Abstracts tagged "Adhesion, Adhesion molecules"

Abstract Number: 2601 • ACR Convergence 2024
Platelets Specifically Interact with Remigrating Neutrophils and Promote Immunogenic Cellular Death in Systemic Lupus
Marie nansion¹, Eloi Schmauch², Pierre Vacher³, Jean Sibilia⁴, Nathan Broussaudier¹, Adeline Bruchon¹, Pierre Grenot¹, Anne-Sophie Korganow⁵, Thierry Martin⁵, Sophie Caillard⁶, Anna Duval⁶, Jacques-Eric Gottenberg⁷, Raphaël Carapito¹, Séiamak Bahram¹, Patrick Blanco⁸ and Marc Scherlinger⁹, ¹UMR_INSERM 1109, Strasbourg, France, ²Broad Institute of MIT and Harvard, Cambridge, MA, USA., Boston, MA, ³Inserm U1045, Bordeaux, France, ⁴Strasbourg University Hospital, National reference center for autoimmune disease, Rheumatology, Strasbourg, France, ⁵Strasbourg University Hospital, National reference center for autoimmune disease, Clinical Immunology, Strasbourg, France, ⁶Nephrology department, HUS, Strasbourg, France, ⁷Rheumatology Department, Strasbourg University Hospital,, Strasbourg, France, ⁸UMR_CNRS 5164 Immunoconcept, BORDEAUX CEDEX, France, ⁹Strasbourg University Hospital; INSERM 1109, Strasbourg, France
Background/Purpose: In SLE, platelet activation (express P-selectin+) follows the disease activity, which plays a role in thrombosis as well as in inflammation (1). Neutrophils express high levels of PSGL-1,…
Abstract Number: 0057 • ACR Convergence 2023
GM-CSF receptor/SYK/JNK/FOXO1/CD11c Signaling Enhances Cell Migration to Promote Atherosclerosis
Daisuke Tsukui¹, Kimura Yoshitaka¹ and Hajime Kono², ¹Teikyo University School of Medicine, Itabashi-ku, Japan, ²Teikyo University School of Medicine, Tokyo, Japan
Background/Purpose: Atherosclerosis involves both dyslipidemia and chronic inflammatory disease; however, lipid-lowering agents do not completely eliminate the risks of cardiovascular events. In addition, chronic systemic…
Abstract Number: 0795 • ACR Convergence 2023
The Focal Adhesion Protein Lasp1 Links the Arp2/3 Complex to Cell-to-cell Contact Formation in Arthritic Fibroblast-like Synoviocytes
Denise Beckmann¹, Annika Krause¹, Uwe Hansen², Hans-Peter Kiener³, Joachim Kremerskothen¹, Hermann Pavenstädt¹, Adelheid Korb-Pap¹ and Thomas Pap¹, ¹University Hospital Münster, Münster, Germany, ²University Muenster, Muenster, Germany, ³Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
Background/Purpose: In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) undergo a stable transformation leading to an aggressive phenotype that mediates cartilage damage through increased levels of…
Abstract Number: 0963 • ACR Convergence 2023
Anti-Topoisomerase Antibody in dcSSc: Unravelling Its Intracellular Effects in Systemic Sclerosis
Maithri Aspari¹, Josephine Geertsen Keller-Socin¹, Stinne Greisen², Esben Naeser³, Klaus Soendergaard⁴, Birgitta R Knudsen⁵, Voon Ong⁶, Christopher Denton⁷, David Abraham⁷ and Bent Deleuran¹, ¹Aarhus University, Aarhus, Denmark, ²Aarhus University/Aarhus University Hospital, Aarhus, Denmark, ³Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁴Aarhus University Hospital, Aarhus, Denmark, ⁵Institute for molecular Biology, Aarhus University, Aarhus, Denmark, ⁶UCL Medical School Royal Free Campus, London, United Kingdom, ⁷University College London, London, United Kingdom
Background/Purpose: The presence of autoantibodies, especially directed towards topoisomerase I (ATA), in diffuse cutaneous Systemic Sclerosis (dcSSc) is known to be associated with severe clinical…
