meeting

    Fucosylated Tumor Necrosis Factor α Is Expressed in Rheumatoid Arthritis Synovial Tissues and Is Involved in Monocyte Adhesion

    Takeo Isozaki, Shinichiro Nishimi and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan

    Background/Purpose: Glycosylation has been reported to associate with tumor invasion and metastasis. Fucosylation is involved in the biological functions of adhesion molecules and growth factor…
  • Abstract Number: 2127 • 2018 ACR/ARHP Annual Meeting

    A Role of Vascular Cell Adhesion Molecule 1 and Activated Leukocyte Cell Adhesion Molecule in Lupus Nephritis

    Ioannis Parodis1,2, Sirisha Gokaraju3, Agneta Zickert1,2, Ting Zhang3, Deena Habazi3, Anders Larsson4, Elisabet Svenungsson1,2, Chandra Mohan3 and Iva Gunnarsson1,2, 1Division of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, 2Rheumatology, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, 3Department of Biomedical Engineering, University of Houston, Houston, Texas, USA, Houston, TX, 4Department of Medical Sciences/Clinical Chemistry, Uppsala University, Uppsala, Sweden, Uppsala, Sweden

    Background/Purpose: Reliable non-invasive biomarkers for lupus nephritis (LN) are lacking. We investigated two adhesion molecules as urinary biomarkers in LN, i.e. vascular cell adhesion molecule…
  • Abstract Number: 851 • 2018 ACR/ARHP Annual Meeting

    Integrin Mac-1 Potentiates Neutrophil Adhesion and NET Release in Antiphospholipid Syndrome

    Gautam Sule1, William J. Kelley1, Srilakshmi Yalavarthi1, Alison Banka1, Andrew Vreede2, Omolola Eniola-Adefeso1 and Jason S. Knight3, 1University of Michigan, Ann Arbor, MI, 2Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 3., University of Michigan, Ann Arbor, MI

    Background/Purpose: While the role of antiphospholipid antibodies in activating endothelial cells has been extensively studied, the impact of these antibodies on the adhesive potential of…
  • Abstract Number: 8 • 2017 ACR/ARHP Annual Meeting

    Antiphospholipid Syndrome Leukocytes Demonstrate Increased Adhesive Potential:  a Search for Novel Therapeutic Targets

    Gautam Sule1, William J. Kelley1, Srilakshmi Yalavarthi1, Alison Banka1, Omolola Eniola-Adefeso1 and Jason S. Knight2, 1University of Michigan, Ann Arbor, MI, 2., University of Michigan, Ann Arbor, MI

    Background/Purpose: Adhesion of leukocytes to the endothelium is an initiating event in the thrombosis inherent to antiphospholipid syndrome (APS). Over the years, a number of…
  • Abstract Number: 960 • 2017 ACR/ARHP Annual Meeting

    ADAM-17 Is Expressed on Rheumatoid Arthritis Synovial Fibroblasts and Mediates Monocyte Migration and Adhesion

    Sho Ishii, Takeo Isozaki, Airi Nishimi, Shinichiro Nishimi, Takahiro Tokunaga, Hidekazu Furuya, Kuninobu Wakabayashi and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan

    Background/Purpose: A disintegrin and metalloproteinase 17 (ADAM-17), also known as tumor necrosis factor-α converting enzyme (TACE), have been reported to be involved in a number…
  • Abstract Number: 1921 • 2017 ACR/ARHP Annual Meeting

    Urine Angiostatin and VCAM-1 Surpass Conventional Metrics in Predicting Elevated Renal Pathology Activity Indices in Lupus Nephritis

    Samar Soliman1,2, Fatma Mohamed3, Faten Ismail3, Ramesh Saxena4 and Chandra Mohan2, 1Rheumatology and rehabilitation, University of Minya, Minya, Egypt, 2Biomedical Engineering, University of Houston, Houston, TX, 3Rheumatology and Rehabilitation, University of Minya, Minya, Egypt, 4Internal Medicine/Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: The goal of this study is to investigate how urinary angiostatin, VCAM-1 and established measures of renal function relate to specific histologic findings in…
  • Abstract Number: 2642 • 2017 ACR/ARHP Annual Meeting

    Lupus Serum Induces Glomerular Endothelial Cell Neutrophil Adhesion in Association with Soluble Mediators of Chemotaxis and Adhesion

    Dayvia Russell1, Margaret Markiewicz2 and Jim C. Oates3,4, 1Research Service, Ralph H. Johnson VA Medical Center, Charleston, SC, 2Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 3Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 4Medical Service, Ralph H. Johnson VA Medical Center, Charleston, SC

    Background/Purpose: Systemic lupus erythematosus (SLE) is associated with endothelial dysfunction, which can accelerated inflammation. Ingress of neutrophils into tissue requires chemotaxis and adhesion to endothelial…
  • Abstract Number: 1112 • 2016 ACR/ARHP Annual Meeting

    Hypoxia Modulates Neutrophil Integrin Expression, Adhesion and Trans-Endothelial Migration

    Akif A. Khawaja1,2, Charis Pericleous3,4, Vera M. Ripoll1, Joanna C. Porter5 and Ian Giles3, 1Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, 2Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, 3Centre for Rheumatology, University College London, Centre for Rheumatology, University College London, London, United Kingdom, 4Imperial College Vascular Sciences, National Heart and Lung Institute, Imperial College Vascular Sciences, National Heart and Lung Institute, London, United Kingdom, 5Centre for Inflammation and Tissue Repair, Division of Medicine, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom

    Background/Purpose: Dysregulation of neutrophil activation is important in the pathogenesis of various inflammatory and autoimmune rheumatic diseases (ARDs), including RA, SLE and APS. Neutrophils are…
  • Abstract Number: 2127 • 2016 ACR/ARHP Annual Meeting

    Dicam Promotes Proliferation and Hypertrophic Differentiation of Chondrocyte through Indian Hedgehog Signaling of Primary Cilia

    Seungwoo Han1,2, Hye-Ri Park2, Min-Su Han2, Eun-Ju Lee2, Ji-Ae Jang2, Ji-Min Kim3, Gun-Woo Kim2,4 and Younkwan Jung2, 1Internal Medicine, Daegu Fatima hospital, Daegu, Korea, The Republic of, 2Fatima Research Institute, Daegu, Korea, The Republic of, 3Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea, The Republic of, 4Rheumatology, Daegu Fatima hospital, Daegu, Korea, The Republic of

    Background/Purpose: Chondrocytes in growth plate is known to respond to hydrostatic loading by increasing Indian hedgehog (Ihh) signaling, and that the primary cilium is required…
  • Abstract Number: 2148 • 2016 ACR/ARHP Annual Meeting

    Recruitment of Circulating Monocytes By TNF/IL-6-Induced Expression of Vascular Cell Adhesion Molecule 1 (VCAM-1) Drives Valvular Inflammation in K/B/g7 Mice

    Lee Meier1, Jennifer L. Auger2, Brianna J. Engelson3, Elise Breed4, Joshua Boyer5 and Bryce A. Binstadt2, 1Peadiatrics, University of Minnesota, Minneapols, MN, 2Center for Immunology and Department of Pediatrics, University of Minnesota, Minneapolis, MN, 3Pediatrics, University of Minnesota, Minneapolis, MN, 4Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 5Medicine, University of Minnesota, Minneapolis, MN

    Background/Purpose: Cardiovascular (CV) comorbidity is common in rheumatic diseases and includes accelerated atherosclerosis and inflammatory valvular heart disease (iVHD). KRN T cell receptor (TCR) transgenic…
  • Abstract Number: 2149 • 2016 ACR/ARHP Annual Meeting

    Adipokines Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts Adhesion and Endothelial Cells

    Rebecca Hasseli1, Klaus W. Frommer2, Markus Prof. Dr. Schönburg3, Stefan Prof. Dr. Rehart4, Ulf Müller-Ladner5,6 and Elena Neumann2, 1Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 2Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, 3Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, 4Department of Orthopedics and Trauma Surgery, Markus Hospital, Frankfurt, Frankfurt, Germany, 5Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 6Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany

    Background/Purpose: Synovial fibroblast plays a key role in rheumatoid arthritis (RA), which is a chronic polyarticular inflammatory disease. SF are able to migrate long distances…
  • Abstract Number: 1 • 2015 ACR/ARHP Annual Meeting

    The Integrin Very Late Antigen-4 Plays a Key Role in the Recruitment of B Cells at the Inflammatory Foci

    Estefanía Armas-González1, Ana Díaz-Martín2, María Jesús Domínguez-Luis3, María Teresa Arce-Franco2 and Federico Díaz-González4, 1Universidad de La Laguna, Pharmacology Department, Tenerife, Spain, 2Hospital Universitario de Canarias, Rheumatology Service, Tenerife, Spain, 3CIBICAN, Center of Biomedical Research of the Canary Islands, University of La Laguna, Tenerife, Spain, 4Investigation Unit, Sociedad Española de Reumatológía, Madrid, Spain

    Background/Purpose: Experimental data suggest that B cells must migrate and accumulate into the synovial membrane to exert their pathogenic role in rheumatoid arthritis (RA). Leukocyte…
  • Abstract Number: 4 • 2015 ACR/ARHP Annual Meeting

    The Influence of Adipokines on the Interaction of Rheumatoid Arthritis Synovial Fibroblasts with Endothelial Cells

    Rebecca Hasseli1, Klaus W. Frommer2, Thomas Dr. Umscheid3, Markus Prof. Dr. Schönburg4, Stefan Rehart5, Ulf Müller-Ladner2 and Elena Neumann2, 1Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 2Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 3William Harvey Klinik; Bad Nauheim, Germany, Bad Nauheim, Germany, 4Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, 5Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany

    Background/Purpose: Rheumatoid Arthritis (RA) is a systemic chronic inflammatory disease. Adipose tissue, being an endocrine organ, plays an important role in inflammatory processes. Adipokines are…
  • Abstract Number: 209 • 2015 ACR/ARHP Annual Meeting

    Different Autoimmune Rheumatic Diease IgG Have Differential Effects upon Neutrophil Binding, Activation and Neutrophil Extracellular Trap Formation

    Akif A. Khawaja1,2, Charis Pericleous3, Vera M. Ripoll2, Joanna C. Porter4 and Ian Giles5, 1Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, 2Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, 3Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, 4Centre for Inflammation and Tissue Repair, Division of Medicine, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, 5Rayne Intitiute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom

    Background/Purpose: Dysregulation of neutrophil activation and function is important in the pathogenesis of various inflammatory and autoimmune rheumatic diseases (ARDs). Neutrophil dysfunction is well recognised…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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