Abstract Number: 0020 • ACR Convergence 2022
Redoxosomes Mediate a Feed-forward Loop of Cartilage Matrix Destruction Through α5β1 Integrin Signaling in Response to a Fibronectin Matrikine
Michael Miao¹, Peter Su², Yang Cui¹, John Collins³, Edward Bahnson¹, Susan Chubinskaya⁴ and Richard Loeser¹, ¹University of North Carolina, Chapel Hill, NC, ²University of Technology, Ultimo, Australia, ³Thomas Jefferson University, Philadelphia, PA, ⁴Rush University, Chicago, IL
Background/Purpose: Degradation of pericellular matrix proteins creates bioactive fragments called "matrikines" that include fibronectin fragments (FN-f). FN-f found in OA cartilage and synovial fluid exhibit…
Abstract Number: 0585 • ACR Convergence 2022
Baricitinib Inhibits Proinflammatoly Cytokine Production, Proliferation and Cell Migration in Human Lung Fibroblasts
Takeo Isozaki¹, Rei Takahashi², Kohei Maeda², Toshihiro Tanioka², Kunika Shimizu³, Kazutaka Kawamori³, Noriko Konishi⁴, Shinichiro Nishimi³, Sho Ishii³, Kuninobu Wakabayashi³ and Tsuyoshi Kasama³, ¹Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan, ²Division of Pathogenesis and Translational Medicine, Department of Clinical Pharmacy, Showa University School of Pharmacy, Tokyo, Japan, ³Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Shinagawa-ku, Japan, ⁴Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by inflammation and joint destruction. Baricitinib is a selective small molecule inhibitor of JAK 1…
Abstract Number: 0587 • ACR Convergence 2022
Increase of Intercellular Adhesion Molecule-1 Linked to Lung Damage of Interstitial Lung Disease in Patients with Autoimmune Diseases
Veronica Pulito-Cueto¹, Sara Remuzgo-Martinez¹, Fernanda Genre¹, Belén Atienza-Mateo¹, David Iturbe-Fernández¹, Víctor M. Mora-Cuesta¹, Leticia Lera-Gómez¹, Diana Prieto-Peña¹, Virgi Portilla¹, Ricardo Blanco², Oreste Gualillo³, Alfonso Corrales¹, José M. Cifrián¹, Raquel Lopez Mejias⁴ and Miguel Ángel González-Gay⁵, ¹Research Group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ²Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ³Hospital Clínico Universitario de Santiago, SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Research Laboratory 9, Santiago de Compostela, Spain, ⁴IDIVAL, Santander, Spain, ⁵Department of Medicine and Psychiatry, Universidad de Cantabria; Rheumatology Division, Hospital Universitario Marqués de Valdecilla; Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic diseases of the musculoskeletal system, IDIVAL, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Background/Purpose: Intercellular adhesion molecule-1 (ICAM-1) regulates leukocyte recruitment from circulation to sites of inflammation, being considered as a marker of underlying endothelial damage [1]. Moreover,…
Abstract Number: 0607 • ACR Convergence 2022
Cadherin 6 Regulates Rheumatoid Arthritis Fibroblasts-Like Synoviocyte Aggressiveness
Camilla Machado¹, Hyeonjeong Lee², Sho Sendo³, Narayanan Perumal⁴, Wei Wang⁵, David Boyle⁵ and Gary S. Firestein⁶, ¹UCSD, San Diego, CA, ²University of California San Diego, San Diego, CA, ³University California, San Diego (UCSD), La Jolla, CA, ⁴Eli Lilly Company, San Diego, ⁵University of California San Diego, San Diego, ⁶University of California, San Diego, San Diego, CA
Background/Purpose: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) display an aggressive behavior. Previous studies have implicated cadherins in FLS function in this phenotype, which are type…
Abstract Number: 1356 • ACR Convergence 2022
Patient-perceived Disease Burden and Self-reported Medication Adherence in Systemic Autoimmune Diseases: A Monocentric Observational Study
Camille Mettler¹, Veronique Le Guern², Paul Legendre¹, Caroline Morbieu¹, Tali-Anne Swebel¹, Xavier Puéchal³, Pascal Cohen³, Hicham Kardaoui¹, Alexandre Moores¹, Luc Mouthon³, Nathalie Costedoat-Chalumeau⁴ and Benjamin Terrier³, ¹Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Cochin Hospital, Paris, France, ²Hôpital Cochin, Paris, France, ³National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, ⁴Inserm DR Paris 5, Paris, France
Background/Purpose: Systemic autoimmune diseases (AID) are chronic conditions with significant burden related to the disease itself, its management, and treatments. Burden refers to the workload…
Abstract Number: 0031 • ACR Convergence 2021
A New Pharmacostatistical Model to Assess MTX-adherence in RA Patients
Marion Geoffroy¹, Claire Gozalo², Loic Pauvele², Elise Abboud², Zoubir Djerada³ and Jean hugues Salmon⁴, ¹CHU Reims, France, REIMS, France, ²CHU Reims, Reims, France, ³CHU Riems, Reims, France, ⁴Rheumatology, CHU Maison blanche, Reims, Reims, France
Background/Purpose: Methotrexate (MTX) is the first-line therapy for rheumatoid arthritis (RA). While therapeutic adherence is essential to the successful management of the patient, an estimated…
Abstract Number: 0057 • ACR Convergence 2021
Molecular Profiling of Radiographic Axial Spondyloarthritis Patients Reveals an Association Between Innate and Adaptive Cell Populations and Therapeutic Response to Adalimumab
Rita Torres¹, Daniel Sobral², Ana Fernandes³, Atlas Sardoo⁴, Miguel Bernardes⁵, Patrícia Pinto⁶, Helena Santos⁷, João Gomes⁸, Jose Tavares-Costa⁹, José Silva¹⁰, João Dias¹¹, Alexandra Bernardo⁵, Jean Gailard¹², Jean Armengaud¹³, Vladimir Benes¹⁴, Lúcia Domingues¹⁵, Sara Maia¹⁶, Jaime Branco¹⁷, Ana Varela¹⁸ and Fernando Santos¹⁹, ¹Rheumatology Department, Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal, ²Faculdade Ciências e Tecnologia, Lisboa, Lisboa, Portugal, ³Instituto de Tecnologia Química e Biológica, Lisboa, Portugal, ⁴CEDOC, NOVA Medical School, UNL, Lisboa, Lisboa, Portugal, ⁵Rheumatology Department, Centro Hospitalar Universitário de São João EPE, Porto, Portugal, ⁶Centro Hospitalar de Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal, ⁷Portuguese Institute of Rheumatology, Lisbon, Portugal, ⁸Hospital Egas Moniz, Lisboa, Lisboa, Portugal, ⁹Rheumatology Department - Unidade Local de Saude do Alto Minho, Ponte de Lima, Portugal, ¹⁰Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, ¹¹Centro Hospitalar Médio Tejo, Abrantes, Portugal, ¹²Centre dénergie atomique; Service de Pharmacologie et Immunoanalyse (SPI), Paris, France, ¹³Service de Pharmacologie et Immunoanalyse (SPI), Paris, France, ¹⁴The European Molecular Biology Laboratory, Heidelberg, Germany, ¹⁵CEDOC - Chronic Diseases Research Center - Nova Medical School|Faculdade de Ciências Médicas, Lisboa, Lisboa, Portugal, ¹⁶NOVA Medical School, Nova University of Lisbon, Lisboa, Lisboa, Portugal, ¹⁷EpiDoC Unit, CEDOC, Nova Medical School, Comprehensive Health Research Centre (CHRC), Lisbon, Portugal, ¹⁸Instituto Tecnologia Química e Biológica; Universidade NOVA de Lisboa, Lisboa, Lisboa, Portugal, ¹⁹Hospital Egas Moniz, Lisboa, Portugal
Background/Purpose: The response to treatment in spondylarthropaties is heterogeneous, due to factors yet to be better described. For that reason, it is important to find…
Abstract Number: 0514 • ACR Convergence 2021
Extracellular Sulfatase-2 Mediates TNF-α Inflammatory Signaling in Human Rheumatoid Arthritis Synovial Fibroblasts
Ruby Siegel¹, Anil singh¹, Judy Vinh¹, H. Mark Kenney², Edward Schwarz³, David Fox⁴, Sadik Khuder⁵ and Salah-uddin Ahmed¹, ¹Washington State University, Spokane, WA, ²University of Rochester Medical Center, Rochester, NY, ³University of Rochester, Rochester, NY, ⁴Division of Rheumatology, University of Michigan Medical School, Ann Arbor, MI, ⁵Department of Medicine and Public Health, University of Toledo,, Toledo, OH
Background/Purpose: TNF-α drives RA synovial fibroblast (RASF)-mediated hyperplasia and joint tissue destruction. Extracellular sulfatase-2 (Sulf-2) influences receptor/ligand binding and subsequent signaling of chemokines, cytokines, and…
Abstract Number: 0552 • ACR Convergence 2021
Long Non-coding RNA H19X as a Regulator of Endothelial Adhesion Molecules in Systemic Sclerosis
Francesca Tirelli¹, Elena Pachera¹, Robert Lafyatis², Menqi Huang³, Francesco Zulian⁴, Gabriela Kania¹ and Oliver Distler⁵, ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ²University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, ⁴Rheumatology Unit, Department of Woman and Child Health - University of Padova, Padova, Italy, ⁵Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich/University of Zurich, Zurich, Switzerland
Background/Purpose: Long non-coding RNAs (lncRNAs) are non-coding transcripts involved in the regulation of gene expression; their role in disease development, to date, remains largely under…
Abstract Number: 0286 • ACR Convergence 2020
An SLE-linked ITGAM Gene Variant Changes Mac-1 Structure, Signaling, and Surface Expression and Enhances IFNg Production and Antigen Presentation by B Cells
Joseph Blake¹, Alexander Szalai², Jeffrey Edberg³ and James Mobley³, ¹UAB, Birmingham, ²University of Alabama at Birmingham, birmingham, AL, ³UAB, Birmingham, AL
Background/Purpose: SLE is a chronic and debilitating disease; in the USA with an estimated incidence of 3-10 per 100,000 people and currently affecting an estimated…
Abstract Number: 1530 • ACR Convergence 2020
Activin a and Follistatin Alter Endothelial Cell and Rheumatoid Arthritis Synovial Fibroblast Adhesion and Interaction
Helge Scholz¹, Iris Aykara¹, Klaus Frommer², Stefan Rehart³, Ulf Müller-Ladner⁴ and Elena Neumann¹, ¹Department of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus Liebig University Giessen, Bad Nauheim, Germany, ²Justus-Liebig-University Giessen, Campus Kerckhoff, Dept. of Rheumatology and Clinical Immunology, Bad Nauheim, Germany, ³Department of Orthopaedics and Trauma Surgery, Agaplesion Markus Hospital, Frankfurt, Frankfurt, Germany, ⁴Department of Rheumatology, Immunology, Osteology and Physical Medicine, Justus Liebig University Gießen, Campus Kerckhoff, Bad Nauheim, Germany, Bad Nauheim, Germany
Background/Purpose: Activin A and follistatin belong to an anti-inflammatory auto-regulatory cycle. Patients with rheumatoid arthritis (RA) have increased activin A levels in the synovial fluid…

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